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Sana Barindra B School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Dr., Block N1.3, Singapore, 637457, - - 2015
The application of magnetic resonance imaging (MRI) is often limited by low magnetic relaxivity of currently used contrast agents. This problem can be addressed by developing more sensitive contrast agents by synthesizing new types of metal complex or metallic nanoparticles. Protein cage has been used as a template in biological ...
Filli Lukas L Department of Diagnostic and Interventional Radiology, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland, - - 2014
To evaluate metal artifacts induced by biodegradable magnesium-a new class of degradable biomaterial that is beginning to enter the orthopedic routine-on CT and MRI compared to standard titanium and steel controls. Different pins made of titanium, stainless steel, and biodegradable magnesium alloys were scanned using a second-generation dual-energy multidetector CT ...
Saminathan Mookiah M Institute of Bioscience, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, - - 2014
Molecular weights (MWs) and their chemical structures are the primary factors determining the influence of condensed tannins (CTs) on animal nutrition and methane (CH4 ) production in ruminants. In this study, the MWs of five CT fractions from Leucaena leucocephala hybrid-Rendang (LLR) were determined and the CT fractions were investigated ...
Melnyk Angela D AD Department of Mechanical Engineering, University of British Columbia, Vancouver, BC, Canada; Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada; International Collaboration on Repair Discoveries, Vancouver Coastal Health Research Institute, Vancouver, BC, - - 2014
Many pathologies involving disc degeneration are treated with surgery and spinal implants. It is important to understand how the spine behaves mechanically as a function of disc degeneration. Shear loading is especially relevant in the natural and surgically stabilized lumbar spine. The objective of our study was to determine the ...
Martinez Bermudez Claudia A CA Associate Professor of Clinical Medicine, Cardiology and Interventional Cardiology, University of Miami Miller School of - - 2014
The transcatheter treatment of paravalvular leaks (PVL) are technically challenging procedures; they pose increasing difficulty in cases where there is a stentless valve, without the usual fluoroscopic landmarks. Hence, there is limited experience in treating this defect percutaneously. We present a case of a patient with an aortic PVL of ...
Li Ruibin R Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, CA 90095, - - 2014
Functionalized carbon nanotubes (f-CNTs) have been widely used in bio-medicine as drug carriers, bio-sensors, imaging agents and tissue engineering additives, which demands better understanding of their in vivo behavior because of the increasing exposure potential to humans. However, there are limited studies to investigate the in vivo biodistribution and elimination ...
Matsui Kazuhiro K Departments of Medicine, Tokyo Women's Medical University Medical Center East, 2-1-10 Nishiogu, Arakawa-ku, Tokyo, 116-8567, - - 2014
Clinical cardiac applications of single-source dual-energy computed tomography (DECT) have recently been introduced. This study aimed to analyze the components of coronary arterial calcification (CAC) in vivo by material decomposition achieved with DECT. We reconstructed computed tomography (CT) angiography images for 51 consecutive patients with CACs who had undergone electrocardiography-gated ...
Church P C PC Division of Gastroenterology, Hepatology & Nutrition, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, - - 2014
In the treatment of Crohn's disease (CD), mucosal healing has become a major goal, with the hope of avoiding intestinal damage from chronic inflammation. Magnetic resonance enterography (MRE) has emerged as a non-invasive means of monitoring inflammation and damage. As part of the development of MRE-based multi-item measures of inflammation ...
Sundström Henrik H Department of Radiation Sciences, Umeå University, Umeå, - - 2014
Knowledge of patient exposure during magnetic resonance imaging (MRI) procedures is limited, and the need for such knowledge has been demonstrated in recent in vitro and in vivo studies of the genotoxic effects of MRI. This study focuses on the dB/dt of the switched gradient field (SGF) and its geometric ...
Sun Hong-Mei HM Inst. of Agro-food Science and Technology, Chinese Academy of Agricultural Sciences/Comprehensive Key Laboratory of Agro-Products Processing, Ministry of Agriculture, Beijing, - - 2014
Flavor quality, including non-volatile and volatile compounds, of hydrolyzed chicken bone extracts (HCBE) during Maillard reaction (MR) was evaluated with HPLC, tasting sensory system, Electronic-Nose (E-nose), and GC-MS. Results showed that flavor amino acids (AA) accounted for 72% to 74% of total free AA in HCBE. Taste of umami increased ...
Bovenkamp Philipp Rene PR Department of Clinical Radiology, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A16, 48149, Münster, - - 2014
In this study, we established and validated a time-resolved three-dimensional phase-contrast magnetic resonance imaging method (4D PC MRI) on a 9.4 T small-animal MRI system. Herein we present the feasibility of 4D PC MRI in terms of qualitative and quantitative flow pattern analysis in mice with transverse aortic constriction (TAC). 4D ...
Komlosi Peter P Division of Neuroradiology, Department of Radiology and Medical Imaging, - - 2014
OBJECT Monoenergetic imaging with dual-energy CT has been proposed to reduce metallic artifacts in comparison with conventional polychromatic CT. The purpose of this study is to systematically evaluate and define the optimal dual-energy CT imaging parameters for specific cervical spinal implant alloy compositions. METHODS Spinal fixation rods of cobalt-chromium or ...
Gao Yang Y Department of Mechanical Engineering, Eindhoven University of Technology, Den Dolech 2, 5600 MB Eindhoven, The Netherlands. - - 2014
Magnetic microparticles, assembled into chains that are actuated with rotating magnetic fields, can be used as microstirrers to promote fluid transport and biochemical reactions in microfluidic systems. We show that, within a certain range of magnetic field rotation frequency, the microstirrers exhibit a coherent collective motion: the rotating magnetic particle ...
Xu Zhiyuan Z Departments of - - 2014
OBJECT In biological tissues, it is known that the creation of gas bubbles (cavitation) during ultrasound exposure is more likely to occur at lower rather than higher frequencies. Upon collapsing, such bubbles can induce hemorrhage. Thus, acoustic inertial cavitation secondary to a 220-kHz MRI-guided focused ultrasound (MRgFUS) surgery is a ...
LaPrade Robert F RF The Steadman Clinic, 181 W. Meadow Dr. Ste. 1000, Vail, CO, 81657, - - 2014
The purpose of this study was to determine the diagnostic accuracy of 3 T MRI, including sensitivity, specificity, negative and positive predictive values, for detection of posterior medial and lateral meniscus root tears and avulsions. All patients who had a 3 T MRI of the knee, followed by arthroscopic surgery, were included ...
Yang Guixin G Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China. yangpiaoping@hrbeu.edu.cn - - 2014
A facile solution-based thermal decomposition strategy, using very cheap polyisobutylene succimide (PIBSI) and paraffin oil as a surfactant and solvent, respectively, has been developed for the controllable synthesis of magnetic MnFe2O4 and CoFe2O4 nanocrystals (NCs) with high dispersibility, uniform shape, and high yield. By fine-tuning the reaction temperature and growth ...
Liu Dong-Fang DF Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Medical School, Zhongda Hospital, Southeast University, No. 87, Dingjiaqiao, Nanjing 210009, China. - - 2014
Blood-brain barrier (BBB) damage during ischemia may induce devastating consequences like cerebral edema and hemorrhagic transformation. This study presents a novel strategy for dynamically imaging of BBB damage with PEGylated supermagnetic iron oxide nanoparticles (SPIONs) as contrast agents. The employment of SPIONs as contrast agents made it possible to dynamically ...
Gücük Adnan A Adnan Gücük, U─čur Üyetürk, Department of Urology, Faculty of Medicine, Abant Izzet Baysal University, 14280 Bolu, - - 2014
Computed tomography (CT) is widely used to examine stones in the urinary system. In addition to the size and location of the stone and the overall health of the kidney, CT can also assess the density of the stone in Hounsfield units (HU). The HU, or Hounsfield density, measured by ...
Gao Tian T College of Animal Science and Technology, Key Laboratory of Animal Origin Food Production and Safety Guarantee, Jiangsu Province; Synergetic Innovation Center of Food Safety and Nutrition, Nanjing Agricultural University, Nanjing, 210095, P.R. - - 2014
Recently, in consideration of the rapidly increasing demand for meat products and great trend towards fast food consumption, the prepared boneless pork chop, as a new style of value-added product, is cut from pork loins and welcomed by consumers after marinated or further-cooked. The effect of different tumbling marinade treatments ...
Fruytier A-C AC Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, - - 2014
Dynamic contrast-enhanced (DCE)-MRI is useful to assess the early effects of drugs acting on tumor vasculature, namely anti-angiogenic and vascular disrupting agents. Ultra-high-field MRI allows higher-resolution scanning for DCE-MRI while maintaining an adequate signal-to-noise ratio. However, increases in susceptibility effects, combined with decreases in longitudinal relaxivity of gadolinium-based contrast agents ...
Kwiecinski Wojciech W Institut Langevin ESPCI ParisTech, CNRS UMR7587, INSERM U797, Paris 75005, - - 2014
Radio frequency catheter ablation (RFCA) is a well-established clinical procedure for the treatment of atrial fibrillation (AF) but suffers from a low single-procedure success rate. Recurrence of AF is most likely attributable to discontinuous or nontransmural ablation lesions. Yet, despite this urgent clinical need, there is no clinically available imaging ...
Werthel Jean-David R JD Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic, Rochester, - - 2014
Carpal tunnel syndrome (CTS) is a very common pathology. Its most common diagnosis is idiopathic. Although it is accepted that chronic increase in pressure within the carpal tunnel is responsible for median nerve neuropathy, the exact pathophysiology leading to this pressure increase remains unknown. All the histological studies of the ...
Chang Chang-Cheng CC From the Departments of *Plastic Surgery, Chang Gung Memorial Hospital; †Diagnostic Radiology, ‡Plastic Surgery, and §Oral-Maxillofacial Surgery, Chang Gung Memorial Hospital, Lin Kuo, and Chang Gung University Medical College, Taoyuan, - - 2014
This study investigates the efficacy of oral submucous fibrosis release and free flap reconstruction. Pneumo-computerized tomography (pneumo-CT) was used to evaluate postoperative changes in the buccal vestibular volume during maximum blowing. From March 2003 to November 2008, 9 patients underwent 18 microvascular flap reconstructions after oral submucous fibrosis release. The ...
Vogel Susanne S 1] Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands [2] Radboud University Medical Center, Department of Cognitive Neuroscience, Nijmegen, the - - 2014
Two research lines argue for rapid stress-induced reallocations of neural network activity involving the amygdala. One focuses on the role of norepinephrine in mediating the shift towards the salience network and improving vigilance processing, while the other focuses on the role of cortisol in enhancing automatic, habitual responses. It has ...
Hingorani Dina V DV Department of Chemistry and Biochemistry, University of Arizona, - - 2014
This review focuses on MRI contrast agents that are responsive to a change in a physiological biomarker. The response mechanisms are dependent on six physicochemical characteristics, including the accessibility of water to the agent, tumbling time, proton exchange rate, electron spin state, MR frequency or superparamagnetism of the agent. These ...
Sohn Sung-Min - - 2014
Magnetic resonance imaging (MRI) is a widely used nonionizing and noninvasive diagnostic instrument to produce detailed images of the human body. The radio-frequency (RF) coil is an essential part of MRI hardware as an RF front-end. RF coils transmit RF energy to the subject and receive the returning MR signal. ...
Wong Jessica J Department of Radiology, Auckland City Hospital, Auckland, New - - 2014
This study compares the performance of two neutral oral contrast agents in CT enterography (CTE). Mannitol 2.5%, an oral osmotic agent, is compared with psyllium fibre (Metamucil). Both these agents are commonly used, but to our knowledge, they have not been compared in CTE. CTE data were collected from 25 ...
Pavlovic Davor D Cardiovascular Division, King's College London, Rayne Institute, St. Thomas' Hospital, London, - - 2014
Cardiotonic steroids (CTS) are a new class of hormones that circulate in the blood and are divided into two distinct groups, cardenolides, such as ouabain and digoxin, and bufadienolides, such as marinobufagenin, telocinobufagin and bufalin. They have the ability to bind and inhibit the ubiquitous transport enzyme sodium potassium pump, ...
Wetterling Friedrich F Department of Psychiatry, School of Medicine, Trinity College, The University of Dublin, College Green, Dublin, - - 2014
Tissue sodium concentration increases in irreversibly damaged (core) tissue following ischemic stroke and can potentially help to differentiate the core from the adjacent hypoperfused but viable penumbra. To test this, multinuclear hydrogen-1/sodium-23 magnetic resonance imaging (MRI) was used to measure the changing sodium signal and hydrogen-apparent diffusion coefficient (ADC) in ...
Xiong Fei F State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, - - 2014
Over the last decade, various magnetic nanomaterials have been developed as magnetic resonance imaging (MRI) contrast agents; the greatest challenges encountered for clinical application have been insufficient stability. In this paper, a lyophilization method for 2, 3-dimercaptosuccinic acid-modified iron oxide (γ-Fe2 O3 @DMSA) nanoparticles was developed to simultaneously overcome two ...
Ranjan Ravi R CARMA Center, Division of Cardiology, Internal Medicine, University of Utah, 30 North 1900 East, Rm 4A100, Salt Lake City, UT 84132, USA - - 2014
Late gadolinium enhanced (LGE) magnetic resonance imaging (MRI) is a useful tool for facilitating ventricular tachycardia (VT) ablation. Unfortunately, most VT ablation candidates often have prophylactic implantable cardioverter-defibrillator (ICD) and do not undergo cardiac MRI largely due to image artefacts generated by ICD. A prior study has reported success of ...
Hallinan James Thomas Patrick Decourcy JT Diagnostic Imaging, National University Health System, Singapore, - - 2014
To evaluate the effect of intravenous gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) on estimation of liver stiffness using magnetic resonance elastography (MRE) for detection of liver fibrosis. Liver MRI with MRE was performed in 210 subjects on a single 1.5 Tesla clinical MRI scanner. Liver MRE was performed before intravenous Gd-DTPA injection ...
Guo Gepu G Key Laboratory of Modern Acoustics (MOE), Institute of Acoustics, Nanjing University, Nanjing 210093, People's Republic of - - 2014
Development of magnetic encapsulated microbubble agents that can integrate multiple diagnostic and therapeutic functions is a key focus in both biomedical engineering and nanotechnology and one which will have far-reaching impact on medical diagnosis and therapies. However, properly designing multifunctional agents that can satisfy particular diagnostic/therapeutic requirements has been recognized ...
Chandarana Hersh H From the *Department of Radiology, Center for Biomedical Imaging, and †Division of Gastroenterology, Department of Medicine, New York University Langone Medical Center, New York, - - 2014
The purpose of this study was to estimate perfusion metrics in healthy and cirrhotic liver with pharmacokinetic modeling of high-temporal resolution reconstruction of continuously acquired free-breathing gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced acquisition in patients undergoing clinically indicated liver magnetic resonance imaging. In this Health Insurance Portability and Accountability Act-compliant prospective study, 9 ...
Burke Benjamin P BP Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK. - - 2014
The investigation of iron oxide-based positron emission tomography/magnetic resonance (PET/MR) multimodal imaging agents is an expanding field in which a variety of nanoparticle sizes, shapes, surface coatings and radioisotopes are open for exploration. This study develops iron oxide nanorods which are coated with various mixtures of poly(ethylene glycol) (PEG) and ...
Villar L M LM Multiple Sclerosis Unit, Department of Immunology, Ramón y Cajal Hospital, IRYCIS, Madrid, - - 2014
Cerebrospinal fluid (CSF) neurofilament light protein (NFL) is a promising biomarker of axonal injury and neurodegeneration. Here CSF lymphocyte subpopulations and antibodies, potential players of neurodegeneration, are examined in relation to CSF NFL shedding in MS. Cerebrospinal fluid NFL from 127 consecutive untreated MS patients was analysed. Samples from 37 ...
Zhu Gui-Ping GP School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, Singapore - - 2014
Magnetic manipulation is a promising technique for lab-on-a-chip platforms. The magnetic approach can avoid problems associated with heat, surface charge, ionic concentration and pH level. The present paper investigates the migration of diamagnetic particles in a ferrofluid core stream that is sandwiched between two diamagnetic streams in a uniform magnetic ...
Ekanger Levi A LA Department of Chemistry, Wayne State University, 5101 Cass Ave., Detroit, MI 48202, USA. - - 2014
An oxidation-responsive contrast agent for magnetic resonance imaging was synthesized using Eu(2+) and liposomes. Positive contrast enhancement was observed with Eu(2+), and chemical exchange saturation transfer was observed before and after oxidation of Eu(2+). Orthogonal detection modes render the concentration of Eu inconsequential to molecular information provided through imaging.
Choi Sun Young SY Department of Radiology and Medical Research Institute, Ewha Womans University School of Medicine, Seoul, Republic of Korea. - - 2014
We aimed to compare polyvinyl alcohol (PVA) particles with calibrated superparamagnetic iron oxide (SPIO) nanoparticle-loaded chitosan microspheres in a rabbit model, specifically regarding the relative distribution of embolic agents within the uterus based on magnetic resonance imaging (MRI) and pathological evaluation. Twelve New Zealand white rabbits underwent uterine artery embolization ...
Langer Christoph C Department of Cardiology, Angiology and Critical Care Medicine, University Medical Center Schleswig-Holstein, Campus Kiel, Christian-Albrechts-Universität Kiel, Schittenhelmstr. 12, 24105, Kiel, Germany, - - 2014
Late enhancement (LE) multi-slice computed tomography (leMDCT) was introduced for the visualization of (intra-) myocardial fibrosis in Hypertrophic Cardiomyopathy (HCM). LE is associated with adverse cardiac events. This analysis focuses on leMDCT derived LV muscle mass (LV-MM) which may be related to LE resulting in LE proportion for potential risk ...
Yveborg Moa - - 2014
Any method using dual energy CT has to make prior assumptions in order to quantify k-edge contrast agents. This work evaluates the ability of a dual energy system to quantify iodine and gadolinium using a clinically implemented method based on assigning each reconstructed voxel a ratio of soft tissue and ...
Kee Patrick P The University of Texas Health Science Center of Houston, 1881 East Road, 3SCRB 6.4607, Houston, TX, 77054, USA, - - 2014
Macrophage plays an important role in plaque destabilization in atherosclerosis. By harnessing the affinity of macrophages to certain phospholipid species, a liposomal contrast agent containing phosphatidylserine (PS) and X-ray computed tomographic (CT) contrast agent was prepared and evaluated for CT imaging of plaque-associated macrophages in rabbit models of atherosclerosis. Liposomes ...
Zhou X X Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, the Netherlands. - - 2014
Rapid and accurate detection of VRE (vancomycin resistant enterococci) is required for adequate antimicrobial treatment and infection prevention measures. Previous studies using PCR for the detection of VRE, including the Cepheid's Xpert vanA/vanB assay, reported accurate detection of vanA VRE, however many false positive results were found for vanB VRE. ...
Abdesselem Mouna - - 2014
Collecting information on multiple pathophysiological parameters is essential for understanding complex pathologies, especially given the large inter-individual variability. We here report on multifunctional nanoparticles which are luminescent probes, oxidant sensors and contrast agents in magnetic resonance imaging (MRI). Eu3+ ions in an yttrium vanadate matrix have been demonstrated to emit ...
Carrasco Muñoz S S Servicio de Radiodiagnóstico, Hospital General Universitario Gregorio Marañón, - - 2014
Gadolinium-based contrast agents are increasingly being used in magnetic resonance imaging. These agents can improve the contrast in images and provide information about function and metabolism, increasing both sensitivity and specificity. We describe the gadolinium-based contrast agents that have been approved for clinical use, detailing their main characteristics based on ...
Roemer Frank W FW From the Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, FGH Building, 3rd Floor, 820 Harrison Ave, Boston, MA 02118 (F.W.R., A.G.); Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); University of Arizona Arthritis Center & University of Arizona College of Medicine, Tucson, Ariz (C.K.K.); Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pa (M.J.H., Z.W.); Department of Rheumatology, Royal North Shore Hospital and Kolling Institute, University of Sydney, St Leonards, NSW, Australia (D.J.H.); Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria (F.E.); Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa (R.M.B.); Novartis Pharma AG, Basel, Switzerland (M.R.J.); and Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, Calif - - 2014
Purpose To assess whether magnetic resonance (MR) imaging-based cross-sectional measures of structural joint damage can be used to predict knee replacement during the following year. Materials and Methods Participants were drawn from the Osteoarthritis Initiative, a longitudinal observational study that includes 4796 participants who have knee osteoarthritis or are at ...
Cho Minjung M Department of Chemistry, Rice University, Houston, TX 77005, USA. colvin@rice.edu - - 2014
Molecular-based contrast agents for magnetic resonance imaging (MRI) are often characterized by insufficient relaxivity, thus requiring the systemic injection of high doses to induce sufficient contrast enhancement at the target site. In this work, gadolinium oxide (Gd2O3) nanoplates are produced via a thermal decomposition method. The nanoplates have a core ...
Bedoya Maria A MA 1 Department of Radiology, The Children's Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA - - 2014
OBJECTIVE. The purpose of this study is to use dynamic contrast-enhanced MRI to evaluate the perfusion characteristics of the proximal femur in the growing skeleton. MATERIALS AND METHODS. We evaluated 159 subjects (mean age, 5.67 years) who underwent a well-controlled protocol of contrast-enhanced MRI of the abdomen and hips. Perfusion ...
Branca M M CNRS, LCC (Laboratoire de Chimie de Coordination), 205, route de Narbonne, F-31077 Toulouse, France. - - 2014
A variety of imaging technologies are now routinely used in the medical field, their use being continuously enlarged through the development of contrast agents. Recently nanoparticles (NPs) proved efficient to improve imaging in vivo by increasing contrast and targeting capabilities. The current trend is now focused on the development of ...
Owens Sean S From the *Department of Anesthesiology and Critical Care Medicine and †Division of MR Research, Russell H. Morgan Department of Radiology and Radiologic Science, The Johns Hopkins University and School of Medicine, Baltimore, - - 2014
Many epidural and peripheral nerve catheters contain conducting wire that could heat during magnetic resonance imaging (MRI), requiring removal for scanning. We tested 2 each of 6 brands of regional analgesia catheters (from Arrow International [Reading, Pennsylvania], B. Braun Medical Inc [Bethlehem, Pennsylvania], and Smiths Medical/Portex [Keene, New Hampshire]) for ...
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