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Diehl-Schmid Janine J Department of Psychiatry and Psychotherapy, Technische Universität München, München, - - 2014
The term frontotemporal lobar degeneration (FTLD) refers to a group of neurodegenerative disorders that target the frontal and temporal lobes. It accounts for approximately 10 % of pathologically confirmed dementias but has been demonstrated to be as prevalent as Alzheimer's disease in patients below the age of 65. The 3 major ...
Chen Bo B Department of Neurology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. - - 2014
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, a recently defined and frequently misdiagnosed disease characterized by psychiatric symptoms, seizures, movement disorders and autonomic dysfunction, has been observed predominantly in young females with ovarian teratoma. Conventional imaging techniques, including computed tomography (CT) and magnetic resonance imaging (MRI), are often ineffective for diagnosis of the ...
Cachia David D Department of Neuro-Oncology, MD Anderson Cancer Center, Houston, - - 2014
A 62-year-old man presented with rapidly progressive cognitive decline associated with ataxia, spasticity, and eventually seizures. Multiple bihemispheric foci of calcification in the brain were seen on computed tomography scan, with magnetic resonance imaging (MRI) showing relatively symmetrical areas of enhancement in the brain corresponding mostly to the areas of ...
Goto Masami M Department of Radiological Technology, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan, - - 2014
Our aim was to show whether sensitivity for detecting volume changes in regional gray matter in default mode network (DMN) at converted [from mild cognitive impairment to Alzheimer's disease (from MCI to AD)] phase was improved by use of a standardized volume with global gray-matter volume. T1-weighted MR images (T1WI) ...
Delli Pizzi Stefano S Department of Neuroscience, Imaging and Clinical Sciences Aging Research Centre, Ce.S.I. and Institute for Advanced Biomedical Technologies (ITAB), "G. d'Annunzio" University, Chieti, - - 2014
Dementia with Lewy bodies (DLB) is characterized by fluctuation in cognition and attention. Thalamocortical connectivity and integrity of thalami are central to attentional function. We hypothesize that DLB patients with marked and frequent fluctuating cognition (flCog) have a loss of thalamocortical connectivity, an intrinsic disruption to thalamic structure and imbalances ...
Okamoto Nobuhiko N Department of Medical Genetics, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, - - 2014
Neurodegeneration with brain iron accumulation (NBIA) comprises a clinically and genetically heterogeneous group of progressive brain disorders with several distinguishable subtypes. Recently, WDR45 mutations were reported in patients with β-propeller protein-associated neurodegeneration (BPAN), characterized by early intellectual disability followed by delayed progressive motor and cognitive deterioration with onset in the ...
Pessa Maria Elena ME Clinica Neurologica e di Neuroriabilitazione, Azienda Ospedaliero-Universitaria S. Maria della Misericordia, Udine, Italy - - 2014
Limbic encephalitis (LE) is an inflammation of structures of limbic system. It may be an autoimmune disease or secondary to a neoplasia. Onset is subacute within a few weeks and clinical presentation is characterized by behavioral changes, psychiatric symptoms, short-term memory loss, and epileptic seizures. Diagnosis is typically set after ...
Telischak Nicholas A NA Department of Radiology, Stanford University Medical Center, Stanford, California, - - 2014
Visualization of cerebral blood flow (CBF) has become an important part of neuroimaging for a wide range of diseases. Arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) sequences are increasingly being used to provide MR-based CBF quantification without the need for contrast administration, and can be obtained in conjunction ...
Dohan Anthony A Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France; Université Paris-Diderot, Sorbonne Paris Cité, 10, rue de Verdun, 75010 Paris, France. Electronic address: - - 2014
Vertebral Paget's disease produces a large panel of radiologic appearances sometimes atypical and pseudotumoral. Classical classifications of bone alterations based on pathophysiological hypotheses do not always match the imaging findings. This article will review the computed tomography (CT) and magnetic resonance imaging (MRI) features of Paget's disease of the spine with ...
Giannantoni Nadia Mariagrazia NM Institute of Neurology, Catholic University, Rome, - - 2014
Neurofibromatosis type 1 (NF1) is a heterogeneous, common, neurocutaneous disorder presenting different complications during a life span, including cerebrovascular dysplasia. To our knowledge this is the first reported case of NF1 associated with vertebrobasilar dolichoectasia and pontine ischemic stroke. We describe a 57-year-old man with NF1 who presented an acute ...
de Flores Robin R INSERM, U1077, Caen, France; Université de Caen Basse-Normandie, UMR-S1077, Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France; CHU de Caen, U1077, Caen, - - 2014
Growing interest has developed in hippocampal subfield volumetry over the past few years and an increasing number of studies use the automatic segmentation algorithm implemented in FreeSurfer. However, this approach has not been validated on standard resolution T1-weighted magnetic resonance (MR) as used in most studies. We aimed at comparing ...
Bonnici K S KS Department of Acute Medicine, Chelsea & Westminster Hospital NHS Trust , London , - - 2014
Introduction. Corrosive ingestions are common, although most ingestions do not result in clinically significant effects. Limited guidance is available on the role of endoscopy and/or computerised tomography (CT) in the investigation of individuals with corrosive ingestion, and the present data regarding predictors of poor outcome are confusing. Furthermore, whilst there ...
Burgess Alison A From the Physical Sciences Platform (A.B., S.Y., O.H., N.E., K.H.) and Biological Sciences Platform (S.D., I.A.), Sunnybrook Research Institute, 2075 Bayview Ave, C713, Toronto, ON, Canada M4N 3M5; Department of Laboratory Medicine and Pathobiology (S.D., I.A.) and Department of Medical Biophysics (K.H.), University of Toronto, Toronto, Ontario, - - 2014
Purpose To validate whether repeated magnetic resonance (MR) imaging-guided focused ultrasound treatments targeted to the hippocampus, a brain structure relevant for Alzheimer disease (AD), could modulate pathologic abnormalities, plasticity, and behavior in a mouse model. Materials and Methods All animal procedures were approved by the Animal Care Committee and are ...
Ishida Atsushi - - 2014
Vasospasm is the most common cause of complication after a subarachnoid hemorrhage and tremendous efforts have been made to prevent it. A subarachnoid clot is the cause of the vasospasm and dissolving and washing it out is considered to be the best practice. Cisternal irrigation with urokinase and ascorbic acid ...
Tepmongkol Supatporn S Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Chulalongkorn University, Rama 4 Road, Pathumwan, Bangkok, 10330, Thailand, - - 2014
Extratemporal lobe epilepsy is difficult to localize. We aimed to define the best parameter(s) of SPECT for confirmation of seizure origin among the region of maximum cerebral perfusion in ictal phase (MP), maximum change of cerebral perfusion from interictal to ictal phase (MC), and maximum extent of hyperperfusion in ictal ...
Zou Jian-Xun JX Department of Radiology, Lishui People's Hospital, Lishui 323000, PR China. Electronic address: - - 2014
The purpose of this study was to investigate the changes in the cerebral blood flow (CBF) and spectrum variables in the posterior cingulate region of patients with AD under the detection of arterial spin labeling (ASL) and magnetic resonance spectroscopy (MRS). A total of 20 AD patients (8 males and ...
Imabayashi Etsuko E Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, 187-8551, Japan, - - 2014
Statistical analysis in neuroimaging (referred to as "neurostatistical imaging") is important in clinical neurology. Here, neurostatistical imaging and its superiority for diagnosing dementia are reviewed. In neurodegenerative dementia, the proportional distribution of brain perfusion, metabolism, or atrophy is important for understanding the symptoms and status of patients and for identifying ...
Vuorinen Miika M Department of Neurology, School of Medicine, University of Eastern Finland, Kuopio, - - 2014
Background: CAIDE Dementia Risk Score is a validated tool for estimating 20-year dementia risk in the general population based on a midlife risk profile. Objective: To investigate the associations between CAIDE score and dementia-related brain changes up to 30 years later on magnetic resonance imaging (MRI). Methods: Participants in the ...
Thordardottir Steinunn S Karolinska Institutet, Department NVS, Division of Neurogeriatrics, Center for Alzheimer Disease Research, Huddinge, Sweden Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, - - 2014
Background: It is currently believed that therapeutic interventions will be most effective when introduced at the preclinical stage of Alzheimer's disease (AD). This underlines the importance of biomarkers to detect AD pathology in vivo before clinical disease onset. Objective: To examine the evolution of cerebrospinal fluid (CSF) biomarker and brain ...
Polonsky Tamar S TS Department of Medicine, University of Chicago, Chicago, IL, USA. Electronic address: - - 2014
We used magnetic resonance imaging (MRI) to study the prevalence and associated clinical characteristics of high-risk plaque (defined as presence of lipid-rich necrotic core [LRNC] and intraplaque hemorrhage) in the superficial femoral arteries (SFA) among people with peripheral artery disease (PAD). The prevalence and clinical characteristics associated with high-risk plaque ...
Broski Stephen M SM From the Departments of Radiology (S.M.B., C.H.H., G.B.J., V.J.L., P.J.P.), Immunology (G.B.J.), and Medical Illustration (R.F.M.), Mayo Clinic, 200 First St SW, Rochester, MN - - 2014
Movement disorders with parkinsonian features are common, and in recent years imaging has assumed a greater role in diagnosis and management. Thus, it is important that radiologists become familiar with the most common imaging patterns of parkinsonism, especially given the significant clinical overlap and diagnostic difficulty associated with these disorders. ...
Rodkong A A Department of Radiological Technology, Faculty of Associated Medical Sciences, Chiang Mai University, - - 2014
Reduction of cortical thickness and Hippocampal volume (HV) in Methamphetamine abusers (MA) has been reported. However, change of white matter volume (WMV) in MA group is inconclusive. We aim to compare cortical thickness, Hippocampal volume (HV), and WMV per intra-cranial volume (ICV) among MA in Thai adolescents. 3D T1-wighted high ...
Khalesi Maryam M Department of Pediatrics, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, - - 2014
Moyamoya disease is a rare vaso-occlusive illness with an unknown etiology characterized by stenosis of the internal carotid arteries with spontaneous development of a collateral vascular network. A 15-month-old girl was referred to the emergency ward of Imam Reza Hospital due to decreased level of consciousness, focal seizures and fever ...
Prados Ferran F Centre for Medical Image Computing (CMIC), Department of Medical Physics and Bioengineering, University College London, London, UK; NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, UK. Electronic address: - - 2014
Brain atrophy measured using structural magnetic resonance imaging (MRI) has been widely used as an imaging biomarker for disease diagnosis and tracking of pathologic progression in neurodegenerative diseases. In this work, we present a generalized and extended formulation of the boundary shift integral (gBSI) using probabilistic segmentations to estimate anatomic ...
Ni Jun J J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA The Department of Neurology, Peking Union Medical College Hospital, Peking, - - 2014
The extent of cortical involvement of cerebral amyloid angiopathy (CAA)-related microbleeds (CMBs) remains unclear. We examined five consecutive patients with probable CAA and three non-demented elderly subjects with ultra-high-field 7T MRI, to identify the precise location of CAA-related CMBs. In five CAA patients, 169 of a total of 170 lobar ...
Eskildsen Simon F SF Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark. Electronic address: - - 2014
Optimized magnetic resonance imaging (MRI)-based biomarkers of Alzheimer's disease (AD) may allow earlier detection and refined prediction of the disease. In addition, they could serve as valuable tools when designing therapeutic studies of individuals at risk of AD. In this study, we combine (1) a novel method for grading medial ...
Aylward Elizabeth H EH Seattle Children's Research Institute, Seattle, Washington, - - 2014
An abundance of research shows that magnetic resonance imaging (MRI) striatal volumes decrease long before diagnosis of Huntington's disease (HD) and closely track disease progression. Additional research indicates that these volumetric measures meet important criteria for a biomarker that can be used in clinical trials: They are 1) objectively measureable; ...
De Cocker Laurens J L LJ Department of Radiology, University Medical Center Utrecht, Utrecht, The - - 2014
Background: Small cerebellar cavities (≤15 mm) are often observed coincidentally in ageing subjects and have also been associated with migraine. Although generally assumed to be of ischaemic origin, descriptive imaging studies are sparse and imaging findings have not been correlated with histopathology. We aimed to investigate whether small ischaemic cavities ...
Bourgeat Pierrick P Preventative Health Flagship, CSIRO Digital Productivity and Services Flagship, Herston, Queensland, Australia. Electronic address: - - 2014
(11)C-Pittsburgh compound B (PiB) is a positron emission tomography (PET) tracer designed to bind to amyloid-β (Aβ) plaques, one of the hallmarks of Alzheimer's disease (AD). The potential of PiB as an early marker of AD led to the increasing use of PiB in clinical research studies and development of several ...
Erdener Sefik Evren SE Department of Neurology, School of Medicine, Hacettepe University, Ankara, Turkey - - 2014
In dacrystic seizures lacrimation has previously been reported as an ictal autonomic event accompanying emotional and somatic signs. However, it has not been observed as an isolated event in autonomic seizures. We report a patient experiencing complex partial seizures characterized by lacrimation as the initial and most prominent ictal event, ...
Augustinack Jean C JC Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, - - 2014
H.M., Henry Molaison, was one of the world's most famous amnesic patients. His amnesia was caused by an experimental brain operation, bilateral medial temporal lobe resection, carried out in 1953 to relieve intractable epilepsy. He died on December 2, 2008, and that night we conducted a wide variety of in ...
Uchiyama Shigeharu S Department of Orthopaedic Surgery, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, 390-8621, Japan, - - 2014
The clinical characteristics of wild-type transthyretin amyloid deposition among patients with carpal tunnel syndrome (CTS) have not been well investigated. One-hundred and seven patients with idiopathic CTS who underwent carpal tunnel release were enrolled. They underwent physical examination of the hand, nerve-conduction study, and magnetic resonance imaging (MRI) study of ...
Thurfjell Lennart L GE Healthcare, Uppsala, Sweden Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden - - 2014
Clinical trials of the PET amyloid imaging agent (18)F-flutemetamol have used visual assessment to classify PET scans as negative or positive for brain amyloid. However, quantification provides additional information about regional and global tracer uptake and may have utility for image assessment over time and across different centers. Using postmortem ...
Bocchetta Martina M LENITEM (Laboratory of Epidemiology, Neuroimaging and Telemedicine), IRCCS Istituto Centro S. Giovanni di Dio Fatebenefratelli, Brescia, Italy; Department of Molecular and Translational Medicine, University of Brescia, Brescia, - - 2014
We investigated the use of Alzheimer's disease (AD) biomarkers in European Alzheimer's Disease Consortium centers and assessed their perceived usefulness for the etiologic diagnosis of mild cognitive impairment (MCI). We surveyed availability, frequency of use, and confidence in diagnostic usefulness of markers of brain amyloidosis (amyloid positron emission tomography [PET], ...
Tubbs R Shane RS Pediatric Neurosurgery, Children's Hospital of Alabama, Birmingham, AL, USA, - - 2014
Few innovations in the method of tunneling shunt tubing for cerebrospinal fluid (CSF) shunt diversion have been made since this treatment of hydrocephalus was first developed. Therefore, this feasibility study was performed with the hope of identifying an improved technique that could potentially carry fewer complications. On 10 cadaver sides ...
Willette Auriel A AA Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, - - 2014
Identifying predictors of mild cognitive impairment (MCI) and Alzheimer׳s disease (AD) can lead to more accurate diagnosis and facilitate clinical trial participation. We identified 320 participants (93 cognitively normal or CN, 162 MCI, 65 AD) with baseline magnetic resonance imaging (MRI) data, cerebrospinal fluid biomarkers, and cognition data in the ...
Kawashiri Shin-Ya SY Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences , Nagasaki , - - 2014
A 43-year-old Japanese woman with adult T-cell leukemia (ATL) developed rheumatoid arthritis-like polyarthritis with dermatitis and skin erosion. Her rheumatoid factor and C-reactive protein results were positive. Musculoskeletal ultrasonography showed intra-articular and peritendinous power Doppler signal-positive synovitis. Plain magnetic resonance imaging showed synovitis of the above lesion and remarkable bone ...
Göbel K K Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, - - 2014
The aim of this study was to demonstrate the feasibility of a custom-made phased-array microcoil within a 400 MHz animal system for the morphological characterization of human skin tissue in correlation with histopathology. A dedicated 7-channel microcoil-based MR detector arranged in a phased-array geometry was developed to combine the advantages of ...
Koehler M J MJ Department of Dermatology, SRH Waldklinikum Gera, Gera, Germany; Department of Dermatology, University Hospital Jena, Jena, - - 2014
In vivo multiphoton tomography (MPT) of human skin has become a valuable tool for non-invasive examination of morphological and biophysical skin properties and their alterations. So far, skin changes after UVB irradiation were mainly evaluated clinically and histologically. The present study aimed at non-invasive imaging of histological changes during acute ...
Watson Rosie R Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom; Department of Aged Care, The Royal Melbourne Hospital, Parkville, Australia. Electronic address: - - 2014
To compare magnetic resonance imaging (MRI) patterns of cortical thinning in subjects with dementia with Lewy bodies (DLB), Alzheimer's disease (AD), and normal aging and investigate the relationship between cortical thickness and clinical measures. Study participants (31 DLB, 30 AD, and 33 healthy comparison subjects) underwent 3-Tesla T1-weighted MRI and ...
AlSharif Shaza S McGill University Health Center, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, PQ, H3H 1A1, - - 2014
We report a case of 43-year-old man who presented with an enlarging, painless, palpable mass in the left breast for one year associated with surface blue discoloration of the skin. Mammogram showed a well-defined 2.3-cm mass with microcalcifications. Ultrasound revealed a well-defined, subcutaneous hypoechoic mass adherent to the skin with ...
Brickman Adam M AM Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address: - - 2014
Accumulating evidence implicates small vessel cerebrovascular disease, visualized as white matter hyperintensities (WMH) on T2-weighted magnetic resonance imaging, in the pathogenesis and diagnosis of Alzheimer's disease (AD). Cross-sectional volumetric measures of WMH, particularly in the parietal lobes, are associated with increased risk of AD. In the present study, we sought ...
Chance Aaron A Division of Neurological Surgery, Departments of Pediatric Surgery and Neurosurgery, University of Texas Health Science Center at Houston, Children's Memorial Hermann Hospital, and Mischer Neuroscience Institute, 6431 Fannin Street, MSB 5.144, Houston, TX, 77030, - - 2014
Hydrocephalus is common in patients with open neural tube defects (NTDs), but association with closed NTDs has rarely been reported. We describe three patients with untreated closed NTDs who required surgery for hydrocephalus. Case 1: A full-term newborn presented with a skin-covered midline lumbar spine lipoma. Magnetic resonance imaging (MRI) ...
Iino Morio M Department of Legal Medicine (Forensic Medicine), Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Electronic address: - - 2014
A 9months-old infant has died of scald burn by the hot water from the fallen electric pot at home. Postmortem computed tomography (CT) scanning prior to autopsy contributed to exclude the possibilities of old and new bone fractures or hidden massive hemorrhages. This procedure helped the pathologists to avoid dissecting ...
Winters Stephen J SJ Division of Endocrinology, Metabolism and Diabetes (SJW), University of Louisville School of Medicine, Louisville, Kentucky; Department of Radiation Oncology (CS), University of Louisville School of Medicine, Louisville, Kentucky; Brain Tumor Center (TV), Norton Neuroscience Institute; and Departments of Pathology (MRN), Radiology (DCC), Norton Health Care, Louisville, - - 2014
: A 60-year-old man with Addison's disease, primary hypothyroidism and type 2 diabetes mellitus who was treated with stable doses of hydrocortisone and fludrocortisone developed increasing skin pigmentation and a bitemporal hemianopia. The plasma ACTH level was 14,464 pg/mL, and an invasive pituitary macroadenoma with suprasellar extension was found on ...
Spaccarelli Natalie N Hospital of the University of Pennsylvania, 3400 Spruce Street 4283, Philadelphia, Pennsylvania, 19104, USA. - - 2014
Primary cutaneous lymphomas (PCLs) include both cutaneous T-cell and B-cell lymphomas and comprise the second most common type of extra-nodal non-Hodgkin's lymphomas. The treatment and prognosis of PCLs typically depend on the extent of disease. In evaluating extent of disease in oncological processes, computed tomography (CT) provides a purely anatomical ...
Karunanithi Sellam S From the Departments of *Nuclear Medicine, and †Pathology, All India Institute of Medical Sciences, New Delhi, - - 2014
Dermatofibrosarcoma protuberans (DFSP) is an uncommon cutaneous soft tissue sarcoma tumor that arises from the dermis of the skin. Sarcomas of the intestines are rare, and a DFSP arising from the small intestine is a very rare occurrence. Here we present F-FDG PET/CT imaging findings of a 60-year-old man with ...
Mallinson Paul Ian PI 1 Department of Radiology, Vancouver General Hospital and University of British Columbia, 899 W 12th Ave, Vancouver, BC V5Z 1M9, - - 2014
OBJECTIVE. The objective of our study was to discover the types and incidence of artifacts in dual-energy CT (DECT) using datasets of 50 consecutive patients who underwent a four-limb DECT protocol for the evaluation of suspected gout. Identification of artifacts and techniques for artifact reduction are discussed. CONCLUSION. Artifacts commonly ...
Islam M N MN Dr Mohammad Nazrul Islam, Assistant Professor & Head, Department of Neuro Radiology & Imaging, National Institute of Neuro Sciences & Hospital, Sher-E-Bangla Nagar, Dhaka - - 2014
Imaging cerebral infarction in first few hours after the onset of clinical symptoms is a challenge. The role of stroke imaging underwent a paradigm shift from confirmation of infarction from and exclusion of hemorrhage to the detection of the tissue at risk that may be rescued with restoration of circulation. ...
Matera Giovanni G Institute of Microbiology, Department of Health Sciences, "Magna Graecia" University, Catanzaro, - - 2014
Late/chronic Lyme neuroborreliosis (LNB) represents a challenging entity whose diagnosis requires a combination of clinical and laboratory findings, surrounded by much controversy. Here we describe a patient who had a peculiar form of late LNB with CNS lesions shown by magnetic resonance imaging (MRI), and epileptic seizures, etiologically diagnosed by ...
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