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Jafari Samineh - - 2014
Context • Traditional systems of medicine have attained great popularity among patients in recent years. Success of this system in the treatment of disease warrants consideration, particularly in cases for which conventional medicine has been insufficient. Objective • This study investigates the similarities in principles and approaches of 3 traditional ...
Zhou Xuezhong X School of Computer and Information Technology and Beijing Key Lab of Traffic Data Analysis and Mining, Beijing Jiaotong University, Beijing, 100044, China, - - 2014
Traditional Chinese medicine (TCM) investigates the clinical diagnosis and treatment regularities in a typical schema of personalized medicine, which means that individualized patients with same diseases would obtain distinct diagnosis and optimal treatment from different TCM physicians. This principle has been recognized and adhered by TCM clinical practitioners for thousands ...
Joly Yann Y Centre of Genomics and Policy, McGill University, Montreal, - - 2014
Personalized medicine encompasses the use of biological information such as genomics to provide tailored interventions for patients. The review explores the ethical, legal, and social issues that have emerged with personalized medicine and must be considered because of the complex nature of providing individualized care within a clinical setting. Recent ...
Viteri Jusué A A Servicio de Radiodiagnóstico, Hospital Universitario Basurto, Bilbao, Bizkaia, España. Electronic address: - - 2014
Eponyms reflect the history of medicine, of disease, and of physicians, but eponyms also reflect the history of the societies in which these physicians lived. Both loved and hated, eponyms are at the center of an interminable debate about whether they should continue to be used or whether they should ...
Dobrota Rucsandra R Division of Rheumatology, University Hospital Zurich, Gloriastrasse 25, 8091, Zurich, - - 2014
The concept of personalized medicine has led to a paradigm shift in recent years. It integrates multiple clinical and biological levels of investigation aimed at offering the best possible and patient-tailored healthcare. This holds great potential in a rare and heterogeneous disease such as systemic sclerosis (SSc). The development of ...
Shulimzon Tiberiu R - - 2014
Interventional pulmonology (IP) is the newest chapter in respiratory medicine. IP includes both diagnostic and therapeutic methods. Nanotechnology, in both instrumental engineering and optical imaging, will further advance this competitive discipline towards cell diagnosis and therapy as part of the future's personalized medicine.
Weijs Cynthia A CA Department of Population Medicine, Ontario Veterinary College (C.W., J.C.), and Psychology Department (A.M., E.C., S.D.), University of Guelph, Guelph, ON, Canada. - - 2014
Social media use by health professionals occurs in a digital environment where etiquette has yet to be solidly defined. The objectives of this study were to explore veterinarians' personal use of Facebook, knowledge of privacy settings, and factors related to sharing personal information online. All American Animal Hospital Association member ...
Petersen Katelin E KE Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, Ohio, - - 2014
Background: The success of personalized medicine depends on factors influencing the availability and implementation of its new tools to individualize clinical care. However, little is known about physicians' views of the availability of personalized medicine across racial/ethnic groups and the relationship between perceived availability and clinical implementation. This study examines ...
Cheung Melissa Mei Yin MM Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, - - 2014
Abstract Objective Personality traits have been found to be associated with the management of chronic disease, however there is limited research on these relationships with respect to asthma. Asthma management and asthma control are often suboptimal, representing a barrier to patients achieving good health outcomes. This explorative study aimed to ...
Matsumoto Tomoshige T Department of Clinical Laboratory, Osaka Anti-Tuberculosis Association Osaka Hospital, Neyagawa, Osaka, - - 2014
Personalized medicine uses technology to enable a level of personalization not previously practical. Currently, tuberculosis (TB) therapy is not personalized. Previous reports have shown that a genetic polymorphism of NAT2 is associated with large interindividual and inter-racial differences in the toxicity and efficacy of isoniazid. Herein, we show the safety ...
Ozdemir Vural V 1 Pacific Rim Association for Clinical Pharmacogenetics, Associate Member Society of the International Union of Basic and Clinical Pharmacology - - 2014
Abstract This article announces the recipient of the 2014 inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine by the Pacific Rim Association for Clinical Pharmacogenetics (PRACP): Bernard Lerer, professor of psychiatry and director of the Biological Psychiatry Laboratory, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. The Werner ...
Pacanowski M A MA Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, - - 2014
Application of personalized medicine in drug development and regulation has been limited by similar logistical, informatics, and cultural barriers that limit use of pharmacogenetics in the clinic. An additional challenge is coordinated codevelopment of new drugs and diagnostic tests. Nevertheless, the impact of personalized medicine strategies (e.g., pharmacogenomics) is being ...
Parker Scott S Simmons & Simmons LLP, CityPoint, One Ropemaker Street, London, EC2Y 9SS, - - 2014
In this review, we take a look at the patentability issues surrounding personalized medicine patent claims. We examine how the USA and European Patent Office have dealt with such patent claims, and then review the UK 'inherency' and 'selection' decisions to take a view as to how the UK courts ...
Breen James O - - 2014
In our family medicine program, applicants' personal statements largely speak to the value of trusting, continuous doctor-patient relationships. They give poignant examples of patient interactions that have allowed the applicants to experience the privilege of the intimacy with which patients relate to their doctors. Whatever their true motivations for choosing ...
Waldman S A SA 1] Department of Pharmacology and Experimental Therapeutics, Delaware Valley Institute for Clinical and Translational Science [2] Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, - - 2014
Personalized medicine epitomizes an evolving model of care tailored to the individual patient. This emerging paradigm harnesses radical technological advances to define each patient's molecular characteristics and decipher his or her unique pathophysiological processes. Translated into individualized algorithms, personalized medicine aims to predict, prevent, and cure disease without producing therapeutic ...
Olsson Tomas T Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, - - 2014
This issue of the Journal of Internal Medicine features two comprehensive reviews on the dramatic evolution, current status and future challenges in the field of multiple sclerosis (MS) therapy. Both reviews are very timely and encouraging in terms of the ultimate goal of curative treatments. Here I will also discuss ...
Williams Shawn P SP Assistant Professor, Department of Health Professions, CUNY-York College, Jamaica, NY. Electronic address: - - 2014
The purpose of this study was to establish the frequency of burnout among doctors of chiropractic in the United States. Using a nonprobability convenience sampling methodology, we e-mailed the Maslach Burnout Inventory-Human Services Survey and a sociodemographic questionnaire to a randomized sample of licensed doctors of chiropractic (n = 8000). ...
Glauber Harry S HS Department of Endocrinology, Northwest Permanente, Portland, Oregon, USA; ; Galil Center for Telemedicine, Medical Informatics and Personalized Medicine, RB Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, - - 2014
The world is facing an epidemic rise in diabetes mellitus (DM) incidence, which is challenging health funders, health systems, clinicians, and patients to understand and respond to a flood of research and knowledge. Evidence-based guidelines provide uniform management recommendations for "average" patients that rarely take into account individual variation in ...
Hayes Daniel F - - 2014
Personalized medicine is increasingly being employed across many areas of clinical practice, as genes associated with specific diseases are discovered and targeted therapies are developed. Mobile apps are also beginning to be used in medicine with the aim of providing a personalized approach to disease management. In some areas of ...
Alzu'bi Amal A The Department of Health Information Management at the University of Pittsburgh in Pittsburgh, - - 2014
In recent years, the term personalized medicine has received more and more attention in the field of healthcare. The increasing use of this term is closely related to the astonishing advancement in DNA sequencing technologies and other high-throughput biotechnologies. A large amount of personal genomic data can be generated by ...
Rossolatos David D Department of Psychiatry, University of Alberta, Edmonton, AB T6G 2E1, - - 2014
Personal Genomes and Pharmacogenomics meeting, Cold Spring Harbor Laboratory, USA, November 13-16, 2013.
Gu Jiang J *Department of Pathology, Shantou University Medical College, Shantou, Guangdong, China †Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, - - 2014
The traditional task of the pathologist is to assist physicians in making the correct diagnosis of diseases at the earliest possible stage to effectuate the optimal treatment strategy for each individual patient. In this respect surgical pathology (the traditional tissue diagnosis) is but a tool. It is not, of itself, ...
Jayachandran D D School of Chemical Engineering, Purdue University, West Lafayette, Indianapolis, - - 2014
Despite recent advancements in "omic" technologies, personalized medicine has not realized its fullest potential due to isolated and incomplete application of gene expression tools. In many instances, pharmacogenomics is being interchangeably used for personalized medicine, when actually it is one of the many facets of personalized medicine. Herein, we highlight ...
Karczewski Konrad J KJ Biomedical Informatics Training Program, Stanford University School of Medicine, Stanford, CA 94305, USA. - - 2013
A report on the Cold Spring Harbor Laboratory meeting on Precision Medicine: Personal Genomes and Pharmacogenomics, held in Cold Spring Harbor, New York, USA, November 13-16, 2013.
Schleidgen Sebastian - - 2013
Recently, individualized or personalized medicine (PM) has become a buzz word in the academic as well as public debate surrounding health care. However, PM lacks a clear definition and is open to interpretation. This conceptual vagueness complicates public discourse on chances, risks and limits of PM. Furthermore, stakeholders might use ...
Daniels Vijay J - - 2013
There has been a decline in interest in general internal medicine that has resulted in a discrepancy between internal medicine residents' choice in the R4 subspecialty match and societal need. Few studies have focused on the relative importance of personal goals and their impact on residents' choice. The purpose of ...
Chen J Y - - 2013
Network medicine is a new approach that focuses on applying systems biology to pharmacology by "understanding the molecular system [and its perturbations] as a whole" so as to unravel the complex relationships among disease processes, genes, drugs, therapeutic indicators, and adverse effects.(1,2.)
Naughton Louise - - 2013
A new report into female genital mutilation (FGM) highlights that, despite the barbaric practice being illegal in the U.K., not one single person has been held to account for their involvement in the act.
Kim Taewoo - - 2013
Abstract Objectives: This paper examines the meanings of classical texts in contemporary East Asian medicine. Methods: This study conducted anthropological fieldwork of the Hyungsang Medical Society, the major practitioner association in South Korea, which follows the teachings of Donguibogam (Bogam), one of the most influential texts in contemporary Korean medicine. ...
Butts C - - 2013
The burden of cancer for Canadian citizens and society is large. New technologies have the potential to increase the use of genetic information in clinical decision-making, furthering prevention, surveillance, and safer, more effective drug therapies for cancer patients. Personalized medicine can have different meanings to different people. The context for ...
Diaz V A - - 2013
Background/Aims: Patient concerns regarding personalized medicine may limit its use. This study assesses racial differences in attitudes toward personalized medicine, evaluating variables that may influence these attitudes. Methods: A convenience sample of 190 adults (≥18 years) from an academic primary care practice was surveyed regarding awareness and acceptance of personalized ...
Signore Alberto - - 2013
Inflammatory and infectious diseases include many different clinical conditions not often well recognised and characterized with conventional radiology and biochemical tests. Radiological techniques (TC, MRI, US) show anatomical changes that usually occur in chronic stages of the disease leading to a delayed diagnosis and therapy. The possibility of Nuclear Medicine ...
Frueh Felix W - - 2013
There is undisputed evidence that personalized medicine, that is, a more precise assessment of which medical intervention might best serve an individual patient on the basis of novel technology, such as molecular profiling, can have a significant impact on clinical outcomes. The field, however, is still new, and the demonstration ...
Towse Adrian - - 2013
The preceding articles in this volume have identified and discussed a wide range of methodological and practical issues in the development of personalized medicine. This concluding article uses the resulting insights to identify implications for the economic incentives for evidence generation. It argues that promoting an efficient path to personalized ...
Redekop W Ken - - 2013
The objective of this article was to provide a framework for understanding the different definitions of the term "personalized medicine." The term personalized medicine is used regularly but interpreted in different ways. This article approaches the term by starting with a broad view of clinical medicine, where three components can ...
O'Donnell John C - - 2013
The decade since the completion of the sequencing of the human genome has witnessed significant advances in the incorporation of genomic information in diagnostic, treatment, and reimbursement practices. Indeed, as case in point, there are now several dozen commercially available genomic tests routinely applied across a wide range of disease ...
Payne Katherine - - 2013
This article aims to provide an overview of the current literature focusing on the reimbursement of personalized medicine across the European Union. The article starts by describing types of perspectives that are possible (general public, patient, payer, provider, service commissioner, and policymaker). The description of perspectives also explains the importance ...
D'Silva Krittika - - 2013
Background:Daily changes in the shape and size of the residual limb affect prosthetic socket fit. Prosthetic socks are often added or removed to manage changes in limb volume. Little has been published about how persons with transtibial amputations use socks to manage diurnal changes in volume and comfort.Objectives:To investigate prosthetic ...
Abi-Jaoudeh Nadine N Radiology and Imaging Sciences, National Institutes of Health, Rockville Pike, Bethesda, MD 20892, USA. - - 2013
As personalized medicine becomes more applicable to oncologic practice, image-guided biopsies will be integral for enabling predictive and pharmacodynamic molecular pathology. Interventional radiology has a key role in defining patient-specific management. Advances in diagnostic techniques, genomics, and proteomics enable a window into subcellular mechanisms driving hyperproliferation, metastatic capabilities, and tumor ...
Pellowska M - - 2013
Pharmacogenomics offers an entrance in the field of personalized medicine. This form of adapted therapy is going to be the future concerning the reduction of side effects and efficacy of the treatment of severe diseases. Vemurafenib and Ivacaftor are the first FDA approved drugs specially addressing mutated proteins. Both substances ...
Overby Casey Lynnette - - 2013
Personalized medicine can be defined broadly as a model of healthcare that is predictive, personalized, preventive and participatory. Two US President's Council of Advisors on Science and Technology reports illustrate challenges in personalized medicine (in a 2008 report) and in use of health information technology (in a 2010 report). Translational ...
Vaiopoulou A - - 2013
Personalized Medicine is more than just a metabolic activity of a person. Pharmacogenomics, pharmacogenetics, pharmacoproteomics, and metabolomics play an important role in the development of personalized medicines. Personalized medicine uses information about a person's genes, proteins, enzyme activities, and cellular environment to diagnose and treat disease, cancer included. A major ...
Fins Joseph J - - 2013
Although the appellation of personalized medicine is generally attributed to advanced therapeutics in molecular medicine, deep brain stimulation (DBS) can also be so categorized. Like its medical counterpart, DBS is a highly personalized intervention that needs to be tailored to a patient's individual anatomy. And because of this, DBS like ...
Alfirevic Ana - - 2013
The Wolfson Centre for Personalised Medicine is part of the Institute of Translational Medicine at the University of Liverpool (Liverpool, UK). It houses a multidisciplinary team of personalized medicine researchers engaged in collaborative research with partners across the globe. The primary focus of the centre is the identification of predictive ...
Bragazzi Nicola Luigi - - 2013
Food has societal, economic, medical and ethical implications, being fundamental for life. It plays an important role also in sports medicine, since a healthy diet is an important part of an athlete's training. Nutrigenomics and nutriproteomics are emerging as a result of a convergence of nutritional, genomics and proteomics knowledge ...
Mudge Suzie - - 2013
Abstract Purpose: This study aimed to understand our shared conflicting response and discomfort to person-centred rehabilitation within the context of our physiotherapy rehabilitation culture by reflecting on our own experiences as research physiotherapists and clinicians. Method: This study used autoethnographical methods to explore the personal and professional experiences of two ...
Wang Zhong - - 2013
Deconstructing networks and rewiring alterable modules in a rational way is critical to optimize drug discovery and develop personalized medicine.
Ozomaro Uzoezi - - 2013
The central theme of personalized medicine is the premise that an individual's unique physiologic characteristics play a significant role in both disease vulnerability and in response to specific therapies. The major goals of personalized medicine are therefore to predict an individual's susceptibility to developing an illness, achieve accurate diagnosis, and ...
Jefferys Benjamin R BR Centre for Computational Science, Department of Chemistry , University College London , London WC1H 0AJ , - - 2013
Personalized medicine relies in part upon comprehensive data on patient treatment and outcomes, both for analysis leading to improved models that provide the basis for enhanced treatment, and for direct use in clinical decision-making. A data warehouse is an information technology for combining and standardizing multiple databases. Data warehousing of ...
Sawitzke Allen Dale - - 2013
Personalized medicine is a much talked about subject that is a timely and important development to healthcare in general and also specifically for patients affected by osteoarthritis. This review uses biomarker examples pertinent to osteoarthritis to highlight the current status of the field, while also highlighting probable future developments. It ...
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