OBJECTIVE: To review the therapeutic options for immune-mediated thrombocytopenia (IMT). DATA SOURCES: Original research publications and review articles using the PubMed search engine for the phrases "immune-mediated thrombocytopenia" or "immune thrombocytopenic purpura" or "immune thormbocytopenia." VETERINARY AND HUMAN DATA SYNTHESIS: There are a number of therapeutic options for adult-onset immune ...

To review and summarize the body of literature regarding human intravenous immunoglobulin (hIVIG) therapy in veterinary medicine. Mechanism of action, usage in human medicine, adverse effects of therapy, implications for veterinary use, and administration recommendations are discussed. Current human and veterinary peer-reviewed medical literature including original research articles and scientific ...

Context and Objective: We used the wing somatic assay in Drosophila melanogaster to test the hypothesis that two phytoextracts from Cecropia obtusifolia Bertol (Cecropiaceae) and Equisetum myriochaetum Schlecht. et Cham (Equisetaceae), which are used in folk medicine to treat type 2 diabetes mellitus, could detoxify the mutagen hydrogen peroxide. Materials ...

Within the array of measures for improving medicines access for the world's neediest populations, governments of many countries have turned to compulsory licensing, a statutory mechanism to enable third parties to manufacture a product or process still under patent. In this paper, we focus on a historic case example from ...

Unintentional poisonings are a major public health issue in the United States (US). With the increasing number of Hispanics in the US, childhood poisoning is a salient public health issue to address within this population. There is a paucity of research examining the relationship between acculturation in Hispanics and the ...

to examine the association between co-morbidities and the use of antidiabetic medications or adjunctive cardiovascular medicines among Australian veterans with diabetes. data were sourced from the Australian Department of Veterans' Affairs Health Claims database. All veterans aged 65 years and over who were dispensed medicines for diabetes from July to ...

Data linkage of population administrative data is being investigated as a tool for pharmacovigilance in pregnancy in Australia. Records of prescriptions of known or suspected teratogens dispensed to pregnant women have been linked to a birth defects registry to determine if defects associated with medicine exposure can be detected. The ...

Leading European nations with strong biotech sectors, such as the UK and Germany, are investing heavily in regenerative medicine, seeking competitive advantage in this emerging sector. However, in the broader biopharmaceutical sector, the EU is outperformed by the USA on all metrics, reflecting longstanding problems: limited venture capital finance, a ...

The aim of this study was to investigate medicine use and associated factors among adolescents. This was a prospective cohort study including 4,452 adolescents born in Pelotas, Rio Grande do Sul State, Brazil, in 1993. Information on medicine use in the 15 days prior to the interviews was collected from ...

The aim of this study was to investigate the prevalence and concomitant use of prescription medicines and self-medication, including over-the-counter (OTC) medicines, vitamins, and complementary and alternative medicines (CAMs) among Finnish children aged under 12 years. We carried out a nationwide postal survey of the use of medicines by a ...

Radiation was discovered just slightly more than a century ago, with a profound effect on both industry and medicine. Several notable scientists were key in bringing radiation to the forefront. Historical review of scientists who played key roles in the discovery of radiation and its use in medicine are reviewed. ...

Variations introduced to medicinal product documentation must not affect the quality, efficacy, and safety of the product. Croatian Medicinal Products Act and accompanying ordinances are largely aligned with the EU regulations. The EU has now tried to simplify the issue of variations with a new Regulation, creating differences in the ...

This article examines the positive and negative aspects of psychiatry encompassing sexual medicine within its purview. MEDLINE searches for the period between 1980 to the present were performed with the terms "psychiatry," "sexual medicine," and "sexual dysfunction." In addition, sexual medicine texts were reviewed for chapters relevant to this topic. ...

The primary objective of this research was to evaluate the pharmacist's views on self-medication, their perceptions of advertisements for OTC medicines, and their knowledge and awareness of people that purchase OTC medicines. The data were gathered in Hungarian pharmacies with questionnaires distributed as inserts in two trade journals--Gyógyszertár and Pirulatrend. ...

We sought to investigate, across different socioeconomic groups, the proportion of household medicine expenses that were paid by households and the proportion paid by the Brazilian national health system. We carried out a survey in Porto Alegre, Brazil, that included 2988 individuals of all ages. We defined 2 expenditure variables: ...

The term 'regenerative medicine' refers to a new and expanding field in biomedical research that focuses on the development of innovative therapies allowing the body to replace, restore and regenerate damaged or diseased cells, tissues and organs. It combines several technological approaches including the use of soluble molecules, biomaterials, tissue ...

Two crucial topics in the philosophy of medicine are the philosophy of nature and philosophical anthropology. In this essay I engage the philosophy of nature by exploring Anne Fagot-Largeault's study of norms in nature as a way of articulating a Confucian philosophy of medicine. I defend the Confucian position as ...

Two varieties of Paris polyphylla Smith (Melanthiaceae), P. polyphylla Smith var. chinensis (Franch.) Hara, and P. polyphylla Smith var. yunnanensis (Franch.) Hand.-Mazz., are used as medicinal Paris in China. Their dried rhizomes are the major source of raw material for some medicines. In recent years, medicinal PARIS has been found ...

In the above-cited article which appeared in the Keio Journal of Medicine Vol. 53(3): 151-158(2004), the author's name of José Luis Vela appeared incorrectly as José Luis Skog.

This study assessed the impact of the Thai-US Free Trade Agreement (FTA) on access to medicines in Thailand. We first interpreted the text of the sixth round of Thai-US negotiations in 2006 on intellectual property rights (IPR). The impact was estimated using a macroeconomic model of the impact of changes ...

We formerly reported the most suitable volumes of medicinal solution for continuous 5FU infusion over 46 hours in the FOLFOX6 and FOLFIRI regimens, respectively, by analyzing the relation of the total volume of the medicinal solution in a portable disposable infusion pump (SUREFUSER A) and the duration of infusion using ...

BACKGROUND: This paper reports dielectric dispersion occurring in potentised homeopathic medicines subjected to variable frequency electric field using an instrumentation method developed by the authors. Oscillations occur in the direction of electric field, and are usually termed longitudinal/acoustic-mode vibrations. METHODS: The test material was lactose soaked with homeopathic medicine. Multiple ...

PURPOSE: To provide an overview of and discuss newly authorised medicines with an improved efficacy. METHODS: This analysis focussed on new medicines with an improved efficacy based on the results of randomised active control trials. Information on comparative efficacy was obtained from the European Medicines Agency European Public Assessment Reports. ...

A review of the recent foundation by The Australasian College of Tropical Medicine of the Sub-Faculty of Expedition Medicine is presented. Information is given on aims, professional grades of membership, and the various activities of the Sub-Faculty, including publications and scientific meetings.

Europe, because of its geographical location, strategic position on trade routes, and colonial past, has a long history of caring for travellers' health. Within Europe, there is great diversity in the practice of travel medicine. Some countries have travel medicine societies and provisions for a periodic distribution of recommendations, but ...

OBJECTIVES: To assess the prevalence of counterfeit anthelminthic medicines in Cambodia, and to determine influential factors. METHODS: Commonly used anthelminthic medicines were collected from private drug outlets. Medicines were carefully observed including their registration labelling, and their authenticity was investigated with the manufacturers and the Medicines Regulatory Authorities. Samples were ...

The appearance of counterfeit medicines in supply chains is a global public health problem that may seriously affect patients. Counterfeit drugs do not meet quality standards and do not declare their real composition and/or source for the purposes of fraud. They may be generic or innovative, they may contain genuine ...

The World Health Organization has identified nicotine, alcohol, and illicit drugs as among the top 10 contributors of morbidity and mortality in the world. Substance use disorders are preventable conditions that are major contributors to poor health, family dysfunction, and various social problems in the United States-problems that have a ...

The expiry of medicines in the supply chain is a serious threat to the already constrained access to medicines in developing countries. We investigated the extent of, and the main contributing factors to, expiry of medicines in medicine supply outlets in Kampala and Entebbe, Uganda. A cross-sectional survey of six ...

AIM: To determine which high sugar cough syrups sell most frequently in pharmacies in Barcelona. METHODS: 300 pharmacies in 10 districts of Barcelona (Spain) were visited and data collected on the type of syrup-based medicines dispensed most often over a 3-month period in 2008. RESULTS: Data was collected in 142 ...

Although North American physicians commonly identify William Osler as their best example of excellence in both medicine and the humanities, Osler himself held Oliver Wendell Holmes as the best example of such an avatar. Holmes made substantial contributions to medicine, including a landmark essay on the 'Contagiousness of Puerperal Fever', ...

Plasma contains several therapeutically important proteins. Currently more than 25 of them are commercially available to treat life-threatening diseases. Some of these medicines already included in the WHO Model List of Essential Medicines indicating their importance from a global perspective. However, unfortunately due to very high cost of treatment with ...

Increasing attention is being paid to the affordability of medicines in low- and middle-income countries (LICs and MICs) where medicines are often highly priced in relation to income levels. The impoverishing effect of medicine purchases can be estimated by determining pre- and postpayment incomes, which are then compared to a ...

ABSTRACT: A new section of the Journal of Translational Medicine has been launched, devoted to promoting the field of Immunovirology.

Biomedical informatics involves a core set of methodologies that can provide a foundation for crossing the "translational barriers" associated with translational medicine. To this end, the fundamental aspects of biomedical informatics (e.g., bioinformatics, imaging informatics, clinical informatics, and public health informatics) may be essential in helping improve the ability to ...

BACKGROUND: Medicine access is an important goal of medicine policy; however the evaluation of medicine access is a subject under conceptual and methodological development. The aim of this study was to describe quantitative methodologies to measure medicine access on household level, access expressed as paid or unpaid medicine acquisition. METHODS: ...

Access to quality assured artemisinin-based combination therapy (ACT) has remained very low in most malaria endemic countries. A number of reasons, including unaffordable prices, have contributed to the low accessibility to these life-saving medicines. The Affordable Medicines Facility-Malaria (AMFm) is a mechanism to increase access to quality assured ACT. The ...

Kant taught that, 'Where we find . . . illusions and fallacies . . . , there seems to be required a . . . code of mental legislation . . . founded upon the nature of reason and the objects of its exercise . . . which no fallacy ...

AIM: To describe over-the-counter (OTC) medicine use by Australian parents for children aged birth to 24 months; types of medicines used and indications for use. METHODS: A cross-sectional survey of parents was conducted using a self-administered over-the-counter medicine use questionnaire. A total of 640 questionnaires were distributed to parents of ...

The purpose of this study was to compare the electromyogram (EMG) activity of the trunk musculature for long throwers and short throwers during the side medicine-ball throw. The study consisted of 2 sessions. Thirty athletes performed the side medicine-ball throw (S-MBT) in the first session. The top 5 subjects (long ...

The history of Armenian medicine is that of the common practice of medicine in caring for the sick through the ages, using mainly local medicinal herbs and natural products. Over the years, its practitioners persistently collected and recorded an expanding body of information on therapeutics and put it to use ...

The main source of all inspirational knowledge in Islam is indeed the Holy Qur'an. The verses of the Qur'an as well as the Hadeeth and Sunnah literature have also accumulated a number of teachings and practices in relation to cardiovascular medicine. Islam is actually a comprehensive system of life, which ...

This report presents the recommendations to the ISSCR leadership from the industry panel session at the 2009 annual conference. The seven recommendations address core issues essential for the promotion of stem cell and regenerative medicine translation and commercialization.

The Medicines Act 1968 governs who can supply medicines in the U.K. The Act allows dentists to issue any medicine directly to a patient. However, this only applies if patients are receiving private treatment. The current NHS terms of service do not allow dentists to supply any medicines, other than ...

The rapidly evolving field of regenerative medicine holds much promise for cell-based therapies for a range of debilitating conditions from spinal cord injury to haematological and neurological diseases. The groundbreaking discovery of induced pluripotent stem (iPS) cells has offered new perspectives on disease progression and the possibility of patient-specific cell ...

To identify differences in the range of medicines available and subsidized for ambulatory care in Finland and New Zealand. Medical entities listed in national product information sources and their subsidy statuses were compared. The number and overlap of entities available and subsidized were determined. Differences in the age of subsidized ...

OBJECTIVES Like many other developing countries, South Africa provides free medicines through its public health care facilities. Recent policies encourage generic substitution in the private sector. This study explored South African consumer perceptions of drug quality and whether these perceptions influenced how people procured and used their medicines. METHODS The ...

AIM: The International Classification of Functioning, Disability and Health (ICF) provides a useful framework for the comprehensive description of the patients' functional health. The aim of this study was to identify the ICF categories that represent the patients' problems treated by manual medicine practitioners in order to facilitate its application ...

AIMS: Regenerative medicine is an emerging field with the potential to provide widespread improvement in healthcare and patient wellbeing via the delivery of therapies that can restore, regenerate or repair damaged tissue. As an industry, it could significantly contribute to economic growth if products are successfully commercialized. However, to date, ...

AIM: The aim of this study was to explore the prevalence of dizziness in a general population and the association between dizziness and socio-demographic variables, self-reported diseases and medicines used. We hypothesize that dizziness was associated with different diseases and medicines as well as the number of diseases and the ...