Search Results
Results 1 - 50 of 1115
1 2 3 4 5 6 7 8 9 10 >
Trivedi Evan R ER Department of Chemistry, Northwestern University, Evanston, IL, USA; Department of Molecular Biosciences, Northwestern University, Evanston, IL, - - 2014
Porphyrazines (Pz), or tetraazaporphyrins, are being studied for their potential use in detection and treatment of cancer. Here, an amphiphilic Cu-Pz-Gd(III) conjugate has been prepared via azide-alkyne Huisgen cycloaddition or 'click' chemistry between an azide functionalized Pz and alkyne functionalized DOTA-Gd(III) analog for use as an MRI contrast agent. This ...
Ghadiri Hossein H Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, - - 2014
Uptake value in quantitative PET imaging is biased due to the presence of CT contrast agents when using CT-based attenuation correction. Our aim was to examine spectral CT imaging to suppress inaccuracy of 511 keV attenuation map in the presence of multiple nanoparticulate contrast agents. Using a simulation study we examined ...
Beziere N N Chair for Biological Imaging, Technische Universität München and Institute for Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, - - 2014
Objectives Rheumatoid Arthritis (RA) is one of the most frequent inflammatory diseases, causing pain and disability in the affected joints. Early diagnosis is essential for the efficiency of symptomatic treatment, and relies on careful clinical, serologic and imaging examinations, such as Magnetic Resonance Imaging (MRI), which is both expensive and ...
Rizzitelli Silvia S Department of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Torino, Via Nizza 52, I-10126, Torino, - - 2014
The work aimed at developing a MRI-guided protocol for the visualization of the release of material entrapped in liposomes stimulated by the local application of pulsed Low Intensity Non Focused Ultrasound (pLINFU). The task was achieved by formulating liposomes filled up with the clinically approved paramagnetic agent Gadoteridol, because the ...
Liu Zhi-Jun ZJ Institute for Advanced Study, Nanchang University, Nanchang 330031, People's Republic of - - 2014
Nanoparticular MRI contrast agents are rapidly becoming suitable for use in clinical diagnosis. An ideal nanoparticular contrast agent should be endowed with high relaxivity, biocompatibility, proper plasma retention time, and tissue-specific or tumor-targeting imaging. Herein we introduce PEGylated KMnF3 nanoparticles as a new type of T1 contrast agent. Studies showed ...
Cisneros Brandon T BT Department of Chemistry & Richard E Smalley Institute for Nanoscale Science & Technology, Rice University, 1900 Rice Blvd, Houston, TX 77005, - - 2014
Aims: Simultaneous positron emission tomography/MRI has recently been introduced to the clinic and dual positron emission tomography/MRI probes are rare and of growing interest. We have developed a strategy for producing multimodal probes based on a carbon nanotube platform without the use of chelating ligands. Materials & methods: Gd(3+) and ...
Fananapazir Ghaneh G Department of Radiology (G.F.), UC Davis Medical Center, 4860 Y Street, Suite 3100, Sacramento, CA 95817. Electronic address: - - 2014
To describe an artifact that mimics thrombosis when assessing abdominal vasculature on magnetic resonance (MR) imaging using ferumoxytol in patients with contraindications to gadolinium-based contrast agents and to evaluate factors that may contribute to this artifact. Three radiologists in consensus retrospectively evaluated 61 abdominal MR imaging examinations using ferumoxytol as ...
Xue Shenghui S Departments of Chemistry and Biology, Georgia State University, Atlanta, Georgia; Center for Diagnostics & Therapeutics (CDT), Georgia State University, Atlanta, Georgia; Center for Biotechnology and Drug Design, Georgia State University, Atlanta, - - 2014
Magnetic resonance imaging (MRI) is the leading imaging technique for disease diagnostics, providing high resolution, three-dimensional images noninvasively. MRI contrast agents are designed to improve the contrast and sensitivity of MRI. However, current clinically used MRI contrast agents have relaxivities far below the theoretical upper limit, which largely prevent advancing ...
Haber Marc D MD From the Department of Radiology, Baystate Medical Center, Tufts University School of Medicine, 759 Chestnut Rd, Springfield, MA - - 2014
Focal spinal cord displacement can be caused by idiopathic spinal cord herniation (ISCH), in which the cord protrudes through a dural defect into the epidural space, causing cord displacement and tethering. ISCH is uncommon and often is misdiagnosed initially, which results in delayed management. ISCH can be mimicked by space-occupying ...
Cheng Liang L Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou, Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, - - 2014
Z. Liu and co-workers introduce on page 1886 a new generation of photothermal theranostic agents based on functionalized WS2 nanosheets, a two-dimensional transition-metal dichalcogenide. Bimodal in vivo CT/photoacoustic imaging reveals strong tumor contrast after either local or systemic injection of WS2 -PEG, which then enables highly effective photothermal ablation of ...
Brüßler Jana J University of Marburg, Department of Pharmaceutical Technology and Biopharmaceutics, Ketzerbach 63, 35037 Marburg, Germany. Electronic address: - - 2014
Ultrasound is a common tool for clinical diagnosis due to its safety and economic. Especially the addition of ultrasound contrast agents leads to a high diagnostic reliability. In recent years ultrasound has been used as a trigger for directed drug delivery or to enhance thrombolysis. We developed a nanoscaled ultrasound ...
Masselli Gabriele G Umberto I Hospital, Radiology Department, Sapienza University, Viale del Policlinico 155, 00161, Rome, Italy, - - 2014
Acute pelvic pain in pregnancy presents diagnostic and therapeutic challenges. Standard imaging techniques need to be adapted to reduce harm to the foetus from X-rays because of their teratogenic and carcinogenic potential. Ultrasound remains the primary imaging investigation of the pregnant abdomen. Magnetic resonance imaging (MRI) has been shown to ...
Ghiassi Kamran B KB Department of Chemistry, University of California, One Shields Avenue, Davis, CA, USA. - - 2014
Gadolinium-containing endohedral fullerenes represent a new class of effective relaxation agents for magnetic resonance imaging (MRI). The range of different structures possible for this class of molecules and their properties as MRI agents are reviewed here.
Blasiak Barbara B Department of Clinical Neurosciences, University of Calgary, 3330 Hospital Dr NW, Calgary,Alberta, T2N 4N1, Canada; Polish Academy of Sciences, Institute of Nuclear Physics, Krakow,152Radzikowskiego, Krakow, Malopolska, 31-342, - - 2014
Glioma is the most common and most difficult to treat brain cancer. Despite many efforts treatment, efficacy remains low. As neurosurgical removal is the standard procedure for glioma, a method, allowing for both early detection and exact determination of the location, size and extent of the tumor, could improve a ...
Van Roosbroeck Ruben - - 2014
We present the top-down synthesis of a novel type of MRI T2 contrast agent with great control over size and shape using a colloidal lithography technique. The resulting synthetic antiferromagnetic nanoparticles (SAF-NPs) yield improved relaxivities compared to superparamagnetic iron oxide alternatives (SPIONs). For T2 weighted imaging, the outer sphere relaxation ...
Mitsumori Lee M LM From the University of Washington, - - 2014
The purpose of this article was to review the basic properties of available gadolinium-based magnetic resonance contrast agents, discuss their fundamental differences, and explore common and evolving applications of gadolinium-based magnetic resonance contrast throughout the body excluding the central nervous system. A more specific aim of this article was to ...
Yang Jun J Yuhuangding Hospital, Yantai, Shandong Province, China. Electronic address: - - 2014
A recent international, multicenter, double-blinded, randomized trial shows delayed-enhanced magnetic resonance imaging (DE-MRI) using contrast doses of ≥0.2mmol/kg is effective in the detection and assessment of myocardial infarction (MI), and 0.1mmol/kg is not enough; intermediate doses between 0.1 and 0.2mmol/kg have not been tested. The aim of this study was ...
Chopier J J Radiology Department, hôpital Tenon, 56, avenue Gambetta, 75020 Paris, France. Electronic address: - - 2014
MRI-guided biopsy is a recent interventional breast technique. Validating the procedure poses a new problem because the signal targeted is created by the injection of a paramagnetic contrast agent and is thus transitory. In the first instance, the procedure is validated by the radiologist, who checks that targeting is accurate ...
Dibb Russell R Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina, USA; Biomedical Engineering, Duke University, Durham, North Carolina, - - 2014
MR histology based on magnetic susceptibility can be used to visualize diamagnetic myelin (and its deterioration) in the central nervous system and is facilitated by the application of high magnetic field strengths and paramagnetic contrast agents. Characterizing the effect of these tools will aid in assessing white matter myelin content ...
Phinikaridou Alkystis A From the Division of Imaging Science and Biomedical Engineering (A.P., M.E.A., A.I., R.M.B.), Academic Department of Surgery, Cardiovascular Division (A.S., P.S.), BHF Centre of Excellence, Cardiovascular Division (A.P., A.S., P.S., R.M.B.), and Wellcome Trust and EPSRC Medical Engineering Center (R.M.B.), King's College London, The Rayne Institute, 4th Floor, Lambeth Wing, St Thomas' Hospital, London SE1 7EH, England; and Lantheus Medical Imaging, North Billerica, Mass (D.C.O., R.R.C., - - 2014
Purpose To compare delayed-enhancement (DE) magnetic resonance (MR) imaging with an elastin-specific contrast agent and unenhanced black-blood (BB) MR imaging with regard to vessel wall delineation and assessment of vascular remodeling and to test the prospective value for predicting plaque disruption in a rabbit model of atherosclerosis. Materials and Methods ...
Wha Lee Seung LS Department of Radiology, Korea University Ansan Hopsital, # 516 GoJan 1-dong, Ansan-si, Gyeonggi-do, Korea, - - 2014
To describe the patterns of bile distribution in the biliary tree, duodenum, jejunum, and stomach, and to determine the gallbladder ejection fraction (GBEF) by using functional magnetic resonance cholangiography (MRC) with gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) in healthy volunteers. Forty subjects were included in this study. After conventional MRC, pre-fatty meal ...
Yang Yuping Y School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, People's Republic of China, - - 2014
A binary targeting vector that consists of peptide sequences of Arg-Gly-Asp (RGD) and Asn-Gly-Arg (NGR) motifs has been designed and synthesized using solid-phase peptide synthesis procedure. The vector is then coupled with Gd-DOTA to work as a targeting contrast agent (CA1) for magnetic resonance imaging of human lung adenocarcinoma cells ...
Pierre Valérie C VC Department of Chemistry, University of Minnesota, Minneapolis, MN, 55455, USA, - - 2014
Thirty years ago, Schering filed the first patent application for a contrast agent for magnetic resonance imaging (MRI) covering the forefather of the gadolinium contrast agents and still the most widely used gadolinium probe: gadolinium(III) diethylenetriaminepentaacetate (Magnevist). To date, 11 contrast agents have been approved by the US Food and ...
García-Carrasco Mario M Systemic Autoimmune Diseases Research Unit, HGR 36, Instituto Mexicano del Seguro Social, Puebla, México; Department of Rheumatology and Immunology, Benemérita Universidad Autónoma de Puebla, - - 2014
Susac syndrome (SS) is an autoimmune disease characterized by the clinical triad of encephalopathy, branch retinal artery occlusions and neuro-sensorial hearing loss; it is due to a microangiopathy affecting the precapillary arterioles of the brain, retina and inner ear. SS is characterized by typical radiological features on magnetic resonance imaging ...
Nofiele Joris Tchouala JT The Research Institute and Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, - - 2014
To evaluate a new formulation of manganese porphyrin as a potential gadolinium (Gd)-free extracellular magnetic resonance imaging (MRI) contrast agent for dynamic contrast-enhanced (DCE) MRI of tumors. A previously reported new contrast agent, MnTCP, was evaluated in six female tumor-bearing nude rats. MRI was performed on a 3 T clinical ...
de Rosales Rafael T M RT Department of Imaging Chemistry & Biology, Division of Imaging Sciences and Biomedical Engineering, King's College London, St. Thomas' Hospital, London, SE1 7EH, - - 2014
The introduction to the clinic of positron emission tomography-magnetic resonance imaging scanners opens up the possibility to evaluate the real potential of bimodal imaging agents. In this mini-review, the limitations in the design and applications of these materials are summarised and the unique properties that may result in real clinical ...
Ni Dalong - - 2014
Surgical resection, one of the main clinical treatments of intracranial glioblastoma, bears the potential risk of incomplete excision due to the inherent infiltrative character of the glioblastoma. To maximize the accuracy of surgical resection, the magnetic resonance (MR) and fluorescence imaging are widely used for the tumor preoperative diagnosis and ...
Kording Fabian F Department of Radiology Medical Physics, University Medical Center, Freiburg, - - 2014
Combining multiple imaging biomarkers in one magnetic resonance imaging (MRI) session would be beneficial to gain more data pertaining to tumor vasculature under therapy. Therefore, simultaneous measurement of perfusion, permeability, and vessel size imaging (VSI) using a gradient echo spin echo (GE-SE) sequence with injection of a clinically approved gadolinium ...
Jakhmola Anshuman A University of Strasbourg, Faculty of Pharmacy, 74 Route du Rhin, 67401 Illkirch, France; CNRS 7199, Laboratoire de Conception et Application de Molécules Bioactives, équipe de Pharmacie Biogalénique, 67401 Illkirch, - - 2014
Inorganic nanomaterials based on heavy elements represent a new class of contrast agents for X-ray computed tomography (CT). Recent advances have shown that these materials are highly suited for CT imaging due to their high density and X-ray absorption capabilities. In this contribution, we demonstrated that tungsten oxide (WO3) nanoparticles ...
Dong Kai K State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Changchun, 130022, China. jren@ciac.jl.cn - - 2014
In the present work, a novel non-lanthanide dual-modality contrast agent, manganese tungstate (MnWO4), has been successfully constructed by a facile and versatile hydrothermal route. With the merits of a high atomic number and a well-positioned K-edge energy of tungsten, our well-prepared non-lanthanide nanoprobes provide a higher contrast efficacy than routine ...
Huhtala Tuulia - - 2014
The main goal in modern biomedicine is to develop specific diagnostic and therapeutic agents for different diseases. Especially in cancer research tumor targeted molecules are the key factor in the development of new anti-tumor drugs. In addition, the early diagnosis of the disease is an important factor for a successful ...
Shimizu Hisao H Department of Neurology, Nara City - - 2014
A 60-year-old man visited our hospital because of left hemiparesis in September 2006. Magnetic resonance imaging (MRI) revealed a high-intensity lesions in the right corona radiata on diffusion-weighted images and a high-intensity lesions in the basal ganglia and deep white matter on T2-weighted images. He recovered with no sequelae. Antithrombotic ...
Nakashima Yoshito Y National Institute of Advanced Industrial Science and Technology, Geological Survey of Japan, Tsukuba, Ibaraki, - - 2014
Iodine is commonly used as a contrast agent in nonmedical science and engineering, for example, to visualize Darcy flow in porous geological media using X-ray computed tomography (CT). Undesirable beam hardening artifacts occur when a polychromatic X-ray source is used, which makes the quantitative analysis of CT images difficult. To ...
Liu Yanlan Y State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, People's Republic of China; Chinese Academy of Sciences, Beijing, 100039, People's Republic of - - 2014
X-ray computed tomography (CT) imaging is one of the most widely used diagnostic imaging techniques in the clinic, and has raised significant interest in recent years both in research and practice owing to its many advantages such as deep penetration depth, high resolution and facile image processing. Developing heavy metal-based ...
Hagberg Gisela E GE Department for Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen, - - 2014
Calcium-sensitive MRI contrast agents can only yield quantitative results if the agent concentration in the tissue is known. The agent concentration could be determined by diffusion modeling, if relevant parameters were available. We have established an MRI-based method capable of determining diffusion properties of conventional and calcium-sensitive agents. Simulations and ...
Cormode David P DP Departments of Radiology, University of Pennsylvania, 3400 Spruce St, 1 Silverstein, Philadelphia, PA, 19104, - - 2014
Computed tomography (CT) is an X-ray-based whole-body imaging technique that is widely used in medicine. Clinically approved contrast agents for CT are iodinated small molecules or barium suspensions. Over the past seven years there has been a great increase in the development of nanoparticles as CT contrast agents. Nanoparticles have ...
Ferrauto Giuseppe - - 2013
Chemical Exchange saturation Transfer (CEST) agents are a new class of frequency-encoding MRI contrast agents with a great potential for molecular and cellular imaging. As for other established MRI contrast agents, the main drawback deals with their low sensitivity. The sensitivity issue may be tackled by increasing the number of ...
Hu Yun Hang YH Department of Materials Science and Engineering, Michigan Technological University, Houghton, Michigan, 49931, - - 2013
Fluorinated graphene oxide (FGO), which can exhibit contrast in T2 mode, is the first carbon-based MRI contrast agent without the incorporation of magnetic nanoparticles. Furthermore, FGO can also be used as a promising agent for the ultrasound imaging and the therapeutic application.
Cheng Liang L Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou, Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, - - 2013
A new generation of photothermal theranostic agent is developed based on PEGylated WS2 nanosheets. Bimodal in vivo CT/photoacoustic imaging reveals strong tumor contrast after either intratumoral or intravenous injection of WS2 -PEG. In vivo photothermal treatment is then conducted in a mouse tumor model, achieving excellent therapeutic efficacy with complete ...
Qazi Shefah S Chemistry and Biochemistry Department, Montana State University, Bozeman, MT, 59717, - - 2013
Virus-like particles are powerful platforms for the development of functional hybrid materials. Here, we have grown a cross-linked polymer (cross-linked aminoethyl methacrylate) within the confines of the bacteriophage P22 capsid (P22-xAEMA) and functionalized the polymer with various loadings of paramagnetic manganese(III) protoporphyrin IX (MnPP) complexes for evaluation as a macromolecular magnetic ...
Watcharin Waralee W Institute of Pharmaceutical Technology, Goethe-University, Frankfurt, D-60438 - - 2013
Tumor visualization by magnetic resonance imaging (MRI) and nanoparticle-based contrast agents may improve the imaging of solid tumors such as hepatocellular carcinoma (HCC). In particular, human serum albumin (HSA) nanoparticles appear to be a suitable carrier due to their safety and feasibility of functionalization. In the present study HSA nanoparticles ...
Cheng Weiran - - 2013
Mn(III)Porphyrin (MnP) holds the promise to address the emerging challenges associated with Gd-based clinical MRI contrast agents (CAs), namely Gd-related adverse effect and decreasing sensitivity at high clinical magnetic fields. Two complementary strategies for developing new MnPs as Gd-free CAs with optimized biocompatibility were established to improve relaxivity or clearance ...
Fujimoto Kenji K Department of Neurosurgery, National Hospital Organization Kumamoto Medical Center, 1-5, Ninomaru, Chuo-ku, Kumamoto 860-0008, Japan; Department of Neurosurgery, Faculty of Life Sciences, Kumamoto University School of Medicine, 1-1-1, Honjo, Kumamoto, Kumamoto 861-8556, Japan. Electronic address: - - 2013
Acute subdural hematoma (ASDH) usually requires emergency surgical decompression, but rare cases exhibit rapid spontaneous resolution. The aim of this retrospective study was to identify factors predictive of spontaneous ASDH resolution. A total of 366 consecutive patients with ASDH treated between January 2006 and September 2012 were identified in our ...
Das Raj - - 2013
This study was designed to undertake systematic review and meta-analysis of published comparative trials comparing embolic agents used in uterine artery embolisation (UAE) for uterine leiomyomata. Systematic literature searches were performed in MEDLINE, Embase, PubMed, and Cochrane Central databases from database inception to July 2012. Randomised and nonrandomised trials comparing ...
Wasser Elliot J - - 2013
OBJECTIVE. The purpose of this study is to quantify the time expenditure associated with radiologist ordering of CT oral contrast media when using an integrated protocoling portal and to determine radiologists' perceptions of the ordering process. SUBJECTS AND METHODS. This prospective study was performed at a large academic tertiary care ...
Zeng Meng-Su - - 2013
Contrast agents help to improve visibility in magnetic resonance (MR) imaging. However, owing to the large interstitial spaces of the liver, there is a reduction in the natural contrast gradient between lesions and healthy tissue. This study was undertaken to evaluate the efficacy and safety of the liver-specific MR imaging ...
Lee Ji Youn JY Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, South Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea; Department of Radiation Applied Life Science, Seoul National University College of Medicine, Seoul, South - - 2013
Positron emission tomography (PET) may provide more accurate quantification of kidney function such as glomerular filtration rate (GFR) than gamma imaging. The purpose of these experiments was to prepare and evaluate Ga-68 complexes as potential PET agents for measurement of GFR. We labeled EDTA, DTPA, DOTA, and NOTA with Ga-68 ...
Zhu Jing - - 2013
Water-soluble Au-Fe3O4 heterostructured nanoparticles with high biocompatibility were synthesized and applied as a dual modality contrast agent. These nanoparticles present strong CT/MRI contrast enhancement in a rabbit model. Low concentrations of Au-Fe3O4 were found to obtain a similar effect to high concentrations of a commercial iodine agent in the CT ...
Tsitovich Pavel B - - 2013
Trigger ready: A redox-activated MRI contrast agent can cycle between paramagnetic Co(II) (MRI-active) and diamagnetic Co(III) (MRI-silent). The paramagnetic Co(II) form produces a highly shifted CEST signal at 135 ppm (37 °C). The redox state of the Co complex is altered by O2 partial pressure and reductant concentration (thiols) on a ...
Cheng Hai-Ling Margaret - - 2013
To evaluate a new class of manganese porphyrins with tunable pharmacokinetics as potential gadolinium (Gd)-free T1 agents for contrast-enhanced magnetic resonance imaging (MRI). Two new contrast agents, MnTCP and MnP2, were evaluated in four female rats. MRI was performed daily up to 3 days postinjection (0.05 mmol/kg) on a 3 ...
1 2 3 4 5 6 7 8 9 10 >