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Rubbiani Riccardo R Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstraße 55, 38106, Braunschweig, - - 2014
The medicinal chemistry and biomedical applications of gold complexes have been intensively studied over the last decades. Some complexes have been used for the treatment of rheumatoid arthritis, and a considerable number of new metallodrug candidates have been developed as new anticancer drugs and anti-infectives. However, the therapeutic use of ...
Iwayama Daisuke D Hitachi, Ltd., Tokyo, Japan; Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, - - 2014
When conducting clinical studies of regenerative medicine, compliance to good manufacturing practice (GMP) is mandatory, and thus much time is needed for manufacturing and quality management. It is therefore desired to introduce the manufacturing execution system (MES), which is being adopted by factories manufacturing pharmaceutical products. Meanwhile, in manufacturing human ...
Phan Chia-Wei CW Mushroom Research Centre, Institute of Biological Sciences, Faculty of Science, University of Malaya , Kuala Lumpur , Malaysia - - 2014
Abstract Mushrooms have long been used not only as food but also for the treatment of various ailments. Although at its infancy, accumulated evidence suggested that culinary-medicinal mushrooms may play an important role in the prevention of many age-associated neurological dysfunctions, including Alzheimer's and Parkinson's diseases. Therefore, efforts have been ...
Chen Jian-Bo JB Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, - - 2014
Microscopic identification using optical microscopes is a simple and effective method to identify powdered traditional medicines made from plants, animals and fungi. Sometimes, the criteria based on physical properties of the microscopic characteristics of drug powder may be ambiguous, which makes the microscopic identification method subjective and empirical to some ...
Mekhail Mina M Biomedical Engineering, Duff Medical Building, Room 313, McGill, Montreal, H3A 2B4, - - 2014
Injectable scaffolds (IS) are polymeric solutions that are injected in vivo and undergo gelation in response to physiological or non-physiological stimuli. Interest in using IS in regenerative medicine has been increasing this past decade. IS are administered in vivo using minimally invasive surgery, which reduces hospitalization time and risk of ...
Forsythe Peter P The Dermatology Referral Service, 528 Paisley Road West, Glasgow G51 1RN, - - 2014
Ciclosporin is a lipophilic cyclic polypeptide with powerful immunosuppressive and immunomodulatory properties that has been used in veterinary medicine for two decades. It is a calcineurin inhibitor whose principal mode of action is to inhibit T cell activation. The drug is principally absorbed from the small intestine and is metabolised ...
Liu Peng P State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, - - 2014
To identify bioactive equivalent combinatorial components (BECCs) in herbal medicines. The exact composition of effective components in herbal medicines is often elusive due to the lack of adequate screening methodology. Herein, we propose a hypothesis that BECCs accounting for the whole efficacy of original herbal medicines could be discovered from ...
Brose Nils N Max Planck Institute of Experimental Medicine, Department of Molecular Neurobiology, Hermann-Rein-Straße 3, 37075 Göttingen, Germany. Electronic address: - - 2014
Numerous metaphors have been employed to describe the achievements of the 2013 Nobel Laureates in Physiology or Medicine, James E. Rothman, Randy W. Schekman, and Thomas C. Südhof, who were honored for "their discoveries of machinery regulating vesicle traffic, a major transport system in our cells." Most of these metaphors ...
Lim Chiao Yuen CY Division of Respiratory and Critical Care Medicine, National University Hospital, Singapore, - - 2014
A middle-aged Indian woman with knee pain had consumed ayurvedic medicine (Ostolief and Arthrella tablets) daily for 6 months. She presented to the respiratory clinic with worsening dyspnea, cough and weight loss of 2 months' duration. She was a homemaker, never-smoker and did not keep birds. Physical examination detected fine ...
Wu Rui-Bo RB School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of - - 2014
Aristoyunnolins G () and H (), two new diastereoisomeric sesquiterpenes featuring a rare aristophyllene skeleton, were isolated from the traditional Chinese medicine Aristolochia yunnanensis. Their absolute stereochemistry involving three chiral centers was determined by combined chemical, spectral, and Density Functional Theory (DFT) calculation methods. Chirality 00:000-000, 2014. © 2014 Wiley ...
Boekhoven Job J Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, Illinois, - - 2014
In supramolecular materials, molecular building blocks are designed to interact with one another via non-covalent interactions in order to create function. This offers the opportunity to create structures similar to those found in living systems that combine order and dynamics through the reversibility of intermolecular bonds. For regenerative medicine there ...
Barnes-Seeman David - - 2014
In recent years, several new fluorinated functional groups have been employed in medicinal chemistry. This review will highlight some recent developments in this area. We draw attention to useful synthetic advances for the installation of fluorine-containing groups. In addition, we examine the application of some fluorinated functional groups that have ...
Zhou Yubo Y College of Chemistry and Chemical Engineering, Shaoxing University, West of Ring Road 508, Shaoxing 312000, China. Electronic address: - - 2014
Studies on in vitro bioaccessibility and safety assessment of 6 elements namely Fe, Zn, Cu, Mn, As and Cd in decoction of eight commonly consumed "Zhebawei" herbal medicines were carried out. The method was based on simulation of human digestion in the gastrointestinal tract. Total content and content in extracts ...
Qin Jing J Department of Pharmaceutics, School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, Fudan University, Shanghai, - - 2014
This study was performed to investigate the influence of traditional Chinese medicines in the Zhenju antihypertensive compound (ZJAHC) on the oral absorption of hydrochlorothiazide (HCT) both in vitro and in vivo. Caco-2 cells and the in situ closed loop system were used to investigate the possible mechanism of the Chinese-Western ...
Ali Robin R RR UCL Institute of Ophthalmology, Bath St, London EC1V 9EL, - - 2014
Those working in the regenerative medicine field currently face numerous regulatory and related challenges. This Perspective captures some of the key ideas of a UK-based working group drawn from academic, clinical and industrial communities and also identifies some key steps that should be taken in the UK and elsewhere to ...
Kubo Miwa M Faculty of Pharmaceutical Sciences, Tokushima Bunri - - 2014
A new spiroindene pigment, phelliribsin A, was isolated from the medicinal fungus Phellinus ribis, and its structure was determined by two dimensional (2D)-NMR methods. Phelliribsin A is an unprecedented spiroindene compound, and was found to have cytotoxic activity against PC12 cells at a concentration of 30 µM.
Miyazaki Yasunori Y Department of Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of - - 2014
We introduced the application of a planetary centrifugal mixer to dispensing powdered medicines to prevent from individual variation in the skills of pharmacists with a manual blending. The blending performance of the mixer was explored in terms of four operational variables, namely, operation speed (400-1000 rpm), operation time (10-60 s), charging rate ...
Helfer Markus M Institute of Virology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, - - 2014
Global HIV-1 treatment would benefit greatly from safe herbal medicines with scientifically validated novel anti-HIV-1 activities. The root extract from the medicinal plant Pelargonium sidoides (PS) is licensed in Germany as the herbal medicine EPs®7630, with numerous clinical trials supporting its safety in humans. Here we provide evidence from multiple ...
Jang Shih-Fan SF School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei 11221, Taiwan. - - 2014
In recent decades, nanotechnology has attracted major interests in view of drug delivery systems and therapies against diseases, such as cancer, neurodegenerative diseases, and many others. Nanotechnology provides the opportunity for nanoscale particles or molecules (so called "Nanomedicine") to be delivered to the targeted sites, thereby, reducing toxicity (or side ...
Casaroli-Marano Ricardo P RP Department of Surgery, School of Medicine, University of Barcelona, Barcelona, - - 2014
Rapid development in the fields of cellular and molecular biology, biotechnology, and bioengineering medicine has brought new, highly innovative treatments and medicinal products, some of which contain viable cells and tissues associated with scaffolds and devices. These new cell-based therapy approaches in regenerative medicine have great potential for use in ...
Shen Bojiang - - 2013
Age is the leading risk factor for acute and chronic neurodegenerative diseases. The Shen Nong Ben Cao Jing, the oldest known compendium of Chinese materia media, lists herbal medicines that were believed to exert neither fast acting pharmacological effects nor discernible toxicity, but to promote general health and longevity. In ...
Sadrozinski Hartmut F-W - - 2013
Selected particle detectors are described which find an application in medicine and have been the topic of presentations at the 2013 Vienna Conference of Instrumentation (VCI).
Fu Lina L National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, - - 2013
A major challenge in regenerative medicine is the generation of functionally effective target cells to replace or repair damaged tissues. Transdifferentiation in vivo is a novel strategy to achieve cell fate conversion within the native physiological niche; this technology may provide a time- and cost-effective alternative for applications in regenerative ...
Zachariades Nicholas A NA Duane Morris LLP , Boca Raton, - - 2013
Abstract The topic of stem cells for use in regenerative medicine, especially embryonic stem cells, inspires much debate, discussion, and outrage as it slices through the very core moral values of society. These social and moral issues have, in turn, resulted in government policies that have influenced the study of ...
Webster William D WD Department of Engineering, University of Cambridge, Cambridge, CB2 1PZ, United Kingdom. Electronic address: - - 2013
The field of nuclear medicine is reliant on radionuclides for medical imaging procedures and radioimmunotherapy (RIT). The recent shut-downs of key radionuclide producers have highlighted the fragility of the current radionuclide supply network, however. To ensure that nuclear medicine can continue to grow, adding new diagnostic and therapy options to ...
Hudak Jason E - - 2013
The beginning of the 20(th) century marked the dawn of modern medicine with glycan-based therapies at the forefront. However, glycans quickly became overshadowed as DNA- and protein-focused treatments became readily accessible. The recent development of new tools and techniques to study and produce structurally defined carbohydrates has spurred renewed interest ...
Lu Baisong - - 2013
Regenerative medicine is an emerging, multidisciplinary science that aims to replace or regenerate human cells, tissues or organs, to restore or establish normal function. Research on small molecules and small molecule drugs in regenerative medicine is currently increasing. In this review, we discuss the potential applications of small molecules and ...
Thompson J G - - 2013
The history of in vitro maturation (IVM) of mammalian oocytes, especially of human oocytes, holds a special place for Robert Edwards. He was the first to comprehensively examine and demonstrate maturation of human oocytes in vitro and in so doing he changed the course of medicine by fertilizing them in ...
Nagarajan Surya - - 2013
Herbal and herbo-mineral preparations are being traditionally used in Indian medicines. The herbo-mineral preparations have several benefits that have been instrumental in their widespread use in treatment of different disorders by traditional medicinal practitioners. These include better stability, lower dosage, ease of storability and sustained availability. Naga bhasma (lead sulphide ...
Bishop Corey J - - 2013
To realize the potential of regenerative medicine, controlling the delivery of biomolecules in the cellular microenvironment is important as these factors control cell fate. Controlled delivery for tissue engineering and regenerative medicine often requires bioengineered materials and cells capable of spatiotemporal modulation of biomolecule release and presentation. This review discusses ...
Andújar Isabel - - 2013
The naphthoquinone shikonin is the main active principle of Zicao, a traditional Chinese herbal medicine made from the dried root of Lithospermum erythrorhizon. Studies carried out over the past 30 years have provided a scientific basis for the use of Zicao which has been long employed in folk medicine to ...
Ranasinghe Priyanga - - 2013
In traditional medicine Cinnamon is considered a remedy for respiratory, digestive and gynaecological ailments. In-vitro and in-vivo studies from different parts of the world have demonstrated numerous beneficial medicinal effects of Cinnamomum zeylanicum (CZ). This paper aims to systematically review the scientific literature and provide a comprehensive summary on the ...
Mallidis Con - - 2013
BACKGROUNDThe last 20 years have seen an enormous upsurge in the number of publications reporting findings obtained by Raman spectroscopy, a non-invasive, non-destructive method which uses the inelastic scattering of light to provide a 'fingerprint' of the sample's chemical composition and constituents. Long neglected because of practical difficulties, the technique ...
Cebrian-Serrano Alberto - - 2013
Induced pluripotent stem cells (iPSCs) can now be derived from a tissue biopsy and represent a promising new platform for disease modelling, drug and toxicity testing, biomarker development and cell-based therapies for regenerative medicine. In regenerative medicine, large animals may represent the best models for man, and thereby provide invaluable ...
Mahata C R - - 2013
Avogadro's Number gives 12c as the limit beyond which no original substance can be present in a highly diluted and succcussed (potentised) homeopathic medicine, implying that chemically such dilutions consist of nothing but the vehicle. But there is evidence that living systems react to homeopathic medicines diluted even above 12c. ...
Scarano A A Department of Medical, Oral and Biotechnological Sciences, University of ChietiĀ–Pescara, Chieti, - - 2013
Many oral surgeons in their daily practice have the problem of controlling postoperative bleeding. In surgical, oral and maxillofacial practice, standard anti-hemorrhagic protocols, especially in high risk patients, are obviously required and need to be continuously updated. The purpose of this review is to give a rational insight into the ...
Rising Anna - - 2013
Recent biotechnological progress has enabled the production of spider silk proteins, spidroins, in heterologous hosts. Matrices based on recombinant spidroins support stem cell growth and are well tolerated when implanted in living tissue, thus the material is highly attractive for use in regenerative medicine. However, the matrices made are far ...
Gaskin Sharyn - - 2013
Accidental or intentional toxic gas releases may result in significant public health and psychological consequences. Management of exposed individuals during HAZMAT incidents should be risk-based and supported by a suitable scientific evidence base. There appear to be large evidence gaps in relation to dermal absorption of gases, as well as ...
Teiten Marie-Hélène - - 2013
Since centuries, natural compounds from plants, animals and microorganisms were used in medicinal traditions to treat various diseases without a solid scientific basis. Recent studies have shown that plants that were used or are still used in the medieval European medicine are able to provide relieve for many diseases including ...
Serra Tiziano - - 2013
Rapid prototyping (RP), also known as additive manufacturing (AM), has been well received and adopted in the biomedical field. The capacity of this family of techniques to fabricate customized 3D structures with complex geometries and excellent reproducibility has revolutionized implantology and regenerative medicine. In particular, nozzle-based systems allow the fabrication ...
Guo Jingjing - - 2013
Regenerative medicine is a new interdisciplinary field in biomedical science, which aims at the repair or replacement of the defective tissue or organ by congenital defects, age, injury, or disease. Various cell-related techniques such as stem cell-based biotherapy are a hot topic in the current press, and stem cell research ...
Kumar Gunjan - - 2013
Herbs are staging a comeback and herbal 'renaissance' is happening all over the globe. The herbal products, today, symbolize safety, in contrast to the synthetics that are regarded as unsafe to humans and the environment. A herb, botanically speaking, is any plant that lacks the woody tissue which is characteristic ...
Harink Björn - - 2013
The aim of regenerative medicine is to restore or establish normal function of damaged tissues or organs. Tremendous efforts are placed into development of novel regenerative strategies, involving (stem) cells, soluble factors, biomaterials or combinations thereof, as a result of the growing need caused by continuous population aging. To satisfy ...
Chauhan Monika - - 2013
Pyrazolopyrimidines are the fused heterocyclic ring systems which structurally resemble purines which prompted biological investigations to assess their potential therapeutic significance. They are known to play a crucial role in numerous disease conditions. The advent of their first bioactivity as adenosine antagonistic property divulged their medicinal potential. Radioactivity test on ...
Baskar Suresh Kumar P - - 2013
Sulcona, a Siddha proprietary medicine used for the treatment of burns, has been in practice for more than 50 years. This medicine has been successfully used on several burned patients with an excellent recovery and safety record. In this manuscript, we investigate some of its pharmacological and safety profiles. Treatment ...
Leontis Neocles - - 2013
The second International Conference on RNA Nanotechnology and Therapeutics was held on the 3-5 April in Lexington, (KY, USA). The focus of the conference was on leveraging the unique chemical and biological properties of RNA to promote transformative advances in medicine. The conference convened more than 200 researchers from 15 ...
Loomba Leena - - 2013
The article highlights the synthesis, properties and recent advances in therapeutic possibilities of metallic nanoparticles. Nanometallic structures that behave as drug-carrying agents, gene regulators, imaging agents and photoresponsive assemblies have been discussed in the context of cells and many debilitating diseases. These structures not only act as alternatives to molecule-based ...
Santo Vítor E - - 2013
The current limitations of regenerative medicine strategies may be overcome through the use of magnetic nanoparticles (MNPs), a class of nanomaterial typically composed of magnetic elements that can be manipulated under the influence of an external magnetic field. Cell engineering approaches following the internalization of these MNPs by cells and/or ...
Ratajczak Mariusz Z - - 2013
There are presented the most important sources of pluripotent stem cells for potential application in the regenerative medicine. This review summarizes also advantages and disadvantages for potential application of these cells in clinical medicine.
Khanavi M M Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, - - 2013
Pomegranate (Punica granatum L.) is native to the Mediterranean region and has been used extensively as a medicine in many counties. Hyperoside is known as an important flavonoid with antioxidant activity and anti hypertension effect. Anthocyanins are the active component in several herbal medicines, thus accurate measurement of hyperoside and ...
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