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Massarotti Alberto A Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale "A. Avogadro", L.go Donegani 2, 28100 Novara (Italy). - - 2014
Over the last decade, 1,2,3-triazoles have received increasing attention in medicinal chemistry thanks to the discovery of the highly useful and widely applicable 1,3-dipolar cycloaddition reaction between azides and alkynes (click chemistry) catalyzed by copper salts and ruthenium complexes. After a decade of medicinal chemistry research on 1,2,3-triazoles, we feel ...
Jimenez Francisco F Mediteknia Dermatology Clinic. Las Palmas de Gran Canaria, - - 2014
Clinicians have long reported that hair-bearing areas tend to heal more rapidly than those lacking hair follicles. In the past decade, numerous scientific studies have corroborated clinical evidence, showing a direct nexus between the human hair follicle and the wound healing process. The migration of epithelial follicular stem cells to ...
McGuigan Moira M 52 Newlands Road, Glasgow G43 2JG, Lanarkshire, Scotland, UK. Electronic address: - - 2014
Samuel Hahnemann described incidences where the homeopathic response was disrupted by noxious smells in the environment. An earlier paper proposed that homeopathic medicines may be sensed by vomeronasal cells (VNCs) i.e. microvillus or brush cells in the vomeronasal organ (VNO), the taste buds and associated with the trigeminal nerve and ...
Zhao Qi-Tao QT School of Basic Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. Electronic address: - - 2014
To improve the function of endothelial progenitor cells (EPCs) is one of the goals in Chinese traditional therapy to treat various cardio-celebrovascular diseases. In the past decades, scholars in the field of traditional Chinese medicine (TCM) have found fifteen active compounds to regulate the function of EPC. These metabolites are ...
Owaki Toshiyuki T Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women's Medical University, Tokyo, - - 2014
Substantial progress made in the areas of stem cell research and regenerative medicine has provided a number of innovative methods to repair or regenerate defective tissues and organs. Although previous studies regarding regenerative medicine, especially those involving induced pluripotent stem cells, have been actively promoted in the past decade, there ...
Lopez M J MJ Laboratory for Equine and Comparative Orthopedic Research, Equine Health Studies Program, Department of Veterinary Clinical Sciences, Louisiana State University, Baton Rouge, LA 70803, - - 2014
According to Greek mythology, Prometheus' liver grew back nightly after it was removed each day by an eagle as punishment for giving mankind fire. Hence, contrary to popular belief, the concept of tissue and organ regeneration is not new. In the early 20(th) century, cell culture and ex vivo organ ...
Laptev D S DS Laboratory of Blood Cryophysiology, Institute of Physiology, Komi Research Center, Ural Division of the Russian Academy of Sciences, Syktyvkar, - - 2014
We studied the possibility of cryopreservation of human blood nuclear cells under protection with inert gas xenon. A method for inducing clathrate anabiosis of leukocytes was developed that preserved the cells for practical use in biology and medicine.
Sánchez-Espejo Rita R Andalusian Institute of Earth Sciences, CSIC-University of Granada, Avda. de las Palmeras 4, 18100, Armilla, Granada, - - 2014
Clays are naturally occurring ingredients of many natural health products, being included in most of ancient Mediterranean/European medical texts and currently used to prepare therapeutic hot-muds (peloids) in several thermal stations of the Mediterranean region. Clays are included in the formulation of peloids as vehicles of the mineral-medicinal water, to ...
Fratila Raluca M - - 2014
The field of nanotechnology applied to medicine (nanomedicine) is developing at a fast pace and is expected to provide solutions for early diagnosis, targeted therapy and personalized medicine. However, designing nanomaterials for biomedical applications is not a trivial task. Avoidance of the immune system, stability in physiological media, control over ...
Bahramsoltani Roodabeh R Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, - - 2014
Burn wound healing is a complicated process including inflammation, re-epithelialization, granulation, neovascularization and wound contraction. Several biochemicals are involved in burn healing process including antioxidants, cytokines and liver and kidney damage biomarkers. Although several preparations are available for the management of burn wound, there is still a necessity of researching ...
Calzone Laurence L Institut Curie, 26 rue d'Ulm, 75248 Paris, France, INSERM U900, 75248 Paris, France, Mines ParisTech, 77300 Fontainebleau, - - 2014
Precision medicine in oncology is becoming reality thanks to the next-generation sequencing of tumours and the development of targeted inhibitors enabling tailored therapies. Many clinical trials base their strategy on the identification of mutations to deliver the targeted inhibitor that counteract supposedly the effect of a mutated gene. Recent results ...
Tatullo Marco M Tecnologica Research Institute, Regenerative Medicine Section, St. E. Fermi, Crotone, - - 2014
Dental pulp stem cells (DPSCs) are a promising source of cells for numerous and varied regenerative medicine applications. Their natural function in the production of odontoblasts to create reparative dentin support applications in dentistry in the regeneration of tooth structures. However, they are also being investigated for the repair of ...
Matsuura Katsuhisa K Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku, Tokyo 162-8666, Japan; Department of Cardiology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku, Tokyo 162-8666, Japan. Electronic address: - - 2014
After the biotech medicine era, regenerative medicine is expected to be an advanced medicine that is capable of curing patients with difficult-to-treat diseases and physically impaired function. Our original scaffold-free cell sheet-based tissue engineering technology enables transplanted cells to be engrafted for a long time, while fully maintaining their viability. ...
Tseng Yen-Hsun YH Department of Chemical - - 2014
Nanoscale characterization tools hold the potential to overcome long-standing medicinal and pharmaceutical challenges. For example, electrospray differential mobility analysis (ES-DMA) is an emerging tool that rapidly provides label-free multimodal size distributions for proteins and particles from ~1nm to <500nm with subnanometer precision. Here we critically review the contributions of this ...
Mak Shinghung S Division of Life Science, Center for Chinese Medicine and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong, - - 2014
Alzheimer's disease is a multi-factorial neurodegenerative disorder devastatingly affecting the aged population worldwide. Previous studies have shown that medicinal herbs used in traditional Chinese medicine might be benefit to Alzheimer's disease patients. Berberine and palmatine, two isoquinoline alkaloids found in several medicinal herbs, were used for memory enhancement in China. ...
Pattini Linda - - 2014
Heart failure (HF) is a complex syndrome which can be the exit of different etiologies which lead to a common clinical picture. Treatment outcome is modest and new insights into pathophysiology are needed to improve effectively diagnosis, prognosis, and therapy. As a complex disease, it can really benefit from the ...
Rubbiani Riccardo R Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstraße 55, 38106, Braunschweig, - - 2014
The medicinal chemistry and biomedical applications of gold complexes have been intensively studied over the last decades. Some complexes have been used for the treatment of rheumatoid arthritis, and a considerable number of new metallodrug candidates have been developed as new anticancer drugs and anti-infectives. However, the therapeutic use of ...
Iwayama Daisuke D Hitachi, Ltd., Tokyo, Japan; Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, - - 2014
When conducting clinical studies of regenerative medicine, compliance to good manufacturing practice (GMP) is mandatory, and thus much time is needed for manufacturing and quality management. It is therefore desired to introduce the manufacturing execution system (MES), which is being adopted by factories manufacturing pharmaceutical products. Meanwhile, in manufacturing human ...
Phan Chia-Wei CW Mushroom Research Centre, Institute of Biological Sciences, Faculty of Science, University of Malaya , Kuala Lumpur , Malaysia - - 2014
Abstract Mushrooms have long been used not only as food but also for the treatment of various ailments. Although at its infancy, accumulated evidence suggested that culinary-medicinal mushrooms may play an important role in the prevention of many age-associated neurological dysfunctions, including Alzheimer's and Parkinson's diseases. Therefore, efforts have been ...
Chen Jian-Bo JB Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, - - 2014
Microscopic identification using optical microscopes is a simple and effective method to identify powdered traditional medicines made from plants, animals and fungi. Sometimes, the criteria based on physical properties of the microscopic characteristics of drug powder may be ambiguous, which makes the microscopic identification method subjective and empirical to some ...
Mekhail Mina M Biomedical Engineering, Duff Medical Building, Room 313, McGill, Montreal, H3A 2B4, - - 2014
Injectable scaffolds (IS) are polymeric solutions that are injected in vivo and undergo gelation in response to physiological or non-physiological stimuli. Interest in using IS in regenerative medicine has been increasing this past decade. IS are administered in vivo using minimally invasive surgery, which reduces hospitalization time and risk of ...
Forsythe Peter P The Dermatology Referral Service, 528 Paisley Road West, Glasgow G51 1RN, - - 2014
Ciclosporin is a lipophilic cyclic polypeptide with powerful immunosuppressive and immunomodulatory properties that has been used in veterinary medicine for two decades. It is a calcineurin inhibitor whose principal mode of action is to inhibit T cell activation. The drug is principally absorbed from the small intestine and is metabolised ...
Brose Nils N Max Planck Institute of Experimental Medicine, Department of Molecular Neurobiology, Hermann-Rein-Straße 3, 37075 Göttingen, Germany. Electronic address: - - 2014
Numerous metaphors have been employed to describe the achievements of the 2013 Nobel Laureates in Physiology or Medicine, James E. Rothman, Randy W. Schekman, and Thomas C. Südhof, who were honored for "their discoveries of machinery regulating vesicle traffic, a major transport system in our cells." Most of these metaphors ...
Liu Peng P State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, - - 2014
To identify bioactive equivalent combinatorial components (BECCs) in herbal medicines. The exact composition of effective components in herbal medicines is often elusive due to the lack of adequate screening methodology. Herein, we propose a hypothesis that BECCs accounting for the whole efficacy of original herbal medicines could be discovered from ...
Lim Chiao Yuen CY Division of Respiratory and Critical Care Medicine, National University Hospital, Singapore, - - 2014
A middle-aged Indian woman with knee pain had consumed ayurvedic medicine (Ostolief and Arthrella tablets) daily for 6 months. She presented to the respiratory clinic with worsening dyspnea, cough and weight loss of 2 months' duration. She was a homemaker, never-smoker and did not keep birds. Physical examination detected fine ...
Wu Rui-Bo RB School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of - - 2014
Aristoyunnolins G () and H (), two new diastereoisomeric sesquiterpenes featuring a rare aristophyllene skeleton, were isolated from the traditional Chinese medicine Aristolochia yunnanensis. Their absolute stereochemistry involving three chiral centers was determined by combined chemical, spectral, and Density Functional Theory (DFT) calculation methods. Chirality 00:000-000, 2014. © 2014 Wiley ...
Boekhoven Job J Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, Illinois, - - 2014
In supramolecular materials, molecular building blocks are designed to interact with one another via non-covalent interactions in order to create function. This offers the opportunity to create structures similar to those found in living systems that combine order and dynamics through the reversibility of intermolecular bonds. For regenerative medicine there ...
Barnes-Seeman David - - 2014
In recent years, several new fluorinated functional groups have been employed in medicinal chemistry. This review will highlight some recent developments in this area. We draw attention to useful synthetic advances for the installation of fluorine-containing groups. In addition, we examine the application of some fluorinated functional groups that have ...
Zhou Yubo Y College of Chemistry and Chemical Engineering, Shaoxing University, West of Ring Road 508, Shaoxing 312000, China. Electronic address: - - 2014
Studies on in vitro bioaccessibility and safety assessment of 6 elements namely Fe, Zn, Cu, Mn, As and Cd in decoction of eight commonly consumed "Zhebawei" herbal medicines were carried out. The method was based on simulation of human digestion in the gastrointestinal tract. Total content and content in extracts ...
Qin Jing J Department of Pharmaceutics, School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, Fudan University, Shanghai, - - 2014
This study was performed to investigate the influence of traditional Chinese medicines in the Zhenju antihypertensive compound (ZJAHC) on the oral absorption of hydrochlorothiazide (HCT) both in vitro and in vivo. Caco-2 cells and the in situ closed loop system were used to investigate the possible mechanism of the Chinese-Western ...
Ali Robin R RR UCL Institute of Ophthalmology, Bath St, London EC1V 9EL, - - 2014
Those working in the regenerative medicine field currently face numerous regulatory and related challenges. This Perspective captures some of the key ideas of a UK-based working group drawn from academic, clinical and industrial communities and also identifies some key steps that should be taken in the UK and elsewhere to ...
Kubo Miwa M Faculty of Pharmaceutical Sciences, Tokushima Bunri - - 2014
A new spiroindene pigment, phelliribsin A, was isolated from the medicinal fungus Phellinus ribis, and its structure was determined by two dimensional (2D)-NMR methods. Phelliribsin A is an unprecedented spiroindene compound, and was found to have cytotoxic activity against PC12 cells at a concentration of 30 µM.
Miyazaki Yasunori Y Department of Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of - - 2014
We introduced the application of a planetary centrifugal mixer to dispensing powdered medicines to prevent from individual variation in the skills of pharmacists with a manual blending. The blending performance of the mixer was explored in terms of four operational variables, namely, operation speed (400-1000 rpm), operation time (10-60 s), charging rate ...
Helfer Markus M Institute of Virology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, - - 2014
Global HIV-1 treatment would benefit greatly from safe herbal medicines with scientifically validated novel anti-HIV-1 activities. The root extract from the medicinal plant Pelargonium sidoides (PS) is licensed in Germany as the herbal medicine EPs®7630, with numerous clinical trials supporting its safety in humans. Here we provide evidence from multiple ...
Jang Shih-Fan SF School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei 11221, Taiwan. - - 2014
In recent decades, nanotechnology has attracted major interests in view of drug delivery systems and therapies against diseases, such as cancer, neurodegenerative diseases, and many others. Nanotechnology provides the opportunity for nanoscale particles or molecules (so called "Nanomedicine") to be delivered to the targeted sites, thereby, reducing toxicity (or side ...
Casaroli-Marano Ricardo P RP Department of Surgery, School of Medicine, University of Barcelona, Barcelona, - - 2014
Rapid development in the fields of cellular and molecular biology, biotechnology, and bioengineering medicine has brought new, highly innovative treatments and medicinal products, some of which contain viable cells and tissues associated with scaffolds and devices. These new cell-based therapy approaches in regenerative medicine have great potential for use in ...
Miyazaki Yasunori Y Department of Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of - - 2014
  On dispensing powdered antineoplastic medicines, it is important to prevent cross-contamination and environmental exposure. Recently, we developed a method for blending powdered medicine in a disposable ointment container using a planetary centrifugal mixer. The disposable container prevents cross-contamination. In addition, environmental exposure associated with washing the apparatus does not arise ...
Miyazaki Yasunori Y Department of Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of - - 2014
We developed a color difference signal method to evaluate the degree of blending powdered medicines in pharmacies. In the method, the degree of blending is expressed as the relative standard deviation of the color difference signal value (Cb or Cr) of the YCbCr color space after digital photos of the ...
Crapanzano John P JP Address: Department of Pathology and Cell Biology, Columbia University Medical Center, New York-Presbyterian Hospital, New York, NY, - - 2014
In the recent past, algorithms and recommendations to standardize the morphological, immunohistochemical and molecular classification of lung cancers on cytology specimens have been proposed, and several organizations have recommended cell blocks (CBs) as the preferred modality for molecular testing. Based on the literature, there are several different techniques available for ...
Joshi Kalpana S KS Department of Biotechnology, Sinhgad College of Engineering, University of Pune, Maharashtra, - - 2014
Ayurveda, the traditional Indian system of medicine has given great emphasis to the promotion of health. Ayurveda therapies are based on restoration of body balance and nourishment of dhatus or tissues. Rasayana concept of Ayurveda explains tissue regeneration and cell renewal. The drugs and therapies explained as rasayana provide research ...
Kunjadia Prashant D PD Department of Biotechnology, M. B. Patel Science College, Anand, India; B. N. Patel Institute of Paramedical and Science, - - 2014
Oyster mushrooms, species of the genus Pleurotus, are recognized for producing secondary metabolites with important medicinal properties. Investigations were carried out to evaluate the antioxidative and antimicrobial properties of the edible mushroom Pleurotus ostreatus (MTCC142) extracts cultivated on banana agrowastes. Ethanolic extracts showed antimicrobial activities against gram-positive and gram-negative bacteria, ...
Wong Kam Lok KL School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong Special Administrative Region, - - 2014
Some protein pharmaceuticals from Chinese medicine have been developed to treat cardiovascular diseases, genetic diseases, and cancer. Bioactive proteins with various pharmacological properties have been successfully isolated from animals such as Hirudo medicinalis (medicinal leech), Eisenia fetida (earthworm), and Mesobuthus martensii (Chinese scorpion), and from herbal medicines derived from species ...
Shen Bojiang - - 2013
Age is the leading risk factor for acute and chronic neurodegenerative diseases. The Shen Nong Ben Cao Jing, the oldest known compendium of Chinese materia media, lists herbal medicines that were believed to exert neither fast acting pharmacological effects nor discernible toxicity, but to promote general health and longevity. In ...
Sadrozinski Hartmut F-W - - 2013
Selected particle detectors are described which find an application in medicine and have been the topic of presentations at the 2013 Vienna Conference of Instrumentation (VCI).
Fu Lina L National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, - - 2013
A major challenge in regenerative medicine is the generation of functionally effective target cells to replace or repair damaged tissues. Transdifferentiation in vivo is a novel strategy to achieve cell fate conversion within the native physiological niche; this technology may provide a time- and cost-effective alternative for applications in regenerative ...
Zachariades Nicholas A NA Duane Morris LLP , Boca Raton, - - 2013
Abstract The topic of stem cells for use in regenerative medicine, especially embryonic stem cells, inspires much debate, discussion, and outrage as it slices through the very core moral values of society. These social and moral issues have, in turn, resulted in government policies that have influenced the study of ...
Webster William D WD Department of Engineering, University of Cambridge, Cambridge, CB2 1PZ, United Kingdom. Electronic address: - - 2013
The field of nuclear medicine is reliant on radionuclides for medical imaging procedures and radioimmunotherapy (RIT). The recent shut-downs of key radionuclide producers have highlighted the fragility of the current radionuclide supply network, however. To ensure that nuclear medicine can continue to grow, adding new diagnostic and therapy options to ...
Hudak Jason E - - 2013
The beginning of the 20(th) century marked the dawn of modern medicine with glycan-based therapies at the forefront. However, glycans quickly became overshadowed as DNA- and protein-focused treatments became readily accessible. The recent development of new tools and techniques to study and produce structurally defined carbohydrates has spurred renewed interest ...
Lu Baisong - - 2013
Regenerative medicine is an emerging, multidisciplinary science that aims to replace or regenerate human cells, tissues or organs, to restore or establish normal function. Research on small molecules and small molecule drugs in regenerative medicine is currently increasing. In this review, we discuss the potential applications of small molecules and ...
Thompson J G - - 2013
The history of in vitro maturation (IVM) of mammalian oocytes, especially of human oocytes, holds a special place for Robert Edwards. He was the first to comprehensively examine and demonstrate maturation of human oocytes in vitro and in so doing he changed the course of medicine by fertilizing them in ...
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