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Kallianos Kimberly K Department of Radiology and Biomedical Imaging, University of California, San Francisco, 350 Parnassus Avenue, San Francisco, CA 94117, - - 2015
The role of cardiac magnetic resonance (MR) imaging as a prognostic tool in patients with ischemic heart disease is well established. However, an increasing body of data now demonstrates that cardiac MR imaging can provide prognostic information in a variety of nonischemic and diffuse myocardial diseases including myocarditis, dilated and ...
da Costa Leodante L Division of Neurosurgery, Department of Surgery, Sunnybrook Hospital, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Room A1-37, Toronto, ON, Canada, - - 2015
Delayed cerebral ischemia (DCI) continues to be a major cause of morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage (aSAH) because it can only be diagnosed after the onset of clinical symptoms, contributing to poor clinical outcomes and huge use of clinical resources. We hypothesized that early disturbances in ...
Gallivanone F F Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM--CNR), Milan, Italy - - - 2014
Statistical Parametric Mapping (SPM) has been applied for single--subject evaluation of [18F]FDG uptake in Alzheimer Disease (AD). In a single--subject framework, the patient is compared to a dataset of [18F]FDG PET images from healthy subjects (HS) evaluating brain metabolic abnormalities. No studies exist that assess the effects on SPM analysis ...
Brendel Matthias M Dept. of Nuclear Medicine, University of Munich, - - 2014
Amyloid positron-emission-tomography (PET) offers an important research and diagnostic tool for investigating Alzheimer's disease (AD). The majority of amyloid PET studies have used the cerebellum as a reference region, and clinical studies have not accounted for atrophy-based partial volume effects (PVE). Longitudinal studies using cerebellum as reference tissue have revealed ...
Klein Carina C Division Neuropsychology, Institute of Psychology, University of Zurich, Switzerland. Electronic address: - - 2014
Besides the benefit of combining the imaging methods electroencephalography (EEG) and magnetic resonance imaging (MRI), much effort has been spent to develop algorithms aimed at successfully cleaning the EEG data from MRI-related gradient and ballistocardiological artefacts. However, previous studies have also shown a negative influence of the EEG on MRI ...
Murray Melissa E ME http://orcid.org/0000-0001-7379-2545 Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, - - 2014
Proton magnetic resonance spectroscopy ((1)H-MRS) is sensitive to early neurodegenerative processes associated with Alzheimer's disease (AD). Although (1)H-MRS metabolite ratios of N-acetyl aspartate (NAA)/creatine (Cr), NAA/myoinositol (mI), and mI/Cr measured in the posterior cingulate gyrus reveal evidence of disease progression in AD, pathologic underpinnings of the (1)H-MRS metabolite changes in ...
Estey Chelsie M CM Neurology Service, College of Veterinary Medicine, Cornell University, Ithaca, NY - - 2014
Case Description-A 4-year-old 26-kg (57.2-lb) spayed female Staffordshire Bull Terrier mix was evaluated because of a 24-hour history of cluster seizures. Clinical Findings-Neurologic examination revealed altered mentation and multifocal intracranial signs; MRI was performed. The MRI findings included multifocal, asymmetric forebrain lesions affecting both the gray and white matter, an ...
Jolesz Ferenc A FA Department of Radiology Brigham and Women's Hospital 75 Francis St, Boston, MA - - 2014
Summary Burgess et al ( 1 ) present intriguing results of repetitive transient opening of the blood-brain barrier (BBB) in a transgenic mouse model of advanced Alzheimer disease (AD). The results underscore the potential of using magnetic resonance (MR) imaging-guided focused ultrasound and microbubble ultrasonography (US) contrast agents for the ...
Lee G Ky GK Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong - - 2014
We report a case of spontaneous intracranial hypotension with classic symptoms of orthostatic headache and acute presentation of subdural haematoma on computed tomographic scan. Conventional approach with conservative treatment was initially adopted. The patient's condition, however, deteriorated after 2 weeks, requiring surgical evacuation of the intracranial haemorrhage. We reviewed the ...
Khalatbari Mahmoud Reza MR Department of Neurosurgery, Arad Hospital; Tehran, Iran - - - 2014
Cerebral echinococcosis is very rare, representing 2% of all cystic echinococcosis (CE) cases. Primary echinococcal cysts of the brain are extremely rare in pediatric patients. We report on a 16-year-old boy referred to our tertiary center with intractable epilepsy for the previous three years despite receiving full doses of three ...
Mandell Jason G JG Center for Neural - - 2014
OBJECT The incidence of temporal lobe epilepsy (TLE) due to mesial temporal sclerosis (MTS) can be high in developing countries. Current diagnosis of MTS relies on structural MRI, which is generally unavailable in developing world settings. Given widespread effects on temporal lobe structure beyond hippocampal atrophy in TLE, the authors ...
Caroli Anna A *Institute of Brain, Behaviour, and Mental Health University of Cambridge Cambridge, Medical Imaging Unit, Biomedical Engineering Department, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Bergamo †Laboratory of Epidemiology and Neuroimaging, IRCCS Fatebenefratelli, Brescia §Department of Decision Science, Bocconi University, Milan, Italy ‡Department of Engineering, University of Cambridge, Cambridge **University of Manchester, Manchester, UK ∥Banner Alzheimer's Institute, Phoenix, AZ ¶Helen Wills Neuroscience Institute, University of California, Berkeley, CA #Hannover Medical School, Clinic for Nuclear Medicine, Hannover, Germany ††Departments of Internal Medicine and Psychiatry, University Hospitals and University of Geneva, Geneva, - - 2014
Aim of this study was to compare the performance and power of the best-established diagnostic biological markers as outcome measures for clinical trials in patients with mild cognitive impairment (MCI). Magnetic resonance imaging, F-18 fluorodeoxyglucose positron emission tomography markers, and Alzheimer's Disease Assessment Scale-cognitive subscale were compared in terms of ...
Dhesi Balraj B Department of Clinical Radiology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, - - 2014
Neurocysticercosis is a parasitic neurological infection caused by the ingestion of larvae from the adult tapeworm Taenia solium. We describe a man who presented with generalised tonic-clonic seizures. He had been previously diagnosed with epilepsy in Malawi, where he had emigrated from 2 years before this episode. An MRI was performed ...
Hsu Phillip J PJ Department of Radiology, Washington University School of Medicine, St. Louis, MO, - - 2014
The earliest sites of brain atrophy in Alzheimer's disease are in the medial temporal lobe, following widespread cerebral cortical amyloid deposition. We assessed 74 cognitively normal participants with clinical measurements, amyloid-β-PET imaging, MRI, and a newly developed technique for MRI-based hippocampal subfield segmentation to determine the differential association of amyloid ...
Brucher Nicolas N Department of Radiology, Toulouse University Hospital, Toulouse, - - 2014
To objectify and quantify inter- and intra-observer variability of brain 18-FDG PET-CT interpretation in the context of cognitive and functional impairment amongst the elderly. 25 patients underwent brain 18-FDG PET-CT for investigation of dementia/MCI and frail elderly patients. Three observers interpreted studies in two forms: standardised datasets reconstructed by an ...
Nasrallah Ilya M IM University of Pennsylvania, United - - 2014
Neurodegenerative diseases, such as Alzheimer disease, result in cognitive decline and dementia and are a leading cause of mortality in the growing elderly population. These progressive diseases typically have an insidious onset, with overlapping clinical features early in the disease course that make diagnosis challenging. The neurodegenerative diseases are associated ...
Atangana Etienne N EN Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, - - 2014
Brain atrophy after subarachnoid hemorrhage (SAH) has been detected in humans and might serve as a functional read-out parameter for neuropsychological deficits. To determine whether serial magnetic resonance imaging (MRI) can provide information on brain atrophy in animals as well, mice that had undergone experimental SAH were scanned repeatedly after ...
Staack Anke Maren AM Kork Epilepsy Centre, Landstrasse 1, 77694, Kehl-Kork, Germany, - - 2014
Hypothalamic hamartomas (HHs) are rare developmental malformations consisting of mixed neurons and glial cells, usually unilaterally attached to the tuber cinereum or mammillary bodies. We report on two patients, both suffering from pharmacoresistant epilepsy, behavioural and cognitive disturbances. Ictal and interictal electroencephalographic (EEG) abnormalities appeared bilaterally and multiregionally with right-sided ...
Maier Florian C FC Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Tübingen, - - 2014
The dynamics of β-amyloid deposition and related second-order physiological effects, such as regional cerebral blood flow (rCBF), are key factors for a deeper understanding of Alzheimer's disease (AD). We present longitudinal in vivo data on the dynamics of β-amyloid deposition and the decline of rCBF in two different amyloid precursor ...
Shim Yong Soo YS Department of Neurology, The Catholic University of Korea College of Medicine, Seoul, South - - 2014
Background/Aims: We investigated the histopathological correlates of white matter hyperintensities (WMHs) in participants with Alzheimer's disease (AD) or cerebrovascular disease, and in aged controls. Methods: We reviewed 57 participants who had neuropathology and in whom neuroimaging was done. In addition to AD pathology, cortical microinfarcts, lacunes, and cerebral hemorrhages were ...
Sarbu Nicolae N Department of Neuroradiology, Hospital Clinic, Barcelona, Catalonia, - - 2014
To describe brain magnetic resonance imaging (MRI) abnormalities in newly diagnosed neuropsychiatric lupus (NPSLE). To correlate them with clinical and laboratory data. This retrospective cross-sectional study included patients presenting NPSLE undergoing brain MRI within 6months after onset between 2003 and 2012. Clinical and laboratory data were recorded. MRI findings were ...
Penolazzi Barbara B a Department of General Psychology , University of Padua , - - 2014
In the present study we tested the cognitive effects of transcranial direct current stimulation (tDCS) in a case of probable Alzheimer disease (AD). The patient (male, 60 years, mild AD) underwent two cycles of treatments, separated by 2 months. In the first cycle, active stimulation (10 sessions, 2 mA for 20 min; anode over ...
Jang Jae-Won JW Department of Neurology, Kangwon National University Hospital, Chuncheon, Republic of - - 2014
Background: Brain magnetic resonance imaging (MRI) shows cerebral structural changes. However, a unified comprehensive visual rating scale (CVRS) has seldom been studied. Thus, we combined brain atrophy and small vessel disease scales and used an MRI template as a CVRS. Objective: The aims of this study were to design a ...
O'Brien John T JT Department of Psychiatry, Cambridge Biomedical Campus, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom Institute for Neuroscience, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, United Kingdom - - 2014
Brain imaging with glucose ((18)F-FDG) PET or blood flow (hexamethylpropyleneamine oxime) SPECT is widely used for the differential diagnosis of dementia, though direct comparisons to clearly establish superiority of one method have not been undertaken. Subjects with Alzheimer disease (AD; n = 38) and dementia with Lewy bodies (DLB; n ...
Kim J-H JH Department of Neurology, Keyo Medical Foundation, Keyo Geriatric Hospital, Uiwang, - - 2014
Cerebral microbleeds (CMBs) have been extensively studied in healthy controls and patients with cerebrovascular disease and Alzheimer's disease. Our aim was to characterize the clinical and radiological features of CMBs in idiopathic Parkinson's disease (IPD). This cross-sectional study included consecutive parkinsonian patients who attended the authors' movement disorders clinic from ...
Coras Roland R Clinical Epileptology and Experimental Neurophysiology Unit, IRCCS Foundation Neurological Institute "C. Besta,", Milan, Italy; Department of Neuropathology, University Hospital Erlangen, - - 2014
Hippocampal sclerosis (HS) is the major structural brain lesion in patients with temporal lobe epilepsy (TLE). However, its internal anatomic structure remains difficult to recognize at 1.5 or 3 Tesla (T) magnetic resonance imaging (MRI), which allows neither identification of specific pathology patterns nor their proposed value to predict postsurgical ...
Caverzasi Eduardo E 1 Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA 2 Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143, USA - - 2014
Sporadic Creutzfeldt-Jakob disease is considered primarily a disease of grey matter, although the extent of white matter involvement has not been well described. We used diffusion tensor imaging to study the white matter in sporadic Creutzfeldt-Jakob disease compared to healthy control subjects and to correlated magnetic resonance imaging findings with ...
Reijmer Yael D YD 1 Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, - - 2014
Cerebral amyloid angiopathy is a common form of small-vessel disease and an important risk factor for cognitive impairment. The mechanisms linking small-vessel disease to cognitive impairment are not well understood. We hypothesized that in patients with cerebral amyloid angiopathy, multiple small spatially distributed lesions affect cognition through disruption of brain ...
Bogaert Jan J From the Department of Radiology, Gasthuisberg University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium (J.B.); and Referral Center for Myocardial Diseases, Azienda Universitaria Careggi, Florence, Italy - - 2014
Hypertrophic cardiomyopathy ( HCM hypertrophic cardiomyopathy ), the most common genetically transmitted cardiac disorder, has been the focus of extensive research over the past 50 years. HCM hypertrophic cardiomyopathy is a multifaceted disease with highly heterogeneous genetic background, phenotypic expression, clinical presentation, and long-term outcome. Though most patients have an ...
Rosskopf Johannes J Department of Neurology, University of Ulm, Ulm, - - 2014
Background: Frontal lobe involvement is considered a clinical and magnetic resonance imaging (MRI) feature in later stages of progressive supranuclear palsy (PSP). Objective: Diffusion tensor imaging (DTI) was used to investigate the integrity of frontal pathways in PSP and Parkinson's disease (PD) patients. Methods: DTI and 3-D MRI were performed ...
Friedland Bernard - - 2014
Dentists contemplating sinus augmentation frequently take a cone beam computed tomography (CBCT) scan as part of the work-up. Maxillary sinus pathology is common, and such dentists will be faced with pathologic sinus findings. Not all sinus pathology needs to be treated. The purpose of this article is twofold: to describe ...
Su Li L Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Level E4, Cambridge Biomedical Campus, Cambridge, Box 189, CB2 0SP, UK, - - 2014
We aimed to characterize dementia with Lewy bodies (DLB) by the quantitative MRI parameters of longitudinal relaxation time (qT1) and transverse relaxation time (qT2). These parameters reflect potential pathological changes in tissue microstructures, which may be detectable noninvasively in brain areas without evident atrophy, so may have potential value in ...
Choi Mihyun M Haemaru Referral Animal - - 2014
A 3-year-old, intact female Pomeranian presented with a 1-month history of coughing. Thoracic radiography showed focal infiltration of the left cranial lung lobe and widening of the cranial mediastinum. Subsequent computed tomography revealed torsion of the caudal segment of the left cranial lung lobe, which was confirmed by exploratory thoracotomy. ...
Danière F F INSERM UMR 894, Department of Neuroradiology, Université Paris Descartes, Sorbonne Paris Cité, Centre Hospitalier Sainte-Anne, Paris, - - 2014
Stroke mimics account for up to a third of suspected strokes. The main causes are epileptic deficit, migraine aura, hypoglycemia, and functional disorders. Accurate recognition of stroke mimics is important for adequate identification of candidates for thrombolysis. This decreases the number of unnecessary treatments and invasive vascular investigations. Correctly identifying ...
Hoza David D Department of Neurosurgery, Hospital Dessau, Auenweg 38, 06847, Dessau-Roßlau, Germany, - - 2014
Normal pressure hydrocephalus (NPH) is a clinical syndrome characterized by gait disturbances, urinary incontinence and dementia. Clinical presentation overlaps with Alzheimer disease (AD). Early recognition thus early intervention (shunting) is important for successful treatment, but lack of a diagnostic test with sufficient sensitivity and specificity complicates the diagnosis. We performed ...
Ayuso C C 1] Department of Genetics, Health Research Institute-Fundación Jiménez Díaz University Hospital (IIS-FJD, UAM), Madrid, Spain [2] Center for Biomedical Network Research on Rare Diseases CIBERER ISCIII, Madrid, - - 2014
Whole-genome/exome sequencing used in clinical trials (CTs) to identify 'druggable' mutations and targets uncovers incidental findings unrelated to the trial objectives but of value for participants, although ethically challenging. To be disclosed to trial participants, the analytical validity, clinical validity, clinical utility, clinical relevance and actionability of incidental genomic findings ...
Feng Rui R Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, PR - - 2014
Introduction: Using retrospective and comparative methods, we aim to discuss the surgical treatment of magnetic resonance imaging (MRI)-negative temporal lobe epilepsy (TLE) presented with positive positron emission tomography (PET) results. Methods: From the viewpoint of semiology, demography, surgical treatment and prognosis evaluation, we compared 19 MRI-negative, PET-positive TLE patients to ...
Kantarci Kejal K Department of Radiology, Mayo Clinic, Rochester, - - 2014
Pathophysiologic mechanisms leading to loss of white matter integrity and the temporal positioning of biomarkers of white matter integrity relative to the biomarkers of gray matter neurodegeneration and amyloid load in the course of Alzheimer disease (AD) are poorly understood. To investigate the effects of AD-related gray matter neurodegeneration and ...
Timmers Inge I Department of Cognitive Neuroscience, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands, - - 2014
White matter abnormalities have been observed in patients with classic galactosemia, an inborn error of galactose metabolism. However, magnetic resonance imaging (MRI) data collected in the past were generally qualitative in nature. Our objective was to investigate white matter microstructure pathology and examine correlations with outcome and behaviour in this ...
Falahati Farshad F Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, - - 2014
Background/Aims: The use of structural brain imaging [computed tomography (CT)/magnetic resonance imaging (MRI)] and the analysis of cerebrospinal fluid biomarkers are included in the guidelines for the diagnosis of dementia. The influence of variables such as age, gender and disease severity on the use of MRI, CT and lumbar puncture ...
Penner Jacob J Centre for Functional and Metabolic Mapping (CFMM), Robarts Research Institute, and Department of Medical Biophysics, University of Western Ontario, London, Ont., - - 2014
Aim: To determine whether 4 months of rivastigmine treatment would result in metabolic changes and whether metabolic changes correlate with changes in cognition in people with Alzheimer's disease (AD). Methods: Magnetic resonance spectra were acquired from the posterior cingulate cortex of subjects with AD at 3 T. Magnetic resonance imaging ...
Noh Young Y From the Department of Neurology (Y.N., K.H.P.), Gachon University Gil Medical Center, Incheon; Department of Biomedical Engineering (S.J., J.M.L.), Hanyang University, Seoul; Department of Neurology (S.W.S., H.J.K., J.C., D.L.N.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; Department of Neurology (G.H.K.), Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul; Department of Neurology (H.C.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul; Department of Neurology (B.S.Y.), Yonsei University College of Medicine, Seoul; Department of Neurology (C.W.Y.), Inha University Hospital, Inha University School of Medicine, Incheon, Korea; and Department of Neurology (K.M.H.), University of Florida and Veterans Affairs Medical Center, - - 2014
Because the signs associated with dementia due to Alzheimer disease (AD) can be heterogeneous, the goal of this study was to use 3-dimensional MRI to examine the various patterns of cortical atrophy that can be associated with dementia of AD type, and to investigate whether AD dementia can be categorized ...
Meijer F J A FJ http://orcid.org/0000-0001-5921-639X From the Departments of Radiology and Nuclear Medicine (F.J.A.M., B.A.C.M.F., B.G.) and Laboratory Medicine (M.M.V.), and Department of Neurology (A.v.R., I.T., M.A., R.E., B.R.B., M.M.V.), Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands; and Department of Diagnostic Imaging (B.G.), Medical Center of Postgraduate Education, Warsaw, Poland. - - 2014
The differentiation between Parkinson disease and atypical parkinsonian syndromes can be challenging in clinical practice, especially in early disease stages. Brain MR imaging can help to increase certainty about the diagnosis. Our goal was to evaluate the added value of SWI in relation to conventional 3T brain MR imaging for ...
Saleem Sahar N SN Professor in Radiology Department, Kasr Al Ainy Faculty of Medicine, Cairo, - - 2014
Objective: We aimed to study the computed tomography (CT) scans of the royal Ancient Egyptian mummies dated to the eighteenth to early twentieth Dynasties for the claimed diagnoses of Ankylosing spondylitis and diffuse idiopathic skeletal hyperostosis (DISH) and to correlate the findings with the archaeology literature. Methods: We studied the ...
Jentzen Walter W Klinik für Nuklearmedizin, Universität Duisburg-Essen, Essen, Germany; and - - 2014
(124)I PET/CT images from differentiated thyroid cancer patients were retrospectively analyzed to assess the relationship between absorbed radiation dose (AD) to lesions and their response after radioiodine therapy. Patients received serial (124)I PET/CT scans before and after their first radioiodine treatment. The pretherapy PET data were used to segment the ...
Ong Yi-Ting YT Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, - - 2014
Neurodegeneration in dementia is mainly evaluated by assessing cerebral atrophy, while retinal neurodegeneration can be quantified in vivo using optical coherence tomography (OCT). We examined the association of retinal nerve fibre layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) thinning with global and regional cerebral atrophy on magnetic resonance imaging ...
Turan Tanya N TN Department of Neurology and Neurosurgery at Medical University of South Carolina, Charleston, SC, USA. Electronic address: - - 2014
High-resolution MRI (HRMRI) is a promising tool for studying intracranial atherosclerotic disease (ICAD) in-vivo, but its use to understand the pathophysiology of ICAD has been limited by a lack of correlation between MRI signal characteristics and pathology in intracranial arteries. A patient with symptomatic left cavernous carotid stenosis underwent 3T ...
Erdélyi-Bótor Szilvia S Department of Neurology, University of Pécs, Pécs, - - 2014
The aim of this longitudinal study was to investigate changes of migraine-related brain white matter hyperintensities 3 years after an initial study. Baseline quantitative magnetic resonance imaging (MRI) studies of migraine patients with hemispheric white matter hyperintensities performed in 2009 demonstrated signs of tissue damage within the hyperintensities. The hyperintensities ...
Kim Yeon-Jung YJ Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Republic of - - 2014
Status migrainosus (SM) and persistent aura (PA) without infarction are complications of migraine. Although several patients have been reported to have reversible brain lesions associated with complications of migraine, their nature and pathophysiology remain unclear. We report on a 38-year-old male who presented with nine episodes of SM and PA ...
Del Brutto Oscar H OH School of Medicine, Universidad Espíritu Santo, Guayaquil, - - 2014
Background: Calcified cysticerci share the morphology and signal properties with true cerebral microbleeds, but this condition is neglected at the time of evaluating MRIs for clinical or research purposes. We report our experience with the MRI reading obtained from the Atahualpa Project, a population-based stroke study, conducted in a village ...
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