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Kennedy Robert R Barnet & Chase Farm Hospital, Department of Oral & Maxillofacial Surgery, The Ridgeway, Enfield Middlesex, EN2 8JL, United Kingdom. Electronic address: - - 2014
Tetracyclines are used to treat a range of oral conditions. Their efficacy in the treatment of periodontitis is well established, and they are authoritatively recommended in the management of avulsed teeth. There is a growing evidence base to support the use of tetracycline to treat recurrent aphthous stomatitis, but its ...
Almeida Michell O - - 2014
In the last centuries, there have been many important discoveries in medicine that were crucial for a better knowledge of several physiological processes. Molecular modeling techniques are powerful tools that have been successful used to analyze and interface medicinal chemistry studies with electrochemical experimental results. This special combination can help ...
Ingram Susan L SL Department of Neurological Surgery, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: - - 2014
The search for analgesics with fewer side effects and less abuse potential has had limited success. A recent study identifies an analgesic alkaloid compound from Corydalis yanhusuo, a traditional Chinese medicinal herb that has a surprising mechanism of action.
Zhang Xi-Ping XP The 9 Ward of Tumor Surgery Department, Zhejiang Cancer Hospital, Hangzhou, 310022, China, - - 2014
Obstructive jaundice (OJ) is classififi ed as extrahepatic OJ or intrahepatic OJ. Extrahepatic OJ is attributed to a variety of intricate etiological factors. Research has begun with Chinese medicine (CM), which can be used as an adjunctive therapy for extrahepatic OJ. Particular attention has been paid to the therapeutic effects ...
Soriano-Ursúa Marvin A MA Departamento de Fisiología and Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional , Plan de San Luis y Díaz Mirón s/n, Col. Casco de Santo Tomas, Del. Miguel Hidalgo, México City, D.F, 11340 , México +52 555 7296000 ; +52 555 7296000-Ext 62751 ; - - 2014
Introduction: Although the medicinal use of boron-containing compounds (BCCs) had long been limited to antiseptics, in the last few decades, these compounds have been used as antibiotics or chemotherapeutic agents. In the last few years, boron has been included in the moieties of many known drugs to improve their capacity ...
Larcos George S GS Nuclear Medicine and Ultrasound, Westmead Hospital, Sydney, NSW, Australia. - - 2014
To describe the incidence, type, causes and consequences of nuclear medicine maladministrations. Review of prospectively acquired maladministration reports within the Australian Radiation Incident Register (ARIR), a mandatory incident register managed by the Australian Radiation Protection and Nuclear Safety Agency. Individual reports from 2007 to 2011 were evaluated for dose of radiation exposure ...
Shastri Madhur D MD University of Tasmania, School of Pharmacy , Private Bag 26, Hobart, Tasmania , Australia +61 3 6226 1079 ; +61 3 6226 2870 ; - - 2014
Introduction: Approximately 300 million people worldwide are currently affected by asthma. Improvements in the understanding of the mechanisms involved in such inflammatory airway disorders has led to the recognition of new therapeutic approaches. Heparin, a widely used anticoagulant, has been shown to be beneficial in the management of asthma. It ...
Bonifacino Juan S JS Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: - - 2014
The field of intracellular traffic is celebrating the awarding of the 2013 Nobel Prize in Physiology or Medicine to three of its most distinguished scientists - James Rothman, Randy Schekman, and Thomas Südhof - for their discoveries on the molecular mechanisms of vesicular transport. Their outstanding achievements serve as inspiration ...
Ng Chooi Fei CF School of Mathematics and Physics, The University of Queensland, Brisbane, Queensland, Australia; Australian Research Council Centre of Excellence for Environmental Decisions, The University of Queensland, Brisbane, Queensland, Australia; National Environmental Research Program Environmental Decisions Hub, The University of Queensland, Brisbane, Queensland, - - 2014
Finding cost-effective management strategies to recover species declining due to multiple threats is challenging, especially when there are limited resources. Recent studies offer insights into how costs and threats can influence the best choice of management actions. However, when implementing management actions in the real-world, a range of impediments to ...
Guck Jochen - - 2013
A new high-throughput measurement technique moves mechanical phenotyping of cells in malignant pleural effusions closer to the clinic (Tse et al., this issue).
Barbosa Naiara S NS Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55901, USA. Electronic address: - - 2014
Complementary and alternative medicine (CAM) is a group of non-traditional medical practices that includes natural products, manipulations, and mind and body medicine. CAM use has grown and become popular among patients. In dermatology, honey, green tea, and vitamin C have been used as topical treatments for a variety of diseases. ...
Riley Paul - - 2013
Purpose Because physician knowledge of patient exposure to ionizing radiation from computed tomography (CT) procedures previously has been recognized as poor, the purpose of this systematic review is to determine whether physician or physician trainee knowledge of patient exposure to radiation from nuclear medicine procedures is similarly insufficient. Methods Online ...
Sienkiewicz Zenon - - 2013
An international workshop brought together a range of stakeholders to consider protection from non-ionizing radiation used in medicine, research and cosmetics. Presentations on specific topics were followed by a general discussion on possible improvements in protection. Participants considered that adherence to science-based, harmonized exposure guidelines to limit exposures for clinical ...
Utter Garth H - - 2013
Clinicians place chest tubes approximately 1 million times each year in the United States, but little information is available to guide their management. Specifically, use of the rate of pleural fluid drainage as a criterion for tube removal is not standardized. Absent such tubes, pleural fluid drains primarily through parietal ...
Ernst Sabine - - 2013
This review attempts to give practical advice for invasive electrophysiologists on personal radiation protection. Applying all measures of the "As low as reasonably achievable" ALARA concept should be a daily and indeed routine practice for all staff in the electrophysiology laboratory. A substantial number of technical options have been recently ...
Piscitelli Marina A - - 2013
Cetaceans possess diverse adaptations in respiratory structure and mechanics that are highly specialized for an array of surfacing and diving behaviors. Some of these adaptations and air management strategies are still not completely understood despite over a century of study. We have compiled the historical and contemporary knowledge of cetacean ...
Hagerman Shannon M - - 2013
A major challenge facing conservation experts is how to adapt biodiversity planning and practice to the impacts of climate change. To date, most commonly advocated adaptation actions mirror conventional approaches (e.g. protected areas) despite decades of concern regarding their efficacy and widespread discussion of less conventional, interventionist actions. This survey ...
Yarmohammadi Hassan - - 2013
Since antiquity, heart function and the mechanism of blood circulation within the human body have been the focus of attention of scientists from different parts of the world. Over the passage of time, the theories and works of these scientists have resulted in the achievement of today's knowledge of circulation. ...
Partonen Timo - - 2013
Our understanding on the functions of circadian clocks has deepened at a pace in recent years. Elucidation of the mechanisms of action might pave the way to a range of interventions of use in clinical practice in many fields of medicine.
Heale Margaret - - 2013
Managing a stoma with persistent output presents challenges for both the WOC nurse and the patient. Traditional approaches are not always effective. Presenting a new and different way to assist people with pouching in such circumstances or when they have dexterity or visual problems, increases the options at our disposal ...
Mi Xue-Song - - 2013
Progressive loss of retinal ganglion cells (RGCs) and their axons is the main pathogenesis of glaucoma. The cause of glaucoma is not fully understood, but the neurodegeneration of glaucoma involves many mechanisms such as oxidative stress, glutamate toxicity and ischemia/reperfusion insult. In order to target these mechanisms, multiple neuroprotective interventions ...
Georgakopoulou Ea - - 2013
Systemic non-biological agents (NBAs) have been extensively used for immunosuppression in clinical medicine, often with considerable efficacy, although sometimes accompanied with adverse effects as with all medicines. With the advent of biological agents, all of which currently are restricted to systemic use, there is a rising need to identify which ...
Li Xiaoming - - 2013
As a dynamic and hierarchically organized composite, native extracellular matrix (ECM) not only supplies mechanical support which the embedded cells needs but also regulates the functions of various cellular through interaction with them. Based on the ECM-mimetic principle, good biocompatibility and appropriate mechanical properties are the two basic requirements that ...
Samrao Aman - - 2013
Actinic (solar) keratoses (AK) have the potential for malignant transformation and are the second most common diagnosis in dermatologic practices. No well-established clinical criteria are available to determine which AK are more likely to undergo malignant transformation; therefore, many dermatologists utilize field-directed approaches to treat all visible and subclinical AK ...
Piwowarska-Bilska Hanna - - 2013
The appropriate radiation protection measures applied in departments of nuclear medicine should lead to a reduction in doses received by the employees. During 1991-2007, at the Department of Nuclear Medicine of Pomeranian Medical University (Szczecin, Poland), nurses received on average two-times higher (4.6 mSv) annual doses to the whole body ...
Loros Jennifer - - 2013
Book review of Neurospora Genomics and Molecular Biology (Durgadas P. Kasbekar and Kevin McCluskey). Durgadas Kasbekar and Kevin McCluskey have edited an engaging new book called Neurospora Genomics and Molecular Biology on the scientific contributions of Neurospora crassa, the model system made famous with George Beadle and Edward Tatum's 1958 ...
Shorter Edward - - 2013
This paper demonstrates that in the treatment of psychiatric disorders, there are striking similarities between the mechanisms of psychoactive agents used in Traditional Chinese Medicine (TCM) and those of western psychopharmacology. While western researchers search for new treatments and novel mechanisms of action, investigators in Asia are analyzing traditional remedies ...
Moens Yves - - 2013
The mechanical ventilation of horses during anesthesia remains a crucial option for optimal anesthetic management, if the possible negative cardiovascular side effects are managed, because this species is prone to hypercapnia and hypoxemia. The combined use of capnography and pitot-based spirometry provide complementary information on ventilation and respiratory mechanics, respectively. ...
Robinson Clive - - 2013
Existing therapies for allergic asthma are far from perfect: the global prevalence of disease increases despite them and they are poorly effective in dealing with the exacerbations that account for hospitalization and asthma deaths. Commercially, there are pressures on these existing medicines too - a growing threat from generics and ...
Bylka Wiesława W Department of Pharmacognosy, Poznan University of Medical Sciences, Poland. Head: Prof. Irena - - 2013
Centella asiatica known as Gotu Kola is a medicinal plant that has been used in folk medicine for hundreds of years as well as in scientifically oriented medicine. The active compounds include pentacyclic triterpenes, mainly asiaticoside, madecassoside, asiatic and madecassic acids. Centella asiatica is effective in improving treatment of small ...
Kerai Sukhyanti - - 2013
The Montgomery silicone t-tube used for post-procedural tracheal stenosis has advantage of acting as both stent and tracheostomy tube. The anesthetic management of patient with t-tube in situ poses a challenge. Safe management of such patients requires careful planning. We describe anesthetic management for direct laryngoscopy of a patient with ...
Satoh Hiroyasu - - 2013
Herbal medicine in Japan is termed as Kampo medicine, which is derived from traditional Chinese medicine. Shakuyakukanzoto (Shao-Yao-Gan-Cao-Tang) as a kind of Kampo formulations is composed of just two components; Paeoniae Radix and Glycyrrhizae Radix, which produced marked relaxation of intestinal tract. Mokuboito (Mu-Fang-Ji-Tang) inhibited cardiac ionic channel currents, and ...
Zheng Zhan - - 2013
This paper is a systematic review of evidence-based studies of the effectiveness of Chinese herbal medicine (CHM) in the treatment of liver cancer. After a detailed analysis of the literature, five animal studies and four human clinical trials met the criteria for inclusion. Analysis revealed that results of the clinical ...
Yi B Alexander - - 2013
The past few years have seen unexpected new developments in direct cardiomyocyte reprogramming. Direct cardiomyocyte reprogramming potentially offers an entirely novel approach to cardiovascular regenerative medicine by converting cardiac fibroblasts into functional cardiomyocytes in situ. There is much to be learned, however, about the mechanisms of direct reprogramming in order ...
Wang Linli - - 2013
Chinese medicine has evolved from thousands of years of empirical applications and experiences of combating diseases. It has become widely recognized that the Chinese medicine acts through complex mechanisms featured as multicompound, multitarget and multipathway. However, there is still a lack of systematic experimental studies to elucidate the mechanisms of ...
Hanauer Stephen B - - 2013
As we enter into the era of 'personalized medicine', many of the recommendations of 'evidence-based medicine' require scrutiny and adaptation to optimize individual outcomes. Several examples of these discrepancies are exemplified by the topics of aminosalicylate use in Crohn's disease, early use of biologic agents that target TNF and the ...
de la Cruz Michael - - 2013
Mid-tracheal, postintubation stenosis can be managed with an extended length tracheostomy tube to bypass the stenotic area. However these extra-long tracheostomy tubes are not fenestrated, and when the stenotic tracheal lumen sits against the tracheostomy tube, phonation is not possible as there is no translaryngeal airflow. A 59-year-old man developed ...
Shimizu Tadamichi T 0000-0002-3231-0279 Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, - - 2013
Atopic dermatitis (AD) is a common inflammatory skin disease with recurring episodes of itching and a chronic relapsing course. Current treatment options for AD include topical agents, such as topical corticosteroids and oral antiallergic drugs. Providing effective long-term treatment is sometimes difficult due to the chronic, relapsing nature of AD; ...
Hansen J J Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York, New York, New York, - - 2013
Over the past 50 years, like molecular cell biology, medicine and pharmacology have been driven by a reductionist approach. The focus on individual genes and cellular components as disease loci and drug targets has been a necessary step in understanding the basic mechanisms underlying tissue/organ physiology and drug action. Recent ...
Sun Z - - 2012
Rapid technological developments in medicine have taken place in the Asia-Pacific region over the last decades. Radiology, in particular, has seen enormous growth with the latest medical equipment and practices being commonplace in this region. The use of radiation in medicine must be carefully considered with regard to the potential ...
Deng Liping - - 2012
This review summarizes the progress that has been made recently in the medicinal chemistry of cantharidin, a potent antitumor agent from traditional Chinese medicine. Thousands of analogues have been synthesized on the basis of cantharidin, a part of which show excellent properties, in particular, norcantharidin and norcantharimide. Despite the enormous ...
Lonsdale M N - - 2012
Two scientific committees (physics & dosimetry) of the European Association of Nuclear Medicine (EANM) commented on the draft 'Radiation Protection 162: radiation criteria for acceptability of radiological equipment used in diagnostic radiology, nuclear medicine and radiotherapy' (RP 162). This document updates and extends the acceptability criteria mentioned in 'Radiation Protection ...
Beaulieu Michele J - - 2012
This article reviews the history of hyaluronidase, contributing factors that predispose neonates to peripheral intravenous (IV) infiltration; terms associated with infiltration and extravasation; the mechanism of action of hyaluronidase; staging and treatment of extravasated tissue, along with the economic cost and liability associated with IV infiltrates.
Clarke Brendan - - 2012
According to current hierarchies of evidence for EBM, evidence of correlation (e.g., from RCTs) is always more important than evidence of mechanisms when evaluating and establishing causal claims. We argue that evidence of mechanisms needs to be treated alongside evidence of correlation. This is for three reasons. First, correlation is ...
Waghmare Chaitali Manohar - - 2012
Radiation burn can occur with diagnostic or therapeutic use of ionizing radiation. A nonintentional radiation burn is relatively uncommon. Skin has a specific tolerance to radiation, above which different grades of radiation burn can occur. Being a rare and less studied problem, no precise guideline is present for its management. ...
Andersen Holly - - 2012
Even though the evidence-based medicine (EBM) movement labels mechanisms a low quality form of evidence, consideration of the mechanisms on which medicine relies, and the distinct roles that mechanisms might play in clinical practice, offers a number of insights into EBM itself. In this paper, I examine the connections between ...
Bonanno Fabrizio Giuseppe - - 2012
A shift of approach from 'clinics trying to fit physiology' to the one of 'physiology to clinics', with interpretation of the clinical phenomena from their physiological bases to the tip of the clinical iceberg, and a management exclusively based on modulation of physiology, is finally surging as the safest and ...
Vañó E - - 2012
Committee 3 of the International Commission on Radiological Protection (ICRP) is concerned with protection in medicine, and develops recommendations and guidance on the protection of patients, staff, and the public against radiation exposure in medicine. This paper presents an overview of the work of Committee 3 over recent years, and ...
Macchi V - - 2012
Tullio Terni (1888-1946) was a brilliant anatomist in the School of Medicine of Padova, Italy. He was a versatile scientist who gave fundamental and pioneering contributions in descriptive and experimental cytology, human and comparative morphogenesis, neuroanatomy, embryology and teratology, and regenerative biology. His most famous discovery, which bears his name, ...
- - 2012
This issue of Macromolecular Bioscience contains articles of the Special Series "Advanced Polymers in Stem Cell Biology & Medicine".
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