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Tseng Hung-Yu - - 2010
Preparation of a high-concentration Au nanoring (NR) water solution and its applications to the enhancement of image contrast in optical coherence tomography (OCT) and the generation of the photothermal effect in a bio-sample through localized surface plasmon (LSP) resonance are demonstrated. Au NRs are first fabricated on a sapphire substrate ...
Byrne A J - - 2010
Dry skin (also known as xerosis) is a cutaneous reaction pattern indicative of abnormal desquamation, which has not only cosmetic considerations, but can also lead to the penetration of irritants and allergens through the stratum corneum (SC). Over the last few decades, our understanding of the structure, composition, formation and ...
Gros Stephanie J - - 2010
We describe the development of an aggressive orthotopic metastatic model of esophageal cancer, which is visualized in real time with combined magnetic resonance imaging (MRI) and fluorescence imaging. The aim of the study was to describe the development of a novel model of metastatic tumor disease of esophageal carcinoma and ...
Wan Jiaqi - - 2010
Bifunctional nanoprobes with both magnetic and optical contrast have been developed for ultra-sensitive brain tumor imaging at the cellular level. The nanoprobes were synthesized by simultaneously incorporating a magnetite nanoparticle cluster and fluorescence dyes into silica encapsulation by a sol-gel approach under ultrasonic treatment. The nanoprobes maintain superparamagnetic behavior at ...
You Youngmin - - 2010
A paramagnetic manganese complex of a fluorescein-based probe affords a dual-modality zinc sensor featuring an improved fluorescence dynamic range and an MRI readout.
Khurana Rahul N - - 2010
PURPOSE: To compare fluorescein leakage from choroidal neovascularization (CNV) with signs of intraretinal or subretinal fluid on time-domain optical coherence tomography (TD-OCT) and spectral-domain optical coherence tomography (SD-OCT) in patients receiving anti-vascular endothelial growth factor (anti-VEGF) therapy for CNV caused by age-related macular degeneration (AMD). DESIGN: Retrospective, consecutive case series. ...
Tanitame Keizo - - 2010
PURPOSE: To compare a half-Fourier single-shot rapid acquisition with relaxation enhancement (RARE) sequence with a balanced steady-state free precession (b-SSFP) sequence in the evaluation of the eye using magnetic resonance (MR) microscopy imaging and to clarify the usefulness of RARE microscopy imaging in evaluating nonoperative glaucoma patients and patients who ...
Li Yan - - 2010
To evaluate the repeatability of Fourier-domain optical coherence tomography (OCT) pachymetric mapping and compare central corneal thickness (CCT) measurements by OCT, ultrasound pachymetry, and scanning-slit tomography. Doheny Eye Institute, University of Southern California, Los Angeles, California, USA. A Fourier-domain OCT system was used to map the corneal thickness in normal ...
John Renu - - 2010
Dynamic magnetomotion of magnetic nanoparticles (MNPs) detected with magnetomotive optical coherence tomography (MM-OCT) represents a new methodology for contrast enhancement and therapeutic interventions in molecular imaging. In this study, we demonstrate in vivo imaging of dynamic functionalized iron oxide MNPs using MM-OCT in a preclinical mammary tumor model. Using targeted ...
Guo Kevin - - 2010
A new gadolinium chelating NIR fluorescent molecular probe increases T(1) relaxivity of water protons, facilitating combined optical and magnetic resonance imaging.
Roberts David W - - 2011
The aim of this study was to investigate the relationships between intraoperative fluorescence, features on MR imaging, and neuropathological parameters in 11 cases of newly diagnosed glioblastoma multiforme (GBM) treated using protoporphyrin IX (PpIX) fluorescence-guided resection. In 11 patients with a newly diagnosed GBM, δ-aminolevulinic acid (ALA) was administered to ...
Bear David M - - 2010
Optical coherence tomography (OCT) and T2 mapping are emerging clinical imaging technologies with potential to detect subsurface changes in cartilage retaining a macroscopically intact articular surface. This study tests the hypothesis that OCT correlates with magnetic resonance imaging (MRI) T2 values, and that OCT signal is sensitive to cartilage matrix ...
Hong Samin - - 2010
PURPOSE: To verify the effect of the scan angle of the optic nerve head (ONH) on measurements of peripapillary retinal nerve fiber layer (RNFL) thickness by using spectral-domain optical coherence tomography (OCT). METHODS: Both eyes of 64 healthy volunteers were scanned by the optic disc cube 200 x 200 scan ...
Cooper Michael L - - 2010
There is considerable research activity in multiresonator optical circuits in silicon photonics, e.g., for higher-order filters, advanced modulation format coding/decoding, or coupled-resonator optical waveguide delay lines. In diagnostics of such structures, it is usually not possible to measure each individual microring resonator without adding separate input and output waveguides to ...
Zheng Kathy - - 2010
Current treatments for osteoarthritis are pain relief and total joint arthroplasty. There is a clinical need for early osteoarthritis diagnostic methods for potential preventive interventions. The resolution achieved with radiography, magnetic resonance imaging (MRI), and arthroscopy is too limited for the assessment of early disease. The high resolution, small fiber-optic ...
Davis Scott C - - 2010
This report demonstrates the diagnostic potential of magnetic resonance imaging (MRI)-coupled fluorescence molecular tomography (FMT) to determine epidermal growth factor receptor (EGFR) status in brain cancer. Two orthotopic glioma xenograft models were used in this study: one represented high EGFR expression and the other low expression. Nude mice were inoculated ...
Guo Hai - - 2010
Rational combination of different functional lanthanide materials within a single nanocrystal presents a feasible way to develop a multifunctional nanoplatform for various biomedical applications. The conventional methods of synthesizing and integrating two kinds of material together generally involve laborious procedures, whilst codoping different functional ions inside a single lanthanide nanocrystal ...
Han Ian C - - 2010
To characterize the types and frequencies of image artifacts associated with macular scanning using 2 common spectral-domain optical coherence tomography (SD OCT) instruments and to evaluate the impact of artifacts on foveal thickness measurements. Retrospective, observational chart review. For the Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA), scans of 98 ...
Schwarze Thomas - - 2010
The [6.6](9,10)anthracenophane 1 (Scheme 1) is a selective fluoroionophore for the detection of PdCl(2) with a large fluorescence enhancement factor (I/I(0) > 250).
Barber W C - - 2010
Initial results from a novel dual modality preclinical imager which combines non-contact fluorescence tomography (FT) and x-ray computed tomography (CT) for preclinical functional and anatomical in vivo imaging are presented. The anatomical data from CT provides a priori information to the FT reconstruction to create overlaid functional and anatomical images ...
Sun Pan - - 2010
The synthesis of a new kind of magnetic, fluorescent multifunctional nanoparticles (approximately 30 nm in diameter) was demonstrated, where multiple fluorescent CdTe quantum dots (QDs) are covalently linked to and assembled around individual silica-coated superparamagnetic Fe(3)O(4) nanoparticles and active carboxylic groups are presented on the surface for easy bioconjugation with ...
Danielli Amos - - 2010
A magnetic modulation biosensing system (MMB) [1,2] rapidly and homogeneously detected biological targets at low concentrations without any washing or separation step. When the IL-8 target was present, a 'sandwich'-based assay attached magnetic beads with IL-8 capture antibody to streptavidin coupled fluorescent protein via the IL-8 target and a biotinylated ...
Garc?a-Alonso Javier - - 2010
Saccharomyces cerevisiae containing fluorescent markers are ideal candidates for applications in microfluidic screening systems as fluorescence signal is emitted without the need of additional reagents. Here we develop a method for magnetic functionalization of such cells which allows their handling and immobilization in micro-screening devices. After exposure of the magnetized ...
Patra M - - 2009
Electrical transport properties as a function of magnetic field and time have been investigated in polycrystalline, Nd(0.84)Sr(0.16)CoO(3). A strong exchange bias (EB) effect is observed associated with the fairly large intragranular magnetoresistance (MR). The EB effect observed in the MR curve is compared with the EB effect manifested in the ...
Zhu Zhenshu - - 2010
Paclitaxel (PTX)-loaded poly(N-vinylpyrrolidone)-b-poly(epsilon-caprolactone) (PVP-b-PCL) nanoparticles with high drug payload were successfully prepared by a modified nano-precipitation method and characterized by transmission electron microscopy (TEM), atomic force microscopy (AFM), dynamic light scattering (DLS) and zeta potential. The satisfactory drug loading content (>25%) and high encapsulation efficiency (>85%) were achieved. The in ...
Hellgren Kerstin - - 2009
PURPOSE: We aimed to evaluate visual fields (VFs) and optic disc morphology in very low birthweight (VLBW) adolescents compared with age- and gender-matched controls, and to relate the findings to magnetic resonance imaging (MRI) results. METHODS: Fifty-nine VLBW adolescents and 55 age- and gender-matched controls with normal birthweight were examined. ...
Setua Sonali - - 2010
Targeted cancer imaging using rare-earth oxide nanocrystals, free from heavy metals (Cd, Se, Te, Hg and Pb), showing bright red-fluorescence and magnetic resonance imaging (MRI) is presented. Y(2)O(3) nanocrystals (YO NC) doped in situ with fluorescent (Eu(3+)) and paramagnetic (Gd(3+)) impurities and conjugated with a potential cancer targeting ligand, folic ...
Sturzu Alexander - - 2010
The extracellular glycoprotein Tenascin-C (TN-C) is highly upregulated in gliomas. Therefore, many chemotherapies with radiolabeled antibodies against TN-C have been performed. However, TN-Cs binding partner Syndecan-4 did not play any role as a therapeutic or imaging target in gliomas. We constructed an imaging compound containing the magnetic resonance imaging (MRI) ...
Sadda Srinivas R - - 2010
To investigate the relationship between B-scan density and retinal thickness measurements obtained by spectral domain optical coherence tomography (SDOCT) in eyes with retinal disease. Data were collected from 115 patients who underwent volume OCT imaging with Cirrus HD-OCT using the 512 x 128 horizontal raster protocol. Raw OCT data, including ...
Weeks Tyler - - 2009
Doubly-resonant four-wave mixing (DR-FWM) is a nondegenerate four-wave mixing process in which four photons interact to coherently probe two distinct Raman resonances. We demonstrate DR-FWM microscopy as a label-free and nondestructive molecular imaging modality with high chemical specificity on the submicron scale by imaging alkyne-substituted oleic acid in both aqueous ...
Henschel Andreas - - 2009
PURPOSE: To assess the sensitivity and specificity of optical coherence tomography (OCT) for monitoring patients with choroidal neovascularization (CNV) after photodynamic therapy (PDT) in comparison to fluorescein angiography (FA). METHODS: Prospective study of 14 patients with CNV secondary to age-related macular degeneration receiving PDT. Best-corrected visual acuity (BCVA), fluorescein angiography, ...
Eter Nicole - - 2010
Molecular imaging plays an increasingly powerful role in elucidating pathophysiological pathways, in advancing drug discovery and in deciphering developmental processes. Multiple modalities, including optical imaging, ultrasound, nuclear imaging, computed tomography and various techniques of MRI are now being used to obtain fundamental new insights at the cellular and molecular level, ...
Kellner S - - 2009
AIMS: To compare spectral domain optical coherence tomography (sdOCT) with melanin-related near-infrared fundus autofluorescence (NIA, excitation 787 nm, emission >800 nm), lipofuscin-related fundus autofluorescence (FAF, excitation 488 nm, emission >500 nm) and multifocal electroretinography (mfERG) in patients with long-term chloroquin (CQ) treatment. METHODS: Eight patients with 5.5-22 years of CQ ...
Park Joseph - - 2009
Novel bifunctional fluorescent magneto polymeric nanoprobes (FMPNs) were synthesized to provide simultaneous diagnostic information via magnetic resonance imaging (MRI) and optical imaging. FMPNs consist of ultra-sensitive magnetic nanocrystals that function as MR probes combined with Nile Red, which functions as a fluorescent probe. FMPNs were encapsulated by a nano-emulsion method ...
Reich Daniel S - - 2009
To determine whether damage to the optic radiation (OR) in multiple sclerosis (MS) is associated with optic nerve injury and visual dysfunction. Case-control study. Referral center. Ninety referred patients with MS and 29 healthy volunteers. Magnetic resonance imaging indices along the OR were reconstructed with diffusion tensor tractography. Retinal nerve ...
Stockhammer Florian - - 2009
PURPOSE: Malignant gliomas are highly infiltrative tumours with a fatal prognosis. F18-fluoroethyl-tyrosine (FET)-positron emission tomography (PET) often reveals a broader extension of these tumours compared with contrast-enhanced magnetic resonance imaging (MRI). Complete resection of the contrast-enhancing lesion is aspired. Fluorescence-guided resection using 5-aminolevulinic acid (5-ALA) improved the extent of resection. ...
Coxson Harvey O - - 2009
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by both small airway and parenchymal abnormalities. There is increasing evidence to suggest that these two morphologic phenotypes, although related, may have different clinical presentations, prognosis, and therapeutic responses to medications. With the advent of novel imaging modalities, it is ...
Nahrendorf Matthias - - 2009
Proteases are emerging biomarkers of inflammatory diseases. In atherosclerosis, these enzymes are often secreted by inflammatory macrophages, digest the extracellular matrix of the fibrous cap, and destabilize atheromata. Protease function can be monitored with protease activatable imaging probes and quantitated in vivo by fluorescence molecular tomography (FMT). To address 2 ...
Rawat R - - 2009
Magnetoresistance studies on RPd(2)Si (R = Tb, Dy and Lu) compounds show large negative magnetoresistance (MR) in TbPd(2)Si and DyPd(2)Si near the magnetic ordering temperature. Positive MR at low temperature in the ferromagnetic Dy compound is shown to arise from the orbital contribution (the Lorentz force effect). As a consequence, ...
Muduli P K - - 2009
Magnetic anisotropy, magnetization reversal and the magnetooptic Kerr effect in Co(x)Mn(y)Ge(z) have been studied over a range of compositions between 0 and 50 at.% of Ge and between 1 and 3 in the Co to Mn atomic ratio, including the Heusler alloy Co(2)MnGe. A strong quadratic magnetooptic Kerr effect has been ...
Duong Timothy Q - - 2009
This paper reviews recent developments in high-resolution magnetic resonance imaging (MRI) and its application to image anatomy, physiology, and function in the retina of animals. It describes technical issues and solutions in performing retinal MRI, anatomical MRI, blood oxygenation level-dependent functional MRI (fMRI), and blood-flow MRI both of normal retinas ...
Lochhead J - - 2010
Cerebral malaria (CM) is a disease of high mortality worldwide. It can be associated with malarial retinopathy (MR) resulting from impaired perfusion within the retinal microvasculature. Areas of capillary non-perfusion (CNP) appear white (retinal whitening) on ophthalmoloscopy. In this study, electrophysiological investigations were performed to investigate the physiological consequences of ...
Tian Zhi-Quan - - 2009
We have developed a convenient strategy for preparing color-tunable fluorescent-magnetic core/shell multifunctional nanocrystals, which exhibit excellent photoluminescence (PL) properties (fluorescing tunably from 550 nm to 630 nm by modifying the shell thickness) and ferromagnetic material properties (a magnetization of 4.4 emu g(-1) and a coercivity of 95 Oe).
Domalpally Amitha - - 2009
PURPOSE: To analyze the scan characteristics associated with poor-quality Stratus optical coherence tomograms submitted to a reading center for multicenter clinical trials. METHODS: Data from evaluation of 6,741 fast macular thickness map reports from trials involving age-related macular degeneration (AMD), diabetic macular edema, and retinal vein occlusion were analyzed. Optical ...
Borin D Yu - - 2009
Magnetic measurements on frozen ferrofluids with and without significant structure formation in an applied magnetic field have been performed. The results of these investigations were compared with the magnetic field dependent rheological properties for two different kinds of ferrofluids. Magnetic experiments performed similarly to conventional field cooled-field warming magnetic tests ...
Planes Antoni - - 2009
Magnetic Heusler alloys which undergo a martensitic transition display interesting functional properties. In the present review, we survey the magnetocaloric effects of Ni-Mn-based Heusler alloys and discuss their relation with the magnetic shape-memory and magnetic superelasticity reported in these materials. We show that all these effects are a consequence of ...
Keane Pearse A - - 2009
To compare the sensitivities of high-speed Fourier-domain optical coherence tomography (FD-OCT) and conventional time-domain (TD) OCT for the detection of clinical findings important in the management of common vitreoretinal disorders. Prospective, observational study. FD-OCT scans (128 B scans x 512 A scans) were obtained using a prototype instrument (3 D-OCT; ...
Qiu Chengxuan - - 2009
To investigate whether the severity and location of cerebral white matter hyperintensities (WMHs) and brain infarcts are correlated with the signs of retinal microvascular abnormalities in the elderly. The study included 4,176 men and women (mean age, 76 years) who participated in the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study. Digital retinal ...
Testoni P A - - 2009
BACKGROUND: Type 1 sphincter of Oddi dysfunction is a clinical entity characterised by biliary-type pain, elevated liver biochemical tests, and common bile duct dilation. Sphincter fibrosis is a common finding in this type of dysfunction and may require in some cases a differential diagnosis with a malignant intra-papillary disease. Optical ...
Li Lin Z - - 2009
Noninvasive or minimally invasive prediction of tumor metastatic potential would facilitate individualized cancer management. Studies were performed on a panel of human melanoma xenografts that spanned the full range of metastatic potential measured by an in vivo lung colony assay and an in vitro membrane invasion culture system. Three imaging ...
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