2011 marks the 50th anniversary of the discovery of ibuprofen. This article is a focus on the personal reflections and career of Dr Stewart Adams OBE, the scientist whose research lead to the discovery of the cyclooxygenase inhibitor. When Dr Adams discovered ibuprofen, he was working as a pharmacologist in ...

In this true story, an Eritrean man's wife rapidly becomes unconscious, and he tenaciously pursues a diagnosis and procures treatment. His personal struggle, juxtaposed with reflection on Eritrea's 30-year fight for independence from Ethiopia, highlights the power of persistence in the face of some of the most adverse conditions in ...

The historiography of penicillin has tended to overlook the importance of developing and disseminating know-how in fermentation technology. A focus on this directs attention to work before the war of a network in the US and Europe concerned with the production of organic acids, particularly gluconic and citric acids. At ...

In this article, David Bittner explodes the myth, restated in Brideshead Revisited (1945), that Polynesians are "happy and harmless." He does so for the same reason that Evelyn Waugh does: "the grim invasion of trader, administrator, missionary, and tourist" has changed all that (p. 174). Touring Hawaii in July of ...

Under the Euthanasia Program of Nazi Germany, more than 200,000 psychiatric patients were killed by doctors in psychiatric institutions. After summarising the historical facts and the slow and still going-on process of illuminating and understanding what happened, some ethical consequences are drawn. What can we learn from history? The following ...

This paper examines the attractions of passionate involvement in wanting particular outcomes, which is popularly known as rooting. The author's lifelong personal experience is the source of his analysis, along with the insights provided by spiritual literature and especially the work of Dr. Thomas Hora, with whom the author studied ...

The present research addressed fundamental questions about the visual perspective of autobiographical memories: Are stable personality characteristics associated with visual perspective? Does visual perspective influence the memory's phenomenological qualities? Participants in Study 1 (N=1684) completed individual-difference measures and indicated the perspective from which they generally retrieve memories. Participants in Study ...

A letter by Lucien Herr, a highly regarded leading French intellectual at the time of World War I, provides capsule portraits of chemists such as Gabriel Bertrand, Paul Lebeau, Charles Moureu, and Georges Urbain. It makes us better aware of who they were and of how their contemporaries saw their ...

Self-projection, the capacity to re-experience the personal past and to mentally infer another person's perspective, has been linked to medial prefrontal cortex (mPFC). In particular, ventral mPFC is associated with inferences about one's own self, whereas dorsal mPFC is associated with inferences about another individual. In the present fMRI study, ...

An invited commentary is a short article that describes an author's personal experience of a specific topic. Unlike a review article, the author gives his own opinions and perspectives. It typically addresses a current, hot and often controversial subject. It may take two formats, namely, provide an expert author's personal ...

Although in his later years Giovanni Pico della Mirandola (1463-1494) vehemently rejected astrology, he earlier used it in a variety of ways, but primarily to provide further evidence for positions to which he had arrived by other means. One such early use appears in his commentary on his friend Girolamo ...

Nicole le Douarin has shown a long lasting interest for developmental hematopoiesis. Starting from her early research experience, we travel along the main discoveries and concepts that have shaped the modern view of developmental hematopoiesis. All through, we survey the seminal contribution of the "Ecole de Nogent" about lymphocyte homing ...

In the fall of 1732, William Cosby, a member of the British aristocracy, became the colonial governor of New York. As an incompetent, tyrannical and self-serving ruler, he quickly alienated the citizens of New York and, as a result, a core group instigated a broad-based popular uprising against him. In ...

The discernible aim of torture as everyone believes--and rightly so--is to destroy the personality of an individual in a way that would render his compliance in future. But to destroy a personality is easier said than done. It requires long sessions of detention and torture. The torturers risk themselves getting ...

The purpose of this paper is to describe commonalities of the lived experience of being a spouse caregiver of a person with mild cognitive impairment (MCI). The Colaizzi method of empirical phenomenology was used for inter-viewing and analyzing data obtained from 10 spouse caregivers of persons with MCI. Four major ...

Lemogne and colleagues offer an interesting extension to their previous work on visual perspective and depression: Individuals at-risk for depression (defined as higher scores on Harm Avoidance), without a history of mood disorders, report retrieval of positive memories from the 3rd person perspective. Their findings suggest that the retrieval of ...

INTRODUCTION: People often show a bias of attributing their own actions to more positive causes (e.g., generosity) than other persons' actions. Models of paranoia suggest links between paranoia and negative construals of others' intentions. Research on these biases has focused on causal attributions from two explainer perspectives, the agent (the ...

In "Theory Is Personal," Allen Siegel MD, a Chicago psychoanalyst and Assistant Professor of Clinical Psychiatry at Rush University Medical Center, shares the very personal story of how he came to his theory. Sometimes we find our theory. Other times, Siegel argues, it is our theory that finds us. In ...

As the concept of schizophrenia began to develop over a century ago, it was accompanied by little hope of recovery. As the second half of the 20th century began, new treatments and changing social conditions resulted in most long-term patients being discharged into the community. Many of these expatients showed ...

We report a patient with severe anosognosia for hemiplegia, who recovered instantly and permanently when viewing herself in a video replay. We believe the observed dramatic reinstatement of the patient's awareness related to her self-observation 'from the outside' (3rd person perspective) and 'off-line' (at a time later than the actual ...

There is now abundant evidence that Freud was correct in believing Edward de Vere (1550-1604) wrote under the pseudonym "William Shakespeare." One common reaction is "What difference does it make?" I address that question by examining many significant connections between de Vere's life and The Tempest. Such studies promise to ...

This article raises the nature of Evil as a dimension of spiritual reality and indicates some experience-based and some theologically based perspectives on the nature of Evil. The author offers a new perspective on the nature of Evil based on an extension of earlier work on a six-factor model of ...

Fly fishers around the world frequently use terms such as religious, spiritual, sacred, divine, ritual, meditation, and conversion to describe their personal angling experiences. Further, drawing upon religious terminology, anglers will refer to rivers as their church and to nature as sacred. Often these latter pronouncements drive a concern for ...

We all need to take a deep breath and remind ourselves that sports do not grant us our identity-personal or national. Sports are, after all, just a game.

Human self-consciousness depends on the metarepresentation of mental and bodily states as one's own mental and bodily states. First-person-perspective taking is not sufficient, but necessary for human self-consciousness. To assign a first-person-perspective is to center one's own multimodal experiential space upon one's own body, thus operating in an egocentric reference ...

We examined the relations between college students' control beliefs and future time perspective (FTP) and their academic achievement and studying using canonical correlation. We identified two statistically significant canonical correlations. One associated primarily competency belief, as reflected by self-efficacy, and FTP connectedness with grades. The other associated primarily contingency beliefs, ...

Please note that these are the personal opinions of the author and do not necessarily represent those of AstraZeneca.

A method for dividing quadrilateral spaces is described to assist artists with perspective illustrations. Linear perspective, key to realistic drawings, can be time-consuming to use, hampering illustrators who need to be efficient to compete in today's market. Using this method, art benefits in speed from an overlooked geometry based on ...