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Benavente-Pérez Alexandra - - 2010
To evaluate the repeatability and reproducibility of subfoveal choroidal thickness (CT) calculations performed manually using optical coherence tomography (OCT). The CT was imaged in vivo at each of two visits on 11 healthy volunteers (mean age, 35.72 ± 13.19 years) using the spectral domain OCT. CT was manually measured after ...
Saikia Parykshit - - 2010
To describe a presentation of painless posterior scleritis. This study was an interventional case report. An 18-year-old boy was admitted to the authors' clinic with symptoms of low degree of vision and no ocular pain. Ophthalmologic examination, ocular ultrasonography, magnetic resonance imaging, fundus fluorescein angiography (FFA), optical coherence tomography (OCT), ...
Ichhpujani Parul - - 2010
The iStent (Glaukos Corporation, Laguna Hills, CA) is a 1-mm, titanium trabecular bypass stent implanted across the inner wall of Schlemm's canal under direct gonioscopy. This study was designed to determine the best modality to identify iStent placement when gonioscopic visualization is not possible. In this in vitro study on ...
Moon Sucbei - - 2010
A forward-view optical coherence tomography (OCT) scanning catheter has been developed based on a fiber-cantilever piezotube scanner by using a semi-resonant scan strategy for a better scan performance. A compact endoscope catheter was fabricated by using a tubular piezoelectric actuator with quartered electrodes in combination with a resonant fiber cantilever. ...
Basiruddin S K - - 2010
A magnetic quantum dot (MQD) based cellular nanoprobe, composed of a magnetic oxide nanoparticle component and a quantum dot component, has been synthesized and used for both imaging and separation. The successful synthesis is based on a reverse micelle based polyacrylate coating in the presence of component nanoparticles, followed by ...
Lim Eun-Kyung - - 2010
We fabricated multimode nanoprobes for acquisition of biological information at different object levels, i.e., in vivo detection and ex vivo validation for characterizing tumor angiogenesis. Fluorescent magnetic nanoprobes (FMNPs) were synthesized by using amphiphilic pyrenyl polyethylene glycol (Py-PEG) and superparamagnetic MnFe(2)O(4) nanocrystals (MNCs). Py-PEG, which is synthesized by conjugation of ...
Nair Govind - - 2011
The retina is nourished by two unique (retinal and choroidal) circulations. The lack of depth-resolved blood volume (BV) imaging techniques hampers investigation of vascular-specific regulation of the retina in vivo. This study presents a high-resolution, laminar-specific magnetic resonance imaging (MRI) study to image retinal and choroidal BVs, their responses to ...
Kim Hoe Suk - - 2010
A combination of reporter genes for magnetic resonance imaging (MRI) and optical imaging can provide an additional level of noninvasive and quantitative information about biological processes occurring in deep tissues. We developed a bimodal lentiviral vector to monitor deep tissue events using MRI to detect myc-tagged human ferritin heavy chain ...
Kiilgaard Jens Folke - - 2011
Background:  Intraocular silicone oil may migrate into the optic nerve or the cerebral ventricles, but little is known about the frequency of these events. The aim of this prospective neuroimaging study was to determine the frequency of extraocular silicone oil migration in humans operated for retinal detachment. Methods:  Nineteen patients ...
JaƄczewski Dominik - - 2011
Fluorescent optical probes have been intensively used in the area of bio-imaging. In this review article, we describe the recent advancements in the synthesis and application of bimodal magnetic-fluorescent probes for bioimaging. The bimodal probes consist of fluorescent [semiconducting quantum dots (e.g., CdSe/ZnS) or rare-earth doped (e.g., NaYF(4) :Yb,Er)] nanoparticles ...
Howes Philip - - 2010
Hybrid nanoparticles which incorporate multiple functionalities, such as fluorescence and magnetism, can exhibit enhanced efficiency and versatility by performing several tasks in parallel. In this study, magnetic-fluorescent semiconductor polymer nanospheres (MF-SPNs) have been synthesized by encapsulation of hydrophobic conjugated polymers and iron oxide nanoparticles in phospholipid micelles. Four fluorescent conjugated ...
Tseng Hung-Yu - - 2010
Preparation of a high-concentration Au nanoring (NR) water solution and its applications to the enhancement of image contrast in optical coherence tomography (OCT) and the generation of the photothermal effect in a bio-sample through localized surface plasmon (LSP) resonance are demonstrated. Au NRs are first fabricated on a sapphire substrate ...
Byrne A J - - 2010
Dry skin (also known as xerosis) is a cutaneous reaction pattern indicative of abnormal desquamation, which has not only cosmetic considerations, but can also lead to the penetration of irritants and allergens through the stratum corneum (SC). Over the last few decades, our understanding of the structure, composition, formation and ...
Gros Stephanie J - - 2010
We describe the development of an aggressive orthotopic metastatic model of esophageal cancer, which is visualized in real time with combined magnetic resonance imaging (MRI) and fluorescence imaging. The aim of the study was to describe the development of a novel model of metastatic tumor disease of esophageal carcinoma and ...
Wan Jiaqi - - 2010
Bifunctional nanoprobes with both magnetic and optical contrast have been developed for ultra-sensitive brain tumor imaging at the cellular level. The nanoprobes were synthesized by simultaneously incorporating a magnetite nanoparticle cluster and fluorescence dyes into silica encapsulation by a sol-gel approach under ultrasonic treatment. The nanoprobes maintain superparamagnetic behavior at ...
You Youngmin - - 2010
A paramagnetic manganese complex of a fluorescein-based probe affords a dual-modality zinc sensor featuring an improved fluorescence dynamic range and an MRI readout.
Khurana Rahul N - - 2010
PURPOSE: To compare fluorescein leakage from choroidal neovascularization (CNV) with signs of intraretinal or subretinal fluid on time-domain optical coherence tomography (TD-OCT) and spectral-domain optical coherence tomography (SD-OCT) in patients receiving anti-vascular endothelial growth factor (anti-VEGF) therapy for CNV caused by age-related macular degeneration (AMD). DESIGN: Retrospective, consecutive case series. ...
Tanitame Keizo - - 2010
PURPOSE: To compare a half-Fourier single-shot rapid acquisition with relaxation enhancement (RARE) sequence with a balanced steady-state free precession (b-SSFP) sequence in the evaluation of the eye using magnetic resonance (MR) microscopy imaging and to clarify the usefulness of RARE microscopy imaging in evaluating nonoperative glaucoma patients and patients who ...
Li Yan - - 2010
To evaluate the repeatability of Fourier-domain optical coherence tomography (OCT) pachymetric mapping and compare central corneal thickness (CCT) measurements by OCT, ultrasound pachymetry, and scanning-slit tomography. Doheny Eye Institute, University of Southern California, Los Angeles, California, USA. A Fourier-domain OCT system was used to map the corneal thickness in normal ...
John Renu - - 2010
Dynamic magnetomotion of magnetic nanoparticles (MNPs) detected with magnetomotive optical coherence tomography (MM-OCT) represents a new methodology for contrast enhancement and therapeutic interventions in molecular imaging. In this study, we demonstrate in vivo imaging of dynamic functionalized iron oxide MNPs using MM-OCT in a preclinical mammary tumor model. Using targeted ...
Guo Kevin - - 2010
A new gadolinium chelating NIR fluorescent molecular probe increases T(1) relaxivity of water protons, facilitating combined optical and magnetic resonance imaging.
Roberts David W - - 2011
The aim of this study was to investigate the relationships between intraoperative fluorescence, features on MR imaging, and neuropathological parameters in 11 cases of newly diagnosed glioblastoma multiforme (GBM) treated using protoporphyrin IX (PpIX) fluorescence-guided resection. In 11 patients with a newly diagnosed GBM, δ-aminolevulinic acid (ALA) was administered to ...
Bear David M - - 2010
Optical coherence tomography (OCT) and T2 mapping are emerging clinical imaging technologies with potential to detect subsurface changes in cartilage retaining a macroscopically intact articular surface. This study tests the hypothesis that OCT correlates with magnetic resonance imaging (MRI) T2 values, and that OCT signal is sensitive to cartilage matrix ...
Hong Samin - - 2010
PURPOSE: To verify the effect of the scan angle of the optic nerve head (ONH) on measurements of peripapillary retinal nerve fiber layer (RNFL) thickness by using spectral-domain optical coherence tomography (OCT). METHODS: Both eyes of 64 healthy volunteers were scanned by the optic disc cube 200 x 200 scan ...
Cooper Michael L - - 2010
There is considerable research activity in multiresonator optical circuits in silicon photonics, e.g., for higher-order filters, advanced modulation format coding/decoding, or coupled-resonator optical waveguide delay lines. In diagnostics of such structures, it is usually not possible to measure each individual microring resonator without adding separate input and output waveguides to ...
Zheng Kathy - - 2010
Current treatments for osteoarthritis are pain relief and total joint arthroplasty. There is a clinical need for early osteoarthritis diagnostic methods for potential preventive interventions. The resolution achieved with radiography, magnetic resonance imaging (MRI), and arthroscopy is too limited for the assessment of early disease. The high resolution, small fiber-optic ...
Davis Scott C - - 2010
This report demonstrates the diagnostic potential of magnetic resonance imaging (MRI)-coupled fluorescence molecular tomography (FMT) to determine epidermal growth factor receptor (EGFR) status in brain cancer. Two orthotopic glioma xenograft models were used in this study: one represented high EGFR expression and the other low expression. Nude mice were inoculated ...
Guo Hai - - 2010
Rational combination of different functional lanthanide materials within a single nanocrystal presents a feasible way to develop a multifunctional nanoplatform for various biomedical applications. The conventional methods of synthesizing and integrating two kinds of material together generally involve laborious procedures, whilst codoping different functional ions inside a single lanthanide nanocrystal ...
Han Ian C - - 2010
To characterize the types and frequencies of image artifacts associated with macular scanning using 2 common spectral-domain optical coherence tomography (SD OCT) instruments and to evaluate the impact of artifacts on foveal thickness measurements. Retrospective, observational chart review. For the Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA), scans of 98 ...
Schwarze Thomas - - 2010
The [6.6](9,10)anthracenophane 1 (Scheme 1) is a selective fluoroionophore for the detection of PdCl(2) with a large fluorescence enhancement factor (I/I(0) > 250).
Barber W C - - 2010
Initial results from a novel dual modality preclinical imager which combines non-contact fluorescence tomography (FT) and x-ray computed tomography (CT) for preclinical functional and anatomical in vivo imaging are presented. The anatomical data from CT provides a priori information to the FT reconstruction to create overlaid functional and anatomical images ...
Sun Pan - - 2010
The synthesis of a new kind of magnetic, fluorescent multifunctional nanoparticles (approximately 30 nm in diameter) was demonstrated, where multiple fluorescent CdTe quantum dots (QDs) are covalently linked to and assembled around individual silica-coated superparamagnetic Fe(3)O(4) nanoparticles and active carboxylic groups are presented on the surface for easy bioconjugation with ...
Danielli Amos - - 2010
A magnetic modulation biosensing system (MMB) [1,2] rapidly and homogeneously detected biological targets at low concentrations without any washing or separation step. When the IL-8 target was present, a 'sandwich'-based assay attached magnetic beads with IL-8 capture antibody to streptavidin coupled fluorescent protein via the IL-8 target and a biotinylated ...
Garc?a-Alonso Javier - - 2010
Saccharomyces cerevisiae containing fluorescent markers are ideal candidates for applications in microfluidic screening systems as fluorescence signal is emitted without the need of additional reagents. Here we develop a method for magnetic functionalization of such cells which allows their handling and immobilization in micro-screening devices. After exposure of the magnetized ...
Patra M - - 2009
Electrical transport properties as a function of magnetic field and time have been investigated in polycrystalline, Nd(0.84)Sr(0.16)CoO(3). A strong exchange bias (EB) effect is observed associated with the fairly large intragranular magnetoresistance (MR). The EB effect observed in the MR curve is compared with the EB effect manifested in the ...
Zhu Zhenshu - - 2010
Paclitaxel (PTX)-loaded poly(N-vinylpyrrolidone)-b-poly(epsilon-caprolactone) (PVP-b-PCL) nanoparticles with high drug payload were successfully prepared by a modified nano-precipitation method and characterized by transmission electron microscopy (TEM), atomic force microscopy (AFM), dynamic light scattering (DLS) and zeta potential. The satisfactory drug loading content (>25%) and high encapsulation efficiency (>85%) were achieved. The in ...
Hellgren Kerstin - - 2009
PURPOSE: We aimed to evaluate visual fields (VFs) and optic disc morphology in very low birthweight (VLBW) adolescents compared with age- and gender-matched controls, and to relate the findings to magnetic resonance imaging (MRI) results. METHODS: Fifty-nine VLBW adolescents and 55 age- and gender-matched controls with normal birthweight were examined. ...
Setua Sonali - - 2010
Targeted cancer imaging using rare-earth oxide nanocrystals, free from heavy metals (Cd, Se, Te, Hg and Pb), showing bright red-fluorescence and magnetic resonance imaging (MRI) is presented. Y(2)O(3) nanocrystals (YO NC) doped in situ with fluorescent (Eu(3+)) and paramagnetic (Gd(3+)) impurities and conjugated with a potential cancer targeting ligand, folic ...
Sturzu Alexander - - 2010
The extracellular glycoprotein Tenascin-C (TN-C) is highly upregulated in gliomas. Therefore, many chemotherapies with radiolabeled antibodies against TN-C have been performed. However, TN-Cs binding partner Syndecan-4 did not play any role as a therapeutic or imaging target in gliomas. We constructed an imaging compound containing the magnetic resonance imaging (MRI) ...
Sadda Srinivas R - - 2010
To investigate the relationship between B-scan density and retinal thickness measurements obtained by spectral domain optical coherence tomography (SDOCT) in eyes with retinal disease. Data were collected from 115 patients who underwent volume OCT imaging with Cirrus HD-OCT using the 512 x 128 horizontal raster protocol. Raw OCT data, including ...
Weeks Tyler - - 2009
Doubly-resonant four-wave mixing (DR-FWM) is a nondegenerate four-wave mixing process in which four photons interact to coherently probe two distinct Raman resonances. We demonstrate DR-FWM microscopy as a label-free and nondestructive molecular imaging modality with high chemical specificity on the submicron scale by imaging alkyne-substituted oleic acid in both aqueous ...
Henschel Andreas - - 2009
PURPOSE: To assess the sensitivity and specificity of optical coherence tomography (OCT) for monitoring patients with choroidal neovascularization (CNV) after photodynamic therapy (PDT) in comparison to fluorescein angiography (FA). METHODS: Prospective study of 14 patients with CNV secondary to age-related macular degeneration receiving PDT. Best-corrected visual acuity (BCVA), fluorescein angiography, ...
Eter Nicole - - 2010
Molecular imaging plays an increasingly powerful role in elucidating pathophysiological pathways, in advancing drug discovery and in deciphering developmental processes. Multiple modalities, including optical imaging, ultrasound, nuclear imaging, computed tomography and various techniques of MRI are now being used to obtain fundamental new insights at the cellular and molecular level, ...
Kellner S - - 2009
AIMS: To compare spectral domain optical coherence tomography (sdOCT) with melanin-related near-infrared fundus autofluorescence (NIA, excitation 787 nm, emission >800 nm), lipofuscin-related fundus autofluorescence (FAF, excitation 488 nm, emission >500 nm) and multifocal electroretinography (mfERG) in patients with long-term chloroquin (CQ) treatment. METHODS: Eight patients with 5.5-22 years of CQ ...
Park Joseph - - 2009
Novel bifunctional fluorescent magneto polymeric nanoprobes (FMPNs) were synthesized to provide simultaneous diagnostic information via magnetic resonance imaging (MRI) and optical imaging. FMPNs consist of ultra-sensitive magnetic nanocrystals that function as MR probes combined with Nile Red, which functions as a fluorescent probe. FMPNs were encapsulated by a nano-emulsion method ...
Reich Daniel S DS Department of Neurology, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Phipps Bldg, Room B-112, Baltimore, MD 21287, USA. - - 2009
To determine whether damage to the optic radiation (OR) in multiple sclerosis (MS) is associated with optic nerve injury and visual dysfunction. Case-control study. Referral center. Ninety referred patients with MS and 29 healthy volunteers. Magnetic resonance imaging indices along the OR were reconstructed with diffusion tensor tractography. Retinal nerve ...
Stockhammer Florian - - 2009
PURPOSE: Malignant gliomas are highly infiltrative tumours with a fatal prognosis. F18-fluoroethyl-tyrosine (FET)-positron emission tomography (PET) often reveals a broader extension of these tumours compared with contrast-enhanced magnetic resonance imaging (MRI). Complete resection of the contrast-enhancing lesion is aspired. Fluorescence-guided resection using 5-aminolevulinic acid (5-ALA) improved the extent of resection. ...
Coxson Harvey O - - 2009
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by both small airway and parenchymal abnormalities. There is increasing evidence to suggest that these two morphologic phenotypes, although related, may have different clinical presentations, prognosis, and therapeutic responses to medications. With the advent of novel imaging modalities, it is ...
Nahrendorf Matthias - - 2009
Proteases are emerging biomarkers of inflammatory diseases. In atherosclerosis, these enzymes are often secreted by inflammatory macrophages, digest the extracellular matrix of the fibrous cap, and destabilize atheromata. Protease function can be monitored with protease activatable imaging probes and quantitated in vivo by fluorescence molecular tomography (FMT). To address 2 ...
Rawat R - - 2009
Magnetoresistance studies on RPd(2)Si (R = Tb, Dy and Lu) compounds show large negative magnetoresistance (MR) in TbPd(2)Si and DyPd(2)Si near the magnetic ordering temperature. Positive MR at low temperature in the ferromagnetic Dy compound is shown to arise from the orbital contribution (the Lorentz force effect). As a consequence, ...
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