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da Costa Leodante L Division of Neurosurgery, Department of Surgery, Sunnybrook Hospital, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Room A1-37, Toronto, ON, Canada, - - 2015
Delayed cerebral ischemia (DCI) continues to be a major cause of morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage (aSAH) because it can only be diagnosed after the onset of clinical symptoms, contributing to poor clinical outcomes and huge use of clinical resources. We hypothesized that early disturbances in ...
Estey Chelsie M CM Neurology Service, College of Veterinary Medicine, Cornell University, Ithaca, NY - - 2014
Case Description-A 4-year-old 26-kg (57.2-lb) spayed female Staffordshire Bull Terrier mix was evaluated because of a 24-hour history of cluster seizures. Clinical Findings-Neurologic examination revealed altered mentation and multifocal intracranial signs; MRI was performed. The MRI findings included multifocal, asymmetric forebrain lesions affecting both the gray and white matter, an ...
Atangana Etienne N EN Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, - - 2014
Brain atrophy after subarachnoid hemorrhage (SAH) has been detected in humans and might serve as a functional read-out parameter for neuropsychological deficits. To determine whether serial magnetic resonance imaging (MRI) can provide information on brain atrophy in animals as well, mice that had undergone experimental SAH were scanned repeatedly after ...
Staack Anke Maren AM Kork Epilepsy Centre, Landstrasse 1, 77694, Kehl-Kork, Germany, - - 2014
Hypothalamic hamartomas (HHs) are rare developmental malformations consisting of mixed neurons and glial cells, usually unilaterally attached to the tuber cinereum or mammillary bodies. We report on two patients, both suffering from pharmacoresistant epilepsy, behavioural and cognitive disturbances. Ictal and interictal electroencephalographic (EEG) abnormalities appeared bilaterally and multiregionally with right-sided ...
Maier Florian C FC Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Tübingen, - - 2014
The dynamics of β-amyloid deposition and related second-order physiological effects, such as regional cerebral blood flow (rCBF), are key factors for a deeper understanding of Alzheimer's disease (AD). We present longitudinal in vivo data on the dynamics of β-amyloid deposition and the decline of rCBF in two different amyloid precursor ...
Shim Yong Soo YS Department of Neurology, The Catholic University of Korea College of Medicine, Seoul, South - - 2014
Background/Aims: We investigated the histopathological correlates of white matter hyperintensities (WMHs) in participants with Alzheimer's disease (AD) or cerebrovascular disease, and in aged controls. Methods: We reviewed 57 participants who had neuropathology and in whom neuroimaging was done. In addition to AD pathology, cortical microinfarcts, lacunes, and cerebral hemorrhages were ...
Penolazzi Barbara B a Department of General Psychology , University of Padua , - - 2014
In the present study we tested the cognitive effects of transcranial direct current stimulation (tDCS) in a case of probable Alzheimer disease (AD). The patient (male, 60 years, mild AD) underwent two cycles of treatments, separated by 2 months. In the first cycle, active stimulation (10 sessions, 2 mA for 20 min; anode over ...
Jang Jae-Won JW Department of Neurology, Kangwon National University Hospital, Chuncheon, Republic of - - 2014
Background: Brain magnetic resonance imaging (MRI) shows cerebral structural changes. However, a unified comprehensive visual rating scale (CVRS) has seldom been studied. Thus, we combined brain atrophy and small vessel disease scales and used an MRI template as a CVRS. Objective: The aims of this study were to design a ...
Kim J-H JH Department of Neurology, Keyo Medical Foundation, Keyo Geriatric Hospital, Uiwang, - - 2014
Cerebral microbleeds (CMBs) have been extensively studied in healthy controls and patients with cerebrovascular disease and Alzheimer's disease. Our aim was to characterize the clinical and radiological features of CMBs in idiopathic Parkinson's disease (IPD). This cross-sectional study included consecutive parkinsonian patients who attended the authors' movement disorders clinic from ...
Coras Roland R Clinical Epileptology and Experimental Neurophysiology Unit, IRCCS Foundation Neurological Institute "C. Besta,", Milan, Italy; Department of Neuropathology, University Hospital Erlangen, - - 2014
Hippocampal sclerosis (HS) is the major structural brain lesion in patients with temporal lobe epilepsy (TLE). However, its internal anatomic structure remains difficult to recognize at 1.5 or 3 Tesla (T) magnetic resonance imaging (MRI), which allows neither identification of specific pathology patterns nor their proposed value to predict postsurgical ...
Caverzasi Eduardo E 1 Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA 2 Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143, USA - - 2014
Sporadic Creutzfeldt-Jakob disease is considered primarily a disease of grey matter, although the extent of white matter involvement has not been well described. We used diffusion tensor imaging to study the white matter in sporadic Creutzfeldt-Jakob disease compared to healthy control subjects and to correlated magnetic resonance imaging findings with ...
Reijmer Yael D YD 1 Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, - - 2014
Cerebral amyloid angiopathy is a common form of small-vessel disease and an important risk factor for cognitive impairment. The mechanisms linking small-vessel disease to cognitive impairment are not well understood. We hypothesized that in patients with cerebral amyloid angiopathy, multiple small spatially distributed lesions affect cognition through disruption of brain ...
Bogaert Jan J From the Department of Radiology, Gasthuisberg University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium (J.B.); and Referral Center for Myocardial Diseases, Azienda Universitaria Careggi, Florence, Italy - - 2014
Hypertrophic cardiomyopathy ( HCM hypertrophic cardiomyopathy ), the most common genetically transmitted cardiac disorder, has been the focus of extensive research over the past 50 years. HCM hypertrophic cardiomyopathy is a multifaceted disease with highly heterogeneous genetic background, phenotypic expression, clinical presentation, and long-term outcome. Though most patients have an ...
Rosskopf Johannes J Department of Neurology, University of Ulm, Ulm, - - 2014
Background: Frontal lobe involvement is considered a clinical and magnetic resonance imaging (MRI) feature in later stages of progressive supranuclear palsy (PSP). Objective: Diffusion tensor imaging (DTI) was used to investigate the integrity of frontal pathways in PSP and Parkinson's disease (PD) patients. Methods: DTI and 3-D MRI were performed ...
Friedland Bernard - - 2014
Dentists contemplating sinus augmentation frequently take a cone beam computed tomography (CBCT) scan as part of the work-up. Maxillary sinus pathology is common, and such dentists will be faced with pathologic sinus findings. Not all sinus pathology needs to be treated. The purpose of this article is twofold: to describe ...
Su Li L Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Level E4, Cambridge Biomedical Campus, Cambridge, Box 189, CB2 0SP, UK, - - 2014
We aimed to characterize dementia with Lewy bodies (DLB) by the quantitative MRI parameters of longitudinal relaxation time (qT1) and transverse relaxation time (qT2). These parameters reflect potential pathological changes in tissue microstructures, which may be detectable noninvasively in brain areas without evident atrophy, so may have potential value in ...
Choi Mihyun M Haemaru Referral Animal - - 2014
A 3-year-old, intact female Pomeranian presented with a 1-month history of coughing. Thoracic radiography showed focal infiltration of the left cranial lung lobe and widening of the cranial mediastinum. Subsequent computed tomography revealed torsion of the caudal segment of the left cranial lung lobe, which was confirmed by exploratory thoracotomy. ...
Hoza David D Department of Neurosurgery, Hospital Dessau, Auenweg 38, 06847, Dessau-Roßlau, Germany, - - 2014
Normal pressure hydrocephalus (NPH) is a clinical syndrome characterized by gait disturbances, urinary incontinence and dementia. Clinical presentation overlaps with Alzheimer disease (AD). Early recognition thus early intervention (shunting) is important for successful treatment, but lack of a diagnostic test with sufficient sensitivity and specificity complicates the diagnosis. We performed ...
Ayuso C C 1] Department of Genetics, Health Research Institute-Fundación Jiménez Díaz University Hospital (IIS-FJD, UAM), Madrid, Spain [2] Center for Biomedical Network Research on Rare Diseases CIBERER ISCIII, Madrid, - - 2014
Whole-genome/exome sequencing used in clinical trials (CTs) to identify 'druggable' mutations and targets uncovers incidental findings unrelated to the trial objectives but of value for participants, although ethically challenging. To be disclosed to trial participants, the analytical validity, clinical validity, clinical utility, clinical relevance and actionability of incidental genomic findings ...
Feng Rui R Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, PR - - 2014
Introduction: Using retrospective and comparative methods, we aim to discuss the surgical treatment of magnetic resonance imaging (MRI)-negative temporal lobe epilepsy (TLE) presented with positive positron emission tomography (PET) results. Methods: From the viewpoint of semiology, demography, surgical treatment and prognosis evaluation, we compared 19 MRI-negative, PET-positive TLE patients to ...
Kantarci Kejal K Department of Radiology, Mayo Clinic, Rochester, - - 2014
Pathophysiologic mechanisms leading to loss of white matter integrity and the temporal positioning of biomarkers of white matter integrity relative to the biomarkers of gray matter neurodegeneration and amyloid load in the course of Alzheimer disease (AD) are poorly understood. To investigate the effects of AD-related gray matter neurodegeneration and ...
Timmers Inge I Department of Cognitive Neuroscience, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands, - - 2014
White matter abnormalities have been observed in patients with classic galactosemia, an inborn error of galactose metabolism. However, magnetic resonance imaging (MRI) data collected in the past were generally qualitative in nature. Our objective was to investigate white matter microstructure pathology and examine correlations with outcome and behaviour in this ...
Noh Young Y From the Department of Neurology (Y.N., K.H.P.), Gachon University Gil Medical Center, Incheon; Department of Biomedical Engineering (S.J., J.M.L.), Hanyang University, Seoul; Department of Neurology (S.W.S., H.J.K., J.C., D.L.N.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; Department of Neurology (G.H.K.), Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul; Department of Neurology (H.C.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul; Department of Neurology (B.S.Y.), Yonsei University College of Medicine, Seoul; Department of Neurology (C.W.Y.), Inha University Hospital, Inha University School of Medicine, Incheon, Korea; and Department of Neurology (K.M.H.), University of Florida and Veterans Affairs Medical Center, - - 2014
Because the signs associated with dementia due to Alzheimer disease (AD) can be heterogeneous, the goal of this study was to use 3-dimensional MRI to examine the various patterns of cortical atrophy that can be associated with dementia of AD type, and to investigate whether AD dementia can be categorized ...
Falahati Farshad F Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, - - 2014
Background/Aims: The use of structural brain imaging [computed tomography (CT)/magnetic resonance imaging (MRI)] and the analysis of cerebrospinal fluid biomarkers are included in the guidelines for the diagnosis of dementia. The influence of variables such as age, gender and disease severity on the use of MRI, CT and lumbar puncture ...
Penner Jacob J Centre for Functional and Metabolic Mapping (CFMM), Robarts Research Institute, and Department of Medical Biophysics, University of Western Ontario, London, Ont., - - 2014
Aim: To determine whether 4 months of rivastigmine treatment would result in metabolic changes and whether metabolic changes correlate with changes in cognition in people with Alzheimer's disease (AD). Methods: Magnetic resonance spectra were acquired from the posterior cingulate cortex of subjects with AD at 3 T. Magnetic resonance imaging ...
Meijer F J A FJ http://orcid.org/0000-0001-5921-639X From the Departments of Radiology and Nuclear Medicine (F.J.A.M., B.A.C.M.F., B.G.) and Laboratory Medicine (M.M.V.), and Department of Neurology (A.v.R., I.T., M.A., R.E., B.R.B., M.M.V.), Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands; and Department of Diagnostic Imaging (B.G.), Medical Center of Postgraduate Education, Warsaw, Poland. - - 2014
The differentiation between Parkinson disease and atypical parkinsonian syndromes can be challenging in clinical practice, especially in early disease stages. Brain MR imaging can help to increase certainty about the diagnosis. Our goal was to evaluate the added value of SWI in relation to conventional 3T brain MR imaging for ...
Saleem Sahar N SN Professor in Radiology Department, Kasr Al Ainy Faculty of Medicine, Cairo, - - 2014
Objective: We aimed to study the computed tomography (CT) scans of the royal Ancient Egyptian mummies dated to the eighteenth to early twentieth Dynasties for the claimed diagnoses of Ankylosing spondylitis and diffuse idiopathic skeletal hyperostosis (DISH) and to correlate the findings with the archaeology literature. Methods: We studied the ...
Jentzen Walter W Klinik für Nuklearmedizin, Universität Duisburg-Essen, Essen, Germany; and - - 2014
(124)I PET/CT images from differentiated thyroid cancer patients were retrospectively analyzed to assess the relationship between absorbed radiation dose (AD) to lesions and their response after radioiodine therapy. Patients received serial (124)I PET/CT scans before and after their first radioiodine treatment. The pretherapy PET data were used to segment the ...
Erdélyi-Bótor Szilvia S Department of Neurology, University of Pécs, Pécs, - - 2014
The aim of this longitudinal study was to investigate changes of migraine-related brain white matter hyperintensities 3 years after an initial study. Baseline quantitative magnetic resonance imaging (MRI) studies of migraine patients with hemispheric white matter hyperintensities performed in 2009 demonstrated signs of tissue damage within the hyperintensities. The hyperintensities ...
Bates Jane J - - 2014
Let me set the scene. Mrs Arachnophobe is home alone while her family disappear on various jaunts.
Kim Yeon-Jung YJ Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Republic of - - 2014
Status migrainosus (SM) and persistent aura (PA) without infarction are complications of migraine. Although several patients have been reported to have reversible brain lesions associated with complications of migraine, their nature and pathophysiology remain unclear. We report on a 38-year-old male who presented with nine episodes of SM and PA ...
Del Brutto Oscar H OH School of Medicine, Universidad Espíritu Santo, Guayaquil, - - 2014
Background: Calcified cysticerci share the morphology and signal properties with true cerebral microbleeds, but this condition is neglected at the time of evaluating MRIs for clinical or research purposes. We report our experience with the MRI reading obtained from the Atahualpa Project, a population-based stroke study, conducted in a village ...
Lehéricy Stéphane S Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, Paris, France; ICM Team Control of Normal and Abnormal Movement; Service de neuroradiologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, - - 2014
A hallmark of Parkinson's disease (PD) is the progressive neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). Dopaminergic denervation is commonly imaged using radiotracer imaging in target structures such as the striatum. Until recently, imaging made only a modest contribution to detecting neurodegenerative changes in the substantia ...
Sharma Vishal V Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, - - 2014
Guidelines recommend that contrast-enhanced computed tomography (CT) should be carried out 72 hours after onset of an attack of acute pancreatitis (AP). However, the exact time beyond 72 hours at which CT will produce the best diagnostic yield for local complications, or whether doing a CT early in acute pancreatitis ...
Moradi Elaheh E Department of Signal Processing, Tampere University of Technology, P.O. Box 553, 33101, Tampere, - - 2014
Mild Cognitive Impairment (MCI) is a transitional stage between age-related cognitive decline and Alzheimer's disease (AD). For the effective treatment of AD, it would be important to identify MCI patients at high risk for conversion to AD. In this study, we present a novel Magnetic Resonance Imaging (MRI)-based method for ...
Gonzalez-Martinez Jorge J Epilepsy Center, Neurological Institute, Cleveland Clinic, 9500 Euclid Ave, S60., Cleveland, OH, USA, - - 2014
In order to presurgically define the anatomical location of the epileptogenic zone (EZ) and its proximity to possible cortical and subcortical eloquent areas in pediatric patients with medically intractable focal epilepsy, an array of noninvasive tools are available: recorded seizure semiology, scalp electroencephalographic (EEG) recordings (ictal and interictal epileptic patterns), ...
Grimm Jochen M - - 2014
The purpose of this prospective study was to perform a head-to-head comparison of the two methods most frequently used for evaluation of carotid plaque characteristics: Multi-detector Computed Tomography Angiography (MDCTA) and black-blood 3 T-cardiovascular magnetic resonance (bb-CMR) with respect to their ability to identify symptomatic carotid plaques. 22 stroke unit patients ...
Schrag Matthew M Department of Neurology, Yale University and Yale-New Haven Hospital, New Haven, Connecticut. Electronic address: - - 2014
Susceptibility-weighted and gradient-recalled echo T2* magnetic resonance imaging have enabled the detection of very small foci of blood within the brain, which have been termed "cerebral microbleeds." These petechial intraparenchymal hemorrhages have begun to emerge as diagnostically and prognostically useful markers in a variety of disease states. Severe hypertension and ...
Shi Jie J School of Computing, Informatics, and Decision Systems Engineering, Arizona State University Tempe, AZ, - - 2014
Mild Cognitive Impairment (MCI) is a transitional stage between normal aging and dementia and people with MCI are at high risk of progression to dementia. MCI is attracting increasing attention, as it offers an opportunity to target the disease process during an early symptomatic stage. Structural magnetic resonance imaging (MRI) ...
Diehl-Schmid Janine J Department of Psychiatry and Psychotherapy, Technische Universität München, München, - - 2014
The term frontotemporal lobar degeneration (FTLD) refers to a group of neurodegenerative disorders that target the frontal and temporal lobes. It accounts for approximately 10 % of pathologically confirmed dementias but has been demonstrated to be as prevalent as Alzheimer's disease in patients below the age of 65. The 3 major ...
Chen Bo B Department of Neurology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. - - 2014
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, a recently defined and frequently misdiagnosed disease characterized by psychiatric symptoms, seizures, movement disorders and autonomic dysfunction, has been observed predominantly in young females with ovarian teratoma. Conventional imaging techniques, including computed tomography (CT) and magnetic resonance imaging (MRI), are often ineffective for diagnosis of the ...
D'souza Maria Mathew MM Division of PET Imaging, INMAS, New Delhi, - - 2014
Hemichorea and generalized chorea are rare syndromes associated with nonketotic hyperglycemia. This disorder usually afflicts elderly females, and may herald the onset of new onset diabetes, usually type 2. There are conflicting reports of the underlying pathophysiology of this rare entity. Magnetic resonance imaging findings have been described in the ...
Kehoe Elizabeth G EG The Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, - - 2014
With the prevalence of Alzheimer's disease (AD) predicted to increase substantially over the coming decades, the development of effective biomarkers for the early detection of the disease is paramount. In this short review, the main neuroimaging techniques which have shown potential as biomarkers for AD are introduced, with a focus ...
Agarwal Krishan Kant KK From the Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, - - 2014
Amyloidosis is a rare disorder characterized by variable extracellular accumulation of a complex substance consisting of proteinaceous fibrils (amyloid fibrils) and nonfibrillar glycoprotein or amyloid P component. We present a case of a primary systemic amyloidosis associated with multiple myeloma in a 48-year-old woman whose Tc-MDP SPECT/CT study revealed extraosseous ...
Cachia David D Department of Neuro-Oncology, MD Anderson Cancer Center, Houston, - - 2014
A 62-year-old man presented with rapidly progressive cognitive decline associated with ataxia, spasticity, and eventually seizures. Multiple bihemispheric foci of calcification in the brain were seen on computed tomography scan, with magnetic resonance imaging (MRI) showing relatively symmetrical areas of enhancement in the brain corresponding mostly to the areas of ...
Chandra P S PS Department of Neurosurgery, CN Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, - - 2014
F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and ictally subtracted single photon emission tomography (iSPECT) are important for localizing the epileptogenic focus. The following study analyzes the role of inter-concordance between FDG-PET and iSPECT in predicting long-term outcomes after epilepsy surgery. We prospectively evaluated (January 2003-January 2008) patients undergoing surgery for ...
Goto Masami M Department of Radiological Technology, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan, - - 2014
Our aim was to show whether sensitivity for detecting volume changes in regional gray matter in default mode network (DMN) at converted [from mild cognitive impairment to Alzheimer's disease (from MCI to AD)] phase was improved by use of a standardized volume with global gray-matter volume. T1-weighted MR images (T1WI) ...
Delli Pizzi Stefano S Department of Neuroscience, Imaging and Clinical Sciences Aging Research Centre, Ce.S.I. and Institute for Advanced Biomedical Technologies (ITAB), "G. d'Annunzio" University, Chieti, - - 2014
Dementia with Lewy bodies (DLB) is characterized by fluctuation in cognition and attention. Thalamocortical connectivity and integrity of thalami are central to attentional function. We hypothesize that DLB patients with marked and frequent fluctuating cognition (flCog) have a loss of thalamocortical connectivity, an intrinsic disruption to thalamic structure and imbalances ...
Okamoto Nobuhiko N Department of Medical Genetics, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, - - 2014
Neurodegeneration with brain iron accumulation (NBIA) comprises a clinically and genetically heterogeneous group of progressive brain disorders with several distinguishable subtypes. Recently, WDR45 mutations were reported in patients with β-propeller protein-associated neurodegeneration (BPAN), characterized by early intellectual disability followed by delayed progressive motor and cognitive deterioration with onset in the ...
Naylor A R AR The Department of Vascular Surgery at Leicester Royal Infirmary, Leicester, UK. Electronic address: - - 2014
The 2011 American Heart Association Guidelines on the management of asymptomatic carotid disease recommends that carotid endarterectomy (CEA) (with carotid artery stenting (CAS) as an alternative) may be considered in highly selected patients with 70-99% stenoses. However, no guidance was provided as to what "highly selected" meant. This caveat is, ...
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