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Frisoni Giovanni B GB LENITEM (Laboratory of Epidemiology, Neuroimaging and Telemedicine) IRCCS - Istituto Centro S. Giovanni di Dio - Fatebenefratelli, Brescia, Italy; Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, - - 2014
An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance. Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative ...
Qian Chunqi C NIH - - 2014
The local sensitivity of MRI can be improved with small MR detectors placed close to regions of interest. But in order to maintain such sensitivity advantage, local detectors normally need to communicate with the external amplifier through cable connections, which prevent the use of local detectors as implantable devices. Recently, ...
Harrison Victoria S R VS Department of Chemistry, Molecular Biosciences, Neurobiology, Biomedical Engineering, and Radiology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA. - - 2014
We describe the design, synthesis and in vitro evaluation of a multimodal and multimeric contrast agent. The agent consists of three macrocyclic Gd(iii) chelates conjugated to a fluorophore and possesses high relaxivity, water solubility, and is nontoxic. The modular synthesis is amenable for the incorporation of a variety of fluorophores ...
Motosugi Utaroh U Department of Radiology, University of Wisconsin, Madison, Wisconsin, USA; Department of Radiology, University of Yamanashi, Yamanashi, - - 2014
Hepatocellular carcinoma (HCC) develops via multistep hepatocarcinogenesis, during which hypovascular/early HCC precedes the typical hypervascular HCC. The hypovascular HCC lacks the typical hallmark imaging features of HCC, such as late arterial phase enhancement and portal venous washout, limiting early detection using conventional extracellular contrast agents for dynamic magnetic resonance imaging ...
Cantisani Vito V Vito Cantisani, Hektor Grazhdani, Cristina Fioravanti, Maria Rosignuolo, Daniela Messineo, Maria Giulia Bernieri, Adriano Redler, Carlo Catalano, Ferdinando D'Ambrosio, Department of Radiology, Oncology and Anatomo-Pathology "Sapienza" University of Rome, 00161 Rome, - - 2014
The development of ultrasound contrast agents with excellent tolerance and safety profiles has notably improved liver evaluation with ultrasound (US) for several applications, especially for the detection of metastases. In particular, contrast enhanced ultrasonography (CEUS) allows the display of the parenchymal microvasculature, enabling the study and visualization of the enhancement ...
Koh Dow-Mu DM Department of Radiology Royal Marsden NHS Foundation Trust Downs Road Sutton SM2 5PT, England Supported by the NIHR Biomedical Research Centre and CRUK and EPSRC Cancer Imaging Centre - - 2014
Summary In the study by Joo et al ( 1 ), perfusion-sensitive parameters derived from diffusion-weighted (DW) magnetic resonance (MR) imaging using intravoxel incoherent motion (IVIM) analysis were significantly decreased 4 hours after administration of a vascular disrupting agent (VDA) (CKD-516), in keeping with drug-induced vascular collapse. A larger decrease ...
Beckmann Section of Neurology, Department of Small Animals, Vetsuisse Faculty, University of - - 2014
Tick borne encephalitis virus (TBE) is an endemic infectious agent in northeastern Switzerland causing mainly meningoencephalomyelitis in dogs. We report a canine case of tick born meningoencephalomyelitis resulting in flaccid tetraplegia and, subsequently, fatal respiratory failure. Magnetic resonance imaging (MRI) demonstrated intra-axial bilateral, symmetric, and hyperintense lesions in T2-weighted and ...
Bashir Mustafa R MR Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA. Electronic address: - - 2014
Intravenous contrast agents are important in the performance of liver magnetic resonance (MR) imaging. These agents differ in their physical properties. These differences can be exploited to optimize imaging protocols based on indications for examination. Institutional protocols should be designed to take advantage of the variety of available contrast agent ...
Kuda-Wedagedara Akhila N W AN Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA. - - 2014
Contrast agents are diagnostic tools that often complement magnetic resonance imaging. At ultra-high field strengths (≥7 T), magnetic resonance imaging is capable of generating desirable high signal-to-noise ratios, but clinically available contrast agents are less effective at ultra-high field strengths relative to lower fields. This gap in effectiveness demands the ...
Yang Peng - - 2014
Nanorattles, as promising functional hollow nanomaterials, show considerable advantages in a variety of applications for drug delivery, biosensors and biomedical imaging because of their tailored ability in both the movable core and shell. In this study, we formulate a facile controllable route to synthesize monodisperse magnetic nanorattle with Fe3O4 superparticle ...
Shafieyan Yousef Y Chemical Engineering Department, McGill University, Montreal, - - 2014
Cartilage has a limited capacity for self-repair and focal damage can eventually lead to complete degradation of the tissue. Early diagnosis of degenerative changes in cartilage is therefore essential. Contrast agent-based computed tomography and magnetic resonance imaging provide promising tools for this purpose. However, the common assumption in clinical applications ...
Galbusera Fabio F IRCCS Istituto Ortopedico Galeazzi, via Galeazzi 4, 20161 Milan, Italy. Electronic address: - - 2014
Decreased nutrition has been proposed as a potential mechanism leading to intervertebral disc degeneration. A method to investigate it in vivo is the MRI evaluation of the transport of a paramagnetic contrast agent, which is assumed to diffuse through the endplate to the disc using the same mechanisms as the ...
Trivedi Evan R ER Department of Chemistry, Northwestern University, Evanston, IL, USA; Department of Molecular Biosciences, Northwestern University, Evanston, IL, - - 2014
Porphyrazines (Pz), or tetraazaporphyrins, are being studied for their potential use in detection and treatment of cancer. Here, an amphiphilic Cu-Pz-Gd(III) conjugate has been prepared via azide-alkyne Huisgen cycloaddition or 'click' chemistry between an azide functionalized Pz and alkyne functionalized DOTA-Gd(III) analog for use as an MRI contrast agent. This ...
Pappachan Joseph M JM Department of Endocrinology, Walsall Manor Hospital, West Midlands, WS2 9PS, UK, - - 2014
Pheochromocytomas (PCCs) are rare catecholamine producing neuroendocrine tumors. The majority of these tumors (85 %) arise from the adrenal medulla. Those arising from the extra-adrenal neural ganglia are called paragangliomas (PGLs). Paroxysmal hypertension with sweating, headaches and palpitation are the usual presenting features of PCCs/ PGLs. Gene mutations are reported in ...
Guglielmo Flavius F FF Department of Radiology, Thomas Jefferson University Hospital, 132 South 10th Street, Philadelphia, PA 19107, USA. Electronic address: - - 2014
Proper selection of a gadolinium-based contrast agent (GBCA) for body magnetic resonance imaging (MRI) cases requires understanding the indication for the MRI exam, the key features of the different GBCAs, and the effect that the GBCA has on the selected imaging protocol. The different categories of GBCAs require timing optimization ...
Dori Yoav Y From the Division of Cardiology and Department of Radiology, Children's Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104 (Y.D.); Department of Cardiology, Johns Hopkins Hospital, Baltimore, Md (M.M.Z.); and Division of Interventional Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa - - 2014
Purpose To demonstrate the feasibility of dynamic four-dimensional (4D) intranodal contrast material-enhanced magnetic resonance (MR) lymphangiography with inguinal lymph node injection of gadopentetate dimeglumine. Materials and Methods All procedures were performed in accordance with the guidelines on the use of animals in research and were approved by the animal care ...
Bashir Mustafa R MR Department of Radiology, Duke University Medical Center, Durham, North Carolina, - - 2014
Ferumoxytol is an ultrasmall superparamagnetic iron oxide (USPIO) agent initially approved by the Food and Drug Administration (FDA) as an iron replacement therapy for patients with anemia due to chronic renal failure. Recently, ferumoxytol has been investigated extensively as an intravenous contrast agent in magnetic resonance imaging (MRI). Since it ...
Chen Yilong - - 2014
We herein report a novel dual-modal MRI contrast agent, TPE-2Gd, for both magnetic and fluorescence imaging. TPE-2Gd consists of a hydrophobic tetraphenylethene (TPE) fluorophore and two hydrophilic gadolinium (Gd) diethylenetriaminepentaacetic acids moieties. As an amphiphilic molecule, TPE-2Gd aggregates into micelles at high concentration in aqueous medium. These aggregates are highly ...
Xiao Yan Y State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Renmin Street 5625, Changchun 130022, PR China; National Analytical Research Center of Electrochemistry and Spectroscopy, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Renmin Street 5625, Changchun 130022, PR - - 2014
A novel biocompatible macromolecule (AG-CM-EDA-DOTA-Gd) was synthesized as a liver magnetic resonance imaging (MRI) contrast agent. AG-CM-EDA-DOTA-Gd consisted of a carboxymethyl-arabinogalactan unit conjugated with gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Gd-DOTA) via ethylenediamine, and was specifically designed to bind to hepatocyte asialoglycoprotein in vivo, in an effort to develop a potential new tool for ...
Valero Elsa - - 2014
New long-circulating maghemite nanoparticles of 4 and 6 nm coated with the apoferritin protein capsid exhibit useful properties to act as MRI contrast agents. A full in vivo study of the so-called Apomaghemites, reveals that their long-term MRI properties are better than those of a standard SPIO widely used in ...
Do Quyen N QN Department of Chemistry, The University of Texas at Dallas, 800 West Campbell, BE26, Richardson, TX 75080 - - 2014
The development of responsive or "smart" magnetic resonance imaging (MRI) contrast agents that can report specific biomarker or biological events has been the focus of MRI contrast agent research over the past 20 years. Among various biological hallmarks of interest, tissue redox and hypoxia are particularly important owing to their ...
Bannwarth Markus B MB Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany; Graduate School Materials Science in Mainz, Staudinger Weg 9, 55128, Mainz, - - 2014
The synthesis of a novel nanocapsule-based carrier system is described, possessing a triggered release in remote-controlled fashion upon application of an external magnetic field in combination with the possibility to use the capsules as contrast agents for magnetic resonance imaging (MRI). Therefore, polymeric nanocontainers containing a high amount of superparamagnetic ...
Kadjane Pascal P Department for Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, 72076 Tübingen - - 2014
Responsive or smart magnetic resonance imaging (MRI) contrast agents are molecular sensors that alter the MRI signal upon changes in a particular parameter in their microenvironment. Consequently, they could be exploited for visualization of various biochemical events that take place at molecular and cellular levels. In this study, a set ...
Wang Zhe Z Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, MD, 20892, - - 2014
(19) F MRI and optical imaging are two powerful noninvasive molecular imaging modalities in biomedical applications. (19) F MRI has great potential for high resolution in vivo imaging, while fluorescent probes enable ultracontrast cellular/tissue imaging with high accuracy and sensitivity. A bimodal nanoprobe is developed, integrating the merits of (19) ...
Sutphin Patrick D PD Division of Interventional Radiology, Department of Radiology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8834, - - 2014
MR angiography is a powerful tool in evaluating anatomy and pathology when applied to the male pelvis. MR angiography produces high-quality images of the arterial system approaching the resolution of CT angiography, without ionizing radiation. Additional advantages include the ability to obtain angiographic images in the absence of contrast material ...
López-Cebral Rita R Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela (USC), Campus Sur, 15782 Santiago de Compostela, - - 2014
Significant progress has been made over the last three decades in the field of NMR, a technique which has proven to have a variety of applications in many scientific disciplines, including nanotechnology. Herein we describe how NMR enables the characterization of nanosystems at different stages of their formation and modification ...
Melamud Kira K From the Department of Radiology, Boston University Medical Center, 820 Harrison Ave, 3rd Floor, Boston, MA - - 2014
Although traumatic and iatrogenic bile leaks are rare, they have become more prevalent in recent years due to an increased propensity toward nonsurgical management of patients with liver trauma and an overall increase in the number of hepatobiliary surgeries being performed. Because clinical signs and symptoms of bile leaks are ...
Song Xiaolei X Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, - - 2014
Diamagnetic chemical exchange saturation transfer (diaCEST) agents are a new class of imaging agents, which have unique magnetic resonance (MR) properties similar to agents used for optical imaging. Here we present a series of anthranilic acid analogs as examples of diaCEST agents that feature an exchangeable proton shifted downfield, namely, ...
Jin Erlei E Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, - - 2014
Current clinical CT contrast agents are mainly small molecular iodinated compounds, which often suffer from short blood pool retention for more comprehensive cardiovascular CT imaging and may cause contrast-induced nephropathy. In this work, we prepared polydisulfides containing a traditional iodinated CT contrast agent in order to optimize the pharmacokinetics of ...
Liu Vincent H VH Departments of Electrical Engineering and Computer Science and Materials Science and Engineering and The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA - - 2014
Targeted MRI contrast agents have proven useful in research and clinical studies for highlighting specific metabolites and biomarkers [Davies GL, et al. (2013) Chem Commun (Camb) 49(84):9704-9721] but their applicability in serial imaging is limited owing to a changing concentration postinjection. Solid enclosures have previously been used to keep the ...
Zhang Long Jiang LJ Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210002, China, - - 2014
To evaluate the feasibility, image quality and radiation dose of prospectively ECG-triggered high-pitch coronary CT angiography (CCTA) with 30 mL contrast agent at 70 kVp. Fifty-eight patients with suspected coronary artery disease, a body mass index (BMI) of less than 25 kg/m(2), sinus rhythm and a heart rate (HR) of less than 70 ...
Yip Hon Chi HC Hon Chi Yip, Anthony Yuen Bun Teoh, Charing Ching Ning Chong, James Yun Wong Lau, Department of Surgery, Prince of Wales Hospital, the Chinese University of Hong Kong, Hong Kong, - - 2014
Endoscopic ultrasonography (EUS) is currently an integral investigation of many gastrointestinal disorders. It has been shown to have a higher efficacy than conventional computed tomography in detection and characterization of small lesions especially in the pancreas. Much effort has been put to further improve the sensitivity, specificity and overall accuracy ...
Ghadiri Hossein H Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, - - 2014
Uptake value in quantitative PET imaging is biased due to the presence of CT contrast agents when using CT-based attenuation correction. Our aim was to examine spectral CT imaging to suppress inaccuracy of 511 keV attenuation map in the presence of multiple nanoparticulate contrast agents. Using a simulation study we examined ...
Beziere N N Chair for Biological Imaging, Technische Universität München and Institute for Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, - - 2014
Objectives Rheumatoid Arthritis (RA) is one of the most frequent inflammatory diseases, causing pain and disability in the affected joints. Early diagnosis is essential for the efficiency of symptomatic treatment, and relies on careful clinical, serologic and imaging examinations, such as Magnetic Resonance Imaging (MRI), which is both expensive and ...
Rimkus Carolina de Medeiros Cde M Department of Radiology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, - - 2014
Toxic leukoencephalopathies can be secondary to the exposure to a wide variety of exogenous agents, including cranial irradiation, chemotherapy, antiepileptic agents, drugs of abuse, and environmental toxins. There is no typical clinical picture, and patients can present with a wide array of signs and symptoms. Involvement of white matter is ...
Patenaude Yves Y Sherbrooke - - 2014
Objective: To review the biological effects and safety of magnetic resonance imaging (MRI) in the obstetric patient and to review procedural issues, indications, and contraindications for obstetrical MRI. Outcomes: This guideline is intended to reassure patients and clinicians of the safety of MRI in pregnancy and to provide a framework ...
Rizzitelli Silvia S Department of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Torino, Via Nizza 52, I-10126, Torino, - - 2014
The work aimed at developing a MRI-guided protocol for the visualization of the release of material entrapped in liposomes stimulated by the local application of pulsed Low Intensity Non Focused Ultrasound (pLINFU). The task was achieved by formulating liposomes filled up with the clinically approved paramagnetic agent Gadoteridol, because the ...
Liu Zhi-Jun ZJ Institute for Advanced Study, Nanchang University, Nanchang 330031, People's Republic of - - 2014
Nanoparticular MRI contrast agents are rapidly becoming suitable for use in clinical diagnosis. An ideal nanoparticular contrast agent should be endowed with high relaxivity, biocompatibility, proper plasma retention time, and tissue-specific or tumor-targeting imaging. Herein we introduce PEGylated KMnF3 nanoparticles as a new type of T1 contrast agent. Studies showed ...
Cisneros Brandon T BT Department of Chemistry & Richard E Smalley Institute for Nanoscale Science & Technology, Rice University, 1900 Rice Blvd, Houston, TX 77005, - - 2014
Aims: Simultaneous positron emission tomography/MRI has recently been introduced to the clinic and dual positron emission tomography/MRI probes are rare and of growing interest. We have developed a strategy for producing multimodal probes based on a carbon nanotube platform without the use of chelating ligands. Materials & methods: Gd(3+) and ...
Fananapazir Ghaneh G Department of Radiology (G.F.), UC Davis Medical Center, 4860 Y Street, Suite 3100, Sacramento, CA 95817. Electronic address: - - 2014
To describe an artifact that mimics thrombosis when assessing abdominal vasculature on magnetic resonance (MR) imaging using ferumoxytol in patients with contraindications to gadolinium-based contrast agents and to evaluate factors that may contribute to this artifact. Three radiologists in consensus retrospectively evaluated 61 abdominal MR imaging examinations using ferumoxytol as ...
Xue Shenghui S Departments of Chemistry and Biology, Georgia State University, Atlanta, Georgia; Center for Diagnostics & Therapeutics (CDT), Georgia State University, Atlanta, Georgia; Center for Biotechnology and Drug Design, Georgia State University, Atlanta, - - 2014
Magnetic resonance imaging (MRI) is the leading imaging technique for disease diagnostics, providing high resolution, three-dimensional images noninvasively. MRI contrast agents are designed to improve the contrast and sensitivity of MRI. However, current clinically used MRI contrast agents have relaxivities far below the theoretical upper limit, which largely prevent advancing ...
Haber Marc D MD From the Department of Radiology, Baystate Medical Center, Tufts University School of Medicine, 759 Chestnut Rd, Springfield, MA - - 2014
Focal spinal cord displacement can be caused by idiopathic spinal cord herniation (ISCH), in which the cord protrudes through a dural defect into the epidural space, causing cord displacement and tethering. ISCH is uncommon and often is misdiagnosed initially, which results in delayed management. ISCH can be mimicked by space-occupying ...
Brüßler Jana J University of Marburg, Department of Pharmaceutical Technology and Biopharmaceutics, Ketzerbach 63, 35037 Marburg, Germany. Electronic address: - - 2014
Ultrasound is a common tool for clinical diagnosis due to its safety and economic. Especially the addition of ultrasound contrast agents leads to a high diagnostic reliability. In recent years ultrasound has been used as a trigger for directed drug delivery or to enhance thrombolysis. We developed a nanoscaled ultrasound ...
Masselli Gabriele G Umberto I Hospital, Radiology Department, Sapienza University, Viale del Policlinico 155, 00161, Rome, Italy, - - 2014
Acute pelvic pain in pregnancy presents diagnostic and therapeutic challenges. Standard imaging techniques need to be adapted to reduce harm to the foetus from X-rays because of their teratogenic and carcinogenic potential. Ultrasound remains the primary imaging investigation of the pregnant abdomen. Magnetic resonance imaging (MRI) has been shown to ...
Ghiassi Kamran B KB Department of Chemistry, University of California, One Shields Avenue, Davis, CA, USA. - - 2014
Gadolinium-containing endohedral fullerenes represent a new class of effective relaxation agents for magnetic resonance imaging (MRI). The range of different structures possible for this class of molecules and their properties as MRI agents are reviewed here.
Blasiak Barbara B Department of Clinical Neurosciences, University of Calgary, 3330 Hospital Dr NW, Calgary,Alberta, T2N 4N1, Canada; Polish Academy of Sciences, Institute of Nuclear Physics, Krakow,152Radzikowskiego, Krakow, Malopolska, 31-342, - - 2014
Glioma is the most common and most difficult to treat brain cancer. Despite many efforts treatment, efficacy remains low. As neurosurgical removal is the standard procedure for glioma, a method, allowing for both early detection and exact determination of the location, size and extent of the tumor, could improve a ...
Van Roosbroeck Ruben - - 2014
We present the top-down synthesis of a novel type of MRI T2 contrast agent with great control over size and shape using a colloidal lithography technique. The resulting synthetic antiferromagnetic nanoparticles (SAF-NPs) yield improved relaxivities compared to superparamagnetic iron oxide alternatives (SPIONs). For T2 weighted imaging, the outer sphere relaxation ...
Mitsumori Lee M LM From the University of Washington, - - 2014
The purpose of this article was to review the basic properties of available gadolinium-based magnetic resonance contrast agents, discuss their fundamental differences, and explore common and evolving applications of gadolinium-based magnetic resonance contrast throughout the body excluding the central nervous system. A more specific aim of this article was to ...
Yang Jun J Yuhuangding Hospital, Yantai, Shandong Province, China. Electronic address: - - 2014
A recent international, multicenter, double-blinded, randomized trial shows delayed-enhanced magnetic resonance imaging (DE-MRI) using contrast doses of ≥0.2mmol/kg is effective in the detection and assessment of myocardial infarction (MI), and 0.1mmol/kg is not enough; intermediate doses between 0.1 and 0.2mmol/kg have not been tested. The aim of this study was ...
Chopier J J Radiology Department, hôpital Tenon, 56, avenue Gambetta, 75020 Paris, France. Electronic address: - - 2014
MRI-guided biopsy is a recent interventional breast technique. Validating the procedure poses a new problem because the signal targeted is created by the injection of a paramagnetic contrast agent and is thus transitory. In the first instance, the procedure is validated by the radiologist, who checks that targeting is accurate ...
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