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Fruytier A-C AC Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, - - 2014
Dynamic contrast-enhanced (DCE)-MRI is useful to assess the early effects of drugs acting on tumor vasculature, namely anti-angiogenic and vascular disrupting agents. Ultra-high-field MRI allows higher-resolution scanning for DCE-MRI while maintaining an adequate signal-to-noise ratio. However, increases in susceptibility effects, combined with decreases in longitudinal relaxivity of gadolinium-based contrast agents ...
Guo Gepu G Key Laboratory of Modern Acoustics (MOE), Institute of Acoustics, Nanjing University, Nanjing 210093, People's Republic of - - 2014
Development of magnetic encapsulated microbubble agents that can integrate multiple diagnostic and therapeutic functions is a key focus in both biomedical engineering and nanotechnology and one which will have far-reaching impact on medical diagnosis and therapies. However, properly designing multifunctional agents that can satisfy particular diagnostic/therapeutic requirements has been recognized ...
Burke Benjamin P BP Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK. - - 2014
The investigation of iron oxide-based positron emission tomography/magnetic resonance (PET/MR) multimodal imaging agents is an expanding field in which a variety of nanoparticle sizes, shapes, surface coatings and radioisotopes are open for exploration. This study develops iron oxide nanorods which are coated with various mixtures of poly(ethylene glycol) (PEG) and ...
Villar L M LM Multiple Sclerosis Unit, Department of Immunology, Ramón y Cajal Hospital, IRYCIS, Madrid, - - 2014
Cerebrospinal fluid (CSF) neurofilament light protein (NFL) is a promising biomarker of axonal injury and neurodegeneration. Here CSF lymphocyte subpopulations and antibodies, potential players of neurodegeneration, are examined in relation to CSF NFL shedding in MS. Cerebrospinal fluid NFL from 127 consecutive untreated MS patients was analysed. Samples from 37 ...
Zhu Gui-Ping GP School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, Singapore - - 2014
Magnetic manipulation is a promising technique for lab-on-a-chip platforms. The magnetic approach can avoid problems associated with heat, surface charge, ionic concentration and pH level. The present paper investigates the migration of diamagnetic particles in a ferrofluid core stream that is sandwiched between two diamagnetic streams in a uniform magnetic ...
Ekanger Levi A LA Department of Chemistry, Wayne State University, 5101 Cass Ave., Detroit, MI 48202, USA. - - 2014
An oxidation-responsive contrast agent for magnetic resonance imaging was synthesized using Eu(2+) and liposomes. Positive contrast enhancement was observed with Eu(2+), and chemical exchange saturation transfer was observed before and after oxidation of Eu(2+). Orthogonal detection modes render the concentration of Eu inconsequential to molecular information provided through imaging.
Langer Christoph C Department of Cardiology, Angiology and Critical Care Medicine, University Medical Center Schleswig-Holstein, Campus Kiel, Christian-Albrechts-Universität Kiel, Schittenhelmstr. 12, 24105, Kiel, Germany, - - 2014
Late enhancement (LE) multi-slice computed tomography (leMDCT) was introduced for the visualization of (intra-) myocardial fibrosis in Hypertrophic Cardiomyopathy (HCM). LE is associated with adverse cardiac events. This analysis focuses on leMDCT derived LV muscle mass (LV-MM) which may be related to LE resulting in LE proportion for potential risk ...
Yveborg Moa - - 2014
Any method using dual energy CT has to make prior assumptions in order to quantify k-edge contrast agents. This work evaluates the ability of a dual energy system to quantify iodine and gadolinium using a clinically implemented method based on assigning each reconstructed voxel a ratio of soft tissue and ...
Kee Patrick P The University of Texas Health Science Center of Houston, 1881 East Road, 3SCRB 6.4607, Houston, TX, 77054, USA, - - 2014
Macrophage plays an important role in plaque destabilization in atherosclerosis. By harnessing the affinity of macrophages to certain phospholipid species, a liposomal contrast agent containing phosphatidylserine (PS) and X-ray computed tomographic (CT) contrast agent was prepared and evaluated for CT imaging of plaque-associated macrophages in rabbit models of atherosclerosis. Liposomes ...
Zhou X X Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, the Netherlands. - - 2014
Rapid and accurate detection of VRE (vancomycin resistant enterococci) is required for adequate antimicrobial treatment and infection prevention measures. Previous studies using PCR for the detection of VRE, including the Cepheid's Xpert vanA/vanB assay, reported accurate detection of vanA VRE, however many false positive results were found for vanB VRE. ...
Abdesselem Mouna - - 2014
Collecting information on multiple pathophysiological parameters is essential for understanding complex pathologies, especially given the large inter-individual variability. We here report on multifunctional nanoparticles which are luminescent probes, oxidant sensors and contrast agents in magnetic resonance imaging (MRI). Eu3+ ions in an yttrium vanadate matrix have been demonstrated to emit ...
Carrasco Muñoz S S Servicio de Radiodiagnóstico, Hospital General Universitario Gregorio Marañón, - - 2014
Gadolinium-based contrast agents are increasingly being used in magnetic resonance imaging. These agents can improve the contrast in images and provide information about function and metabolism, increasing both sensitivity and specificity. We describe the gadolinium-based contrast agents that have been approved for clinical use, detailing their main characteristics based on ...
Roemer Frank W FW From the Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, FGH Building, 3rd Floor, 820 Harrison Ave, Boston, MA 02118 (F.W.R., A.G.); Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); University of Arizona Arthritis Center & University of Arizona College of Medicine, Tucson, Ariz (C.K.K.); Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pa (M.J.H., Z.W.); Department of Rheumatology, Royal North Shore Hospital and Kolling Institute, University of Sydney, St Leonards, NSW, Australia (D.J.H.); Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria (F.E.); Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa (R.M.B.); Novartis Pharma AG, Basel, Switzerland (M.R.J.); and Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, Calif - - 2014
Purpose To assess whether magnetic resonance (MR) imaging-based cross-sectional measures of structural joint damage can be used to predict knee replacement during the following year. Materials and Methods Participants were drawn from the Osteoarthritis Initiative, a longitudinal observational study that includes 4796 participants who have knee osteoarthritis or are at ...
Cho Minjung M Department of Chemistry, Rice University, Houston, TX 77005, USA. colvin@rice.edu - - 2014
Molecular-based contrast agents for magnetic resonance imaging (MRI) are often characterized by insufficient relaxivity, thus requiring the systemic injection of high doses to induce sufficient contrast enhancement at the target site. In this work, gadolinium oxide (Gd2O3) nanoplates are produced via a thermal decomposition method. The nanoplates have a core ...
Bedoya Maria A MA 1 Department of Radiology, The Children's Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA - - 2014
OBJECTIVE. The purpose of this study is to use dynamic contrast-enhanced MRI to evaluate the perfusion characteristics of the proximal femur in the growing skeleton. MATERIALS AND METHODS. We evaluated 159 subjects (mean age, 5.67 years) who underwent a well-controlled protocol of contrast-enhanced MRI of the abdomen and hips. Perfusion ...
Branca M M CNRS, LCC (Laboratoire de Chimie de Coordination), 205, route de Narbonne, F-31077 Toulouse, France. - - 2014
A variety of imaging technologies are now routinely used in the medical field, their use being continuously enlarged through the development of contrast agents. Recently nanoparticles (NPs) proved efficient to improve imaging in vivo by increasing contrast and targeting capabilities. The current trend is now focused on the development of ...
Owens Sean S From the *Department of Anesthesiology and Critical Care Medicine and †Division of MR Research, Russell H. Morgan Department of Radiology and Radiologic Science, The Johns Hopkins University and School of Medicine, Baltimore, - - 2014
Many epidural and peripheral nerve catheters contain conducting wire that could heat during magnetic resonance imaging (MRI), requiring removal for scanning. We tested 2 each of 6 brands of regional analgesia catheters (from Arrow International [Reading, Pennsylvania], B. Braun Medical Inc [Bethlehem, Pennsylvania], and Smiths Medical/Portex [Keene, New Hampshire]) for ...
Crema M D MD Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, Sao Paulo, SP, Brazil. Electronic address: - - 2014
To determine the association of MRI-assessed worsening of tibiofemoral cartilage damage, meniscal damage, meniscal extrusion, separately and together, with progression of radiographic joint space narrowing (JSN). The Multicenter Osteoarthitis Study (MOST) Study is a cohort study of subjects with or at risk for knee osteoarthritis (OA). Knees with radiographic OA ...
Kivrak Pfiffner Fatma F University Hospital Zurich, Plastic and Reconstructive Surgery, Zurich, Switzerland ; - - 2014
Adequate vascularization in biomaterials is essential for tissue regeneration and repair. Current models do not allow easy analysis of vascularization of implants in vivo, leaving it a highly desirable goal. A tool that allows to monitor the perfusion capacity of such biomaterials non-invasively in a cheap, efficient and reliable in ...
Jeon Joon Hyeok - - 2014
Ischemic stroke was induced by permanent middle cerebral artery occlusion in 9 healthy experimental dogs. The dogs were divided into 3 groups according to survival time and duration of the experimental period: group A (survived only one day), group B (one-week experimental period), group C (two-week experimental period). Neurologic status ...
Bickelhaupt S S Department of Radiology, University Hospital Zürich, Zürich, Switzerland Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, - - 2014
Small bowel motility analyses using magnetic resonance imaging (MRI) could reduce current invasive techniques in animal studies and comply with the 'three Rs' rule for human animal experimentation. Thus we investigated the feasibility of in vivo small bowel motility analyses in mice using dynamic MRI acquisitions. All experimental procedures were approved ...
Schütz Gunnar G Bayer HealthCare AG, Berlin, - - 2014
When diagnosing cancer, assessing the nodal stage is tremendously important in determining the patient's prognosis. Computed tomography (CT) and magnetic resonance (MR) imaging (MRI) assessments of the regional lymph node (LN) size and shape are currently used for the initial nodal staging in clinical settings, although this approach has a ...
Jeun Minhong M Biomedical Research Institute, Korea Institute of Science and Technology (KIST) , Seoul 136-791, Republic of - - 2014
A superparamagnetic nanoferrite (SPNF) with high magnetic moment, AC magnetically induced heating (AC-heating) capacity, and good biocompatibility is the most vital part of magnetic fluid hyperthermia for utilizing it in the clinics. Herein, we precisely tune magnetic properties and AC-heating characteristics of MgxMn1-xFe2O4 SPNF via chemically controlling the cations' concentration ...
Abbas Kausar K Purdue University, School of Electrical and Computer Engineering, West Lafayette, Indiana, United States ; - - 2014
Long-term neurological damage as a result of head trauma while playing sports is a major concern for football athletes today. Repetitive concussions have been linked to many neurological disorders. Recently, it has been reported that repetitive sub-concussive events can be a significant source of accrued damage. Since football athletes can ...
Yu Y Y Department of Radiology, The First Affiliated Hospital of Soochow University, No. 188, Shi Zi Street, Suzhou 215006, Jiangsu, - - 2014
To explore the value of CT spectral imaging in the differential diagnosis of necrotic hepatocellular carcinoma (nHCC) and hepatic abscess (HA) during the arterial phase (AP) and portal venous phase (PP). Sixty patients with 36 nHCCs and 24 HAs underwent spectral CT during AP and PP. Iodine or water concentration ...
Mulligan Kyle R KR Orthopedics Research Laboratory of McGill University, Montreal General Hospital, 687 Pine Avenue West Suite L-4.65, Montreal, QC, H3A 1A1, - - 2014
The aim of the study was to investigate if axial T1ρ MR images had similar accuracy as established sagittal T1ρ MRI for the assessment of proteoglycan concentration and content in intervertebral degenerated discs (IDDs). T1ρ and T2-weighted MR images of 12 intervertebral discs (IVDs) from 3 harvested human lumbar spines ...
Dykes Thomas M TM Department of Radiology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania. Electronic address: - - 2014
Establish 3 performance benchmarks for intravenous contrast extravasation during CT examinations: extravasation frequency, distribution of extravasation volumes, and severity of injury. Evaluate the effectiveness of implementing practice quality improvement (PQI) methodology in improving performance for these 3 benchmarks. The Society of Abdominal Radiology and ACR developed a registry collecting data ...
Yao Jie J Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, 100191 Beijing, China; National Key Lab of Virtual Reality Technology, Beihang University, 100191 Beijing, - - 2014
Patellofemoral (PF) maltracking is a critical factor predisposing to PF pain syndrome. Many novel techniques of measuring patellar tracking remain research tools. This study aimed to develop a method to measure the in vivo patellar tracking and finite helical axis (FHA) by using a static magnetic resonance (MR) based methodology. ...
Curcic J J Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, - - 2014
The mechanism of reflux protection may involve a 'flap valve' at the oesophago-gastric junction (OGJ). To assess the effects of baclofen, a gamma-aminobutyric acid receptor type-B (GABA-B) agonist known to suppress reflux events, on the 'functional anatomy' of the OGJ and proximal stomach after a large test meal. Twelve healthy ...
Mariano Rodolfo Nicolás - - 2014
An amphiphilic Gd(III) complex has been efficiently loaded in polylactic-co-glycolic acid nanoparticles (PLGA-NP) to yield a novel, high sensitive MRI contrast agent for imaging guided drug delivery applications. As the Gd(III) complex is soluble in organic solvents, the nanoparticles were prepared as oil/water emulsions. PLGA-NP were stable, in buffer, for ...
Zeng ChengCai C College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, Zhejiang Province, P. R. - - 2014
A type of novel macromolecular colloid was prepared from gadolinium-based poly(l-succinimide) and gold nanoparticles (GNPs) with AuS covalent bonds. The colloid displayed improved stability in aqueous media and regular arrays in partial region. Moreover, these materials enhanced the contrast 9 times more than that of the corresponding uncoated Au compound ...
Buchenberg Waltraud B WB Department of Radiology, University Medical Center Freiburg, Medical Physics, Freiburg, - - 2014
Blood flow causes induced voltages via the magnetohydrodynamic (MHD) effect distorting electrograms (EGMs) made during magnetic resonance imaging. To investigate the MHD effect in this context MHD voltages occurring inside the human heart were simulated in an in vitro model system inside a 1.5 T MR system. The model was ...
Nsanzineza I I Department of Physics, Syracuse University, Syracuse, New York 13244-1130, - - 2014
Vortices trapped in thin-film superconducting microwave resonators can have a significant influence on the resonator performance. Using a variable-linewidth geometry for a weakly coupled resonator, we are able to observe the effects of a single vortex trapped in the resonator through field cooling. For resonant modes where the vortex is ...
Shemesh Noam N Department of Chemical Physics, Weizmann Institute of Science, Rehovot, - - 2014
Interruptions in cerebral blood flow may lead to devastating neural outcomes. Magnetic resonance has a central role in diagnosing and monitoring these insufficiencies, as well as in understanding their underlying metabolic consequences. Magnetic resonance spectroscopy (MRS) in particular can probe ischemia via the signatures of endogenous metabolites including lactic acid ...
Lim Elizabeth Yenn Lynn EY ORL Department, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia, - - 2014
High acoustic noise level is one of the unavoidable side effects of 3 T magnetic resonance imaging (MRI). A case of hearing loss after 3 T MRI has been reported in this institution and hence this study. The objective of this study was to determine whether temporary threshold shift (TTS) in high ...
van Grinsven S S Department of Orthopaedics, Rijnstate Hospital, PO Box 9555, 6800 TA, Arnhem, The Netherlands. Electronic address: - - 2014
To prospectively evaluate the influence of observer experience, consensus assessment, and abduction and external rotation (ABER) view on the diagnostic performance of magnetic resonance arthrography (MRA) in patients with traumatic anterior-shoulder instability (TASI). Fifty-eight MRA examinations (of which 51 had additional ABER views) were assessed by six radiologists (R1-R6) and ...
Lugez Elodie E Laboratory for Percutaneous Surgery, School of Computing, Queen's University, Kingston, ON, K7L 3N6, - - 2014
Electromagnetic (EM) tracking of instruments within a clinical setting is notorious for fluctuating measurement performance. Position location measurement uncertainty of an EM system was characterized in various environments, including control, clinical, cone beam computed tomography (CBCT), and CT scanner environments. Static and dynamic effects of CBCT and CT scanning on ...
Wijlemans Joost W JW From the *Department of Radiology, and †Imaging Division, University Medical Center Utrecht, Utrecht, The Netherlands; ‡Philips Medical Systems MR, Vantaa, Finland; and §Image Sciences Institute, University Medical Center Utrecht, Utrecht, The - - 2014
Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) allows for noninvasive thermal ablation under real-time temperature imaging guidance. The purpose of this study was to assess the feasibility and safety of MR-HIFU ablation of liver tissue in a clinically acceptable setting. The experimental protocol was designed with a clinical ablation procedure of ...
Smuck Matthew M PM&R Section, Department of Orthopaedic Surgery, Stanford University, Redwood City, California, - - 2014
To quantitatively evaluate interval magnetic resonance imaging (MRI) changes in disc morphology following plasma-mediated percutaneous discectomy. A retrospective comparison of pretreatment and posttreatment MRIs at a single university spine clinic. From a group of 60 consecutively treated patients, 15 met the study inclusion and exclusion criteria. All had either failed ...
Osti Michael M Department for Trauma Surgery and Sports Traumatology, Academic Hospital Feldkirch, Carinagasse 47, 6800, Feldkirch, Austria, - - 2014
For intra- and postoperative evaluation of precise and anatomic graft tunnel position, radiographs (XR) and computed tomography (CT) scans have been suggested. The purpose of this study was to evaluate the reliability and validity of XR and CT for quality assessment following PCL reconstruction. Postoperative radiographs and CT scans were ...
Iwaki Shimpei S Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. - - 2014
Gadolinium(iii) ion (Gd(3+)) complexes are widely used as contrast agents in magnetic resonance imaging (MRI), and many attempts have been made to couple them to sensor moieties in order to visualize biological phenomena of interest inside the body. However, the low sensitivity of MRI has made it difficult to develop ...
Shi Dejing D Department of Ophthalmology, Forth Affiliated Hospital of Harbin Medical University, Harbin, P.R. - - 2014
The aim of this study was to evaluate effects of intermediate frequency magnetic fields (IFMF) generated by a wireless power transmission (WPT) based on magnetic resonance from the perspective of cellular genotoxicity on cultured human lens epithelial cells (HLECs). We evaluated the effects of exposure to 90 kHz magnetic fields at ...
Fries Peter P Clinic of Diagnostic and Interventional Radiology (Geb. 50.1), Saarland University Medical Center, Homburg, - - 2014
Magnetic resonance imaging (MRI) performed at ultra-high field strengths beyond 3 Tesla (T) has become increasingly prevalent in research and preclinical applications. As such, the inevitable clinical implementation of such systems lies on the horizon. The major benefit of ultra-high field MRI is the markedly increased signal-to-noise ratios achievable, enabling acquisition ...
Siebenrock Klaus A KA Department of Orthopaedic Surgery, Inselspital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland, - - 2014
Cam-type femoroacetabular impingement (FAI) resulting from an abnormal nonspherical femoral head shape leads to chondrolabral damage and is considered a cause of early osteoarthritis. A previously developed experimental ovine FAI model induces a cam-type impingement that results in localized chondrolabral damage, replicating the patterns found in the human hip. Biochemical ...
Tampieri Anna - - 2014
A bio-inspired mineralization process was applied to develop biomimetic hybrid scaffolds made of (Fe2+/Fe3+)-doped hydroxyapatite nanocrystals nucleated on self-assembling collagen fibers and endowed with superparamagnetic properties minimizing the formation of potentially cytotoxic magnetic phases such as magnetite or other iron oxide phases. Magnetic composites were prepared at different temperatures and ...
Mulas Gilberto G Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy; Porto Conte Ricerche Srl, Tramariglio, Alghero (SS), - - 2014
Purpose: To describe and quantify the different relaxation mechanisms operating in suspensions of liposomes that encapsulate paramagnetic lanthanide(III) complexes. Theory and Methods: The transverse relaxation rate of lanthanide-loaded liposomes receives contribution from the exchange between intraliposomal and bulk water protons, and from magnetic susceptibility effects. Phospholipids vesicles encapsulating different Ln(III)-HPDO3A ...
Zhang Zhentao Z From the Department of Internal Medicine, University of Texas Southwestern at Austin, Austin, - - 2014
Paradichlorobenzene (PDB) is an aromatic compound found in several household insect repellents and deodorizers. Paradichlorobenzene may cause dependence and damage when inhaled or ingested. Prior cases of PDB neurotoxicity involved ingestion or inhalation of mothballs or occupational exposure. We report the first case of PDB neurotoxicity from chronic toilet bowl ...
Romano Andrea A San Raffaele Foundation Rome, Rehabilitation Facility Ceglie Messapica, Progetto Merit RBNE08E8CZ, Via della Pisana 235, 00163, Rome, Italy, - - 2014
To assess what kind of information MR examination in flexed and extended positions provides in Down syndrome subjects with suspected cranio-cervical instability. Between 2005 and 2008, 35 subjects with DS were recruited in the study. Ethics committee approval was granted and a signed informed consent was obtained from the parents. ...
Gräfe J L JL Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada - - 2014
Gadolinium (Gd) based contrast agents are routinely used as part of many magnetic resonance imaging (MRI) procedures. The widespread use of these agents and concerns about Gd toxicity, motivated us to develop a monitoring procedure that could non-invasively measure quantitatively potential retention of toxic free Gd in tissues after use ...
Carrera Inés I Division of Diagnostic Imaging, Vetsuisse Faculty, University of Zurich, 8057 Zurich, - - 2014
Objective-To investigate clinical use of proton magnetic resonance spectroscopy ((1)H MRS) and to compare metabolic brain bioprofiles of dogs with and without hepatic encephalopathy. Animals-6 dogs with hepatic encephalopathy and 12 control dogs. Procedures-Conventional MRI and single-voxel (1)H MRS were performed with a 3-T magnet. Images for routine MRI planes ...
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