The Innovative Medicines Initiative (IMI) was launched in 2008 as a large-scale public-private partnership between the European Commission and the European Federation of Pharmaceutical Industries and Associations (EFPIA). With a total budget of €2 billion, the IMI aims to boost the development of new medicines across Europe by implementing new ...

Is canonical thinking inhibiting the flexibility and innovation required for expert clinical reasoning?

Inhaled long-acting β(2)-adrenoceptor agonists (LABAs) are highly effective bronchodilators in the treatment of asthma and chronic obstructive pulmonary disease. There is significant interest in the development of third-generation compounds that improve upon the marketed twice-daily LABAs salmeterol and formoterol. A principal advantage sought from the next generation is duration of ...

Context: Helicobacter pylori is a major causative factor in gastritis-like disorders, and urease plays a key role in Helicobacter pylori colonizing and persisting in the mucous layer of the human stomach. In China, a variety of Chinese medicinal herbs have been prescribed to attenuate or eradicate gastritis-like disorders. However, little ...

To describe current management of posterior epistaxis among Canadian otolaryngology-head and neck surgeons. A cross-sectional Internet-based survey was distributed to all 550 members of the Canadian Society of Otolaryngology-Head and Neck Surgery with an electronic mail contact. The survey consisted of three sections: (1) demographic data, (2) opinions regarding management ...

Background: The development of algorithms and guidelines in medicine is widespread. There are six major guidelines used and/or influencing the treatment of schizophrenia in the United States. The impact of these guidelines on clinical practice is difficult to evaluate. Many studies to date show poor adherence to schizophrenia guideline recommendations. ...

Hospital management teams should be aware of and prepared to avoid eight key problems for healthcare capital projects: Inadequate resources from the start. Over-reliance on equipment planners. Limited coordination between construction and acquisition teams. Insufficient budget management process. Failure to engage proper outside assistance. Limited management experience with large capital ...

To describe the intensive care units (ICU) current infection control practices regarding the management of central venous catheters (CVCs) in Yemeni hospitals and compare the current practices with the evidence-based guidelines. This study was carried out in ICUs of Sana'a hospitals, Republic of Yemen, in July 2010. We gathered the ...

Objective Interpretation of the growing body of global literature on health care risk is compromised by a lack of common understanding and language. This series of articles aims to comprehensively compare laws and regulations, institutional management, and administration of incidence reporting systems on medical risk management in the United Kingdom, ...

Fee splitting and co-management are common practices in ophthalmology. These arrangements may conflict with the ethical principles governing the doctor-patient relationship, may constitute professional misconduct, and at times, may be illegal. Implications and perceptions of these practices may vary between different cultures. Full disclosure to the patient may minimize the ...

A survey-based assessment of dermatopathologists (DPs) regarding their workload, job satisfaction, and compensation has not been previously undertaken. We e-mailed approximately 1000 DPs in the United States requesting them to complete an anonymous and confidential 20-question online survey and received 110 replies. Not all answered each of the questions posed, ...

The minimum inhibitory concentration(MIC)of a traditional medicine containing 17 components against 9 strains of Trichophyton verrucosum and 13 strains of Malassezia pachydermatis was determined using a method recommended by the Clinical and Laboratory Standards Institute(CLSI). We also measured the MIC of each of the 17 components using the same method, ...

BACKGROUND: Since 1963, the Orthopaedic In-Training Examination (OITE) has been administered to orthopaedic residents to assess resident knowledge and measure the quality of teaching within individual programs. The OITE has evolved dramatically over the years and now maintains a standardized format consisting of 275 questions divided among 12 sections. PURPOSE: ...

The lack of a correct diagnostic and therapeutic planning of vestibular diseases is still often observed, and some difficulties are still to deal with in clinical practice, even when treating acute hearing problems, although the needed competence is more easily identified as otologic. A review of the international literature confirms ...

Surveys from the USA, Australia and Spain have shown significant inter-institutional variation in delivery room (DR) management of very low birth weight infants (VLBWI, <1500g) at birth, despite regularly updated international guidelines. To investigate protocols for DR management of VLBWI in Germany, Austria and Switzerland and to compare these with ...

Sickle cell disease (SCD) is associated with serious comorbidities resulting in a shortened lifespan, and many clients suffer from frequent pain episodes. However, others successfully manage their disease in the outpatient setting without the need for frequent health care utilization. The purpose of this project was to describe specific strategies ...

There are more than 100 different types of dwarfism. Achondroplasia is the most common of these conditions. The aim of this report is to describe the anesthetic management of these patient, discussing the anesthetic considerations and emphasizing the difficulties encountered. A 32-year-old achondroplastic parturient underwent cesarean section under general anesthesia. ...

The Scottish Intercollegiate Guidelines Network (SIGN) has published guidelines for the management of children with head injuries. The management of children with head injuries admitted to our local unit under the Paediatric Surgeons has been audited to determine whether or not current practice follows SIGN recommendations. Data were collected retrospectively ...

At first glance, the commonality among synthetic gene networks, nerve cell response times and the emergence of antibiotic resistance is obscure. Yet, when speaking with James (Jim) Collins, the relationship becomes clear: all are applications-oriented problems, and all inspire unique approaches from this unusual engineer who is empowered by his ...

The water sectors of many countries are faced with the need to address simultaneously two overarching challenges; the need to undertake effective asset management coupled with the broader need to evolve business processes so as to embrace sustainability principles. Research has thus been undertaken into the role sustainability principles play ...

SureSmile (OraMetrix, Richardson, Tex) uses advanced technologies, including digital models, virtual simulations, and robotic wire bending to help clinicians provide customized, efficient treatment. Nicole M. Jane has been a solo orthodontic practitioner in South Lake Tahoe, California, since 2004. She has been using SureSmile technology in her practice since December ...

A large component of ambulatory oncology practice is management of telephone calls placed to and from the practice between outpatient appointments, but they are not a reimbursable service, they require staff resources, and they place an unpredictable demand on workload. In this study, telephone calls were examined at a private ...

In June 2009, the Science and Technology Committee of the UK House of Lords published a report on genomic medicine, based on expert evidence collected over an 18-month period. Crucially, the report signaled that the use of genomic medicine was at a crossroads, due to the rapid development of new ...

The volume and time required to manage a nurse telephone triage line in an urogynecology practice can be a concern for staffing, time management, and office patient flow. Therefore, telephone triage logs were retrospectively reviewed for a 12-month period to investigate whether call volume differed on days of the five-day ...

1. In this study, the calling rates of vocalisations known to indicate distress and aversive events (Alarm calls, Squawks, Total vocalisations) and acoustic parameters of flock noise were quantified from feather and non-feather pecking laying flocks. 2. One hour of flock noise (background machinery and hen vocalisations) was recorded from ...

John Astin, PhD, is a health psychologist at the California Pacific Medical Center Research Institute in San Francisco. He studies psychological, attitudinal, and sociocultural barriers to the integration of mind-body factors in medicine and is especially interested in the role of contemplative practices, particularly meditation, in improving mental and physical ...

This invited session is intended to address the needs of current and budding entrepreneurial bioengineers. It will draw on the personal experiences of the panelists, relaying their attempts to meet the demands and delights of their customers, while still managing to act responsibly for their shareholders. The audience will be ...

Malcolm C. K. Soh, Navjot S. Sodh, Robin K. H. Seoh and Barry W. Brook

OBJECTIVE: High-risk antepartum patients often require long and costly hospitalization. The Mother's House facility has been used to house antepartum women on hospital property as an alternative to inpatient management. This study looked at the cost effectiveness of this facility. STUDY DESIGN: A retrospective chart review on occupants (n = ...

In France, as in many other countries, phoning while driving is legally restricted because of its negative impact on driving performance which increases accident risk. Nevertheless, it is still a frequently observed practice and one which has not been analyzed in detail. This study attempts to identify the profiles of ...

Thesis; interviews with Karuk American Indian religious leaders/elders; connection between religious freedom and natural resources/environment; focus on American Indian natural resource management as a component of religion and deserving of religious freedom protections

As with many farmland bird species, the house sparrow Passer domesticus is declining in Europe, mainly due to intensification of agriculture reducing nest sites and food supplies. During 2002-2005, we studied the population size and nest site characteristics of house sparrows breeding within white stork Ciconia ciconia nests in a ...

Controlled clinical trials are unusual in surgery, rare in urology, and almost non-existent as far as the management of urethral stricture is concerned. What data there are come largely from so called "expert opinion" and the quality of this is variable. None the less, the number of so called experts, ...

BACKGROUND: The implementation of the European working time directive has led to an increase in cross-speciality out-of-hours cover. This survey illustrates ENT out-of-hours cover arrangements and assesses the implications for senior house officers (SHOs) responsible for managing emergencies. METHODS: A telephone survey of 100 ENT departments was conducted, asking the ...

This paper tackles the questions raised by the conservation of a multipurpose resource: to assess the impact of different grazing regimes on sward structure during spring. Their impact was assessed in relation to the optimal sward structure for nesting lapwing (Vanellus vanellus). Only 6 fields, with winter grazing and heavy ...

In September of 2005, the North Carolina Marine Fisheries Commission approved regulations in the blue crab fishery for reducing wasteful fishing practices and preserving the spawning stock. Interviews of soft and peeler crab fishermen in Carteret County, North Carolina revealed the perceived effects of these and other regulations on their ...

Based on the her experiences of completing a doctoral study in which semi-structured interviews featured as the primary data collection method, Christine Dearnley offers a reflective insight into using semi-structured interviews as a method of data collection. The processes of reflection in, and on, the interview process are explored, and ...

Selected oil cakes, neem, castor and mahua, were tried independently and in combination with a chemical nematicide (carbofuran 3G) for the management of Pratylenchus delattrei in crossandra under glass house conditions. The neem oil cake was effective compared to other oil cakes used and there was a synergistic effect when ...

Vacuum cleaners with a central exhaust may lead to lower airborne dust and allergen concentrations compared with regular vacuum cleaners. In 12 houses, equipped with a central vacuum cleaning system, a standardized vacuum cleaning protocol was performed comparing airborne dust and allergen concentrations between the central system and a regular ...

David Monro, MD, was a son of the third Professor Monro of Edinburgh. He went into practice in Edinburgh and then emigrated to the Nelson settlement in New Zealand. There he practised a little medicine, but was mostly a gentleman sheep-farmer. He was a member of the first parliament of ...

The influence of ice-nucleating active (INA) bacteria on cold hardiness of the house spider, Achaearanea tepidariorum, was determined by measuring the supercooling point (SCP) of hatchlings given either INA-bacteria-fed or bacteria-free prey (Drosophila melanogaster). Spiders that had eaten INA-bacteria-fed flies showed higher SCPs than those fed on bacteria-free flies. Through ...

This article begins with Jung's description of two predicaments which confront the contemporary psychiatrist: 'the mystery of the patient's difference' and the danger of 'committing psychic murder in the name of therapy.' The article then presents the example of one suffering individual from within a non-Western culture who used Jung, ...

What began as a small shower of questions quickly transformed into a storm of investor protest last week as Tenet Healthcare Corp. underwent a management overhaul and analysts asked questions about its fiscal future. Tenet's business strategy came under scrutiny because a large proportion of its Medicare revenue was generated ...

BACKGROUND: In a general practice in The Netherlands, the demand for direct telephone consultation with the doctor became extreme, which resulted in poorly managed consultations, and poor telephone access due to busy lines. A call-back telephone appointment system was therefore introduced: all calls are answered and, when possible, managed by ...

In 1535, when Jacques Cartier landed in Canada for the second time, he sailed up the Saint-Lawrence, and spent the winter at Stadaconé. His ships were frozen in the ice for five months. A strange disease attacked the indigenous population, and then the French sailors. In a two month period, ...

Annette Innella is just coming into the lunchroom at Concord Machines when Bob Dunn starts screaming at her. After throwing his lunch tray against the wall, he stomps out, leaving Annette stunned. Naturally, Annette, the new senior VP for knowledge management, is beside herself. She knows her proposal to establish ...

The influence of three types of farm management on the occurrence of Q fever in cattle was investigated by means of a serological study carried out in Irpinia in southern Italy. Twenty-one herds were permanently housed, 26 were housed in winter and turned out to graze in the spring, and ...

Library has printed ed. of summaries of the workshop outcomes: access.no.399224, call no.634.96 C45

This analysis of medicines used in a Quechua soul-calling ritual in the southern Peruvian Andes demonstrates that the items in sacrificial bundles (despachos) embody the identity of patients. The manipulation of these medicinal objects gives insight into the meaning of the concept of embodiment in the Andean cultural context and ...

OBJECTIVE: Under managed care, telephone management is crucial to pediatric practice, but an effective method is needed to teach residents telephone skills. Our objective was to design an interactive CD-ROM program to teach residents an organized, consistent approach to telephone complaints and to determine whether use of the program was ...