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Tsai Yi-Shan YS Department of Diagnostic Radiology, National Cheng-Kung University College of Medicine and Hospital, Tainan 704, Taiwan, - - 2014
The aim of the present study was to determine the correlation between dual-energy computed tomography (DECT) Hounsfield units (HU) and iron concentration, as well as the correlation between HU and magnetic resonance imaging (MRI)-derived R2(*) values, in phantoms of the heart and liver tissue. Phantoms were constructed containing pig heart ...
Zhou Zijian - - 2014
Iron oxide have been developed as either T1 or T2 MRI contrast agents by controlling their sizes and compositions, however, the underlying mechanism of T1 and T2 contrasts in one iron oxide entity is still not well understood. Herein, we report that freestanding superparamagnetic magnetite nanoplates with (111) exposed facets ...
Wood John C JC Department of Pediatrics, Children's Hospital, Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA; Department of Radiology, Children's Hospital, Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA. Electronic address: - - 2014
Treatment of iron overload requires robust estimates of total-body iron burden and its response to iron chelation therapy. Compliance with chelation therapy varies considerably among patients, and individual reporting is notoriously unreliable. Even with perfect compliance, intersubject variability in chelator effectiveness is extremely high, necessitating reliable iron estimates to guide ...
Wells Shane A SA Department of Radiology and Medical Imaging, University of Virginia Health System, 1215 Lee Street, PO Box 800170, Charlottesville, VA 22908-0170, USA. Electronic address: - - 2014
Magnetic resonance (MR) imaging is a robust, noninvasive tool with the ability to perform a wide array of diagnostic functions within the abdomen. Over the last decade, there has been tremendous interest in the development of MR imaging-based biomarkers for the qualitative and quantitative assessment of liver fat and iron. ...
Siegelman Evan S ES Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 34th and Spruce Streets, 1st Floor Silverstein, Philadelphia, PA 19104-4283, USA. Electronic address: - - 2014
Magnetic resonance (MR) can characterize specific tissue subtypes, thus facilitating focal liver lesion diagnosis. Focal liver lesions that are isointense to hyperintense to liver on T1-weighted images are usually hepatocellular in origin. Chemical shift imaging can narrow the differential diagnosis by detecting the presence of lipid or iron. T2 and ...
Huang Guoming G State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. - - 2014
In this paper, we demonstrate the tunable T1 and T2 contrast abilities of engineered iron oxide nanoparticles with high performance for liver contrast-enhanced magnetic resonance imaging (MRI) in mice. To enhance the diagnostic accuracy of MRI, large numbers of contrast agents with T1 or T2 contrast ability have been widely ...
Enayat Mostafa M Max-Planck-Institut für Festkörperforschung, Heisenbergstrasse 1, D-70569 Stuttgart, - - 2014
Spin-polarized scanning tunneling microscopy (SP-STM) has been used extensively to study magnetic properties of nanostructures. Using SP-STM to visualize magnetic order in strongly correlated materials on an atomic scale is highly desirable, but challenging. We achieved this goal in iron tellurium (Fe1+ yTe), the non-superconducting parent compound of the iron ...
Hu Lingzhi L Consortium for Translational Research in Advanced Imaging and Nanomedicine (C-TRAIN), Washington University School of Medicine, St. Louis, Missouri, - - 2014
Exosomes are cell derived extracellular nanovesicles that relay molecular signals pertinent to both normal physiologic and disease processes. The ability to modify and track exosomes in vivo is essential to understanding exosome pathogenesis, and for utilizing exosomes as effective diagnostic and therapeutic nanocarriers to treat diseases. We recently reported a ...
Kirkeminde Alec - - 2014
One-pot synthesis of FePd and FePd/Fe2O3 (core/shell) nanoparticles via interdiffusion is reported for the first time. It was found that the size of FePd particles and Fe2O3 shell thickness could be controlled by the ligand and iron precursor amounts, respectively. These FePd/Fe2O3 particles can be reductively annealed at 500 °C ...
Gallo Juan J Comprehensive Cancer Imaging Centre, Department of Surgery and Cancer, Hammersmith Campus, Imperial College London, Du Cane Road, London, W12 0NN (UK); Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ - - 2014
MRI offers high spatial resolution with excellent tissue penetration but it has limited sensitivity and the commonly administered contrast agents lack specificity. In this study, two sets of iron oxide nanoparticles (IONPs) were synthesized that were designed to selectively undergo copper-free click conjugation upon sensing of matrix metalloproteinase (MMP) enzymes, ...
Cervadoro Antonio - - 2014
Iron oxide nanoparticles (IOs) are intrinsically theranostic agents that could be used for magnetic resonance imaging (MRI) and local hyperthermia or tissue thermal ablation. Yet, effective hyperthermia and high MR contrast have not been demonstrated within the same nanoparticle configuration. Here, magnetic nanoconstructs are obtained by confining multiple, ~ 20 ...
Figge Lena L Charité - University Medicine Berlin, Berlin, - - 2014
Annexin A5 (Anx) has been extensively used for imaging apoptosis by single-photon emission computed tomography, positron emission tomography, optical imaging and MRI. Recently we introduced ultrasmall Anx-VSOP (very small iron oxide particles) - the smallest high-relaxivity probe for MRI of apoptosis. Here we present a simplified method for the direct ...
Hope Thomas A TA Department of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0628, - - 2014
Over the past decade the role of MR imaging in the evaluation of diffuse liver disease has become common practice. Although detection of focal liver lesions remains the mainstay of liver imaging, a growing cohort of patients are referred for evaluation of hepatosteatosis, iron deposition diseases, and cirrhosis. In particular, ...
Pyatigorskaya Nadya N Institut du Cerveau et de la Moelle épinière, Centre de Neuroimagerie de Recherche, Paris, - - 2014
To date, the most frequently used Parkinson's disease (PD) biomarkers are the brain imaging measures of dopaminergic dysfunction using positron emission tomography and single photon emission computed tomography. However, major advances have occurred in the development of magnetic resonance imaging (MRI) biomarkers for PD in the past decade. Although conventional ...
Dasgupta Subho S Institute for Nanotechnology, Karlsruhe Institute of Technology (KIT), D-76344, Eggenstein-Leopoldshafen, - - 2014
A new concept of controlling magnetism in bulk ferromagnets via reversible lithium chemistry is illustrated. The approach bridges electrochemistry with magnetism and is pertinent to any volume of an intercalation-friendly ferromagnetic material. An iron oxide (maghemite) nanoparticle ensemble, chosen as a representative system, shows a fully reversible and large variation ...
Moon Hye-Jin HJ Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, - - 2014
Previous T2 relaxometry studies have provided evidence for regional brain iron deficiency in patients with restless legs syndrome (RLS). Measurement of the iron content in several brain regions, and in particular the substantia nigra (SN), in early- and late-onset RLS patients using T2 relaxometry have yielded inconsistent results. In this ...
Sarigianni Maria M Clinical Research and Evidence-Based Medicine Unit, Aristotle University Thessaloniki, Thessaloniki, Greece; Knowledge and Evaluation Research Unit, College of Medicine, Mayo Clinic, Minnesota, - - 2014
Guidelines advocate use of magnetic resonance imaging (MRI) to estimate concentrations of iron in liver, identify patients with iron overload, and guide titration of chelation therapy. However, this recommendation was not based on a systematic synthesis and analysis of the evidence for MRI's diagnostic accuracy. We conducted a systematic review ...
Abdelsayed S S Univ Paris Diderot, Sorbonne Paris Cité, ITODYS, UMR 7086, CNRS, 15 rue Jean-Antoine de Baïf, F-75205 Paris, - - 2014
Chlamydia trachomatis (Ct) is a bacterial human pathogen responsible for the development of trachoma, the worldwide infection leading to blindness, and is also a major cause of sexually transmitted diseases. As iron is an essential metabolite for this bacterium, iron depletion presents a promising strategy to limit Ct proliferation. The ...
Suzuki Michimasa M French Institute of Health & Medical Research (Inserm) U1148, Laboratory for Vascular Translational Science, CHU X Bichat, University Paris 7, 46 rue H Huchard, F-75877, - - 2014
Aim: We have designed ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles associated with fucoidan (USPOI-FUCO), a natural sulfated polysaccharide with high affinity for activated platelets, to visualize by MRI arterial thrombi. Materials & methods: USPIOs were prepared and sizes, zeta-potentials and relaxivities were measured. Elastase perfusion in the infrarenal aorta of ...
Gramoun Azza - - 2014
Rheumatoid arthritis (RA) is a chronic disease causing recurring inflammatory joint attacks. These attacks are characterized by macrophage infiltration contributing to joint destruction. Studies have shown that RA treatment efficacy is correlated to synovial macrophage number. The aim of this study was to experimentally validate the use of in vivo ...
Hocq Aline A Biomedical Physics Department, UMONS, 7000, Mons, - - 2014
Iron accumulation is observed in liver and spleen during hemochromatosis and important neurodegenerative diseases involve iron overload in brain. Storage of iron is ensured by ferritin, which contains a magnetic core. It causes a darkening on T2 -weighted MR images. This work aims at improving the understanding of the NMR ...
Podrouzkova Helena H Department of Cardiovascular Diseases, ICRC, St. Anne's University Hospital in Brno, Czech - - 2014
Advances in nanotechnology have lead to the development of a novel contrast media for Magnetic Resonance Imaging (MRI) - the superparamagnetic iron oxide nanoparticle (SPIO). SPIO nanoparticles are used to image inflammation on the cellular level in various settings. This review covers the physicochemical characteristics of SPIO particles as well ...
Chakravarty Rubel R Department of Radiology, University of Wisconsin - Madison, Madison, WI, USA; Isotope Applications and Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, - - 2014
Intrinsically germanium-69-labeled super-paramagnetic iron oxide nanoparticles are synthesized via a newly developed, fast and highly specific chelator-free approach. The biodistribution pattern and the feasibility of (69) Ge-SPION@PEG for in vivo dual-modality positron emission tomography/magnetic resonance (PET/MR) imaging and lymph-node mapping are investigated, which represents the first example of the successful ...
Garbowski Maciej W - - 2014
There is a need to standardise non-invasive measurements of liver iron concentrations (LIC) so clear inferences can be drawn about body iron levels that are associated with hepatic and extra-hepatic complications of iron overload. Since the first demonstration of an inverse relationship between biopsy LIC and liver magnetic resonance (MR) ...
Adachi Yuko Y From the National Center Hospital of Neurology and Psychiatry Radiology, Kodaira, Tokyo, - - 2014
The purpose of the present retrospective study was to evaluate the sensitivity of susceptibility-weighted imaging (SWI) compared to conventional spin-echo T2-weighted and T2*-weighted images in detecting iron deposition in the motor cortex of amyotrophic lateral sclerosis (ALS) patients in comparison with age-matched normal controls. We also investigated the etiology of ...
Kolling Stefan S Sydney Medical School, University of Sydney, NSW 2006, - - 2014
Due to the current interest in MRI-guided radiotherapy, the magnetic properties of the materials commonly used in radiotherapy are becoming increasingly important. In this paper, measurement results for the magnetization (BH) curves of a range of sintered heavy tungsten alloys used in radiation shielding and collimation are presented. Sintered heavy ...
Maurea Simone S Dipartimento di Scienze Biomediche Avanzate, Università degli Studi di Napoli Federico II (UNINA), Istituto di Biostrutture e Bioimmagini-Consiglio Nazionale delle Ricerche (IBB-CNR); Fondazione SDN (IRCCS), Napoli, - - 2014
To compare the diagnostic value of gadolinium (Gd) and ultrasmall superparamagnetic iron oxide (SPIO) contrast media for characterization of focal liver lesions (FLL), we retrospectively evaluated the results of magnetic resonance (MR) imaging in 68 patients (40 M, 28 F, age from 22 to 81 yrs) of which 36 with ...
Petersmann Astrid A Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald , Greifswald , - - 2014
Background. The majority of subarachnoid hemorrhage (SAH) is diagnosed using imaging techniques. The sensitivity of computed tomography scans decreases with increasing time after the bleeding event which can lead to false negative CT scans. Spectrophotometry and microscopic investigations of the cerebrospinal fluid (Csf) can provide additional diagnostic support, but may ...
Zhou Zhiguo Z The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, - - 2014
The development of photothermal agents (PTAs) with good stability, low toxicity, highly targeting ability and photothermal conversion efficiency is an essential pre-requisite to near-infrared photothermal therapy (PTT) in vivo. Herein, we report the readily available PEGylated Fe@Fe3O4 NPs, which possess triple functional properties in one entity - targeting, PTT, and imaging. ...
Gharib Amir - - 2014
Artemisinin is the major sesquiterpene lactones in sweet wormwood (Artemisia annua L.), and its combination with transferrin exhibits versatile anti-cancer activities. Their non-selective targeting for cancer cells, however, limits their application. The aim of this study was to prepare the artemisinin and transferrin-loaded magnetic nanoliposomes in thermosensitive and non-thermosensitive forms ...
Lee Ung Yeol UY Division of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Republic of Korea. Electronic address: - - 2014
Multimeric grain-marked micelles consisting of an inner core micelle (for Fe3O4 encapsulation) and outer multi-grain micelles [for chlorin e6 (Ce6, a model drug) encapsulation] were fabricated using a micelle-to-micelle conjugation method. Grain micelles (mono-thiol functionalized micelles) were chemically linked to the surface of the core micelle (multi-maleimide functionalized micelle). These ...
Blazejewska Anna I AI Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, United - - 2014
To study iron deposition in the substantia nigra (SN) and red nuclei (RN), in patients with clinically isolated syndrome (CIS) and relapsing remitting MS (RRMS) and healthy controls (HC). Iron deposition was assessed using susceptibility maps and T2*-w images acquired at high resolution MRI at 7 Tesla (T). Mean intensities ...
McDevitt Joseph L JL Department of - - 2014
To test the hypothesis that magnetic resonance (MR) imaging can quantify intratumoral superparamagnetic iron oxide (SPIO) nanoparticle uptake after nanoablation. SPIO nanoparticles functionalized with doxorubicin were synthesized. N1-S1 hepatomas were successfully induced in 17 Sprague-Dawley rats distributed into three dosage groups. Baseline tumor R2* values (the reciprocal of T2*) were ...
Jung Hoesu H Department of Biomedical Engineering, UNIST (Ulsan National Institute of Science & Technology), UNIST-gil 50, Ulsan, - - 2014
Contrast-enhancing magnetic resonance mechanism, employing either positive or negative signal changes, has contrast-specific signal characteristics. Although highly sensitive, negative contrast typically decreases the resolution and spatial specificity of MRI, whereas positive contrast lacks a high contrast-to-noise ratio but offers high spatial accuracy. To overcome these individual limitations, dual contrast acquisitions ...
Strickland Matt M Hospital for Sick Children, Toronto, Ontario, Canada; Division of General Surgery, University of Toronto, Toronto, Ontario, Canada. Electronic address: - - 2014
To examine trends in magnet-related injuries and hypothesize that changes are a result of new neodymium-iron-boron magnets that are smaller, stronger, and commonly sold in sets. In this retrospective chart review, we searched our institution's electronic patient record for patients less than 18 years old who were diagnosed with magnetic foreign ...
Cho Hye Rim HR From the Departments of Radiology (H.R.C., D.H.K., W.K.M., M.H.H., S.H.C.), Radiation Applied Life Science (H.R.C.), and Neurosurgery (C.K.P.), Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-744, Korea; Research Institute, National Cancer Center, Gyeonggi-do, Korea (D.K.); Department of Chemistry and Forensic Science, University of Technology, Sydney, Australia (P.D., D.B., D.H.); and Center for Nanoparticle Research, Institute for Basic Science (S.H.C.), and School of Chemical and Biological Engineering (S.H.C.), Seoul National University, Seoul, - - 2014
Purpose To evaluate the use of 5-aminolevulinic acid (5-ALA) for the noninvasive detection of malignant gliomas by using in vivo magnetic resonance (MR) imaging in a mouse brain tumor model. Materials and Methods The experiments were animal care committee approved. U-87 glioblastoma cells were exposed to 5-ALA (500 µmol/L) for ...
Rudko David A DA From the Department of Physics (D.A.R., R.S.M.), Center for Functional and Metabolic Mapping, Robarts Research Institute (D.A.R., I.S., J.S.G., R.S.M.), and Department of Neurology, University Hospital (M.K.), University of Western Ontario, 1151 Richmond St North, London, ON, Canada N6A - - 2014
Purpose To evaluate the potential of quantitative susceptibility (QS) and R2* mapping as surrogate biomarkers of clinically relevant, age-adjusted demyelination and iron deposition in multiple sclerosis (MS). Materials and Methods All study participants gave written informed consent, and the study was approved by the institutional review board. Quantitative maps of ...
Javed Yasir Y Laboratoire Matériaux et Phénomènes Quantiques, UMR 7162 CNRS/Université Paris Diderot, 10 rue Alice Domon et Léonie Duquet, F-75205, Paris Cedex 13, - - 2014
Understanding the relation between the structure and the reactivity of nanomaterials in the organism is a crucial step towards efficient and safe biomedical applications. The multi-scale approach reported here, allows following the magnetic and structural transformations of multicore maghemite nanoflowers in a medium mimicking intracellular lysosomal environment. By confronting atomic-scale ...
Chan Nicky - - 2014
Ultrasmall superparamagnetic iron oxide nanoparticles (USPIOs) with diameters < 5 nm hold great promise as T1-positive contrast agents for in vivo magnetic resonance imaging (MRI). However, control of the surface chemistry of USPIOs to ensure individual colloidal USPIOs with a ligand monolayer and to impart biocompatibility and enhanced colloidal stability ...
Felton Charlette C Department of Chemistry - - 2014
Abstract Improvements in diagnostic measures for biomedical applications have been investigated in various studies for better interpretations of biological abnormalities and several medical conditions. The use of imaging techniques, such as magnetic resonance imaging (MRI), is widespread and becoming a standard procedure for such specialized applications. A major avenue being ...
Wabler Michele M Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine , Baltimore - - 2014
Abstract Purpose: Magnetic iron oxide nanoparticles (MNPs) are used as contrast agents for magnetic resonance imaging (MRI) and hyperthermia for cancer treatment. The relationship between MRI signal intensity and cellular iron concentration for many new formulations, particularly MNPs having magnetic properties designed for heating in hyperthermia, is lacking. In this ...
Schieda Nicola N The Ottawa Hospital, The University of Ottawa, 1053 Carling Avenue; , Ottawa, Ontario, Canada, K1Y 4E9, - - 2014
Detection and quantification of hepatic iron with dual-echo gradient recalled echo (GRE) has been proposed as a rapid alternative to other magnetic resonance imaging (MRI) techniques. Co-existing steatosis and T1 weighting are limitations. This study assesses the accuracy of routine dual-echo GRE. Between 2010 and 2013, 109 consecutive patients underwent ...
Saharkhiz Hodaiseh H Department of Medical Physics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran ; Student Research Committee, School of Medicine, Tabriz University of Medical Sciences, Tabriz, - - 2014
Magnetic nanoparticles have been widely applied in recent years for biomedical applications. Signal intensity (SI) of magnetic resonance (MR) images depends on the concentration of nanoparticles. It is important to find the minimum concentration of iron oxide nanoparticles that produces maximum SI and determines the minimum injection dose for clinical ...
Teerasamit Wanwarang - - 2014
To assess the benefit on diagnosis of hepatocellular carcinoma (HCC) in patients with chronic liver disease or cirrhosis with double contrast MR imaging compared to the routine gadolinium-based MR imaging. Seventy-one consecutive patients with cirrhosis or chronic hepatitis underwent multiphase, gadolinium-enhanced liver MRI examination and sequentially superparamagnetic iron oxide (SPIO)-enhanced ...
Dai Lingling L Department of Radiology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine (TCM), Nanjing 210029 Jiangsu, - - 2014
Polyethylene glycol (PEG)-coated superparamagnetic iron oxide nanoparticles (PEG·SPIONs) were prepared by a facile one-pot approach. The synthesized PEG·SPIONs were found to be uniform in size with an average hydrodynamic diameter of 11.7nm. PEG·SPIONs exhibited excellent dispersibility in water, colloidal stability, and biocompatibility. The magnetic resonance imaging (MRI) properties of PEG·SPIONs ...
Clavijo Jordan M Veronica MV School of Biological and Health Systems Engineering, Arizona State University, Tempe, Arizona, - - 2014
Inorganic doping was used to create flexible, paramagnetic nanoparticle contrast agents for in vivo molecular magnetic resonance imaging (MRI) with low transverse relaxivity (r2 ). Most nanoparticle contrast agents formed from superparamagnetic metal oxides are developed with high r2 . While sensitive, they can have limited in vivo detection due ...
Apple A C AC From the Departments of Radiology and Biomedical Imaging (A.C.A., J.M.L., A.J., S.J.N., C.P.H.) and Neurology (K.L.P., G.S., E.J., K.W., G.A.K., S.J.S., J.H.K., M.D.G.), University of California, San Francisco; and GE Healthcare (D.A.C.K.), Global Applied Sciences Laboratory, Menlo Park, - - 2014
In vivo MR imaging and postmortem neuropathologic studies have demonstrated elevated iron concentration and atrophy within the striatum of patients with Huntington disease, implicating neuronal loss and iron accumulation in the pathogenesis of this neurodegenerative disorder. We used 7T MR imaging to determine whether quantitative phase, a measurement that reflects ...
Lin Adam Y AY Department of Bioengineering, Rice University, 6100 Main Street., Houston, Texas, - - 2014
Designed and fabrication of a novel magnetic hollow gold nanoshell complexes that incorporates iron oxide nanoparticles in the hollow interior. The combined effect of the smaller IONPs improved the overall magnetic properties of the design and MRI contrast capability. The overall complex could be synthesized in the range of 60-80 ...
Harman Aaron A From the *Department of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI; and †Hematology & Oncology Associates of RI, Inc, Cranston, - - 2014
Ferumoxytol is a parenteral iron therapy that the Food and Drug Administration recently approved for the treatment of iron-deficiency anemia. The form of the iron, ultrasmall superparamagnetic iron oxide nanoparticles, causes T1, T2, and T2* shortening on magnetic resonance imaging, which can mimic hemosiderosis. We report such a case, with ...
Akcay Arzu A Pediatric Hematology-Oncology, Department of Pediatrics, Istanbul Kanuni Sultan Suleyman Education and Research Hospital, Turgut Ozal cad No. 1, Halkali, 34306, Istanbul, Turkey, - - 2014
The aim of the study is to assess the relationship between T2* magnetic resonance imaging (MRI) values and age, serum ferritin level, left ventricular ejection fraction (LVEF), splenectomy status, and to identify appropriate modifications to chelation therapy based on T2* MRI results of children with thalassaemia major. Sixty-four patients with ...
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