The therapeutic value of prenylamine in angina pectoris was tested in two ways. Fourteen patients received 270 mg. of prenylamine per day for one month. This was preceded and followed by one month of placebo therapy. Assessment was made, first by twice-monthly treadmill exercise tests, and secondly by daily records ...

In cats, 24 hr after the administration of 1 mg/kg of reserpine, it was found that (a) the heart is in failure; (b) the sensitivity of the peripheral vessels to adrenaline, noradrenaline and isoprenaline, administered intravenously or close-arterially, is decreased; (c) any blood pressure changes are, as a rule, secondary ...