Search Results
Results 1 - 50 of 872
1 2 3 4 5 6 7 8 9 10 >
Prabhakaran S S From the Departments of Neurology (S.P., R.A.B.) and Radiology (M.S., A.R.H., A.S., M.C.H., S.A.A.), Northwestern University, Chicago, Illinois; and Department of Neurology (V.H.L., J.J.C.), Rush University Medical Center, Chicago, Illinois; and Department of Economics and Decision Sciences (F.D.-V.), Western Illinois University, Macomb, - - 2014
Controversy exists about the role of perfusion imaging in patient selection for endovascular reperfusion therapy in acute ischemic stroke. We hypothesized that perfusion imaging versus noncontrast CT- based selection would be associated with improved functional outcomes at 3 months. We reviewed consecutive patients with anterior circulation strokes treated with endovascular ...
Thomeer Maarten G MG Department of Radiology, Erasmus Medical Center, Rotterdam, The - - 2014
Hepatocellular adenoma (HCA) is a generally benign liver tumor with the potential for malignancy and bleeding. HCAs are categorized into four subtypes on the basis of genetic and pathological features: hepatocyte nuclear factor 1α-mutated HCA, β-catenin-mutated HCA, inflammatory HCA, and unclassified HCA. Magnetic resonance imaging (MRI) plays an important role ...
Eslami Sohrab S Laboratory for Computational Sensing and Robotics (LCSR) at the Johns Hopkins University, Baltimore, MD, - - 2013
This paper undertakes the modular design and development of a minimally invasive surgical manipulator for MRI-guided transperineal prostate interventions. Severe constraints for the MRI-compatibility to hold the minimum artifact on the image quality and dimensions restraint of the bore scanner shadow the design procedure. Regarding the constructive design, the manipulator ...
Van Vugt Raoul R Department of Surgery and Trauma, Radboud University Nijmegen Medical Center, PO Box 9101, Nijmegen, Netherlands, 6500 - - 2013
Trauma is the fifth leading cause of death worldwide, and in people younger than 40 years of age, it is the leading cause of death. During the resuscitation of trauma patients at the emergency department, there are two different commonly used diagnostic strategies. Conventionally, there is the use of physical ...
Wiegerinck E M A - - 2013
The choice of preferred access route for transcatheter aortic valve implantation (TAVI) is mainly guided by the minimal aorto-femoral tract diameter. Currently, projection angiography (XA) and CT-angiography (CTA) are used interchangeably to assess this diameter in the TAVI work-up. We aimed to assess the agreement of XA and CTA diameter ...
Truong Hong H National Institutes of Health, Bethesda, Maryland, - - 2013
Prior studies of volumetric effects of 5α-reductase inhibitors (5ARIs) on the prostate have used transrectal ultrasound which provides poor differentiation of prostatic zones. We utilized high-resolution prostate MRI to evaluate the true dynamic effects of 5ARI in men who underwent multiple MRIs. A retrospective study of patients who underwent serial ...
Learned K O - - 2013
BACKGROUND AND PURPOSE:Absorbable gelatin-thrombin matrix is increasingly being used in neurosurgical procedures; unlike other hemostats, the stable matrix is left undisturbed and fills the surgical bed after achieving hemostasis. We investigated the immediate postoperative radiographic imaging appearance of the gelatin-thrombin matrix in intracranial operative beds.MATERIALS AND METHODS:Thirty-one consecutive patients (18 ...
Lartizien Carole - - 2013
We have designed a computer aided diagnosis system to discriminate between hypermetabolic cancer lesions and hypermetabolic inflammatory or physiological but noncancerous processes in FDG PET/CT exams of lymphoma patients. Detection performance of the support vector machine (SVM) classifier was assessed based on feature sets including 105 PET and CT characteristics ...
Beloueche-Babari M - - 2013
Background:Non-invasive imaging biomarkers underpin the development of molecularly targeted anti-cancer drugs. This study evaluates tumour apparent diffusion coefficient (ADC), measured by diffusion-weighted magnetic resonance imaging (DW-MRI), as a biomarker of response to the MEK1/2 inhibitor selumetinib (AZD6244, ARRY-142886) in human tumour xenografts.Methods:Nude mice bearing human BRAF(V600D) WM266.4 melanoma or BRAF(V600E) ...
Yamano Shigeru - - 2013
Patients with a history of ischemic stroke are known to develop new ischemic stroke. While asymptomatic, the presence and progression of silent brain infarcts and white matter lesions on magnetic resonance imaging are associated with an increased risk of future strokes. Both angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers ...
Niemann Tilo - - 2013
To evaluate the clinical impact of automatic tube voltage selection on chest CT angiography (CTA). Ninety-three patients were prospectively evaluated with a CT protocol aimed at comparing two successive CTAs acquired under similar technical conditions except for the kV selection: (1) the initial CTA was systematically obtained at 120 kVp and ...
Sampath Deepak - - 2013
The phosphatidylinositol 3-kinase (PI3K) pathway is a central mediator of vascular endothelial growth factor (VEGF)-driven angiogenesis. The discovery of small molecule inhibitors that selectively target PI3K or PI3K and mammalian target of rapamycin (mTOR) provides an opportunity to pharmacologically determine the contribution of these key signaling nodes in VEGF-A-driven tumor ...
Betz Martina - - 2013
Solely size-based response criteria may be unreliable in patients with gastrointestinal stromal tumors (GIST) treated with tyrosine kinase inhibitors, because they typically underestimate responses to treatment. As GISTs are generally hypervascularized and novel targeted drugs knowingly affect angiogenic signaling pathways, perfusion measurements are expected to deliver important information about their ...
Kaste Sue C - - 2013
PURPOSE: To evaluate the growing skeleton for potential altered skeletalgenesis associated with antiangiogenesis therapy. PATIENTS AND METHODS: Knee radiographs and magnetic resonance imaging (MRI) were prospectively obtained on patients enrolled on two consecutive clinical trials using vandetanib, a potent oral (VEGF receptor 2) VEGFR-2 inhibitor alone or combined with dasatinib, ...
Di Minno M N D - - 2013
Magnetic resonance imaging (MRI) and ultrasonography (US) are increasingly used in haemophilia A (HA) to detect early joint changes. A total of 40 clinically asymptomatic joints, never involved by bleeding events ["healthy joints" (HJ)], were evaluated by MRI and, in parallel, by US in 20 young subjects with severe HA ...
Schaden Eva - - 2013
PURPOSE: Adequate monitoring of the effect of the direct thrombin inhibitor argatroban may facilitate individualized dosing and perioperative management of anticoagulation. Ecarin Clotting Time is proposed for this purpose, but has the major disadvantage of limited availability. There is a point-of-care applicable ecarin-activated test modification for rotational thrombelastometry (ROTEM®) which ...
Haslem Bryce D - - 2013
Eosinophilic esophagitis was first reported in 1978, and since then it has been increasingly recognized as one of the major etiologies for dysphagia, food impaction, and food regurgitation. To the best of our knowledge, no case of eosinophilic esophagitis (excluding esophageal eosinophilia not responsive to proton pump inhibitor treatment) has ...
Delorenzo Christine - - 2013
Pre-treatment differences in serotonergic binding between those who remit to antidepressant treatment and those who do not have been found using Positron Emission Tomography (PET). To investigate these differences, an exploratory study was performed using a second imaging modality, diffusion-weighted MRI (DW-MRI). Eighteen antidepressant-free subjects with Major Depressive Disorder received ...
Duncan K K Department of Pathology, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA, - - 2013
(18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) and computed tomography (CT) are useful imaging modalities for evaluating tumor progression and treatment responses in genetically engineered mouse models of solid human cancers, but the potential of integrated FDG-PET/CT for assessing tumor development and new interventions in transgenic mouse models of human blood cancers ...
Cho Steve Y - - 2012
Prostate-specific membrane antigen (PSMA) is a type II integral membrane protein expressed on the surface of prostate cancer (PCa) cells, particularly in androgen-independent, advanced, and metastatic disease. Previously, we demonstrated that N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-4-(18)F-fluorobenzyl-L-cysteine ((18)F-DCFBC) could image an experimental model of PSMA-positive PCa using PET. Here, we describe the initial clinical experience ...
Adjobo-Hermans Merel J W - - 2012
Phospholipase C (PLC) β isoforms are implicated in various physiological processes and pathologies. However, mechanistic insight into the localization and activation of each of the isoforms is limited. Therefore, it is crucial to gain more in-depth knowledge as to the regulation of the different isoforms. Here we describe the subcellular ...
Yeh Hsin-Hsien HH Department of Experimental Diagnostic Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, - - 2013
Epigenetic modifications mediated by histone deacetylases (HDACs) play important roles in the mechanisms of different neurologic diseases and HDAC inhibitors (HDACIs) have shown promise in therapy. However, pharmacodynamic profiles of many HDACIs in the brain remain largely unknown due to the lack of validated methods for noninvasive imaging of HDAC ...
Desar Ingrid M E - - 2012
Selumetinib (AZD6244, ARRY-142886) is a potent, selective, uncompetitive inhibitor of MEK 1 / 2, part of the RAF/MEK/ERK protein kinase signal cascade, which is responsible for tumor. This pilot study was used to explore if (18)F-fluoro-l-thymidine (FLT), a thymidine analogue positron emission tomography (PET) tracer and a surrogate marker for ...
Schwarz Sebastian - - 2012
Iron oxide-based magnetic nanoparticles (MNPs) offer unique properties for cell tracking by magnetic resonance imaging (MRI) in cellular immunotherapy. In this study, we investigated the uptake of chemically engineered NPs into antigen-presenting dendritic cells (DCs). DCs are expected to perceive MNPs as foreign antigens, thus exhibiting the capability to immunologically ...
Nanni M - - 2011
Objectives: To report the antenatal pictures of a fetus with multiple intracranial lipomas. Methods: A 36-year-old primigravida, 33 weeks of gestation, was referred to our ultrasound laboratory due to sonographic suspicion of an intracranial hemorrhage. Results: At 2D and 3D ultrasound imaging, three separated round-shaped hyperechoic intracranial masses compatible with ...
de Chickera Sonali N - - 2011
An optimized non-invasive imaging modality capable of tracking and quantifying in vivo DC migration in patients would provide clinicians with valuable information regarding therapeutic DC-based vaccine outcomes. Superparamagnetic iron oxide (SPIO) nanoparticles were used to label bone marrow-derived DC. In vivo DC migration was tracked and quantified non-invasively using cellular ...
Watson Katherine D KD Department of Biomedical Engineering, University of California, Davis, CA 95327, - - 2011
We report a comparison between tumor perfusion estimates acquired using contrast-enhanced MRI and motion-corrected contrast-enhanced ultrasound before and after treatment with AG-028262, a potent vascular endothelial growth factor receptor tyrosine kinase inhibitor. Antiangiogenic activity was determined by assessing weekly ultrasound and MRI images of rats with bilateral hind flank mammary ...
Voss Manja - - 2011
Four incompletely preserved caudal vertebrae lacking the neural arches of two fossil sirenian individuals of Halitherium schinzii (Oligocene) from the Rhine area in Germany and northern Belgium reveal osteological alterations. The caudal vertebrae possess a transverse process with growth retardation. This asymmetry indicates that the affected transverse processes are less ...
Yu X W - - 2011
We present the first space- and time-resolved images of the spin-torque-induced steady-state oscillation of a magnetic vortex in a spin-valve nanostructure. We find that the vortex structure in a nanopillar is considerably more complicated than the 2D idealized structure often-assumed, which has important implications for the driving efficiency. The sense ...
Kim Yong Min - - 2011
OBJECTIVES/HYPOTHESIS: To evaluate the correlation between growth differences of the face and nasal septal deviation, and to evaluate whether developmental differences of the face have an effect on nontraumatic nasal septal deviation (DNS). STUDY DESIGN: Retrospective study. METHODS: Twenty-five patients with DNS who underwent facial aesthetic surgery and had an ...
Lansberg Maarten G - - 2011
The aim of this study was to determine if automated MRI analysis software (RAPID) can be used to identify patients with stroke in whom reperfusion is associated with an increased chance of good outcome. Baseline diffusion- and perfusion-weighted MRI scans from the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke ...
Larson David B - - 2011
To describe nationwide trends and factors associated with the use of computed tomography (CT) in children visiting emergency departments (EDs) in the United States between 1995 and 2008. This study was exempt from institutional review board oversight. Data from the 1995-2008 National Hospital Ambulatory Medical Care Survey were used to ...
Dlouhy Brian J - - 2011
Osteopetrosis is a heterogeneous group of rare, inherited disorders of the skeleton that results in neurological manifestations due to restriction of growth of cranial foramina and calvarial thickening. A 25-year-old woman with a history of autosomal dominant osteopetrosis presented to the authors' institution with headache worsened by exertion and radiating ...
Brady Zoe - - 2011
Introduction: The use of CT has rapidly increased since its introduction. Although an important medical tool for diagnosis and treatment, CT is recognised as being among the highest contributors to population radiation exposure. As the risks associated with exposure are higher for children than for adults, this study assessed the ...
Mattos Sandra S - - 2011
Objective To test whether customised (ct) growth criteria are more reliable than standard (st) ones to predict intrauterine insult. Patients 32 mothers and their singleton term neonates selected as small for gestational age (st-SGA=8) or appropriate for gestational age (st-AGA=24). Main outcome measures Nitric oxide, high-sensitive C reactive protein (hs-CRP), ...
Falsini Benedetto - - 2011
BACKGROUND: To date, no specific therapy is available for optic glioma (OG)-induced visual loss. OBJECTIVE: To evaluate the effects on visual function of murine nerve growth factor (NGF) eye drop administration in children with severe visual impairment due to low-grade OGs. METHODS: Five patients with OGs and advanced optic nerve ...
Bouquet Wim - - 2011
PURPOSE: To evaluate the tumour growth delay of a peritoneal carcinomatosis (PC) of colorectal origin after intraperitoneal chemotherapy with paclitaxel/randomly-methylated-β-cyclodextrin (Pac/RAME-β-CD) versus Taxol® at normo- and hyperthermic conditions in rats. METHODS: Hyperthermic intraperitoneal chemotherapy (HIPEC) was performed 7 days post implantation of the tumour with both formulations at a Pac concentration ...
Sakamoto Ayami - - 2011
The patient is a 20-year-old man with glycogen storage disease type I (GSD-type I). In his teens, multiple focal hepatic masses were detected on abdominal ultrasonography (US), which were diagnosed as multiple hepatocellular adenomas from the imaging. During follow-up, these masses had shown intermittent growth in size. In the evaluation ...
Yang Ce - - 2011
Recent progress in research on Fe(3)O(4) nanocrystals has attracted much attention both for investigating fundamental nanomagnetism and their potential applications in nanocatalysis, biosensing, magnetic resonance imaging (MRI) contrast agents and drug delivery. In this feature article, we provide an overview of synthetic strategies and growth mechanisms of various Fe(3)O(4) nanostructures, ...
Kim Suk Jae - - 2011
Background: We previously reported that intracranial large-artery atherosclerotic stroke (ICAS) had a relatively large salvageable area of less severe hypoperfusion. However, information regarding the outcome after ICAS is lacking. We hypothesized ICAS would show more favorable clinical and radiological outcomes than other stroke mechanisms. Methods: Consecutive patients underwent admission (n ...
Rajagopalan Vidya - - 2011
Existing knowledge of growth patterns in the living fetal human brain is based upon in utero imaging studies by magnetic resonance imaging (MRI) and ultrasound, which describe overall growth and provide mainly qualitative findings. However, formation of the complex folded cortical structure of the adult brain requires, in part, differential ...
van de Langenberg Rick - - 2011
The purpose of this study was to identify factors predicting growth and audiologic deterioration during follow-up (FU) in a wait and scan (W&S) policy of vestibular schwannomas (VSs) using a novel volumetric measuring tool. So far, only consecutive magnetic resonance imaging (MRI) is able to show growth objectively, and growth, ...
Singh Satinder - - 2011
To measure reader agreement in determining whether lung nodules detected at baseline screening computed tomography (CT) had changed at subsequent screening examinations and to evaluate the variability in recommendations for further follow-up. All subjects were enrolled in the National Lung Screening Trial (NLST), and each participant consented to the use ...
Kim Jun Sup - - 2011
Embryonic development is a remarkably complex and rapidly evolving morphogenetic process. Although many of the early patterning events have been well described, understanding the anatomical changes at later stages where clinically relevant malformations are more likely to be survivable has been limited by the lack of quantitative 3D imaging tools. ...
Jeh Su Kyung - - 2011
To evaluate the correlation of the mean and minimal apparent diffusion coefficient values (ADC(mean) , ADC(minimal) ) and dynamic magnetic resonance imaging (MRI) findings with prognostic factors in invasive ductal carcinoma. A total of 107 women with invasive ductal cancer underwent breast MRI. The ADC(mean) and ADC(minimal) of the cancers ...
Tejszerska Dagmara - - 2011
Craniosynostosis represents premature suture fusion of the fetal and neonatal skull. Pathogenesis of craniosynostosis is complex and probably multifactorial. Growth of skull bones is strictly connected with the expanding growth of the brain and cranial malformations or prematurely fused sutures cause abnormal head shape. In order to diagnose the craniosynostosis, ...
Kowalski Marcin - - 2011
Persistent left sided superior vena cava is a congenital abnormality encountered not uncommonly by the echocardiographer or cardiac radiologist. Recognition of its presence is important in the differential diagnosis of dilatation of the coronary sinus. We discuss the echocardiographic and computed tomography findings of this congenital abnormality, and the implications ...
Funayama Emi - - 2011
Although Klippel-Trénaunay syndrome is a mixed vascular malformation characterized by abnormal growth in the extremities, no uniform diagnostic criteria have been established because of the variety in its manifestation. Consequently, no anatomical analysis based on a comparison study has been reported. In this study, the authors determine the frequency of ...
Arora J - - 2011
The temporal Styloid Process is an important anatomical landmark for surgeons while performing skull based surgery, for anaesthetists while injecting local anaesthetic solution and for radiologists during interpretation of CT and MRI scans. Knowledge of morphological variations of the styloid process such as a unique groove on its posterior aspect ...
Chorilli Marlus - - 2011
The objective of this work was to evaluate the preservative effectiveness of liquid crystalline systems containing retynil palmitate (RP) by the challenge test (CT) and D-value. A system was developed containing water, silicon glycol copolymer, and polyether functional siloxane with 1% RP added. The analyses were carried out by methods ...
1 2 3 4 5 6 7 8 9 10 >