Seventy-one patients who demonstrated unilateral ear-dependent positional nystagmus and unilateral labyrinthine weakness were studied to test the hypothesis that ear-dependent positional nystagmus almost always occurs on the side of unilateral labyrinthine impairment. Little, if any, correlation was found between these two parameters. The results of this study with regard to ...

Several techniques that have been used to quantify in vivo insulin-stimulated glucose uptake in patients with noninsulin-dependent diabetes mellitus (NIDDM) have been critically reviewed. An attempt has been made to outline both the advantages and disadvantages of the specific approaches, as well as to summarize the results of the application ...

Patients with noninsulin-dependent diabetes mellitus (NIDDM) are characterized by a loss of the normal ability of insulin to stimulate glucose uptake. The effects of diet, exercise, sulfonylurea compounds, and exogenous insulin on in vivo insulin-stimulated glucose uptake have been reviewed in this presentation. Although there is still a great deal ...

The prevalences of thyroid disease, insulin-dependent and non-insulin-dependent diabetes were compared in first degree relatives of diabetics with and without coexisting autoimmune thyroid disease. Thyroid disease was more common in siblings of diabetics with thyroid disease than in those of diabetics without thyroid disease. Insulin-dependent diabetes was more common in ...

In 55 patients with diabetes mellitus metabolically balanced the activity and intracellular localization of acid phosphatase has been estimated by means of semiquantitative method of Barka and Anderson [3] in peripheral blood lymphocytes. It has been shown that patients in question, both insulin-dependent and those with overweight, in comparison to ...

Ten randomly selected insulin-dependent diabetics with minimal betacell function were studied during treatment with an artificial betacell during two consecutive 24-hour periods. Patients were randomly served diabetic diet for one 24-hour period and average Danish food during the other 24-hour period. No significant (P greater than 0.05) difference was found ...

Palpable thickening and induration of the skin of the fingers were found in 47 (34%) of 137 children with insulin-dependent diabetes mellitus and in none of 52 normal children. Mild flexion contractures of the interphalangeal joints were seen in 26 (19%), mainly in those children with more extensive and severe ...

The serum levels of 1,5-anhydroglucitol were measured by gas chromatography in normal subjects and in patients with type 1 (insulin-dependent) diabetes mellitus and compared with those found in some other common diseases. The identity of the compound was checked by thin-layer chromatography and by means of mass fragmentography. The mean ...

Once thought to be solely a disease of insulin deficiency, diabetes mellitus now is recognized as a disorder with multiple pathogenetic mechanisms. Newer terminology identifies those uncommon patients with true insulin deficiency as having insulin-dependent diabetes (IDDM), while the majority of patients with diabetes have some residual insulin secretion but ...

TxB2 formation in PRP after thrombin stimulus, serum TxB2 and platelet sensitivity to prostacyclin and the correlation with ambient fasting plasma glucose and lipoproteins were determined in 20 insulin-independent diabetics (IID) with macroangiopathy, 10 insulin-dependent diabetics (IDD) with microangiopathy and 30 matched controls. Platelets obtained from insulin-independent diabetics synthetize significantly ...

Peripheral blood from 25 patients with insulin-dependent diabetes mellitus was examined for any alteration in the proportions and or functions of immunoregulatory T-cell subsets, defined with monoclonal antibodies. Ten of 25 (40%) patients demonstrated deficiency of OKT8+ (suppressor/cytotoxic) T-cells. Eight of these 10 patients had abnormally high ratios of OKT4+/OKT8+ ...

Erythrocyte deformability is lower than normal in uncontrolled insulin-dependent diabetics and returns towards normal after 24 h treatment with a feedback-controlled insulin infusion. Deformability of normal erythrocytes is reduced by incubation in plasma from uncontrolled insulin-dependent diabetics but is normal in plasma from insulin-dependent diabetics controlled by 24 h insulin ...

Endorphin levels were measured in 51 cerebrospinal fluid samples from 27 opioid-dependent or postdependent subjects. Radioreceptor assay showed the endorphin levels to be higher than those found in normal subjects. These high levels were found even while subjects were on methadone maintenance. The duration of opioid dependence was positively correlated ...

Serum immunoglobulins G, A and M were investigated by radial immunodiffusion in a group of 217 diabetics (133 males, 84 females) of whom 152 were insulin dependent and 65 non-insulin dependent. Higher values of IgA as compared with IgG and IgM were observed whatever the criteria of clinical analysis used. ...

Leucocyte-mediated phagocytosis and antibody-dependent cellular cytotoxicity (ADCC) were tested in 48 children with type-1 diabetes and in 22 healthy children. Both phagocytosis and ADCC for opsonized 51Cr-erythrocytes significantly decreased in the diabetics. Phagocytosis decreased in well and in poorly balanced diabetics, but the latter, having type-1 diabetes for less than ...

The incidence of insulin dependent diabetes mellitus, as determined from the Pittsburgh Insulin Dependent Diabetes Mellitus Registry, was examined in relationship to social class. The registry consists of all Allegheny County, Pennsylvania, cases of insulin dependent diabetes diagnosed under age 20 years in 1965-1976. Analyses of the registry data revealed ...

An insulin-dependent Diabetes Mellitus Registry has been developed in Allegheny County, Pennsylvania, through hospital record review and surveillance of pediatric practices. The yearly incidence ranged from 10/100,000 for nonwhite males to 16/100,000 for white males. There were no temporal trends in incidence for 1965-1976 nor major sex differences. Nonwhites had ...

Since intrinsic cellular abnormalities have previously have reported in diabetes mellitus, skin fibroblasts from patients with insulin-dependent diabetes and non-insulin-dependent diabetes, and from age-matched young and old controls, were examined for stimulation by insulin (4--4000 ng/ml) of glucose uptake, leucine incorporation into protein, and uridine incorporation into RNA. No differences ...

In six insulin-dependent diabetic subjects, we investigated whether differences between biosynthetic human insulin (BHI) and pork insulin are present as measured by an automatic glucose controlled insulin infusion system (GCIIS) (Biostator). The parameters measured were basal insulin requirement and food-dependent insulin requirement, as well as the blood sugar-lowering and insulin-saving ...

The mode of presentation of 118 insulin-dependent (IDD) and 187 non insulin-dependent diabetics (NIDD) is outlined. The complications as well as associated diseases are presented. Eighty-six males were insulin-dependent and ninety-eight males were non insulin-dependent. Thirty-two females were insulin-dependent while eighty-nine females were non insulin-dependent. The age range was 14-50 ...

This review describes (1) the metabolic and hormonal response to exercise in normal and diabetic man, and (2) the potential benefits of physical training in diabetes. Whereas in normal man plasma glucose varies little during exercise, the insulin-dependent diabetic subject may experience an increase in plasma glucose, a modest decrease ...

This study attempts to determine the ways in which linguistic timing factors combine with each other in the production of English and specifically, to test and explore aspects of the timing model of Klatt [J. Acoust. Soc. Am. 59, 1208-1221 (1976)]. In two experiments the tensity feature of a sentence ...

Eight diabetics were found among 464 children, mean age 11.2 years, of 311 unselected insulin-treated mothers. By a method of age correction the total diabetes prevalence among the children at the age of 25 years was calculated as 3.4%. Three children were non-insulin dependent and these patients and their mothers ...

Diabetes comprises many syndromes whose only common feature is a high blood glucose level. Some are entirely genetic, some partially so, and others not at all. Perhaps the most important advance in the past 10 years is proof that insulin dependent diabetes is genetically different from the insulin independent form. ...

We have measured suppressor activity of the peripheral blood lymphocytes and monocytes from 13 insulin dependent diabetics with established disease for two or more years. A statistically significant increase in suppressor T-lymphocyte activity was demonstrated in patients who had a positive response in this assay. There was no alteration in ...

Cerebral blood-flow (CBF) was measured in 23 insulin-dependent diabetics before and 2--3 h after insulin/breakfast. In 10 of these patients CBF changed significantly during the day, with a significant fall in 9. In 3 patients who had the greatest falls in CBF there was a concomitant sensation of an impending ...

RBC 2,3-DPG resulted statistically increased versus normal subjects in 22 insulin-dependent diabetics affected by arterial vasculopathy and in 19 vasculopathic non-diabetic patients. RBC 2,3-DPG, on the other hand, did not differ from the normal mean in 16 insulin-dependent diabetics without vascular involvement. The increase of RBC 2,3-DPG represents principally a ...

A rare genetic type (Bf F1) of properdin factor B is found in 22.6% of patients with insulin-dependent diabetes mellitus but in only 1.9% of the general population, yielding a relative risk of 15.0. This indicates that a genetic locus for insulin-dependent diabetes mellitus is very close on chromosome 6 ...

The birth weights of infants born to patients with insulin-dependent diabetes (IDD) and insulin-independent diabetes (IID) before the disease was diagnosed were compared. An appreciable excess of infants above the 90th centile for weight was found, the proportions being 27% of infants born to mothers with IDD and 30% of ...

Insulin-dependent diabetics show a significant reduction in blood platelets' monoamine oxidase (MAO) activity when compared with age-matched and sex-matched controls. This does not appear to be the case for diabetics either on diet control or receiving oral hypoglycemic drugs. The important role of this enzyme in the regulation of the ...

In 10 insulin dependent maturity onset diabetics we found elevated basal C-Peptide levels (4.78 +/- 0.5 ng/ml. Normal range 1.1--3.6 ng/ml), which could be suppressed by insulin injection to the same extent as in sulfonylurea treated diabetics could be demonstrated. C-Peptide immunoreactivity in these patients therefore seems to be newly ...

Age, sex, and estimated time of onset of insulin-dependent diabetes were determined for children in Pittsburgh (N = 673), Gainesville (N = 976), Galveston (n = 741), and Melbourne (N = 851). The US cities had a decrease in new cases during the summer and peak incidence in January through ...

The leucocyte migration inhibition test (LMT) was performed by the agarose plate method with thyroid and pancreatic antigens in patients with insulin-dependent or independent diabetes mellitus. The mean migration indices with thyroglobulin, thyroid mitochondria and beef insulin were not significantly different in insulin-dependent diabetics from those in insulin-independent diabetics or ...

Cultured skin fibroblasts from clinically normal offspring of two parents with non-insulin-dependent diabetes have demonstrated premature senescence as a decreased ability of cells to establish colonies when inoculated at low density (plating efficiency). The present study tested the hypothesis that there is an inherent cellular defect affecting viability of diabetic ...

Forty-four cases of insulin-dependent diabetes mellitus with cutaneous allergic reactions to insulin were typed for HLA-A and -B antigens. HLA-B7, which commonly is negatively associated with insulin-dependent diabetes mellitus, showed a positive association with insulin allergy. A second antigen, HLA-Bw21 may also be positively associated with local insulin allergy. These ...

Insulin-dependent diabetics at times of changing stress levels require alterations in their insulin dosage. Determination of the required insulin dosage is not a precise science. At these times, the diabetic may experience insulin overdosage with a resulting rebounding hyperglycemia (Somogyi phenomenon). Adequate data collection and a systematic approach to documentation ...

The effect of insulin was examined with emphasis on the alteration in the force-frequency relation. The results show that insulin does not change the time to peak tension nor the time of contraction. The inotropic effect was significant and did not depend upon the frequency of stimulation. However, there was ...

His bundle electrographic examination was performed during carotid sinus compression as well as atrial pacing in a patient who exhibited intermittent left bundle branch block (LBBB) and first degree A-V block. LBBB was observed at the corrected RR intervals below 920 msec and above 1600 msec. The QRS complexes showed ...

Biochemical and physiological theories of opiate addiction are reviewed in an historical context. The biochemical evidence implicating acetylcholine and norepinephrine in the phenomena of tolerance and physical dependence is described, and the six major biochemical and physiological theories are reviewed, emphasizing their close ties (differing sometimes only linguistically) with late ...

Of the two pharmacologically different possibilities of interfering with the processes of either tolerance or dependence of the morphine type, the so-called maintenance method commonly using methadone is predominantly a matter of tolerance, whereas the blockade with specific opiate antagonists such as cyclazocine intervenes in processes underlying dependence and withdrawal. ...

To assess the sensitivity of tests for early, small airway obstruction, we selected 52 cigarette smokers with a ratio of 1-sec forced expiratory volume to forced vital capacity greater than 70 per cent from a smoking cessation clinic. From these subjects, 29 of the 46 tested demonstrated frequency dependence of ...

Forty-one diabetic patients on insulin were given 100mg. of phenformin daily for six weeks, either before or after a period of six weeks of inert capsules, in a double-blind cross-over trial. Eleven patients while on phenformin noticed hypoglycaemic effects and reduced their insulin on average by almost 20% without resultant ...

Thesis (Ph. D.)--McMaster University, 2000.

Thesis (Ph. D.)--University of Tennessee, Knoxville, 2002.

The purpose of this study was to examine the influence of hardiness, self-efficacy, coping style and psychosocial adaptation to illness on the metabolic control of insulin dependent and non-insulin dependent subjects. After adjustment for age, gender and diabetes type the best predictors for insulin dependent diabetics were found to be ...

We selected five bronchitics and four asthmatics in remission, whose routine lung function tests were not significantly abnormal. Dynamic compliance was measured at different respiratory frequencies and the results compared with those obtained from a normal control group. In all patients compliance was frequency dependent and remained so after the ...