The 2011 annual conference of the American Association of Pharmaceutical Scientists, held in Washington DC, USA, hosted a roundtable entitled: 'Update of the US FDA/European Medicines Agency (EMA) harmonization of their bioanalytical guidance - Global Bioanalytical Consortium activity and impact on small and large molecules.' The roundtable was initiated with ...

This article discusses specific issues related to the market access of biosimilars. Biopharmaceuticals are complex molecules produced by living cells. Copies of these medicines, called biosimilars, are not identical to their reference medicine and therefore specific regulatory requirements apply. When considering the use of biosimilars, the question of the degree ...

Nanomedicine is an interdisciplinary research field where chemistry, physics, biology, engineering, nanotechnology, and medicine meet one other. Many novel nanoparticles have been designed, synthesized, and evaluated for selective targeting of cancer cells, delivering, and releasing the anticancer drugs in a controlled manner. In this review article we discuss the current ...

Applications of regenerative medicine technology may offer novel therapies for patients with injuries, end-stage organ failure, or other clinical problems. Currently, patients suffering from diseased and injured organs can be treated with transplanted organs. However, there is a severe shortage of donor organs that is worsening yearly as the population ...

The Mapuche communities living in the urban areas of Chile have undergone radical cultural changes due to Christian conversion. This article analyzes the influence of these changes on the Mapuche ideas and practices of the traditional healers (machi) and patients in Temuco (IX Region), Chile, and the changes and adaptations ...

Fulton J., Kuit J., Sanders G. & Smith P. (2012) Journal of Nursing Management20, 130-139 The role of the Professional Doctorate in developing professional practice Aims  The present study aims to reflect on, and analyse, one particular approach to the award of a Professional Doctorate. Background  The concept of the ...

Orangutan survival is threatened by habitat loss and illegal killing. Most wild populations will disappear over the next few decades unless threats are abated. Saving orangutans is ultimately in the hands of the governments and people of Indonesia and Malaysia, which need to ensure that habitats of viable orangutan populations ...

The forensic pathologist has always had a central role in the identification of the dead in every day practice, in accidents, and in disasters involving hundreds or thousands of victims. This role has changed in recent years, as advances in forensic odontology, genetics and anthropology have improved the chances of ...

Starting from 4-substituted cyclohexanones, a practical synthetic route to enantiopure 6-substituted cis-decahydroquinolines has been developed, the key steps being a stereoselective cyclocondensation of an unsaturated δ-keto ester derivative with (R)-phenylglycinol and the stereoselective hydrogenation of the resulting tricyclic oxazoloquinolone lactams.

The use of stem cells is galvanizing regenerative medicine research. An analysis of recent trends as typified by articles published between 2009 and 2010 in the journals Cell Transplantation - The Regenerative Medicine Journal and Medical Science Monitor demonstrate the increasing importance of stem cell research as being on the ...

The process of image review and interpretation has become increasingly complex and challenging for today's nuclear medicine physician from many perspectives, especially with regard to workstation integration and reading room ergonomics. With the recent proliferation of hybrid imaging systems, this complexity has increased rapidly, along with the number of studies ...

Interview with Jonathan Thomas We talked to Jonathan Thomas, newly elected Chairman of the California Institute for Regenerative Medicine (CIRM), a few weeks into a role he describes as "the opportunity of the lifetime" to find out what he sees as the key goals for the CIRM and why patient ...

In the context of a competitive knowledge-based economy, the knowledge provided by a firm's founders is one of the most important measures of success. This paper aims to identify the role of national culture on a founder's knowledge practices in a modern organisation. Using data collected from 258 Small to ...

The range of medicines and technologies that are essential for sexual and reproductive health care is well established, but access to them is far from universally assured, particularly in less developed countries. This paper shows how the pharmaceutical industry plays a major role in the lack of access to essential ...

The National Blood Foundation (NBF) support was critical in the author's research career development. The NBF support came in the form of a start-up seed grant that she got from the American Association of Blood Banks, an organization that advances the practice and standards of transfusion medicine and cellular therapies ...

Performance appraisal (PA) is a key human resource activity in organizations. However, in this global economy, we know little about how societal cultures affect PA practices. In this study, we address this gap by focusing on 2 complementary issues: (a) the influence of societal (national) cultural practices on PA practices ...

PARLOUR R and MCCORMACK B. Nursing Inquiry 2011 Blending critical realist and emancipatory practice development methodologies: making critical realism work in nursing research This paper examines the efficacy of facilitation as a practice development intervention in changing practice within an Older Person setting and in implementing evidence into practice. It ...

Abstract Background aims. Regulatory requirements for the manufacturing of cell products for clinical investigation require a significant level of record-keeping, starting early in process development and continuing through to the execution and requisite follow-up of patients on clinical trials. Central to record-keeping is the management of documentation related to patients, ...

Challenges to engage pharmacy customers in medicine dialogues at the counter have been identified comprising a new and extended clinical role for pharmacists in the health care system. This article seeks to expand understanding of factors involved in successful interaction at the pharmacy counter between customers and pharmacy staff to ...

What's known on the subject? and What does the study add? Urology was one of the first specialties to report the introduction of regenerative medicine into clinical practice and has been at the forefront of scientific innovation. Despite the scale of investment and research effort, the promise of regenerative medicine ...

This tutorial review highlights the way in which the Baylis-Hillman reaction has been increasingly attracting the attention of synthetic and medicinal chemists; it not only helps in originating new ideas to create novel methodologies and molecules but also offers intellectual challenges to understand and address the present day needs in ...

The aim of this study was to pay tribute to the memory of extraordinary Croatian Professor of children's and preventive dentistry Sime Kordić on the occasion of the 100th anniversary of his birth. The biography and work of this scientist and teacher were presented, as well as his researches about ...

currie k. & grundy m. (2011) Journal of Nursing Management19, 933-942 Building foundations for the future: the NHS Scotland advanced practice succession planning development pathway Aim  To highlight implications for managers from the implementation of a national advanced practice succession planning development pathway within Scotland. Background  Internationally, advanced practice posts ...

The history of biomaterials research is seriously surveyed. It is found that an immutable way of thinking for developing biomaterials is rooted deeply in Western medicine and biology. It is necessary to modify or change the current status of thinking. In this paper, the author presents an idea to research ...

Shrines associated with the deity Tongnaab in the Talensi region of northern Ghana formed the centre of a precolonial regional cult that encompassed a variety of peoples in the savannas of the Volta basin. Despite attempts by the British colonial state to destroy the shrines and to suppress ritual activity ...

The mineral, organic and elemental composition of medicine clays from three shrines in the Tong Hills in northern Ghana (Gbankil, Kusanaab, and Yaane) are assessed to ascertain what additives they might contain and the implications for their recognition, for example in archaeological contexts. These are clays that are widely used ...

Where does dentistry fit into the field of regenerative medicine? Based on the fact that the goal of regenerative medicine is to restore function to damaged organs and tissues, it is apparent that dentistry, which has long embraced the concept of restoring function of damaged teeth, has embraced this goal ...

Abstract Objectives: The use of complementary and alternative medicine (CAM) has increased in Western countries, with women identified as the primary users. Women's use of CAM in reproductive health is well documented; however, little is known about the use of CAM to enhance fertility, despite anecdotal evidence that this is ...

In Argentina, there are numerous native species which are an important source of natural products and which are traditionally used in medicinal applications. Some of these species are going through an intense extraction process in their natural habitat which may affect their genetic diversity. The aim of this study was ...

On March 9th, 2011, the eminent scholar of Iranian studies, historian, bibliographer, Persian manuscript expert, journalist, biographer and writer, Iraj Afshar passed away at the age of 85 in Tehran. His demise was a great loss to Iranian culture. He edited or wrote around 300 books in various fields of ...

OBJECTIVE: To identify publishers of pharmacotherapeutic information not found in biomedical journals that focuses on evaluating and providing advice on medicines and to develop a search engine to access this information. METHODS: Compiling web sites that publish information on the rational use of medicines and have no commercial interests. Free-access ...

This essay considers the implications of a shift in focus from ideas to practices in the history of alchemy. On the one hand, it is argued, this new attention to practice highlights the diversity of ways that early modern Europeans engaged alchemy, ranging from the literary to the entrepreneurial and ...

With the development of the knowledge economy, knowledge has become one of the most important resources for social progress and economic development. Some countries have proposed measures for the protection of their own traditional knowledge. Traditional Chinese medicine belongs to the category of intangible cultural heritage because it is an ...

Although China embraced the concept of essential medicines in 1979 and issued its first National Essential Medicines List in 1982, until recently China has lacked a comprehensive national essential drug policy. In its most recent health-care reform (2009-2012), the Chinese government explicitly proposed the establishment of a national essential medicines ...

The application of Isodon species in Chinese folk medicine has a long histroy, especially the ones called 'Xihuangcao' in Chinese. 'Xihuangcao' has been successfully applied to treat acute hepatitis, cholecystitis, enteritis, dysentery and trauma. The original species of 'Xihuangcao' is Isodon lophanthoides (Buch.-Ham.ex D.Don). However, there are five sources of ...

BACKGROUND: In 2010, Robert Edwards was awarded the Nobel Prize in Medicine for his pioneering work in the development of in vitro fertilization, a field that has touched millions of lives across the globe. Edwards dedicated his career to helping couples overcome infertility. He first established principles of early embryo ...

Pulmonary nodule detection and characterization continue to improve with technological advancements. The noninvasive methods available for assisting in nodule detection and for characterizing nodules as benign, malignant, or indeterminate will be discussed. Evidence-based guidelines will be reviewed to help guide the appropriate management of pulmonary nodules.

Regenerative medicine aims to restore homeostasis through a broad spectrum of strategies ranging from transplantation of donor organs to augmentation of innate healing processes. Its first clinical application emerged five decades ago when bone marrow-derived stem cells were used to replace defective progenitor cells. Since then, a variety of technological ...

It is important to streamline the interviewing and recruiting process. From the start, it is critical to establish a process that facilitates identification of the right person for the job at this time in the life of your practice. Following the above suggestions will ensure that you comply with state ...

Abstract?Regenerative medicine is a critical frontier in biomedical and clinical research. The major progresses in the last few years were driven by a strong clinical need which could benefit from regenerative medicine outcomes for the treatment of a large number of conditions including birth defects, degenerative and neoplastic diseases, and ...

To review the nonradiologist use of ultrasound (US) in the setting of emergency and critical care, the development, clinical applications, and standardization of veterinary abdominal and thoracic focused assessment with sonography for trauma (FAST) techniques. Since the 1990s, the 4-point FAST US technique has been used for injury surveillance in ...

On 1-2 December 2010 worldwide leaders in the field of co-diagnostics gathered in Boston, MA, USA, to discuss the state of predictive medicine and the complexities of biomarker implementation and partnering. Flanking the primary conference were three workshops where participants could increase their understanding of companion diagnostic commercialization, best practices ...

The practice of antimicrobial stewardship can be defined as optimizing clinical outcomes while minimizing the consequences of antimicrobial therapy such as resistance and superinfection. Antimicrobial stewardship can be difficult to transition to the emergency department (ED) since the traditional activities include the evaluation of broad-spectrum antimicrobial regimens at 72 and ...

I am presenting my 15 years personal Egyptian experience in the management of inhaled veil pins.

During the past decade, the Cochrane Collaboration has been an increasingly important source of information on complementary and alternative medicine (CAM) therapies. From 2007 to 2008, the Cochrane CAM Field developed a topics list that allowed us to categorize all 396 Cochrane reviews related to CAM (as of The Cochrane ...

In the nuclear medicine setting, the task of obtaining informed consent for procedures that require it is frequently left to the nuclear medicine technologist. Unfortunately, a patient's signature on a consent form does not mean the patient has given informed consent, or what legal scholars call valid consent. On completion ...

To cite this article: Kaul S, May S, Lüttkopf D, Vieths S. Regulatory environment for allergen-specific immunotherapy. Allergy 2011; DOI: 10.1111/j.1398-9995.2011.02552.x ABSTRACT: Products for specific immunotherapy (SIT) are medicinal products according to the European Regulations. To obtain a marketing authorization (MA) within the European Community, the quality, safety and efficacy ...

If the risk management for the professional use of dispersive nanomaterials is hampered by a lack of reliable information, the reliable manager and the policy makers have to chose to make the precautionary principle operational for nanotech workplace. This study presents some tools that can be useful for the health ...

Phenomenology is a useful methodology for describing and ordering experience. As such, phenomenology can be specifically applied to the first person experience of illness in order to illuminate this experience and enable health care providers to enhance their understanding of it. However, this approach has been underutilized in the philosophy ...

This study investigated the extent to which recourse to traditional healers depended on biometric variables; ways of knowing in good time what ailments were more likely to be better handled by traditional healers; rationale behind traditional healing methodologies. On the whole, four research questions were engaged. The sample for the ...