Search Results
Results 301 - 350 of 602
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Marinac Jacqueline S - - 2010
To present the member registry survey methods and characterize the first national clinical pharmacy practice-based research network (PBRN). Cross-sectional online survey. A national clinical pharmacy association. American College of Clinical Pharmacy (ACCP) full and associate members, integrated health system groups of pharmacists, and existing PBRNs were invited to participate in ...
Squassina Alessio - - 2010
The implementation of genetic data for a better prediction of response to medications and adverse drug reactions is becoming a reality in some clinical fields. However, to be successful, personalized medicine should take advantage of an informational structured framework of genetic, phenotypic and environmental factors in order to provide the ...
Webb Vanessa - - 2010
Clinical Governance describes a systematic approach to maintaining and improving the quality of patient care. Risk management includes a themes analysis of clinical incidents and positive interventions with the resulting information disseminated to staff through personal performance plans, and publication and development training workshops. Our model of healthcare provision utilises ...
Zhu Man - - 2010
This manuscript is intended to explore and establish a management system and working model which can maximise the development of clinical pharmacy in China. With a study of a series of documents about clinical pharmacists issued by China Ministry of Health and practical experience in clinical pharmacist training, the authors ...
Augoustides John G T - - 2011
Recent advances in the management of acute Stanford type A dissection have highlighted the clinical importance of clinical presentation and extent of dissection. The Penn classification of type A clinical presentations is based on ischemic profiles that not only determine mortality but also influence management options. The extent of type ...
Young Douglas A - - 2010
This article suggests a practical methodology to implement the scientific information presented in the earlier articles into clinical practice. The Caries Balance/Imbalance Model and a practical caries risk assessment procedure for patients aged 6 years through adult illustrate evidence-based treatment options. Neither the forms nor the clinical protocols are meant ...
Viner Bradley - - 2010
Optimising the clinical outcome for the cases we treat has to be of primary importance to every practitioner wherever they are working and whatever their sphere of practice, yet it requires much more than just clinical knowledge. This review discusses how a system of good clinical governance can help to ...
Berdaï Driss - - 2010
Drug evaluation is based on comparison. Thus, the choice of the comparator for any new treatment becomes a key issue, especially when there are great differences in medical practice and of use conditions of the comparators depending on the geographical zones and their evolution with time. The choice of the ...
Aronson Jeffrey K - - 2010
1. This is a manifesto for UK clinical pharmacology. 2. A clinical pharmacologist is a medically qualified practitioner who teaches, does research, frames policy, and gives information and advice about the actions and proper uses of medicines in humans and implements that knowledge in clinical practice. Those without medical qualifications ...
Peters Mathilde C - - 2010
This article provides a state-of-the-art overview of clinically relevant evidence regarding effective, noninvasive management strategies to prevent, arrest, and remineralize caries lesions. With the rapidly increasing knowledge about oral biofilms and the process of caries in itself, the profession is embarking on new strategies. This is an exciting time, with ...
Bounameaux H - - 2010
Pulmonary embolism (PE) cannot be diagnosed solely on a clinical basis, because of the lack of sensitivity and specificity of clinical signs and symptoms. Pulmonary angiography is invasive and resource demanding. Because the prevalence of PE is relatively low (20% or less) amongst individuals who are clinically suspected of having ...
Bindal Taruna - - 2010
BACKGROUND: There is an increasing focus on trainees acquiring management skills which form part of college curricula and the guidance provided by the General Medical Council in the UK. OBJECTIVE: To explore the managerial learning activities of senior paediatric specialist registrars (SpRs). DESIGN, SETTING, PARTICIPANTS: Questionnaire study; West Midlands region, ...
Hajjaj F M - - 2010
Abstract Background Clinical decision making in dermatology is a complex process and might be influenced by a wide range of non clinical factors. Objectives The aim of this study was to explore the role of non clinical influences, beyond diagnosis and severity, on clinical decision making in dermatology. Methods Semi ...
Gharib H - - 2010
American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules are systematically developed statements to assist health care professionals in medical decision making for specific clinical conditions. Most of the content herein is based on ...
Hajjaj F M - - 2010
This article reviews an aspect of daily clinical practice which is of critical importance in virtually every clinical consultation, but which is seldom formally considered. Non-clinical influences on clinical decision-making profoundly affect medical decisions. These influences include patient-related factors such as socioeconomic status, quality of life and patient's expectations and ...
Bowakim Jorge - - 2010
The elbow is a rare location for septic arthritis, and this fact may produce diagnostic errors. The purpose of this study is to determine the most typical clinical presentation and to evaluate the management and functional outcome of these patients. We present our experience with this entity. This is a ...
Goldsmith David - - 2010
The recombinant human erythropoietins and allied proteins (epoetin alfa, attempted copies and biosimilar variants of epoetin alfa, epoetin beta, epoetin delta, epoetin zeta, epoetin theta, epoetin omega, darbepoetin alfa, and methoxy-polyethylene glycol-epoetin beta) are among the most successful and earliest examples of biotechnologically manufactured products to be used in clinical ...
Morrow Angela M - - 2010
The rising prevalence of children with chronic conditions has made quality of life an increasingly important outcome measure in paediatric practice. The discrepancy between doctors' and patients' perceptions of quality of life makes formal assessment necessary. In this paper we use a case scenario to answer commonly asked questions. What ...
Melnick Edward R - - 2010
Clinical practice guidelines are developed to reduce variations in clinical practice, with the goal of improving health care quality and cost. However, evidence-based practice guidelines face barriers to dissemination, implementation, usability, integration into practice, and use. The American College of Emergency Physicians (ACEP) clinical policies have been shown to be ...
De Deyne Cathy S - - 2010
PURPOSE OF REVIEW: Therapeutic hypothermia after traumatic brain injury (TBI)? For the last 10 years, no topic has been more popular and more controversial among neurointensivists. This article reviews the most current findings (experimental, clinical, adult and pediatric TBI), as well as the clinical management of therapeutic hypothermia. RECENT FINDINGS: ...
Deans K J - - 2010
Practice misalignments can occur in any clinical trial investigating a pre-existing therapy that is typically adjusted based on clinical characteristics outside of the trial setting. To eliminate the heterogeneity in clinical practice, recent trials investigating titrated therapies have randomized patients to fixed-dose regimens without including a routine care control group ...
North Trista E - - 2010
Umbilical cord transplants have emerged as an important therapeutic option for patients with leukemia and lymphoma. A recent study in Nature Medicine highlights the potential and challenges of translating cell-based therapies to the clinic.
Mechanick Jeffrey I - - 2010
In 2004, the American Association of Clinical Endocrinologists (AACE) published the "Protocol for Standardized Production of Clinical Practice Guidelines," which was to be implemented in forthcoming clinical practice guidelines (CPG). This protocol formally incorporated subjective factors and evidence-based medicine (EBM) methods that tightly mapped evidence levels to recommendation grades. A ...
Peeler J - - 2010
OBJECTIVE: To investigate the accuracy and reliability of anterior cruciate ligament (ACL) clinical examination in a multidisciplinary sports medicine setting. DESIGN: Retrospective review of patient charting. SETTING: Community-based multidisciplinary sports medicine clinic. PATIENTS: One hundred twelve patients with surgically confirmed ACL tear. INTERVENTIONS: Review of therapist, physician, and orthopedic surgeon ...
Davenport Todd E - - 2010
Fatigue is one of the most common reasons why people consult health care providers. Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is one cause of clinically debilitating fatigue. The underdiagnosis of CFS/ME, along with the spectrum of symptoms that represent multiple reasons for entry into physical therapy settings, places physical therapists in ...
Merli Geno J - - 2010
Thanks to their predictable pharmacokinetics and ease of use, low-molecular-weight heparins (LMWHs) have established uses in the prevention and treatment of thrombotic diseases and as a replacement for unfractionated heparin (UFH). Although LMWHs as a class have similar antithrombotic effects, they comprise a diverse group of agents with distinct biochemical ...
Wittkowsky Ann K - - 2010
The search for an oral anticoagulant with acceptable efficacy and safety in the treatment and prevention of venous and arterial thromboembolism, but with practical advantages over warfarin, has been a focus of drug development for many years. Three oral agents, dabigatran, rivaroxaban, and apixaban, are nearing approval in the US. ...
Sheyn Dima - - 2010
Regenerative medicine appears to take as its patron, the Titan Prometheus, whose liver was able to regenerate daily, as the field attempts to restore lost, damaged, or aging cells and tissues. The tremendous technological progress achieved during the last decade in gene transfer methods and imaging techniques, as well as ...
Hussein Ayman A - - 2010
Niacin is a B-complex vitamin which has been used for decades for the management of mixed dyslipidemias and primary hypercholesterolemia. It decreases the risk of cardiovascular events either when used as a monotherapy or in combination with other lipid lowering medications. However, a major limitation to its use is niacin-induced ...
Farrell Barbara - - 2010
Managing clinical trials, of whatever size and complexity, requires efficient trial management. Trials fail because tried and tested systems handed down through apprenticeships have not been documented, evaluated or published to guide new trialists starting out in this important field. For the past three decades, trialists have invented and reinvented ...
Kiss Joseph E - - 2010
Thrombotic thrombocytopenic purpura is a life-threatening multisystem disorder that represents both a diagnostic and a management challenge to clinicians. Early recognition of the condition coupled with rapid institution of plasma exchange has led to a dramatic improvement in prognosis. Studies performed over the past decade have elucidated the predominant pathophysiology, ...
Lyng Karen Marie - - 2010
This paper presents a case study of clinical guidance within oncology clinics. Close to all patients treated within the observed clinics were treated according to a research or standard treatment protocol. The protocol artifacts were however rarely applied in clinical practice instead we found an extensive application of what we ...
Ismaeel S M - - 2010
The aim of the study was to explore the ultrasound training requirements in acute medicine by comparing the ultrasound skill of an acute medicine trainee (AMT) with that of the radiology department following short ultrasound training. 43 participants (34 males and 9 females).The mean age was 58 (range 20-93 years). ...
Ravanipour Maryam - - 2010
The population of elderly in Iran and in the world is increasing. It is predicted that the population of elderly reaches to 10 millions in Iran by the year 2019. Elders more than other age groups are at risk of chronic diseases and health problems; and elderly affects their self-management ...
Molassiotis Alex A School of Nursing, University of Manchester, UK. - - 2010
Cough is a common and distressing symptom in lung cancer patients. The clinical management of cough in lung cancer patients is suboptimal with limited high quality research evidence available. The aim of the present paper is to present a clinical guideline developed in the UK through scrutiny of the literature ...
Goodwin S Diane - - 2010
The American College of Clinical Pharmacy charged the Clinical Practice Affairs Committee to review and update the College's 1995 White Paper, "Rewards and Advancements for Clinical Pharmacy Practitioners." Because of the limited data on the present state of rewards and advancements for clinical pharmacists, an online survey of "front-line" clinical ...
de Koning Paul - - 2009
Over the past decades, the scope of clinical pharmacology within the pharmaceutical industry has widened considerably. Key growth has been in the area of translational science and exploratory medicine, where clinical pharmacologists are nowadays the mediator between basic research and establishment of clinical usefulness. This role has led to and ...
Waldman Scott A - - 2009
Individualized medicine provides a powerful engine revolutionizing the practice of clinical pharmacology, tailoring genetic and molecular profiles of patients to improve therapeutic specificity, reduce treatment variability and minimize adverse drug events. In that context, advances in individualized medicine have transformed the science of clinical pharmacology and therapeutics from drug discovery ...
Kelly Jill - - 2009
BACKGROUND: Australian general practice networks (GPN) are required to report on national performance indicators under the Australian Government Department of Health and Ageing's National Quality Performance System (NQPS). OBJECTIVE: To investigate the extent to which Victorian GPN are 'ready' to manage clinical data from general practice for reporting under the ...
Zu?iga Leyre - - 2010
For similar biological medicinal products, the so-called biosimilars, clinical trials are required rather than just the bioequivalence studies required to support the registration of a generic small molecule drug product. The EU Directive 2001/83/EC, as amended, stated that where a biological medicinal product which is similar to a reference biological ...
Zerler Harry - - 2009
Motivational Interviewing (MI) can be effectively applied to clinical crises and suicidal patients. A case example of a suicidal patient demonstrates traditional management combined with two evidence-based practices: MI and Collaborative Assessment and Management of Suicidality. The case example illustrates some benefits and limitations of the application of these innovative ...
Provan Drew - - 2010
Previously published guidelines for the diagnosis and management of primary immune thrombocytopenia (ITP) require updating largely due to the introduction of new classes of therapeutic agents, and a greater understanding of the disease pathophysiology. However, treatment-related decisions still remain principally dependent on clinical expertise or patient preference rather than high-quality ...
Kamhi Alan G - - 2011
In this article, I question how practitioners can balance the certainty and confidence that they can help their patients with the uncertainty that makes them continually question their beliefs and assumptions. I compare the mechanisms of science and models of clinical practice that may help practitioners achieve the right balance ...
Sittig Dean F DF UT-Memorial Hermann Center for Healthcare Quality and Safety, University of Texas School of Health Information Science, 6410 Fannin Street, Houston, TX 77030, USA. - - 2010
To explore the need for, and use of, high-quality, collaborative, clinical knowledge management (CKM) tools and techniques to manage clinical decision support (CDS) content. In order to better understand the current state of the art in CKM, we developed a survey of potential CKM tools and techniques. We conducted an ...
Gaster Richard S RS Department of Bioengineering, Stanford University, Stanford, California, - - 2009
Advances in biosensor technologies for in vitro diagnostics have the potential to transform the practice of medicine. Despite considerable work in the biosensor field, there is still no general sensing platform that can be ubiquitously applied to detect the constellation of biomolecules in diverse clinical samples (for example, serum, urine, ...
Tweardy David J - - 2009
BCM faculty members spearheaded the development of a first-generation Personal Genome Profile (Baylor PGP) assay to assist physicians in diagnosing and managing patients in this new era of medicine. The principles that guided the design and implementation of the Baylor PGP were high quality, robustness, low expense, flexibility, practical clinical ...
Puntmann V O - - 2009
A biomarker is a characteristic that can be objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes or pharmacological responses to a therapeutic intervention. Many commonly used tests in clinical practice can serve as biomarkers. The majority have been identified on the basis of insight or ...
Glick Ira D - - 2009
Rapid advances in neuroscience and clinical research have made the practice of quality clinical psychopharmacology increasingly difficult. While practice guidelines, model psychopharmacology curricula, and clinical algorithms have helped "the science" of psychopharmacology, they often fail to provide guidance for clinicians in specific clinical situations with individual patients. Quality psychopharmacology practice ...
Molinari Joseph F - - 2009
PURPOSE: To describe a case of primary open angle glaucoma (POAG) and to illustrate a new principle in detecting and managing the disease using intraocular pressure (IOP) corneal hysteresis as a clinical guide. METHOD: A case report is reviewed of a white 87-year-old male who was detected with ocular hypertension ...
Perez Jose A JA - - 2009
Education in systems-based practice is a required component of all postgraduate medical education programs in the United States. Competency in this area requires that trainees have an understanding of the health care system sufficient to provide optimal care to patients. Most trainees in residency programs have little understanding of the ...
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