Search Results
Results 1 - 50 of 252
1 2 3 4 5 6 >
Chatterjee Barun Kumar BK Department of Physics, Bose Institute, 93/1 A.P.C. Road, Kolkata 700009, India. Electronic address: - - 2014
The major objection to homeopathic medicine is that the doses of medicine prescribed in some cases are too dilute for any active ingredient to be present. The medicines would hence be rendered inactive, necessitating novel explanations for the action. A further examination of dilution in the light of the Langmuir ...
Ce Henderson - - 2014
The Royal College of Obstetrics and Gynecology does not endorse routine active management of Intrahepatic Cholestasis of Pregnancy (ICP) affected pregnancies. In contrast, the American College of Obstetricians and Gynecologists supports active management protocols for ICP. To investigate this controversy, we evaluated the evidence supporting ICP as a medical indication ...
Cruz-Monteagudo Maykel M CIQ, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal; REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal; Centro de Estudios de Química Aplicada (CEQA), Faculty of Chemistry and Pharmacy, Central University of Las Villas, Santa Clara, 54830, Cuba; Molecular Simulation and Drug Design Group, Centro de Bioactivos Químicos (CBQ), Central University of Las Villas, Santa Clara, 54830, Cuba. Electronic address: - - 2014
The impact activity cliffs have on drug discovery is double-edged. For instance, whereas medicinal chemists can take advantage of regions in chemical space rich in activity cliffs, QSAR practitioners need to escape from such regions. The influence of activity cliffs in medicinal chemistry applications is extensively documented. However, the 'dark ...
Korabecnya Jan - - 2014
Organophosphates are used as pesticides and developed as warfare nerve agents. Exposure to them can be fatal and death is usually caused by respiratory arrest. For almost six decades, pyridinium oximes represent a therapeutic tool used for the management of poisoning with organophosphorus (OP) compounds. However, these compounds possess several ...
John Tamara T 1Division of General Pediatrics and Community Health, Children's National Medical Center, Washington, DC, - - 2014
/st>Quality improvement (QI) activities are required to maintain board certification in pediatrics. However, because of lack of training and resources, pediatricians may feel overwhelmed by the need to implement QI activities. Pediatricians also face challenges when caring for overweight and obese children. /st>To create a virtual (online) QI learning collaborative ...
Mohanta Tapan Kumar TK a National Institute of Plant Genome Research (Lab. No. 102) , Aruna Asaf Ali Marg, New Delhi 110067 , - - 2014
Ginkgo biloba L., also popularly known as living fossil, possesses a variety of biological and pharmacological activities. The leaf extract of G. biloba L. (EGb 761) has been used for years to treat age-related memory-deficit problems, including Alzheimer's and dementia. Experimental and clinical studies have revealed its beneficial effects on ...
Alipour Ghazal G Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I.R., - - 2014
Myrtle (Myrtus communis L., Myrtaceae) is a medicinal herb used worldwide in traditional medicine. A large number of components have been isolated from this herb. Polyphenols, myrtucommulone (MC), semimyrtucommulone (S-MC), 1,8-cineole, α-pinene, myrtenyl acetate, limonene, linalool and α-terpinolene are among the compounds considered to be the main biologically active components. ...
Mahmood Sidra S Department of Bioinformatics and Biotechnology, International Islamic University, Islamabad, - - 2014
WHO estimates, around 80% of the especially developing world is indigent on complementary and alternative medicines which are prodigiously derived from herbal material. Parsley (Petroselinum crispum) is an important culinary herb originated from the Mediterranean region. It possesses small and dark seeds with volatile oil content. Petroselinum crispum is now ...
Yan Dan D 1] China Military Institute of Chinese Materia Medica, Military 302 Hospital, Beijing 100039, China [2] National Center of Biomedical Analysis, Beijing 100850, China - - 2014
To identify major active constituents and measure their levels in a typical medicinal herb-Rhizoma coptidis, we applied the concept of removing and adding, taking inspiration from functional genetic methods. As this herb has bacteriostatic properties and is used to treat bacterial diarrhea, we examined the effects of individual constituents (berberine, ...
Jazayeri Seyed Behzad - - 2014
The aim of this study was to evaluate acetylcholinesterase inhibitory activity of some commonly used herbal medicine in Iran to introduce a new source for management of Alzheimer's disease. A total of 18 aqueous-methanolic extract (1:1; v/v) from the following plants: Brassica alba, Brassica nigra, Camellia sinensis, Cinchona officinalis, Citrus ...
Moghadamtousi Soheil Zorofchian SZ Biomolecular Research Group, Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, - - 2014
Loranthus parasiticus Merr (L. parasiticus) is a member of Loranthaceae family and is an important medicinal plant with a long history of Chinese traditional use. L. parasiticus, also known as Sang Ji Sheng (in Chinese), benalu teh (in Malay) and baso-kisei (in Japanese), is a semiparasitic plant, which is mostly ...
Chang Hung-Chi HC Department of Golden-Ager Industry Management, Chaoyang University of Technology, Taichung 41349, - - 2014
Diarrheal disease is one of the most important worldwide health problems. Enterotoxigenic Escherichia coli (ETEC) is the most frequently isolated enteropathogen in diarrheal diseases. In developing countries, a very large number of people, especially children, suffer from diarrhea. To combat this problem, World Health Organization has constituted the Diarrhea Diseases ...
Kao Tzu-Chien - - 2013
Licorice is an herbal plant named for its unique sweet flavor. It is widely used in the food and tobacco industries as a sweetener. Licorice is also used in traditional Chinese medicine (TCM) and complementary medicine. Because the use of licorice has long been a part of TCM, the details ...
Bonifácio Bruna Vidal BV School of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, São Paulo State University, Araraquara, - - 2014
Herbal medicines have been widely used around the world since ancient times. The advancement of phytochemical and phytopharmacological sciences has enabled elucidation of the composition and biological activities of several medicinal plant products. The effectiveness of many species of medicinal plants depends on the supply of active compounds. Most of ...
Chen Pai-Yen PY The University of Texas at Austin, Department of Electrical and Computer Engineering, Austin, Texas 78712, - - 2013
We introduce the concept and practical design of broadband, ultrathin cloaks based on non-Foster, negatively capacitive metasurfaces. By using properly tailored, active frequency-selective screens conformal to an object, within the realm of a practical realization, we show that it is possible to drastically reduce the scattering over a wide frequency ...
Zhu Hui-Ling - - 2013
Epilepsy is a serious neural disease that affects around 50 million people all over the world. Although for the majority patients with epilepsy, seizures are well controlled by currently available antiepileptic drugs (AEDs), there are still >30% of patients suffered from medically refractory epilepsy and approximately 30-40% of all epileptic patients ...
Qi F H FH Department of Traditional Chinese Medicine, Shandong Provincial Hospital affiliated to Shandong University, Ji'nan, - - 2013
Since the significant public health hazard of Hepatitis B virus (HBV) infection and obvious drug resistance and dose-dependent side effects for common antiviral agents (e.g., interferon α, lamivudine, and adefovir), continuous development of agents to treat HBV infection is urgently needed. Traditional Chinese medicine (TCM) is an established segment of ...
Farzaei Mohammad Hosein - - 2013
To summarize comprehensive information concerning ethnomedicinal uses, phytochemistry, and pharmacological activities of parsley. Databases including PubMed, Scopus, Google Scholar, and Web of Science were searched for studies focusing on the ethnomedicinal use, phytochemical compounds and biological and pharmacological activities of parsley. Data were collected from 1966 to 2013. The search ...
He Xirui - - 2013
Eucommia ulmoides Oliv. (Family Eucommiaceae), also known as Dù-zhòng (Chinese: ), Tuchong (in Japanese), is the sole species of the genus Eucommia. The leaf, stem, and bark as well as staminate flower of E. ulmoides have been traditionally used to cure many diseases in China, Japan, Korea, among others. The ...
Beadle-Brown J - - 2013
We hypothesised that a key factor determining the quality of active support was 'practice leadership' - provided by the first-line manager to focus staff attention and develop staff skills in providing direct support to enable people with intellectual disabilities to have a good quality of life. This exploratory study focused ...
Zhou Xidan - - 2013
Carthamus tinctorius L. (Compositae), a widely used traditional Chinese medicine, was known as Hong hua (Chinese: ), safflower. Safflower with a wide spectrum of pharmacological effects has been used to treat dysmenorrhea, amenorrhea, postpartum abdominal pain and mass, trauma and pain of joints, etc. The present paper reviews the advancements ...
Shang Yuan-Hong YH College of Pharmaceutical Sciences, Southwest University, Chongqing Engineering Research Center for Pharmacodynamics Evaluation, Chongqing 400716, China; College of Medicine, Panzhihua University, Panzhihua 617000, - - 2013
The treatment of cerebral ischemic disease by natural medicines has a long history, and has accumulated a rich theoretical knowledge and treatment experience. The objective of this review is to critically evaluate the experimental research situation of the protective effect of the individual compounds from natural medicine on cerebral ischemia ...
Milugo Trizah K - - 2013
The Quinine tree (Rauvolfia caffra) is used as a medicinal plant among traditional communities in many countries to manage tumors and other diseases associated with oxidative stress. To validate indigenous knowledge and possibly position this herb for technology uptake and utilization, we established the level of antioxidant activity in R. ...
Kirshbaum Marilynne N - - 2013
Objectives: This study investigates an approach based on Kaplan's Attention Restorative Theory (ART) to develop a non-pharmacological intervention to help individuals manage the distressing effects of illness related fatigue. The study aims to: identify activities perceived as being enjoyable by individuals who have moderate to severe fatigue related to advanced ...
Kundaković Tatjana - - 2013
Metabolic syndrome (MS) is a modern medical condition characterized by central obesity, hyperglycaemia, hypercholesterolemia and hypertension. The beneficial effects of mushrooms in lowering the symptoms of MS were known from both traditional and conventional medicine. Edible mushrooms, their extracts, polysaccharide fractions and isolated compounds possessed hypoglycaemic, cholesterol and triglyceride lowering ...
Potter David J - - 2013
The quality demands of the pharmaceutical industry require prescription medicines to be consistent in their active ingredient content. Achieving this, using raw cannabis as a feedstock, is especially challenging. The plant material is extremely inhomogeneous, and the ratios of active ingredients are affected by a range of factors. These include ...
Spanos Dimitrios - - 2013
To evaluate the clinical effectiveness of weight management interventions in adults with intellectual disabilities (ID) and obesity using recommendations from current clinical guidelines for the first line management of obesity in adults. Full papers on lifestyle modification interventions published between 1982 to 2011 were sought by searching the Medline, Embase, ...
Peters Lindsay C - - 2013
We evaluated the effects of positive practice overcorrection (PP OC) on levels of motor stereotypy and appropriate engagement in the activity practiced during treatment with 3 young men with autism. We also measured preference for the practiced activities during preference probes to determine if these activities might acquire aversive properties ...
Stumpfe Dagmar - - 2013
The activity cliff concept is of high relevance for medicinal chemistry. Recent studies are discussed that have further refined our understanding of activity cliffs and suggested different ways how to exploit activity cliff information. These include alternative approaches to define and classify activity cliffs in two and three dimensions, data ...
Liu Zhao Lan - - 2013
Fatty liver disease is potentially a reversible condition that may lead to end-stage liver disease. Since herbal medicines such as Crataegus pinnatifida and Salvia miltiorrhiza have increasingly been used in the management of fatty liver disease, a systematic review on herbal medicine for fatty liver disease is needed. To assess ...
van der Kooy Frank - - 2013
Artemisia annua has a long tradition of use for the treatment of intermittent fevers which we now relate to malarial infections. The active principle artemisinin has been isolated from A. annua and today forms the backbone of the global fight against malaria. The traditionally prepared A. annua formulation is however ...
Xu Xu - - 2013
Excessive physical loads and awkward shoulder postures during pushing and pulling are risk factors for shoulder pain. Pushing a medicine cart is a major component of a work shift for nurses and medical assistants in hospitals and other health care facilities. A laboratory experiment was conducted to examine the effects ...
Omran Nedal - - 2013
Bleeding management in cardiac surgery could be a great challenge for the surgeon and a life-threatening moment for the patient. Despite the fact that recombinant activated factor VII is now widely accepted as a useful adjunct in the management of postcardiotomy coagulopathy, its use in the course of recent thromboembolic ...
Hasanuzzaman Faiz M - - 2013
In this paper, we present a new framework to monitor medication intake for elderly individuals by incorporating a video camera and Radio Frequency Identification (RFID) sensors. The proposed framework can provide a key function for monitoring activities of daily living (ADLs) of elderly people at their own home. In an ...
Moraes Suzana Alves de - - 2013
the study aims to evaluate the reproducibility between the International Physical Activity Questionnaire and the American College of Sports Medicine/American Heart Association criteria to classify the physical activity profile in an adult population living in Ribeirão Preto, SP, Brazil. population-based cross-sectional study, including 930 adults of both genders. The reliability ...
Patra Lipika - - 2013
BACKGROUND: Doctors' self-reported physical activity (PA) is associated with their propensity for prescribing PA. METHODS: We surveyed 146 doctors (median age 42 years; men 58.9%), selected by multistage random sampling. Information on demographic details, self-reported PA and counselling offered to their patients was collected using a pretested, structured, self-administered questionnaire. ...
Johnston J D - - 2013
The European pharmaceutical regulatory system has not yet been challenged by issues related to highly-personalised medicines such as those to be found with active substances that affect RNA biochemistry. We review the current status of RNA-based pharmacology and present three possible case histories. The implications for the European pharmaceutical regulatory ...
Wang Dongmei - - 2013
ETHNOPHARMACOLOGICAL RELEVANCE: The aerial parts of Senecio scandens Buch.-Ham. (family Compositae) have a long history in traditional Chinese medicine as a treatment for various ailments, such as bacterial diarrhea, enteritis, conjunctivitis, and respiratory tract infections. MATERIALS AND METHODS: A bibliographic investigation of S. scandens was accomplished by analyzing secondary sources, ...
Burrows Jeremy N - - 2013
In the fight against malaria new medicines are an essential weapon. For the parts of the world where the current gold standard artemisinin combination therapies are active, significant improvements can still be made: for example combination medicines which allow for single dose regimens, cheaper, safer and more effective medicines, or ...
Zhang Ling - - 2013
Imidazole ring is an important five-membered aromatic heterocycle widely present in natural products and synthetic molecules. The unique structural feature of imidazole ring with desirable electron-rich characteristic is beneficial for imidazole derivatives to readily bind with a variety of enzymes and receptors in biological systems through diverse weak interactions, thereby ...
- - 2013
In the June editorial, the PLOS Medicine Editors highlight two papers and associated perspectives published recently in PLOS Medicine on the link between physical activity and noncommunicable diseases, and discuss possible approaches to the "wicked" problem of inactivity. Please see later in the article for the Editors' Summary.
Ma Xiaodong - - 2013
Nowadays, cancer treatment is moving away from conventional cytotoxic drugs to target-based agents. This is primarily attributed to some remarkable leaps made in deciphering the tumor-relevant signaling pathways. Among them, PI3K/Akt/mTOR cascade presently elicits a substantial amount of pharmaceutical interests owing to its intimate role in tumor initiation and progression. ...
Karusisi Noëlla - - 2013
BACKGROUND: Physical activity is considered as a major component of a healthy lifestyle. However, few studies have examined the relationships between the spatial accessibility to sport facilities and sport practice with a sufficient degree of specificity. The aim of this study was to investigate the associations between the spatial accessibility ...
Huang Qingqing - - 2013
Camptothecin (CPT), a natural topoisomerase (Topo) I inhibitor, exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers. However, the poor solubility and the inherent instability of the lactone E-ring in physiological pH resulted in low therapeutic efficacy and severe toxicity. In the past several decades' substantial progress toward ...
Khan Imtiaz - - 2013
Contemporary medicinal chemistry faces diverse challenges from several directions, including the need for both potency and specificity of any therapeutic agent. Therefore, in the present perspective, the triazolothiadiazoles and triazolothiadiazines with broad spectrum biological profile have matured into indispensable heterocyclic scaffolds. This review article is an effort to summarize medicinal ...
Rondanelli Mariangela - - 2013
The artichoke, Cynara scolymus, is one of the most ancient plants grown in the world, and its extracts, obtained from different parts of the plant (leaves, fruits and roots), have been used as medicaments from time immemorial. The pharmacological and therapeutic effects of the artichoke on the liver had already ...
Sarris Jerome - - 2013
Research in the area of herbal psychopharmacology has revealed a variety of promising medicines that may provide benefit in the treatment of general anxiety and specific anxiety disorders. However, a comprehensive review of plant-based anxiolytics has been absent to date. This article (part 1) reviews herbal medicines for which only ...
Peng Xin-Mei - - 2013
Coumarin compounds represent an important type of naturally occurring and synthetic oxygen-containing heterocycles with typical benzopyrone framework. This type of special benzopyrone structure enables its derivatives readily interact with a diversity of enzymes and receptors in organisms through weak bond interactions, thereby exhibit wide potentiality as medicinal drugs. So far, ...
Zhou Jue - - 2013
In the last decades, cases of poisoning due to herbal medicines have occurred in many countries; Chinese herbal medicines (CHMs) are occasionally involved. The experience gained from traditional use is efficient to detect immediate or near-immediate relationship between administration and toxic effects but is quite unlikely to detect medium- to ...
Huang Aiping - - 2013
Pyrroloquinoxalines have proved to be a very attractive scaffold for medicinal chemist in the recent past. These compounds were extensively studied as bioactive compounds and many of them are known to be biologically and medicinally useful molecules, such as anti-HIV agents, antimalarial agents, antagonist agents, anticancer agents, and PARP-1 inhibitors. ...
1 2 3 4 5 6 >