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Crompton Joseph G JG National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge CB2 2QH, UK; Department of Surgery, University of California Los Angeles, Los Angeles, CA 90095, - - 2014
Regenerative medicine holds great promise in replacing tissues and organs lost to degenerative disease and injury. Application of the principles of cellular reprogramming for the treatment of cancer, however, is not well established. Here, we present an overview of cellular reprogramming techniques used in regenerative medicine, and within this context, ...
Watson Brendan M BM Department of Bioengineering, Rice University, 6500 Main Street, Houston, TX 77030, - - 2014
Disease and injury have resulted in a large, unmet need for functional tissue replacements. Polymeric scaffolds can be used to deliver cells and bioactive signals to address this need for regenerating damaged tissue. Phosphorous-containing polymers have been implemented to improve and accelerate the formation of native tissue both by mimicking ...
Wu Xiaoyan X College of Pharmaceutical Science, Nanjing University of Chinese Medicine, Nanjing, People's Republic of - - 2014
Recently, combination therapy with acupuncture and medicine as a practical strategy to treat diseases has gained increasing attention. The present study aimed to investigate whether acupuncture stimulation at ST.36 had a potential impact on the pharmacokinetics and tissue distribution of lignans. An HPLC-ESI/MS analytical method was established and successfully applied ...
Correia S I SI 3B's Research Group-Biomaterials, Biodegradables and Biomimetics, University of Minho, , Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, S. Cláudio de Barco, Taipas, Guimarães 4806-909, - - 2014
Tissue engineering and regenerative medicine (TERM) has caused a revolution in present and future trends of medicine and surgery. In different tissues, advanced TERM approaches bring new therapeutic possibilities in general population as well as in young patients and high-level athletes, improving restoration of biological functions and rehabilitation. The mainstream ...
Wang Yan - - 2013
Hydrogel system, as one of the most important biomaterials, is widely studied because of its tremendous potential in regenerative medicine conferred by its wide range of malleable biochemical and physical characteristics, which include its biocompatibility with the elemental biomolecules in vital tissues, its high water retention capability and adjustable soft-tissue-like ...
Solos Ioannis - - 2013
The ancient teacher-disciple tradition is regarded as one of the most celebrated practices within the Chinese medicine world. Such traditions of secrecy, private wisdom and honor are deeply rooted in the theories of Confucianism. This paper only explores the surface of this ancient culture, by investigating relevant popular ancient texts ...
Shang Yuezai - - 2013
Elastin-like polypeptides (ELPs) are artificial biopolymers composed of the pentapeptide repeat Val-Pro-Gly-Xaa-Gly. They are a class of stimuli responsive biopolymers exhibiting an inverse temperature transition, which are particularly attractive in biological applications. In this paper, the methods of synthesizing ELPs and the applications in medicine and biotechnology such as purification ...
Mollon Brent - - 2013
To provide a comprehensive overview of the basic science and clinical evidence behind cartilage regeneration techniques as they relate to surgical management of chondral lesions in humans. A descriptive review of current literature. Articular cartilage defects are common in orthopaedic practice, with current treatments yielding acceptable short term but inconsistent ...
Turner Neill J - - 2013
The ultimate goal of regenerative medicine is the functional restoration of lost or damaged tissues and organs. Since most tissues in man lack true regenerative properties and instead respond to injury with an inflammatory response and scar tissue formation, regenerative medicine strategies that include combinations of cells, scaffolds, and bioactive ...
Fritz Michael A - - 2013
This review describes a general approach and philosophy in the management of massive facial trauma with extensive tissue loss, with particular highlight on the role of free tissue transfer.
Monks Noel R - - 2013
A successful therapeutic strategy, specifically tailored to the molecular constitution of an individual and their disease, is an ambitious objective of modern medicine. In this report, we highlight a feasibility study in canine osteosarcoma focused on refining the infrastructure and processes required for prospective clinical trials using a series of ...
Terzic Andre A Mayo Clinic Center for Regenerative Medicine, Mayo Clinic, Rochester, MN; Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN; Department of Medical Genetics, Mayo Clinic, Rochester, MN. Electronic address: - - 2013
The pandemic of chronic diseases, compounded by the scarcity of usable donor organs, mandates radical innovation to address the growing unmet needs of individuals and populations. Beyond life-extending measures that are often the last available option, regenerative strategies offer transformative solutions in treating degenerative conditions. By leveraging newfound knowledge of ...
Grippo John O - - 2013
Abstract The objectives are to present a classification of mechanisms which can produce pathological changes in body tissues and fluids, as well as to clarify and define the term biocorrosion, which has had a singular use in engineering. Considering the emerging field of biomedical engineering, it is essential to use ...
Singh Neha - - 2013
Encephalocele is a form of neural tube defect, characterized by protrusion out of the meninges and brain tissue through a bony skull defect. As per the site of origin, these encephaloceles have been classified into different types, out of which the frontoethmoidal one is exclusively common in Southeast Asia with ...
Sekiya Sachiko - - 2013
Tissue engineering is a field of study unto itself, but in reality, it is a fusion of medicine, pharmacology, chemistry, cell biology, molecular biology and engineering. The field has been developing at an ever-increasing pace and already provides benefits to regenerative medicine in areas such as the skin and cornea. ...
Venkatraman Narayan T - - 2013
Reading a slide and rendering a diagnosis is not only a science but also requires us to appreciate the constant artifact that is introduced in a controlled manner by tissue processing and obtaining a stained tissue section. There are a number of steps involved in getting the final stained tissue ...
Simaioforidis Vasileios - - 2013
In the field of Regenerative Medicine, various types of biodegradable and non biodegradable scaffolds have been developed for urinary tract tissue engineering applications. Naturally derived or synthetic materials have been tested to determine their properties and their effectiveness. However, the majority of the current literature focuses on the reconstruction of ...
Schenke-Layland Katja - - 2013
"Strategies in Tissue Engineering": this special issue is edited by Prof. Katja Schenke-Layland and Prof. Heike Walles and covers many salient aspects of tissue engineering and regenerative medicine. The issue includes articles on Raman spectroscopy and its application in tissue engineering; bioreactor design and surface functionalization for tissue culture applications; ...
Rivera Elias A - - 2013
The accurate interpretation of histological outcomes is a critical endpoint in preclinical studies. Thus, the toxicologic pathologist plays a vital role in conducting a comprehensive microscopic evaluation that would ultimately help defining the safety and functionality in Tissue Engineering/Regenerative Medicinal (TERM) products. In spite of many advances in regenerative medicine, ...
Gittard Shaun Davis - - 2013
Two-photon polymerization has developed as a powerful tool for making micro- and nanoscale structures for regenerative medicine applications. This review discusses micro- and nanoscale aspects of tissue engineering, which are followed by a brief description of the two-photon polymerization process and how it has been used thus far in tissue ...
Salgado António J - - 2013
Tissue and organ repair still represents a clinical challenge. Tissue engineering and regenerative medicine (TERM) is an emerging field focused on the development of alternative therapies for tissue/organ repair. This highly multidisciplinary field, in which bioengineering and medicine merge, is based on integrative approaches using scaffolds, cell populations from different ...
Green Eric M EM Harvard Stem Cell Institute and the Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, - - 2013
Regenerative medicine seeks to understand tissue development and homeostasis and build on that knowledge to enhance regeneration of injured tissues. By replenishing lost functional tissues and cells, regenerative medicine could change the treatment paradigm for a broad range of degenerative and ischemic diseases. Multipotent cells hold promise as potential building ...
Drewnowska O O Department of Large Animal Medicine with Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 100, 02-797 Warsaw, Poland. - - 2013
Biomaterials originate from natural substances and are widely used in medicine. Although they have to satisfy many conditions to be useful for treatment, more and more research is carried out with new types of biomaterials that can help replace various tissues such as tendons and bones. Chitosan is a very ...
Rioux Emmanuelle - - 2012
With a worldwide incidence of 1/750 live births, facial clefts rank as the second most frequent congenital malformation. The term "sequelae" is used here to designate the conditions, which follow and are the result of labial-alveolar-palatal clefts. Most sequelae stem in fact from primary treatment and not from the initial ...
Tillman Bryan - - 2012
Cardiac and vascular diseases represent one of the most substantial medical areas for the applications of regenerative medicine. Despite advances in endovascular repair, surgical intervention and disease management, atherosclerosis and heart failure continue to be prominent health problems. This report analyzes the regenerative medicine treatment opportunities in both cardiovascular and ...
De Coppi Paolo - - 2012
Regenerative medicine has developed recently as a new field of science aiming at restoring organ and tissue damage through the use of autologous constructs. Cellular therapies and relatively simple tissue engineering reconstructions have recently been successfully applied into patients. For babies born with congenital diaphragmatic hernia, regenerative medicine may play ...
Aksel Sarp - - 2012
This report examines the implications of female genital cutting and other intra-vaginal practices for offering the TwoDay Method® of family planning.This fertility awareness-based method relies on the identification of cervicovaginal secretions to identify the fertile window. Female genital cutting and traditional vaginal practices, such as the use of desiccants, may ...
Rioux Emmanuelle - - 2012
With a worldwide incidence of 1/750 live births, facial clefts rank as the second most frequent congenital malformation. The term "sequelae" is used here to designate the conditions, which follow and are the result of labial-alveolar-palatal clefts. Most sequelae stem in fact from primary treatment and not from the initial ...
Campagner M V - - 2012
Keeping snakes in captivity to produce venom for scientific research and production of inputs is now a worldwide practice. Maintaining snakes in captivity involves capture, infrastructure investments, management techniques, and appropriate qualified personnel. Further, the success of the project requires knowledge of habitat, nutrition, and reproduction, and control of opportunistic ...
Bleger José - - 2012
The author systematises and examines the relation between theory and practice in psychoanalysis in three directions: one, eminently epistemological, which is only mentioned because it pertains not only to psychoanalysis but to all the sciences; another, the relation between theory and technique; and the third, the relation between theory and ...
Tanabe Genzoh - - 2012
With the aid of an in silico method, α-glucosidase inhibitors with far more potent activities than salacinol (), a potent natural α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata, have been developed.
Cao Gang - - 2012
The sulfur-fumigation process can induce changes in the contents of volatile compounds and the chemical transformation of herbal medicines. Although literature has reported many methods for analyzing volatile target compounds from herbal medicine, all of them are largely limited to target compounds and sun-dried samples. This study provides a comprehensive ...
Nwokediuko Sylvester Chuks - - 2012
To determine the sedation practices and preferences of Nigerian endoscopists for routine diagnostic upper gastrointestinal endoscopy. A structured questionnaire containing questions related to sedation practices and safety procedures was administered to Nigerian gastrointestinal endoscopists at the 2011 annual conference of the Society for Gastroenterology and Hepatology in Nigeria which was ...
Wang Anqi - - 2012
The power of chemical profiling in characterizing the samples' chemical pools has greatly raised the interests of phytomedicine researchers. Unfortunately, the semi-quantitative nature of chemical profiling retards its exploration into the dissolution test of herbal medicines, which is a crucial quantitative measure to evaluate and control the in vitro releasing ...
Barth Caroline - - 2012
Leukotriene B(3) and B(4) are part of an important class of signaling molecules - the leukotrienes, implicated in the inflammation process. Their pro-inflammatory effects have been widely recognized for almost three decades but it is only recently that their benefit in host defense has begun to be acknowledged. Their use ...
Kumar Nitin - - 2012
The discovery of artemisinin from Chinese medicinal plant, Artemisia annua in 1971, opened a new era in the malarial chemotherapy. This discovery was the beginning of exploring peroxides as potential replacements for the traditional antimalarial drugs such as chloroquine and mefloquine. The structurally simple class of peroxides that emerged from ...
Pierce J Matthew R - - 2012
A 29-year-old man, who recently emigrated from India, presented with a 2-week history of abdominal pain, as well as nausea, constipation, and fatigue. He underwent removal of a parathyroid adenoma 6 weeks prior to admission and received a locally made Indian traditional medicine (Ayurveda) for pain control; however, this information ...
Denholm Bonnie - - 2012
Using multidose vials Key words: multidose vials, cross contamination, single-dose vials, safe injection practices. Perioperative incremental local anesthetic injections Key words: multiple injections, safe injection practices, incremental doses, local anesthetics. Placing unsterile solutions on the sterile field Key words: safe medication practices, unsterile solutions, nonmedications, chemical solutions. Sterilizing or disinfecting ...
Li Yu-Bo - - 2012
OBJECTIVE: To investigate the effect of blood-activating Chinese medicinal compounds and water-draining Chinese medicinal compounds on tumor necrosis factor alpha (TNF-α) and nuclear factor kappaB (NF-κB) expressions in rats with intracerebral hemorrhage (ICH) at the acute stage, and to monitor their therapeutic effect and mechanism of action on inflflammation and ...
Hazekamp A - - 2012
The medicinal use of Cannabis is increasing as countries worldwide are setting up official programs to provide patients with access to safe sources of medicinal-grade Cannabis. An important question that remains to be answered is which of the many varieties of Cannabis should be made available for medicinal use. Drug ...
Chishaki Takeharu - - 2012
We investigated the effects of dehydration after a judo practice session on player muscle and immune functions. Subjects included 25 female university judoists. Investigations were performed before and after 2.5 h of regular judo practice. Body composition, serum enzymes (myogenic enzymes, immunoglobulins and complements), neutrophils counts, reactive oxygen species (ROS) production ...
Lin Chien-Ho Janice - - 2012
Practice of tasks in an interleaved order generally induces superior learning compared with practicing in a repetitive order, a phenomenon known as the contextual-interference (CI) effect. Increased neural activity during interleaved over repetitive practice has been associated with the beneficial effects of CI. Here, we used psychophysiological interaction (PPI) analysis ...
Karydis Anastasios - - 2012
Melanin is an endogenous pigment responsible for human tissue coloration of the skin, mucosa, hair, eyes and parts of the brain. In the skin, its function is protection from the harmful effects of UV radiation. Its purpose in oral tissues has not yet been determined. Oral pigmentation could be an ...
Jungong Christian S - - 2012
A practical synthesis of resveratrol 3-O-β-D-glucuronide, suitable for preparation of large quantities, was developed using selective deacetylation of resveratrol triacetate with ammonium acetate. A simplified procedure for large scale preparation of resveratrol is also reported.
Ma Bingji - - 2011
Recently a series of triterpenoids were isolated from ganoderma spores and have drawn the attention of chemists and pharmacists. The aim of this review is to summarize the triterpenoids and their bioactivities of ganoderma spores. The chemical and biological literatures of ganoderma spores dealing with the structural analysis and bioactivity ...
Matthews Kristin A - - 2011
Fluid therapy is an integral component of standard supportive care in veterinary medicine and is often given subcutaneously for ease of administration. Multiple animals may be treated by using the same bag. These bags often are used repeatedly until they are empty or until a time specified by an IACUC ...
Stoopler E T - - 2011
(i) To define the current state of oral medicine clinical practice internationally, and (ii) to make recommendations for future modeling of the practice of oral medicine. A survey was designed by an international panel of oral medicine experts to assess the current state of oral medicine practice internationally. The survey ...
Mayweg Alexander - - 2011
Medicinal chemistry is a complex science that lies at the interface of many fields of research and at the very heart of drug discovery, with property relationships based on chemical structure at its core. It is clear that the effective capture and dissemination of medicinal chemistry knowledge and experience will ...
de Zoysa Piyanjali - - 2011
For over 20 centuries, Buddhism has been the spiritual practice of the majority of Sri Lankans. Though Buddhist practices have been increasingly influencing psychotherapy in the West, the use of such practices in psychotherapy in Sri Lanka is not common. This paper attempts to bridge this gap by presenting a ...
Bhangle Samir - - 2011
In current practice, dietary interventions and over-the-counter dietary supplements, including fish oil, vitamins, and others, comprise a significant proportion of alternate therapy use. The aim of this article is to clarify the appropriate place for the use of fish oil in rheumatologic practice amid the complexities of modern management.
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