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Wang Dongmei - - 2013
ETHNOPHARMACOLOGICAL RELEVANCE: The aerial parts of Senecio scandens Buch.-Ham. (family Compositae) have a long history in traditional Chinese medicine as a treatment for various ailments, such as bacterial diarrhea, enteritis, conjunctivitis, and respiratory tract infections. MATERIALS AND METHODS: A bibliographic investigation of S. scandens was accomplished by analyzing secondary sources, ...
Burrows Jeremy N - - 2013
In the fight against malaria new medicines are an essential weapon. For the parts of the world where the current gold standard artemisinin combination therapies are active, significant improvements can still be made: for example combination medicines which allow for single dose regimens, cheaper, safer and more effective medicines, or ...
Zhang Ling - - 2013
Imidazole ring is an important five-membered aromatic heterocycle widely present in natural products and synthetic molecules. The unique structural feature of imidazole ring with desirable electron-rich characteristic is beneficial for imidazole derivatives to readily bind with a variety of enzymes and receptors in biological systems through diverse weak interactions, thereby ...
- - 2013
In the June editorial, the PLOS Medicine Editors highlight two papers and associated perspectives published recently in PLOS Medicine on the link between physical activity and noncommunicable diseases, and discuss possible approaches to the "wicked" problem of inactivity. Please see later in the article for the Editors' Summary.
Ma Xiaodong - - 2013
Nowadays, cancer treatment is moving away from conventional cytotoxic drugs to target-based agents. This is primarily attributed to some remarkable leaps made in deciphering the tumor-relevant signaling pathways. Among them, PI3K/Akt/mTOR cascade presently elicits a substantial amount of pharmaceutical interests owing to its intimate role in tumor initiation and progression. ...
Karusisi Noëlla - - 2013
BACKGROUND: Physical activity is considered as a major component of a healthy lifestyle. However, few studies have examined the relationships between the spatial accessibility to sport facilities and sport practice with a sufficient degree of specificity. The aim of this study was to investigate the associations between the spatial accessibility ...
Huang Qingqing - - 2013
Camptothecin (CPT), a natural topoisomerase (Topo) I inhibitor, exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers. However, the poor solubility and the inherent instability of the lactone E-ring in physiological pH resulted in low therapeutic efficacy and severe toxicity. In the past several decades' substantial progress toward ...
Khan Imtiaz - - 2013
Contemporary medicinal chemistry faces diverse challenges from several directions, including the need for both potency and specificity of any therapeutic agent. Therefore, in the present perspective, the triazolothiadiazoles and triazolothiadiazines with broad spectrum biological profile have matured into indispensable heterocyclic scaffolds. This review article is an effort to summarize medicinal ...
Rondanelli Mariangela - - 2013
The artichoke, Cynara scolymus, is one of the most ancient plants grown in the world, and its extracts, obtained from different parts of the plant (leaves, fruits and roots), have been used as medicaments from time immemorial. The pharmacological and therapeutic effects of the artichoke on the liver had already ...
Sarris Jerome - - 2013
Research in the area of herbal psychopharmacology has revealed a variety of promising medicines that may provide benefit in the treatment of general anxiety and specific anxiety disorders. However, a comprehensive review of plant-based anxiolytics has been absent to date. This article (part 1) reviews herbal medicines for which only ...
Peng Xin-Mei - - 2013
Coumarin compounds represent an important type of naturally occurring and synthetic oxygen-containing heterocycles with typical benzopyrone framework. This type of special benzopyrone structure enables its derivatives readily interact with a diversity of enzymes and receptors in organisms through weak bond interactions, thereby exhibit wide potentiality as medicinal drugs. So far, ...
Zhou Jue - - 2013
In the last decades, cases of poisoning due to herbal medicines have occurred in many countries; Chinese herbal medicines (CHMs) are occasionally involved. The experience gained from traditional use is efficient to detect immediate or near-immediate relationship between administration and toxic effects but is quite unlikely to detect medium- to ...
Huang Aiping - - 2013
Pyrroloquinoxalines have proved to be a very attractive scaffold for medicinal chemist in the recent past. These compounds were extensively studied as bioactive compounds and many of them are known to be biologically and medicinally useful molecules, such as anti-HIV agents, antimalarial agents, antagonist agents, anticancer agents, and PARP-1 inhibitors. ...
Moulin Thierry - - 2013
Balzac wrote his novels during a time of great literary and scientific change. Romanticism gave way to the school of realism, of which Balzac could be considered the founder. It was via realism, where both the positive and negative aspects of life were depicted, that doctors naturally gained a much ...
Farquhar Jamie C - - 2013
This 3-year longitudinal study examined the associations between regret management, everyday activities, and retirement satisfaction among recent retirees. We hypothesized that the regulation of a severe life regret can facilitate activity engagement and retirement satisfaction, but only if retirees manage their regrets adaptively by either increasing effort and commitment when ...
Khan Md Asaduzzaman - - 2013
Abstract Mushrooms are considered as nutritionally functional foods and source of physiologically beneficial medicines. Hericium erinaceus, also known as Lion's Mane Mushroom or Hedgehog Mushroom, is an edible fungus, which has a long history of usage in traditional Chinese medicine. This mushroom is rich in some physiologically important components, especially ...
Rabbi Sifat E - - 2013
Hand washing is considered as one of the most effective hygiene promotion activities for public health in developing countries. This study compared hand washing knowledge and practices in BRAC's water; sanitation and hygiene (WASH) programme areas over time. This study is a cross-sectional comparative study between baseline (2006), midline (2009) ...
Aweto Happiness A - - 2013
Physiotherapists as primary health care practitioners are well placed in promoting physically active lifestyles, but their role and practice towards its promotion among patients in Nigeria has not been fully investigated. This study was therefore aimed at determining the knowledge, attitude and practice of Nigerian physiotherapists towards promotion of non-treatment ...
Roulston Chris - - 2013
Anne Lister has recently been turned from a relatively obscure figure of scholarly interest into a modern-day icon of lesbian sexuality. This article asks what gesture we perform when we celebrate Lister's life through the lens of modernity. Why do we need Lister to be modern, and what does it ...
Davidson Elyad - - 2013
Cochrane reviews are considered by many to be the "gold standard" or the final word in medical conversation on a topic. We explored the eleven most relevant Cochrane reviews on herbal medicine and identified that frequently herbal medicines in the included studies had not been sufficiently well characterised. If data ...
Zhestovskaja Anna S - - 2013
A personalized medicine, a recent trend of clinical pharmacology, makes possible the individual approach to the choice of the drugs and their dosage. According to the results of a study of the activity of different biomarkers, particularly the isoenzymes of the cytochrome P-450, they provide the efficiency and safety of ...
Abdollahi Fard Mehri - - 2013
Epilepsy is a brain disorder which affects about 50 million people worldwide. Ineffectiveness of the drugs in some cases and the serious side effects and chronic toxicity of the antiepileptic drugs lead to use of herbal medicine as a form of complementary and alternative medicine. In this review modern evidences ...
Moghadamtousi Soheil Zorofchian - - 2013
Swietenia macrophylla King (Meliaceae) is an endangered and medicinally important plant indigenous to tropical and subtropical regions of the World. S. macrophylla has been widely used in folk medicine to treat various diseases. The review reveals that limonoids and its derivatives are the major constituents of S. macrophylla. There are ...
Kruger Lawrence - - 2013
Peter Mark Roget (1779-1869) is best known for his Thesaurus, a project completed late in his long life. He trained as a physician, practiced medicine, and was interested in many branches of science. Much of his life was dedicated to the systematization of knowledge and identifying relationships. Although not an ...
Padilla-Camberos Eduardo - - 2013
The use of vegetal extracts requires toxicological and genotoxic evaluations to establish and verify safety before being added to human cosmetic, pharmaceutical medicine, or alimentary products. Persea americana seeds have been used in traditional medicine as treatment for several diseases. In this work, the ethanolic seed extract of Persea americana ...
Finer Matt M Biodiversity Program, Center for International Environmental Law, Washington DC, United States of America. - - 2013
The western Amazon continues to be an active and controversial zone of hydrocarbon exploration and production. We argue for the urgent need to implement best practices to reduce the negative environmental and social impacts associated with the sector. Here, we present a three-part study aimed at resolving the major obstacles ...
Farzaei Mohammad Hosein MH Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran 1417653761, - - 2013
In traditional Iranian medicine (TIM), several edible fruits and spices are thought to have protective and healing effects on peptic ulcer (PU). The present study was conducted to verify anti-PU activity of these remedies. For this purpose, edible fruits and spices proposed for the management of PU in TIM were ...
Rahimi Roja - - 2013
Foeniculum vulgare Mill. (F. vulgare), commonly known as Fennel, is a popular medicinal plant with various pharmacological activities mentioned in traditional Iranian medicine (TIM) and modern phytotherapy such as antioxidant, cytotoxic, anti-inflammatory, antimicrobial, bronchodilatory, estrogenic, diuretic, lithontripic, galactogogue, emmenagogue, antithrombotic, hypotensive, gastroprotective, hepatoprotective, memory enhancing, and antimutagenic activities. No serious ...
Li Xu-Zhao - - 2012
Herbal medicines have attracted considerable attention in recent years, which are used to treat Parkinson's disease (PD) in China based on traditional Chinese medicine or modern pharmacological theories. We summarized and analyzed the anti-Parkinsonian activities of herbal medicines and herbal formulations investigated in PD models and provide future references for ...
Slana Marko - - 2012
The fate and environmental risk of antimicrobial compounds of different groups of veterinary medicine pharmaceuticals (VMP's) have been compared. The aim was to demonstrate a correlation between the physical and chemical properties of active compounds and their metabolism in target animals, as well as their fate in the environment. In ...
Soni Priyanka - - 2012
India has a great wealth of various naturally occurring plant drugs which have great potential pharmacological activities. Datura stramonium (D. stramonium) is one of the widely well known folklore medicinal herbs. The troublesome weed, D. stramonium is a plant with both poisonous and medicinal properties and has been proven to ...
Oxentenko Amy S - - 2012
Studies have suggested that patient contact time for internal medicine residents is decreasing and being replaced with computer-related activities, yet objective data regarding computer use by residents are lacking. The aim of this study was to objectively measure time use by internal medicine residents while on duty in the hospital ...
Joy Elizabeth Liz - - 2013
Physical activity (PA) is a key component of healthy lifestyle and disease prevention. In contrast, physical inactivity accounts for a significant proportion of premature deaths worldwide. Physicians are in a critical position to help patients develop healthy lifestyles by actively counseling on PA. Sports medicine physicians, with their focus on ...
Hirsch Irl B - - 2012
[Box: see text] CME ACCREDITATION NEEDS ASSESSMENT/PROGRAM OVERVIEW There is a need for greater caution in interpreting glycated hemoglobin (A1C) results, which can be inaccurate in individual patients for a wide variety of reasons beyond the patient's control. In addition, A1C alone may not reflect critical aspects of glycemia. A ...
Lampariello Lucia Raffaella LR Department of Chemistry, University of Siena, - - 2012
Mucuna pruriens (Fabaceae) is an established herbal drug used for the management of male infertility, nervous disorders, and also as an aphrodisiac. It has been shown that its seeds are potentially of substantial medicinal importance. The ancient Indian medical system, Ayurveda, traditionally used M. pruriens, even to treat such things ...
He Yanhua - - 2012
Chinese herbal medicine is increasingly widely used as a complementary approach for control of breast cancer recurrence and metastasis. In this paper, we examined the implicit prescription patterns behind the Chinese medicinal formulae, so as to explore the Chinese medicinal compatibility patterns or rules in the treatment or control of ...
Berghe Wim Vanden - - 2012
Herbal medicine which involves the use of plants for their medicinal value, dates as far back as the origin of mankind and demonstrates an array of applications including cardiovascular protection and anti-cancer activities, via antioxidant, anti-inflammatory and metabolic activities. Even today the popularity of medicinal herbs is still growing like ...
Meagher H - - 2012
To determine the relationship between the level of patient activity in the form of walking and the rate of venous leg ulcer (VLU) healing.
Giannouli Vaitsa - - 2012
Music, since the time of ancient Greek Asclepieia is well-known for its influence on men's behavior. Nuclear Medicine can study the effect of music in humans' brain. Positron emission tomography (PET) studies have shown brain areas to be activated after colored hearing vs after hearing to words. Furthermore, PET studies ...
Jansen Suze A - - 2012
Many plants of the Ericaceae family, Rhododendron, Pieris, Agarista and Kalmia, contain diterpene grayanotoxins. Consumption of grayanotoxin containing leaves, flowers or secondary products as honey may result in intoxication specifically characterized by dizziness, hypotension and atrial-ventricular block. Symptoms are caused by an inability to inactivate neural sodium ion channels resulting ...
Sodha Neel R - - 2012
Hypertension refractory to conventional management with medication remains a significant cause of cardiovascular morbidity and mortality. Alternative strategies are warranted in this subgroup of patients. The target of these strategies centers around sympathetic neural activity, which is thought to play a key role in hypertension. We will review the historic ...
Bailey Alexander M - - 2012
A set of general principles can guide preclinical testing strategies for evaluating the tumorigenicity of regenerative medicine products.
Scarpa Stefano - - 2012
This study examined the relations between peer-victimization during sport practice and physical activity enjoyment. 395 students (219 boys, 176 girls) from a middle school, ages 12 to 13 years (M = 12.2), were surveyed. Few correlations between peer-victimization during sport practice and physical activity enjoyment variables were negative. Linear regression ...
Storer Nicholas P - - 2012
Since initial launch of insect protected transgenic crops, the most effective strategy to manage the potential for target pests to evolve resistance has been the use of a single mode of action with "high dose" and structured refuge. However, the effectiveness of this strategy is limited if mortality of certain ...
Robertson Marilyn - - 2012
This conference brought together an international panel of speakers and delegates to assess the challenges and opportunities in regenerative medicine as we enter the era of clinical delivery in this new therapeutic field. Participants came from academia, clinical practice (human and veterinary), regulatory agencies, biotechnology and supply industries, as well ...
Rajashekar V - - 2012
Bada Gokhru (Pedalium murex L.) is perhaps the most useful traditional medicinal plant in India. Each part of the neem tree has some medicinal property and is thus commercially exploitable. During the last five decades, apart from the chemistry of the Pedalium murex compounds, considerable progress has been achieved regarding ...
Ernest Terry - - 2012
There is some confusion about the types of paediatric pharmaceutical preparation (in a regulatory and pharmaceutical development context) that are acceptable for approval by medicines regulators. Some of the confusion relates to terminology which may mean different things to different stakeholders. It may not always be possible to provide authorised, ...
Awondo Sebastain N - - 2012
Tomato-spotted wilt (TSW) is caused by the tomato-spotted wilt virus (TSWV) and is a major disease affecting the production of tomato and pepper in the Southeastern United States. Before initiating a multistate, regional project addressing this issue, a survey was conducted in North Carolina, South Carolina, Georgia, and Florida to ...
Mosihuzzaman Mohammed - - 2012
It is generally accepted by all concerned that modern pharmaceuticals will remain out of reach of many people and 'health for all' may only be realized by the use of adequately assessed herbal products. Mankind has been using herbal medicine for healing right from the beginning of human civilization. With ...
Mushtaq A - - 2012
In last few years the shortage of molybdenum-99 (99Mo) was felt in developed and developing countries hospitals, where diagnostic nuclear medicine is practiced. To overcome the shortage of 99Mo various routes of its production by accelerators and reactors generating low and high specific activity products have been planned. High specific ...
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