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Shapey J - - 2011
Optic nerve gliomas are highly variable tumours with an unpredictable clinical course. Consequently, the diagnosis and management of these tumours remains complex and a standardised management strategy does not exist. In this paper we describe a patient with optic nerve glioma treated at our institution and then review recent advances ...
Avery Robert A - - 2011
: Childhood optic pathway gliomas (OPGs) are low-grade neoplasms intrinsic to the optic nerve, optic chiasm, tracts, and radiations. The management of OPGs is still a highly controversial topic among neuro-ophthalmologists. : Authors' personal experience and literature review. : This review describes our current understanding of the behavior of OPGs ...
Alici Evren - - 2010
To be able to produce advanced therapy medicinal products, compliance with regulatory standards while maintaining flexibility is mandatory. For this purpose, careful planning is vital in the design or upgrade of a facility. Similarly, extensive foresight is elemental to anticipate upcoming needs and requirements. Failing this may lead to the ...
Inati Adlette - - 2011
Over the last four decades, monumental advances have been made in the understanding, assessment, and management of transfusion-dependent patients, which have translated into significant improvements in patient morbidity and mortality. Important lessons have been learned from extensive clinical experience of iron management in the thalassemias, but greater knowledge of key ...
Seigneuric R - - 2010
Scientific advances have significantly improved the practice of medicine by providing objective and quantitative means for exploring the human body and disease states. These innovative technologies have already profoundly improved disease detection, imaging, treatment and patient follow-up. Today's analytical limits are at the nanoscale level (one-billionth of a meter) enabling ...
Goodnough Lawrence Tim - - 2010
Progress in our understanding of iron-restricted erythropoiesis has been made possible by important advances in defining the molecular mechanisms of iron homeostasis. The detection and diagnostic classification of iron-restricted erythropoiesis can be a challenging process for the clinician. Newer assays for markers of inflammation may allow more targeted management of ...
Yang Yong - - 2010
Cells in most tissues reside in microenvironment surrounded with specific three-dimensional features. The extracellular matrix or substratum with which cells interact often includes topography at the nanoscale. For example, the basement membrane of many tissues displays features of pores, fibers and ridges in the nanometer range. The nanoscale topography has ...
Wong Victor W VW Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University, Stanford, Calif, - - 2010
Novel tissue- and organ-engineering strategies are needed to address the growing need for replacement biological parts. Collective progress in stem cell technology, biomaterials, engineering, and molecular medicine has advanced the state of regenerative medicine, yet many hurdles to clinical translation remain. Plastic surgeons are in an ideal position to capitalize ...
Jiang Yuqiu - - 2010
Despite advances in the management of many human cancers over the past few decades, improvements in survival are marginal, and the overall diagnosis and prognosis for cancer patients remain poor. Tailoring therapy to the individual patient has become a promising approach for maximizing efficacy and minimizing drug toxicity. Aided by ...
Sardesai Maya G - - 2010
PURPOSE OF REVIEW: Facial paralysis is a devastating and debilitating condition for which a range of management options exists; all of them continue to have limitations. We review the recent scientific literature and highlight key developments and opportunities for further exploration with the goal that this may help direct clinical ...
Chalmers Alison - - 2011
Anaesthesia for maxillofacial surgery presents unique challenges for the anaesthetist, and chiefly involves management of the airway. This article will review some of the recent advances in maxillofacial anaesthesia.
Veeraswamy Arathi - - 2010
In recent years, there have been significant changes in many aspects of extragenital endometriosis ranging from the epidemiology to the management of the disease. Advances in minimally invasive surgery and expansion of the field have lead to further research in management of extragenital endometriosis. As a result, treatment has shifted ...
Jain V - - 2010
The management of congenital diaphragmatic hernia (CDH) is undergoing continual change and refinement, fuelled by recent advances in this field. Although many studies have documented the benefits of these recent advances but definite recommendations are lacking. Also, injudicious use of some of these strategies may be counterproductive, underscoring the importance ...
DiMauro Salvatore S Columbia University Medical Center, College of Physicians & Surgeons, 630 West 168th Street, New York, NY 10032, USA. - - 2010
In this review, we trace the origins and follow the development of mitochondrial medicine from the premolecular era (1962-1988) based on clinical clues, muscle morphology, and biochemistry into the molecular era that started in 1988 and is still advancing at a brisk pace. We have tried to stress conceptual advances, ...
Bellmunt Joaquim - - 2011
Sorafenib was the first multikinase inhibitor to be approved for use in renal cell cancer (RCC) in the US (2005) and in Europe (2006). In the Treatment Approaches in Renal Cell Cancer Global Evaluation Trial (TARGET), sorafenib showed a significant progression-free survival advantage over placebo in patients with advanced RCC. ...
Lesko Lawrence J - - 2010
Over the past 10 years, the US FDA has become a strong pharmacogenomics advocate as part of its mission to both protect and advance public health by enabling innovations that make medicines safer to use and more effective. The agency has evolved its advocacy cautiously on a foundation of science-based ...
Conrad Peter - - 2010
Research on barriers to professional advancement for women in academic medicine has not adequately considered the role of environmental factors and how the structure of organizations affects professional advancement and work experiences. This article examines the impact of the hierarchy, including both the organization's hierarchical structure and professionals' perceptions of ...
Blevins W A WA - - 2010
Endovascular management of critical limb ischemia has advanced significantly in the recent past, especially the ability to treat tibial artery lesions with reasonable results. The indications, results, and technical aspects or endovascular management of CLI is reviewed herein. An algorithm for clinical management of CLI in patients with tibial occlusive ...
- - 2010
Advanced therapy medicinal products (ATMPs), which include gene therapy medicinal products, somatic cell therapy medicinal products and tissue-engineered products, are at the cutting edge of innovation and offer a major hope for various diseases for which there are limited or no therapeutic options. They have therefore been subject to considerable ...
Escudier Bernard - - 2010
Targeted agents, such as sunitinib (SUTENT((R))) have become central to the management of advanced and/or metastatic renal cell carcinoma (mRCC). Sunitinib is an oral, multitargeted receptor tyrosine kinase inhibitor that has demonstrated efficacy for the treatment of mRCC in multiple clinical trials. In a Phase III trial in previously untreated ...
Costello Bernard J - - 2010
Many advances in health care are built on the evolution of technology. An entirely new patient has emerged in fetal medicine, with these advances in prenatal imaging allowing one to see and diagnose disease not previously appreciated. Clinicians can better plan for the delivery of the neonate, with identified anomalies ...
Ackerman Michael H - - 2010
The growing number of advanced practice providers in hospital systems has necessitated the establishment of centralized coordinating centers to manage core functions related to regulatory requirements and credentialing and to provide resources for research and evidence-based practice and practice model innovation. The Margaret D. Sovie Center for Advanced Practice was ...
Celis P - - 2010
The Regulation on Advanced Therapies (Regulation (EC) 1394/2007) establishes a new scientific committee, the Committee for Advanced Therapies (CAT), at the European Medicines Agency. The CAT is composed of experts in the field of Advanced Therapy Medicinal Products (ATMPs)--gene and cell therapy and tissue engineered products--and is responsible for the ...
Tarakanov Alexander O - - 2010
This overview focuses on the recent advances in carbon nanotube (CNT)-based biochips and tries to clarify their potential for modern molecular medicine.
Smith Rachel - - 2010
Advanced midwifery practice is a controversial notion in midwifery, particularly at present in Australia. The proposed changes in legislation around access to the publicly funded Medical Benefits Scheme (MBS) and the Pharmaceutical Benefits Scheme (PBS) in 2009-2010 have meant that the issue of advanced midwifery practice has again taken prominence. ...
Holmes Lynne Anne - - 2010
The optimal operative management of babies with necrotizing enterocolitis (NEC) remains uncertain. We report the case of a premature neonate with advanced NEC where areas of necrotic small bowel were successfully managed by intussusception into adjacent distal intestine and we discuss the merits of therapeutic intussusception as an option in ...
Hamid Mohamed A - - 2009
Auditory and Vestibular medicine is becoming more accepted as a specialty of its own, Medical NeurOtology. Recent advances in the field have been instrumental in the understanding of the scientific foundations, pathophysiology, clinical approach and management of patients with hearing and vestibular disorders. This paper will review these advances.
Deakin C D - - 2009
INTRODUCTION: Ambulance paramedics are now trained routinely in advanced airway skills, including tracheal intubation. Initial training in this skill requires the insertion of 25 tracheal tubes, and further ongoing training is attained through clinical practice and manikin-based practice. In contrast, training standards for hospital-based practitioners are considerably greater, requiring approximately ...
Mitchell Carol - - 2009
Echocardiographic examinations require a well-trained and competent sonographer to obtain proper anatomic and physiologic data to establish an accurate diagnosis for clinical decision-making and patient management. Although the formal education and training of cardiovascular sonographers are evolving, many entry-level and staff sonographers may not have sufficient practical or clinical knowledge ...
Al Mahdy Husayn - - 2009
Ischaemic strokes comprise the majority of strokes in clinical medicine. With the widespread use of thrombolytic therapy within 3 hours of presentation the long-term disability as a result of ischaemic stroke has improved markedly. This article summarizes the clinical management of ischaemic strokes including recent advances.
Beresford M W - - 2009
Juvenile idiopathic arthritis (JIA) is the most common paediatric rheumatic disease with significant long-term morbidity and mortality. Major advances have taken place in recent years in our understanding and the evidence base of JIA. The advent of biological therapies has opened a major new era in the medical management of ...
De Marco M - - 2010
Although recent advances in pharmacogenomics are making possible the use of genetic testing to determine the best medication for patients, little is known about how patients view such procedures. The aims for this study that were developed collaboratively as part of a community-academic partnership are: (1) What are the attitudes ...
Ralph Anna - - 2009
BACKGROUND: Australia has among the world's lowest rates of tuberculosis (TB). However, it remains a leading global cause of morbidity and mortality. In Australia, TB remains more common in Indigenous than non-Indigenous Australians, and rates are rising among migrants, reflecting changing immigration patterns and rising rates in their homelands. OBJECTIVE: ...
Chamberlain Douglas - - 2009
PURPOSE OF REVIEW: The standards required for optimal effect of chest compressions and the degree to which most practice falls short of ideal have not been widely appreciated. This review highlights some of the important data now available and offers a haemodynamic explanation that broadens current concepts. RECENT FINDINGS: New ...
Nagler Joshua - - 2009
PURPOSE OF REVIEW: Advanced airway management in children can be challenging, and the potential for morbidity following failed attempts is high. RECENT FINDINGS: Supraglottic rescue devices, including the laryngeal mask airway, esophageal-tracheal combination tube, and laryngeal tube have been shown to be suitable ventilation strategies following failed intubation and in ...
Medland Jacqueline - - 2009
This article describes a unique approach to advancing the competency of new managers in their formative stages of development. The model builds on traditional classroom and on-the-job training by employing the expertise of a dedicated coach. New managers benefit from coaching in ways similar with executives including improved interpersonal skills ...
Ramsay Philip T - - 2009
Clinicians, as well as lay people, have realized the importance of resuscitative maneuvers throughout recorded history. Cardiopulmonary resuscitation has evolved from a relatively primitive technique to one now dictated by data from evidence based medicine. Recent advancements include changes in life support guidelines, the development of an impedance threshold device, ...
Shayya Rana F - - 2009
BACKGROUND: Le Fort colpocleisis is a surgical treatment option for advanced pelvic organ prolapse in women who are willing to give up future vaginal sexual function. Pelvic abscess, or pyometra, after Le Fort colpocleisis has been reported and is thought to be related to inadequate lateral drainage channels. To date, ...
Phukan Julie - - 2009
The terms amyotrophic lateral sclerosis (ALS) or motor neuron disease (MND) refer to a condition characterized by motor system degeneration with relative preservation of other pathways. Although there have been advances in symptomatic treatment, ALS remains an incurable condition. Advances in ALS management prolong survival but simultaneously raise challenging ethical ...
Brandi Maria Luisa - - 2009
Asymptomatic primary hyperparathyroidism (PHPT), a condition defined as hyperparathyroidism that lacks specific symptoms or signs and with calcium levels of less than 1 mg/dL above the upper limit of normal, is a common clinical problem. Two previous conferences on the management of asymptomatic PHPT (a Consensus Development Conference and a ...
Pitkin Joan - - 2009
The last 10-12 years have seen an avalanche of changes in both the management of incontinence and genital prolapse. So many new procedures continue to appear that often the clinician is confused as to which approach to adopt. Complications are now being reported, creating a need to reappraise the situation.
Smith Richard Daron - - 2009
The management of patients with urinary tract stone disease has changed dramatically over recent years, with current treatment modalities focused on their minimal invasiveness. In this article we will discuss the recent advances in the field of urolithiasis management, with a focus on medical expulsive therapy, extra-corporeal shockwave lithotripsy and ...
Willmott Lindy - - 2008
Queensland's guardianship legislation requires that a witness to an enduring power of attorney or advance health directive not only certify that the principal signed the document in their presence, but also that the principal appeared to have the capacity necessary to make the enduring document. This article examines how solicitors ...
Burns Paul - - 2008
PURPOSE OF REVIEW: Globus pharyngeus is a common condition of unknown cause, with no 'current opinion' on the optimum investigation and treatment. As such, the scope of this article is to review the current literature and to describe, from an Irish perspective, the current best practice on the management of ...
Nyirjesy Paul - - 2008
Vulvovaginal candidiasis (VVC) and bacterial vaginosis (BV) are frequently encountered in clinical practice. Recent advances have furthered understanding of pathophysiology. Proper diagnosis, based on appropriate office and, in complicated cases, laboratory tests is the key to rational selection of therapy. For women who have routine uncomplicated episodes of VVC or ...
Kim Hiyun - - 2008
Presented is a review of the advances in synthetic methodology that make use of the allene functional group, with emphasis on catalytic asymmetric transformations and new mechanistic insights. The review covers the period from January 2007 to May 2008 and focuses on intra- and intermolecular cycloaddition, carbocycle cycloisomerization, heterocycle synthesis, ...
Kumana Cyrus R - - 2008
Horizons in Medicine is a series produced annually by the Royal College of Physicians. Volume 19 is based on their Advanced Medicine Conference held in 2007 and offers updates on a wide range of topics in clinical medicine. This 'review of reviews' covers developments described in a selection of chapters. ...
Rudzki J R - - 2008
Partial-thickness cuff tears (PTCTs) are increasingly recognized as a source of pain and athletic impairment, especially in overhead athletes. 1,2 Improvements in diagnostic imaging have enhanced the ability to detect and quantify partial cuff disease, and arthroscopic advances have led to novel techniques by which partial cuff tears can be ...
Laperrière Hélène - - 2008
The conceptual tools prevailing in scientific literature can carry an unexamined ballast of implicit references to current sociopolitical debates that dominate their times. Professional autonomy is not only freedom for action but also freedom for thought. The paper aims to increase external validity by enhancing the awareness of uncontrollable variables ...
Polse Kenneth A - - 2008
Robert B. Mandell is the quintessential modern clinical scientist. Over his long academic career, he has pioneered many advances in contact lens practice, ranging from a more complete understanding of corneal shape to the effects of contact lenses on corneal health. His classic text, Contact Lens Practice, first published in ...
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