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Sana Barindra B School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Dr., Block N1.3, Singapore, 637457, - - 2015
The application of magnetic resonance imaging (MRI) is often limited by low magnetic relaxivity of currently used contrast agents. This problem can be addressed by developing more sensitive contrast agents by synthesizing new types of metal complex or metallic nanoparticles. Protein cage has been used as a template in biological ...
Skinner O T - - 2014
Objective: To assess the effect of arthroscope insertion, using a carbon-fibre rod model, on humero-radial, humero-ulnar and radio-ulnar congruity, as assessed by computed tomography (CT). Methods: Cadaveric Greyhound elbow joints were assessed at a flexion angle of 135 ± 5° using CT. For condition 1, a 36 mm fulcrum induced ...
Chikata Yusuke Y Medical Equipment Center, Tokushima University Hospital, Tokushima, - - 2014
Magnetic resonance imaging (MRI) is indispensable for diagnosing brain and spinal cord abnormalities. Magnetic components cannot be used during MRI procedures; therefore, patient support equipment must use MRI-compatible materials. However, little is known of the performance of MRI-compatible ventilators. At commonly used settings, we tested the delivered tidal volume (VT), ...
Müller Gunilla M GM Department of Radiology, Lund University, Skåne University Hospital, Inga Marie Nilssonsgata 49, 20502, Malmö, Sweden, - - 2014
To evaluate the distortion and artifact area of metal in MR images and to compare artifact reduction using different metal artifact-reducing sequences in patients with metal-on-metal (MoM) and non-MoM total hip prostheses. Thirty-six MoM and 15 non-MoM prostheses were examined in a 1.5-T MR scanner using T1-weighted (T1-w) sequences: turbo ...
Saito Shigeyoshi S Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka, 565-0871, Japan, - - 2014
Chemical exchange saturation transfer (CEST) is a new contrast enhancement approach for imaging exogenous or endogenous substances such as creatine (Cr), amide protons, and glutamate in the human body. An increase in field strength is beneficial for CEST imaging because of the increased chemical shift and longer longitudinal relaxation time ...
Hauspie S S Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, B-9820, Merelbeke, - - 2014
A synovial plica is present at the dorsoproximal aspect of the fetlock joint. The objective of this study was to describe the location of the synovial plica during induced hyperextension using Magnetic Resonance Imaging. For this study 20 cadaver limbs from five Warmblood horses were used. Measurements were made of ...
Priola Adriano Massimiliano AM From the *Department of Diagnostic Imaging, San Luigi Gonzaga University Hospital, Orbassano (Torino); †Department of Mathematics, University of Torino, Torino; Departments of ‡Thoracic Surgery, and §Pathology, San Luigi Gonzaga University Hospital, Orbassano (Torino), - - 2014
The objective of this study was to prospectively investigate the usefulness of chemical-shift and diffusion-weighted (DW) magnetic resonance imaging (MRI) in patients with myasthenia gravis (MG) for distinguishing thymic lymphoid hyperplasia (TLH), normal thymus (NT), and thymoma (THY) by using the signal intensity index (SII) and the apparent diffusion coefficient ...
Schleich N N Université catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, Avenue Mounier, B1 73.12, 1200 Brussels, - - 2014
A major issue in current cancer therapies is the lack of selectivity, which leads to damage in healthy tissues. Therefore, researchers have focused on numerous innovative targeting strategies to address this problem with the goal of increasing selectivity to avoid or minimize accumulation in healthy tissues. These strategies include (i) ...
Huang Hsin-Yang HY Department of Materials Science and Engineering, National Chiao Tung University, No. 1001 Ta-Hsueh Rd., Taiwan, Hsinchu, 300, Republic of - - 2014
A novel magnetically guidable nanobubble is designed for disrupting the blood-brain barrier (BBB) by combining magnetic guidance with focused ultrasound in vivo. The magnetic-nanobubble platform also demonstrates the potential to serve as a unique theranostic tool via performing focused ultrasound (FUS)-induced BBB disruption and magnetic resonance imaging (MRI)/ultrasound dual-modality contrast-agent ...
Jia J B JB Department of Radiological Sciences, University of California, Irvine, 101 The City Drive South, Route 140, Orange, CA 92868, USA. Electronic address: - - 2014
Onyx(®) (ev3, Irvine, CA, USA) is a liquid embolic agent composed of ethylene vinyl alcohol copolymer dissolved in dimethyl sulphoxide used for the treatment of intracranial arteriovenous malformations. Onyx is a preferred embolizing agent due to its unique properties, non-adhesive nature, and durability. In addition to its approved intracranial application, ...
Rayner E L EL Public Health England, Microbiology Services Division, Porton Down, Salisbury, UK. Electronic address: - - 2014
Three rhesus macaques (Macaca mulatta) were challenged with Mycobacterium tuberculosis (Mtb), Erdman strain, as part of studies to investigate lesion development at early time points in tuberculosis (TB) and to assess computed tomography (CT) as a method of monitoring disease progression in vivo. Animals were challenged with either a high, mid ...
Nacev Aleksandar Nelson - - 2014
The ability to use magnets external to the body to focus therapy to deep tissue targets has remained an elusive goal in magnetic drug targeting. Researchers have hitherto been able to manipulate magnetic nano-therapeutics in vivo with nearby magnets, but have remained unable to focus these therapies to targets deep ...
Pichardo Samuel S Sunnybrook Health Sciences Centre , Toronto , Ontario, Canada - - 2014
Abstract Purpose: In this in vivo study, the feasibility to perform hyperthermia treatments in the head and neck using magnetic resonance image-guided high intensity focused ultrasound (MRgHIFU) was established using a porcine acute model. Porcine specimens with a weight between 17 and 18 kg were treated in the omohyoid muscle in ...
Wu Xinping X Loker Hydrocarbon Research Institute, Department of Chemistry, University of Southern California, Los Angeles, California - - 2014
Responsive magnetic resonance imaging (MRI) contrast agents, those that change their relaxivity according to environmental stimuli, have promise as next generation imaging probes in medicine. While several of these are known based on covalent modification of the contrast agents, fewer are known based on controlling non-covalent interactions. We demonstrate here ...
Ipsen S S Radiation Physics Laboratory, Sydney Medical School, The University of Sydney, Sydney, New South Wales 2006, Australia and Institute for Robotics and Cognitive Systems, University of Luebeck, Luebeck 23562, - - 2014
Atrial fibrillation (AFib) is the most common cardiac arrhythmia that affects millions of patients world-wide. AFib is usually treated with minimally invasive, time consuming catheter ablation techniques. While recently noninvasive radiosurgery to the pulmonary vein antrum (PVA) in the left atrium has been proposed for AFib treatment, precise target location ...
Yasuda Mitsuyoshi M Graduate Division of Health Sciences, Komazawa University; Tokyo, Japan - Department of Radiological Technology, Showa University Koto-Toyosu Hospital; Tokyo, Japan - - - 2014
This study aimed to evaluate the effect of a metal artifact reduction (MAR) algorithm using 1D linear interpolation on cone-beam CT (CBCT). We performed phantom and clinical qualitative studies with and without MAR application using 1D linear interpolation. In the phantom study, the standard deviation (SD) was estimated from the ...
Oz Gülin G Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, 2021 6th St. SE, Minneapolis, MN 55455, USA. Electronic address: - - 2014
Suppression of transgene expression in a conditional transgenic mouse model of spinocerebellar ataxia 1 (SCA1) reverses the Purkinje cell pathology and motor dysfunction that are hallmarks of SCA1. We previously showed that cerebellar neurochemical levels measured by magnetic resonance spectroscopy (MRS) correlate with progression of pathology and clinical status of ...
Yu Tong T Department of Orthopaedics, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, - - 2014
The purpose of this study was to predict ONFH-induced collapse based on the percentage of the proximal sclerotic rim. In total, 101 patients satisfying the inclusion criteria who received treatment at Guang'anmen Hospital were enrolled. Bilateral hip-joint computed tomography (CT) of the necrotic tissue was performed, and the largest layer ...
Samoudi Amine M AM Department of Information Technology (INTEC), Ghent University/iMinds, Ghent, - - 2014
We investigated the temporal variation of the induced magnetic field due to the transverse and the longitudinal gradient coils in tungsten collimators arranged in hexagonal and pentagonal geometries with and without gaps between the collimators. We modeled x-, y-, and z-gradient coils and different arrangements of single-photon emission computed tomography ...
Perilli Egon E Medical Device Research Institute, School of Computer Science, Engineering & Mathematics, Flinders University, Bedford Park, SA, 5042, - - 2014
In rodent models of inflammatory arthritis, bone erosion has been non-invasively assessed by micro-computed tomography (micro-CT). However, non-invasive assessments of paw swelling (oedema) are still based on clinical grading by visual evaluation, or measurements by callipers, not always reliable for the tiny mouse paws. The aim of this work is ...
Muftuler L Tugan LT Department of Neurosurgery, Medical College of Wisconsin, Froedtert Hospital, 9200 W. Wisconsin Ave., Milwaukee, WI, 53226, USA, - - 2014
The goal of this study was to study the association between solute transport mechanisms in cartilaginous disc endplates and the degeneration of intervertebral discs. Intervertebral disc degeneration is a multi-factorial process. It is suspected that poor nutrient delivery to discs might be a factor leading to degeneration. Several studies suggest ...
Look Hong Nicole J NJ Division of Surgical Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, - - 2014
Variability exists regarding optimal staging for node-positive melanoma. Options include combinations of physical examination (PE), radiography, computed tomography (CT), and positron emission tomography (PET). Cost-effectiveness of regimens has never been investigated. A modeled cost-effectiveness analysis was performed to examine the cost per surgery performed and per accurate diagnosis achieved with ...
Filli Lukas L Department of Diagnostic and Interventional Radiology, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland, - - 2014
To evaluate metal artifacts induced by biodegradable magnesium-a new class of degradable biomaterial that is beginning to enter the orthopedic routine-on CT and MRI compared to standard titanium and steel controls. Different pins made of titanium, stainless steel, and biodegradable magnesium alloys were scanned using a second-generation dual-energy multidetector CT ...
Saminathan Mookiah M Institute of Bioscience, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, - - 2014
Molecular weights (MWs) and their chemical structures are the primary factors determining the influence of condensed tannins (CTs) on animal nutrition and methane (CH4 ) production in ruminants. In this study, the MWs of five CT fractions from Leucaena leucocephala hybrid-Rendang (LLR) were determined and the CT fractions were investigated ...
Melnyk Angela D AD Department of Mechanical Engineering, University of British Columbia, Vancouver, BC, Canada; Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada; International Collaboration on Repair Discoveries, Vancouver Coastal Health Research Institute, Vancouver, BC, - - 2014
Many pathologies involving disc degeneration are treated with surgery and spinal implants. It is important to understand how the spine behaves mechanically as a function of disc degeneration. Shear loading is especially relevant in the natural and surgically stabilized lumbar spine. The objective of our study was to determine the ...
Martinez Bermudez Claudia A CA Associate Professor of Clinical Medicine, Cardiology and Interventional Cardiology, University of Miami Miller School of - - 2014
The transcatheter treatment of paravalvular leaks (PVL) are technically challenging procedures; they pose increasing difficulty in cases where there is a stentless valve, without the usual fluoroscopic landmarks. Hence, there is limited experience in treating this defect percutaneously. We present a case of a patient with an aortic PVL of ...
Moisan Anaick A Inserm, U836, Grenoble, - - 2014
Background: Microvasculature plays a key role in stroke pathophysiology both during initial damage and extended neural repair. Moreover, angiogenesis processes seem to be a promising target for future neurorestorative therapies. However, dynamic changes of microvessels after stroke still remain unclear, and MRI follow-up could be interesting as an in vivo ...
Li Ruibin R Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, CA 90095, - - 2014
Functionalized carbon nanotubes (f-CNTs) have been widely used in bio-medicine as drug carriers, bio-sensors, imaging agents and tissue engineering additives, which demands better understanding of their in vivo behavior because of the increasing exposure potential to humans. However, there are limited studies to investigate the in vivo biodistribution and elimination ...
Matsui Kazuhiro K Departments of Medicine, Tokyo Women's Medical University Medical Center East, 2-1-10 Nishiogu, Arakawa-ku, Tokyo, 116-8567, - - 2014
Clinical cardiac applications of single-source dual-energy computed tomography (DECT) have recently been introduced. This study aimed to analyze the components of coronary arterial calcification (CAC) in vivo by material decomposition achieved with DECT. We reconstructed computed tomography (CT) angiography images for 51 consecutive patients with CACs who had undergone electrocardiography-gated ...
Church P C PC Division of Gastroenterology, Hepatology & Nutrition, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, - - 2014
In the treatment of Crohn's disease (CD), mucosal healing has become a major goal, with the hope of avoiding intestinal damage from chronic inflammation. Magnetic resonance enterography (MRE) has emerged as a non-invasive means of monitoring inflammation and damage. As part of the development of MRE-based multi-item measures of inflammation ...
Sundström Henrik H Department of Radiation Sciences, Umeå University, Umeå, - - 2014
Knowledge of patient exposure during magnetic resonance imaging (MRI) procedures is limited, and the need for such knowledge has been demonstrated in recent in vitro and in vivo studies of the genotoxic effects of MRI. This study focuses on the dB/dt of the switched gradient field (SGF) and its geometric ...
Yu Tao T Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD, - - 2014
Mucus barriers lining mucosal epithelia reduce the effectiveness of nanocarrier-based mucosal drug delivery and imaging ("theranostics"). Here, we describe liposome-based mucus-penetrating particles (MPP) capable of loading hydrophilic agents, e.g., the diaCEST MRI contrast agent barbituric acid (BA). We observed that polyethylene glycol (PEG)-coated liposomes containing ≥7mol% PEG diffused only ~10-fold ...
Sun Hong-Mei HM Inst. of Agro-food Science and Technology, Chinese Academy of Agricultural Sciences/Comprehensive Key Laboratory of Agro-Products Processing, Ministry of Agriculture, Beijing, - - 2014
Flavor quality, including non-volatile and volatile compounds, of hydrolyzed chicken bone extracts (HCBE) during Maillard reaction (MR) was evaluated with HPLC, tasting sensory system, Electronic-Nose (E-nose), and GC-MS. Results showed that flavor amino acids (AA) accounted for 72% to 74% of total free AA in HCBE. Taste of umami increased ...
Bovenkamp Philipp Rene PR Department of Clinical Radiology, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A16, 48149, Münster, - - 2014
In this study, we established and validated a time-resolved three-dimensional phase-contrast magnetic resonance imaging method (4D PC MRI) on a 9.4 T small-animal MRI system. Herein we present the feasibility of 4D PC MRI in terms of qualitative and quantitative flow pattern analysis in mice with transverse aortic constriction (TAC). 4D ...
Vashaee S S UNB MRI Centre, Department of Physics, University of New Brunswick, Fredericton, New Brunswick E3B 5A3, - - 2014
Magnetic resonance imaging (MRI) in the presence of metallic structures is very common in medical and non-medical fields. Metallic structures cause MRI image distortions by three mechanisms: (1) static field distortion through magnetic susceptibility mismatch, (2) eddy currents induced by switched magnetic field gradients and (3) radio frequency (RF) induced ...
Yang Kai K School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Suzhou Nano Science and Technology & Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou, Jiangsu 215123, China; Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China. Electronic address: - - 2015
In this work, we develop magnetic iron sulfide (FeS) nanoplates as a theranostic agent for magnetic resonance (MR) imaging-guided photothermal therapy of cancer. FeS nanoplates are synthesized via a simple one-step method and then functionalized with polyethylene glycol (PEG). The obtained PEGylated FeS (FeS-PEG) nanoplates exhibit high NIR absorbance together ...
Komlosi Peter P Division of Neuroradiology, Department of Radiology and Medical Imaging, - - 2014
OBJECT Monoenergetic imaging with dual-energy CT has been proposed to reduce metallic artifacts in comparison with conventional polychromatic CT. The purpose of this study is to systematically evaluate and define the optimal dual-energy CT imaging parameters for specific cervical spinal implant alloy compositions. METHODS Spinal fixation rods of cobalt-chromium or ...
Gao Yang Y Department of Mechanical Engineering, Eindhoven University of Technology, Den Dolech 2, 5600 MB Eindhoven, The Netherlands. - - 2014
Magnetic microparticles, assembled into chains that are actuated with rotating magnetic fields, can be used as microstirrers to promote fluid transport and biochemical reactions in microfluidic systems. We show that, within a certain range of magnetic field rotation frequency, the microstirrers exhibit a coherent collective motion: the rotating magnetic particle ...
Xu Zhiyuan Z Departments of - - 2014
OBJECT In biological tissues, it is known that the creation of gas bubbles (cavitation) during ultrasound exposure is more likely to occur at lower rather than higher frequencies. Upon collapsing, such bubbles can induce hemorrhage. Thus, acoustic inertial cavitation secondary to a 220-kHz MRI-guided focused ultrasound (MRgFUS) surgery is a ...
LaPrade Robert F RF The Steadman Clinic, 181 W. Meadow Dr. Ste. 1000, Vail, CO, 81657, - - 2014
The purpose of this study was to determine the diagnostic accuracy of 3 T MRI, including sensitivity, specificity, negative and positive predictive values, for detection of posterior medial and lateral meniscus root tears and avulsions. All patients who had a 3 T MRI of the knee, followed by arthroscopic surgery, were included ...
Yang Guixin G Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China. yangpiaoping@hrbeu.edu.cn - - 2014
A facile solution-based thermal decomposition strategy, using very cheap polyisobutylene succimide (PIBSI) and paraffin oil as a surfactant and solvent, respectively, has been developed for the controllable synthesis of magnetic MnFe2O4 and CoFe2O4 nanocrystals (NCs) with high dispersibility, uniform shape, and high yield. By fine-tuning the reaction temperature and growth ...
Liu Dong-Fang DF Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Medical School, Zhongda Hospital, Southeast University, No. 87, Dingjiaqiao, Nanjing 210009, China. - - 2014
Blood-brain barrier (BBB) damage during ischemia may induce devastating consequences like cerebral edema and hemorrhagic transformation. This study presents a novel strategy for dynamically imaging of BBB damage with PEGylated supermagnetic iron oxide nanoparticles (SPIONs) as contrast agents. The employment of SPIONs as contrast agents made it possible to dynamically ...
Gücük Adnan A Adnan Gücük, U─čur Üyetürk, Department of Urology, Faculty of Medicine, Abant Izzet Baysal University, 14280 Bolu, - - 2014
Computed tomography (CT) is widely used to examine stones in the urinary system. In addition to the size and location of the stone and the overall health of the kidney, CT can also assess the density of the stone in Hounsfield units (HU). The HU, or Hounsfield density, measured by ...
Gao Tian T College of Animal Science and Technology, Key Laboratory of Animal Origin Food Production and Safety Guarantee, Jiangsu Province; Synergetic Innovation Center of Food Safety and Nutrition, Nanjing Agricultural University, Nanjing, 210095, P.R. - - 2014
Recently, in consideration of the rapidly increasing demand for meat products and great trend towards fast food consumption, the prepared boneless pork chop, as a new style of value-added product, is cut from pork loins and welcomed by consumers after marinated or further-cooked. The effect of different tumbling marinade treatments ...
Fruytier A-C AC Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, - - 2014
Dynamic contrast-enhanced (DCE)-MRI is useful to assess the early effects of drugs acting on tumor vasculature, namely anti-angiogenic and vascular disrupting agents. Ultra-high-field MRI allows higher-resolution scanning for DCE-MRI while maintaining an adequate signal-to-noise ratio. However, increases in susceptibility effects, combined with decreases in longitudinal relaxivity of gadolinium-based contrast agents ...
Kwiecinski Wojciech W Institut Langevin ESPCI ParisTech, CNRS UMR7587, INSERM U797, Paris 75005, - - 2014
Radio frequency catheter ablation (RFCA) is a well-established clinical procedure for the treatment of atrial fibrillation (AF) but suffers from a low single-procedure success rate. Recurrence of AF is most likely attributable to discontinuous or nontransmural ablation lesions. Yet, despite this urgent clinical need, there is no clinically available imaging ...
Werthel Jean-David R JD Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic, Rochester, - - 2014
Carpal tunnel syndrome (CTS) is a very common pathology. Its most common diagnosis is idiopathic. Although it is accepted that chronic increase in pressure within the carpal tunnel is responsible for median nerve neuropathy, the exact pathophysiology leading to this pressure increase remains unknown. All the histological studies of the ...
Chang Chang-Cheng CC From the Departments of *Plastic Surgery, Chang Gung Memorial Hospital; †Diagnostic Radiology, ‡Plastic Surgery, and §Oral-Maxillofacial Surgery, Chang Gung Memorial Hospital, Lin Kuo, and Chang Gung University Medical College, Taoyuan, - - 2014
This study investigates the efficacy of oral submucous fibrosis release and free flap reconstruction. Pneumo-computerized tomography (pneumo-CT) was used to evaluate postoperative changes in the buccal vestibular volume during maximum blowing. From March 2003 to November 2008, 9 patients underwent 18 microvascular flap reconstructions after oral submucous fibrosis release. The ...
Masuda Takanori T Department of Radiological Technology, Tsuchiya General Hospital, Nakajima-cho 3-30, Naka-ku, Hiroshima 730-8655, Japan; Department of Diagnostic Radiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. Electronic address: - - 2014
The purpose of our study was to compare test bolus techniques using undiluted or diluted contrast material for their ability to predict aortic enhancement on coronary computed tomographic angiography (c-CTA) images. We divided 200 consecutive patients who underwent c-CTA on a 64-MDCT scanner into two groups. In group A (n = 100), ...
Ajayi N O - - 2014
The compression of the median nerve (MN) in the carpal tunnel (CT) is one of the most common aetiologies of entrapment neuropathy syndromes in clinical practice. The aim of this study was to investigate the relationship of the palpable bony prominences of the distal forearm (radial styloid process [RSP] and ...
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