BACKGROUND: The ACC/AHA/HRS Guidelines provide patient selection criteria for primary prevention implantable cardioverter-defibrillators (ICDs). For unknown reasons, guideline discordant practice is common. OBJECTIVE: To determine referring physicians' concordance with the primary prevention ICD guidelines. METHODS: We mailed a survey regarding ICD guidelines and individual practice characteristics to a random national ...

Proteomic experiments can be difficult to handle because of the large amount of data in different formats that is generated. Samples need to be managed and generated, data needs to be integrated with samples and annotation information. A laboratory information management system (LIMS) can be used to overcome some of ...

This is a practical laboratory overview of current detection methods for malaria parasites, suitable for use in developing countries.

This article represents an overview of recent research from the Innovative Technology Centre in the field of flow chemistry which was presented at the FROST2 meeting in Budapest in October 2009. After a short introduction of this rapidly expanding field, we discuss some of our results with a main focus ...

Owing to lack of governmental regulation of veterinary laboratory performance, veterinarians ideally should demonstrate a commitment to self-monitoring and regulation of laboratory performance from within the profession. In response to member concerns about quality management in veterinary laboratories, the American Society for Veterinary Clinical Pathology (ASVCP) formed a Quality Assurance ...

With the increasing biological threat from emerging infectious diseases and bioterrorism, it has become essential for governments around the globe to increase awareness and preparedness for identifying and containing those agents. This article introduces the basic concepts of laboratory management, laboratory biosafety and laboratory biosecurity. Assessment criteria for laboratories' biorisk ...

The 32nd National Medicinal Chemistry Symposium, held in Minneapolis, MN, USA, included topics covering new developments in the field of medicinal chemistry. This conference report highlights selected presentations on Hsp90 inhibitors and Hsp70 inducers, such as KU-32 and KU-174 (University of Kansas); natural products in drug design, such as minnelide ...

Laboratory medicine has evolved from basic scientific observation and good experimental practice, with a strong emphasis on establishing the mechanisms of disease processes, linked with biomarker discovery, and development of analytical technologies. That evolution is set to move on apace with the mapping of the human genome. However, laboratory medicine ...

In 1997, the European Communities Confederation of Clinical Chemistry and Laboratory Medicine (EC4) set up a Register for European Specialists in Clinical Chemistry and Laboratory Medicine. The operation of the Register is undertaken by a Register Commission (EC4RC). During the last 12 years, more than 2200 specialists in Clinical Chemistry ...

Preparing residents and fellows to manage laboratories and pathology practices increasingly requires awareness of the law and a framework within which to manage legal risk in dealing with compliance, malpractice, and human resources issues. To describe a curriculum for pathology and laboratory medicine residents and fellows that highlights activities most ...

OBJECTIVES: The practice environment in Alberta has emerged as the most unique in North America, including access to laboratory values, a province-wide electronic health record and legislation to support additional prescribing authority for qualified pharmacists. A course to help pharmacists integrate laboratory values in their medication management of patients was ...

Genomics and "medical sequencing" will revolutionize clinical laboratory diagnostics as the foundation for the new era of personalized medicine. However, the medical profession lags far behind the technology and business communities in recognizing and preparing for this change. Pathologists must take the lead in the application of genomics technologies, including ...

Laboratory Animal Management Assistant (LAMA) is an internet-based system for tracking large laboratory mouse colonies. It has a user-friendly interface with powerful search capabilities that ease day-to-day tasks such as tracking breeding cages and weaning litters. LAMA was originally developed to manage hundreds of new mouse strains generated by a ...

At Roche, we set out to think about the future role of medicinal chemistry in drug discovery in a project involving both Roche internal stakeholders and external experts in drug discovery chemistry. To derive a coherent strategy, selected scientists were asked to take extreme positions and to derive two orthogonal ...

Unfortunately, transfusion errors continue to pose a major clinical problem. In practice there is a remarkable lack of understanding of the reasons behind transfusion medicine, a worrying disregard for protocol and an offhand attitude to bedside checking. Clearly transfusion medicine education, as often said, must be more extensively incorporated into ...

Clinical chemistry and laboratory medicine can look back over more than 150 years of eventful history. The subject encompasses all the medicinal disciplines as well as the remaining natural sciences. Clinical chemistry demonstrates how new insights from basic research in biochemical, biological, analytical chemical, engineering, and information technology can be ...

Laboratory medicine is at the heart of modern health care and diagnosis and effective treatment of patients is impossible without high-quality bioanalytical services. The European Federation of Clinical Chemistry and Laboratory Medicine is a professional federation working to ensure high standards across the discipline in all European countries. This article ...

Urinalysis was the first laboratory test performed in medicine and has been used for several thousand years. Today urinalysis continues to be a powerful tool in obtaining crucial information for diagnostic purposes in medicine. Urine is an unstable fluid, and changes to its composition begin to take place as soon ...

ISO 15189's particular requirements for quality management in medical laboratories provide guidance for (a) relating performance specifications to the intended use of a test or examination procedure, (b) designing internal quality control (IQC) procedures to verify the attainment of the intended quality of test results, as well as (c) determining ...

This review presents the status of technological developments of nanogenomics and its applications to medicine. Even if particular emphasis is placed on what has been accomplished in our laboratory in the last few years in the area of genes microarrays, significant reference to the recent activity of numerous other groups ...

The rapid identification of the potentially toxigenic Corynebacterium species, C. diphtheriae, C. ulcerans and C. pseudotuberculosis is essential for diagnosis and treatment of diphtheria and diphtheria-like diseases. We used matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDIT-OF MS) in comparison with classical microbiological and molecular methods on 116 Corynebacterium strains. All ...

This paper discusses the relevance of the notion of "styles of scientific thinking" introduced by Alistair Crombie and revisited by Ian Hacking, for understanding how chemistry shaped its identity. Although neither Crombie nor Hacking applied this notion to individual disciplines, it seems appropriate to use it in the case of ...

Beddoes lectured on chemistry at Oxford in the years that included the French Revolution, the Terror, and the outbreak of war with France, as well as the success in France of the chemical revolution. The very public dispute between Edmund Burke and Joseph Priestley meant that the latter's study of ...

When the CAMMS 223 trial was formally reported in the New England Journal of Medicine in October of 2008, huge interest was generated in the media, among people with multiple sclerosis (MS) and their relatives and friends. The suggestion that a therapy Campath-1H (now known as alemtuzumab) was available which ...

Snapshot from the life of Ernest Everett Just (1883-1941), circa 1920s. Montage includes images of Just in the laboratory at the Marine Biological Laboratory at Woods Hole, MA USA (((c))Alfred Huettner, with permission from the Marine Biological Laboratory Archives) with his autograph; the building housing the Howard University Colleges of ...

Pediatric laboratory medicine is a discipline which encompasses monitoring the normal growth and development of the ultimate dynamic system, the human body, as well as detecting and diagnosing aberrations in that system. Basic metabolic processes and body chemistries change and adapt to accommodate growth as a newborn infant develops through ...

A pathologist may practice telepathology in another room from the original slide using the hospital intranet, he/she may practice it if a CD-ROM is reviewed with a "virtual histologic image" or digital slide. As pathology becomes increasingly subspecialized, and pathologists are progressively more engaged in practices situations where they may ...

The increasing attention paid to patient safety, and the awareness that the information provided by clinical laboratories impacts directly on the treatment received by patients, has made it a priority for clinical laboratories to reduce their error rates and promote an excellent level of quality. The capacity for reporting, analysing ...

Laboratory medicine has been a pioneer in the field of patient safety; indeed, the College of American Pathology first called attention to the issue in 1946. Delivering reliable laboratory results has long been considered a priority, as the data produced in laboratory medicine have the potential to critically influence individual ...

Laboratory animal medicine is a growing field of veterinary practice that emphasizes animal welfare and refinement of research animal care. The Canadian Association for Laboratory Animal Medicine/L'association canadienne de la medecine des animaux de laboratoire (CALAM/ACMAL) and the Canadian Council on Animal Care (CCAC) provide a framework within which laboratory ...

Abstract In 1997, the European Communities Confederation of Clinical Chemistry and Laboratory Medicine (EC4) set up a Register for European Specialists in Clinical Chemistry and Laboratory Medicine. The operation of the Register is undertaken by a Register Commission (EC4RC). During the last 10 years, more than 2000 specialists in Clinical ...

Poor communication between the clinical toxicologist and the toxicology laboratory can result in a variety of problems. Clinicians must familiarize themselves with the toxicology assays that are available in their hospital and how to interpret assay results. Toxicology tests ordered in the emergency department should provide useful information for patient ...

Both the United States and Canada have projected shortages of qualified laboratory-animal veterinarians within the next 10 years. This gap is occurring because of retirement, increased regulatory requirements for research animal oversight, and insufficient numbers of veterinarians entering this field. One of the primary means of increasing student interest in ...

In 1997, the European Communities Confederation of Clinical Chemistry and Laboratory Medicine (EC4) set up a Register for European Specialists in Clinical Chemistry and Laboratory Medicine. The operation of the Register is undertaken by a Register Commission (EC4RC). During the last 10 years, more than 2000 specialists in Clinical Chemistry ...

This article provides an introduction to the fundamental principles of pharmacokinetics (PK) and pharmacodynamics (PD) as they apply to understanding the application of pharmacogenetics (PGx) in a clinical setting. PGx establishes connections between the disciplines of pharmacology and genetics. As such, one functional component of PGx involves establishing relationships between ...

Natural products possess a broad diversity of structure and function, and they provide inspiration for chemistry, biology, and medicine. In this review article, we highlight and place in context our laboratory's total syntheses of, and related studies on, complex secondary metabolites that were clinically important drugs, or have since been ...

BACKGROUND: Medicine is evolving on the whole, so laboratory medicine does. Great emphasis is currently presently placed on personalized medicine, particularly by many of the most influential healthcare-linked institutions, communities, organisations and companies. METHODS: Personalized medicine is an appealing terminology, meaning an individualised approach to patients for either diagnosis or ...

Trueness must be independent of analytical platform and measurements comparable regardless of the analytical procedure used.Traceability requirements for the clinical laboratory are via National Metrology Institutes, Reference (Calibration) laboratories and finally the routine laboratory.Traceability information required by today's clinical laboratory may be requested from the manufacturer of the analytical kits ...

Microwave irradiation has been used to enhance organic reactions since the mid 80's, its use within the field of medicinal chemistry is not so widely evident in the literature. The present review highlights the use of microwave chemistry as an important tool for the fast development of structure activity relationship ...

The European Register of Specialists in Clinical Chemistry and Laboratory Medicine was established by the European Communities Confederation of Clinical Chemistry and Laboratory Medicine (EC4) in 1997. The main aims of the Register are to ensure a high quality of professional standards and practice in the European Union (EU) countries, ...

There are a number of career paths in Laboratory Medicine and several clinical practice models for the discipline. This article summarizes the state of current training at the medical student and residency/post-graduate levels, emphasizing practice in the U.S., and the challenges of education in the discipline to meet the needs ...

A radioactivity measurement comparison for solutions of (131)I was conducted by the International Atomic Energy Agency for participants in one of its Cooperative Research Projects aimed at enhancing quality assurance practices in nuclear medicine. The comparison solutions were prepared from a single master stock solution and distributed to the participating ...

People in the Indian region often apply shankhapushpi and vishnukranti, two Sanskrit-based common names, to Evolvulus alsinoides. These are pre-European names that are applied to a medicinal American species transported into the area. The period of introduction is uncertain, but probably took place in the 1500s or 1600s. Examination of ...

The persea mite Oligonychus perseae is a pest of avocado trees that builds extremely dense webbed nests that protect them against natural enemies, including phytoseiid mites. Nests have one or two marginal entrances that are small and flattened. The predatory mite Neoseiulus californicus co-occurs with O. perseae in the avocado ...

Abstract - SYM01 The laboratory in diabetes and prediabetes S5 - SYM2 The molecular basis of medicine and the clinical laboratory S10 - SYM03 Chagas disease: parasite diversity and diagnosis S15 - SYM04 The concept of traceability in laboratory medicine - a tool for standardisation S21 - SYM05 Analytical quality ...

Olefin metathesis has been established as an important and general reaction in synthetic organic chemistry. Recently, it has attracted interest as a powerful tool for the construction of aromatic heterocycles. The importance of heteroaromatic motifs in medicinal chemistry and biology, as well as the efficiency and wealth of metathesis transformations, ...

Selective estrogen receptor modulators (SERMs) have been the subject of extensive medicinal chemistry efforts at several pharmaceutical companies, including Merck. The Merck effort produced a wide variety of SERMs including ER-alpha selective antagonists and ER-beta agonists in addition to balanced (non-selective) analogs. This article will provide a broad overview of ...

Increased collaboration between investigators at different institutions has increased the number of laboratory animals being transported. The current system of laws and regulations governing animal shipments is inconsistent and government agencies often have areas of overlapping regulatory management. Furthermore, the lack of industry-wide shipping standards and good practices contributes to ...

Successful and ethical management of a clinical laboratory requires vigilant focus on proper business conduct. A comprehensive risk management program must encompass government standards as provided for financial and marketing practices, including fraud and abuse, antitrust, antikickback, privacy, and security. The program also must incorporate the appropriate reaction to medical ...

Following occupational fingernail scratches (OFSs) in a developmental center, the source resident and the injured employee were tested for bloodborne pathogens (BPs). The pros and cons of this practice were scrutinized since fingernails usually contain no blood. Available records revealed no OFS-related BP transmission in 14 years. PubMed displayed no ...