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Lisanti Christopher J CJ 1 Department of Radiology, San Antonio Military Medical Center, 3851 Roger Brooke Dr, Fort Sam Houston, San Antonio, TX - - 2014
OBJECTIVE. The purpose of this study is to compare CT urography (CTU) with unenhanced CT in the evaluation of upper urinary tracts in adults younger than 50 years with asymptomatic microscopic hematuria. MATERIALS AND METHODS. In this study, 1516 CTU examinations were reviewed in adults younger than 50 years. Inclusion ...
Choi Jin-Young JY From the Department of Radiology, Research Institute of Radiological Science, Yonsei University Health System, Seoul, Korea (J.Y.C.); Department of Radiology and Institute of Radiation Medicine, Seoul National University Hospital, Seoul, Korea (J.M.L.); and Liver Imaging Group, Department of Radiology, University of California, San Diego Medical Center, 408 Dickinson St, San Diego, CA 92103-8226 - - 2014
Computed tomography (CT) and magnetic resonance (MR) imaging play critical roles in the diagnosis and staging of hepatocellular carcinoma (HCC). The first article of this two-part review discusses key concepts of HCC development, growth, and spread, emphasizing those features with imaging correlates and hence most relevant to radiologists; state-of-the-art CT ...
Filippo Massimo De MD Department of Surgical Sciences, Section of Diagnostic Imaging, University Hospital of Parma, Parma, Italy. - - 2014
We aimed to assess the correlation between pulmonary hemorrhage and pneumothorax in computed tomography (CT)-guided transthoracic fine needle aspiration (TTFNA), particularly its possible value as protection against the development of pneumotorax. We reviewed the CT images of 538 patients (364 males and 174 females, mean age 70 years, range 36-90 ...
Liu Dan D From the Departments of Diagnostic Radiology (D.L., P.L.K.) and Surgery (A.C.Y.C., R.T.P.P.), Queen Mary Hospital, University of Hong Kong, 102 Pokfulam Rd, Hong Kong; and School of Nursing, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong - - 2014
Purpose To evaluate alternative schedules for surveillance computed tomography (CT) for patients who underwent hepatectomy for hepatocellular carcinoma (HCC) and to demonstrate an appropriate schedule on the basis of stratification for risk of recurrence. Materials and Methods CT and pathologic reports for consecutive patients with HCC who underwent hepatectomy at ...
Kojima Katsuhide K Department of Diagnostic Radiology 2, Kawasaki Hospital, Kawasaki Medical School, 2-1-80, Nakasange Kita-ku, Okayama, 700-8505, Japan, - - 2014
Pulmonary alveolar proteinosis (PAP) is a rare diffuse lung disease caused by abnormal intra-alveolar surfactant accumulation; it commonly appears as a "crazy-paving" pattern on high-resolution computed tomography. Here, we report a rare case of autoimmune PAP appearing as localized ground-glass opacity. An 82-year-old woman underwent chest computed tomography (CT) at ...
Ryu In Sun IS Department of Otolaryngology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of - - 2014
Accurate tumor staging including involvement of laryngeal cartilage is important to treatment planning. Clinicians rely on imaging findings and determine initial laryngectomy for T4-stage cancer with functionless larynx or extralaryngeal spread (ELS). We examined the accuracy and prognostic value of preoperative CT findings for tumor staging in patients with locally ...
Munich Stephan A SA Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois. Electronic address: - - 2014
Iodine-based contrast medium used in diagnostic and therapeutic cerebrovascular imaging may cause renal toxicity, especially in patients with underlying renal impairment. Contrast dilution may impede efforts of the neurointerventionalist to treat intracranial vascular pathology. A 36-year-old man with renal impairment presented with an unruptured A1 segment anterior cerebral artery aneurysm. ...
Grady A T AT From the Departments of Radiology (A.T.G., T.P.T., K.R.C., R.T.G., J.K.H.), Surgery (J.A.S.), and Radiation Oncology (J.K.H.), Duke Cancer Institute (J.A.S.), and Duke Clinical Research Institute (J.A.S.), Duke University Medical Center, Durham, North - - 2014
Variability in radiologists' reporting styles and recommendations for incidental thyroid nodules can lead to confusion among clinicians and may contribute to inconsistent patient care. Our aim was to describe reporting practices of radiologists for incidental thyroid nodules seen on CT and MR imaging and to determine factors that influence reporting ...
Zanotti-Fregonara Paolo - - 2014
The imaging of translocator 18kDa protein (TSPO) in living human brain with radioligands by positron emission tomography (PET) has become an important means for the study of neuroinflammatory conditions occurring in several neuropsychiatric disorders. The widely used prototypical PET radioligand, [(11)C](R)-PK 11195 ([(11)C](R)-1; [N-methyl-(11C)](R)-N-sec-butyl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide), gives low PET signal and is ...
Zegarra-Linares Ricardo - - 2014
Abstract We report the case of a 15-year-old girl who presented with a history of recurrent bitemporal headaches for the last 2 months. In the prior few days, she complained of neck pain, emesis, phonophobia and photophobia, but no fever. Additional symptoms included polydipsia, polyuria and weight gain in the ...
Polyak Andras A National "F.J.C." Research Institute for Radiobiology and Radiohygiene (NRIRR), Budapest, Hungary. Electronic address: - - 2014
A new biocompatible, biodegradable, self-assembled chitosan-based nanoparticulate product was successfully synthesized and radiolabeled with technetium-99m, and studied as a potential new SPECT or SPECT/CT imaging agent for diagnosis of folate receptor overexpressing tumors. In the present study we examined the conditions of a preclinical application of this labeled nanosystem in ...
Lukas Scott E SE McLean Imaging Center, McLean Hospital, NIC Mail Stop 319, 115 Mill St., Belmont, MA 02478; Behavioral Psychopharmacology Research Laboratory, McLean Hospital, NIC Mail Stop 319, 115 Mill St., Belmont, MA 02478; Harvard Medical School, McLean Hospital, NIC Mail Stop 319, 115 Mill St., Belmont, MA 02478. Electronic address: - - 2014
While the recent application of brain imaging to study CNS stimulants has offered new insights into the fundamental factors that contribute to their use and abuse, many gaps remain. Brain circuits that mediate pleasure, dependence, craving and relapse are anatomically, neurophysiologically and neurochemically distinct from one another, which has guided ...
Yang Jun J MIMR-PHI Medical Research Institute, Clayton, Victoria 3168, - - 2014
The mineralocorticoid receptor (MR) plays a central role in salt and water homeostasis via the kidney; however, inappropriate activation of the MR in the heart can lead to heart failure. A selective MR modulator that antagonizes MR signaling in the heart but not the kidney would provide the cardiovascular protection ...
Ambrosini Valentina V Nuclear Medicine, S.Orsola-Malpighi University Hospital, via Massarenti 9, Bologna 40138, Italy. Electronic address: - - 2014
Somatostatin receptors (SSTR) are expressed on neuroendocrine cells widely dispersed in the human body. Neuroendocrine tumors (NET) are characterized by increased SSTR expression and may virtually arise anywhere in the human body. The diagnostic flowchart of NET patients has been completely revolutionized in the past few years as a consequence ...
Malkova Natalia V NV Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125; and - - 2014
Maternal infection during pregnancy increases the risk for schizophrenia in offspring. In rodent models, maternal immune activation (MIA) yields offspring with schizophrenia-like behaviors. None of these behaviors are, however, specific to schizophrenia. The presence of hallucinations is a key diagnostic symptom of schizophrenia. In mice, this symptom can be defined ...
Tang Dewei D Vanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University Medical Center, 1161 21st Ave. S., AA 1105 MCN, Nashville, TN, 37232-2310, - - 2014
Translocator protein (TSPO) concentrations are elevated in glioma, suggesting a role for TSPO positron emission tomography (PET) imaging in this setting. In preclinical PET studies, we evaluated a novel, high-affinity TSPO PET ligand, [(18)F]VUIIS1008, in healthy mice and glioma-bearing rats. Dynamic PET data were acquired simultaneously with [(18)F]VUIIS1008 injection, with ...
Dawson Dana K DK Cardiovascular Medicine Research Unit, University of Aberdeen, Aberdeen, United Kingdom. Electronic address: - - 2014
Insufficient precision remains in accurately identifying left ventricular noncompaction (LVNC) from the healthy normal morphologic spectrum. We aim to provide a better distinction between normal left ventricular trabeculations and LVNC. We used a previously well-defined cohort of 120 healthy volunteers for normal reference values of the trabecular/compacted ratio derived from ...
Lai Ji Ching - - 2014
A new SELEX protocol for the development of DNA aptamers has been demonstrated, referred to as Magnetic-Assisted Rapid Aptamer Selection (MARAS). This method uses magnetic beads and an externally-applied rotating magnetic field to provide the competitive mechanism for the selection aptamers with different affinities to the molecular target. The MARAS ...
Park Jihyun J Department of Nuclear Medicine, Korea Cancer Center Hospital, 75, Nowon-ro, Nowon-gu, Seoul, 139-706 Republic of - - 2014
Increased (18)F-fluorodeoxyglucose (FDG) uptake of brown fat on (18)F-FDG positron emission tomography (PET) originating from physiological activation is a common incidental finding and is usually located in the neck, shoulder, and supraclavicular areas. We present a case of an incidental pheochromocytoma showing diffusely increased (18)F-FDG uptake in bilateral perirenal fat ...
Kalavagunta Chaitanya C Center of Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, - - 2014
To present a novel registration approach called LATIS (Local Affine Transformation guided by Internal Structures) for coregistering post prostatectomy pseudo-whole mount (PWM) pathological sections with in vivo MRI (magnetic resonance imaging) images. Thirty-five patients with biopsy-proven prostate cancer were imaged at 3T with an endorectal coil. Excised prostate specimens underwent ...
Yoon Hai-Jeon HJ Department of Nuclear Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, - - 2014
Imaging biomarkers from functional imaging modalities were assessed as potential surrogate markers of disease status. Specifically, in this prospective study, we investigated the relationships between functional imaging parameters and histological prognostic factors and breast cancer subtypes. In total, 43 patients with large or locally advanced invasive ductal carcinoma (IDC) were ...
Pugash Denise D Department of Radiology, British Columbia Women's Hospital and University of British Columbia, Vancouver, - - 2014
Thanatophoric dysplasia, hypochondroplasia and achondroplasia are all caused by FGFR3 (fibroblast growth factor receptor 3) mutations. Neuropathological findings of temporal lobe dysplasia are found in thanatophoric dysplasia, and recently, temporal and occipital lobe abnormalities have been described in brain imaging studies of children with hypochondroplasia. We describe twins discordant for ...
Peter Luisa L From the *Department of General and Visceral Surgery, Zentralklinik Bad Berka, ENETS Center of Excellence; †Laboratory of Pathology and Cytology; and ‡Department of Molecular Radiotherapy/Center for Molecular Imaging (PET/CT), Zentralklinik Bad Berka, ENETS Center of Excellence, Bad Berka, - - 2014
Ga somatostatin receptor PET/CT, currently the most sensitive imaging modality for well-differentiated neuroendocrine tumors, is based on the molecular imaging of somatostatin receptors (SSTRs) that are expressed in different tumor entities such as neuroendocrine neoplasms, lymphomas, meningiomas, or renal cell cancer (RCC). Most neuroendocrine neoplasms show a high expression of ...
Jadhav Swati S Department of Endocrinology, KEM hospital, Mumbai, - - 2014
Localisation of phosphatonin producing mesenchymal tumours in patients with primary tumour-induced osteomalacia (pTIO) is challenging. Functional imaging plays an important role in the localisation of these tumours. We studied the relative performance of different functional imaging modalities ((18) F-FDG PET CT, (99) Tc HYNIC TOC SPECT CT and (68) Ga ...
Pirayesh Elahe E Department of Nuclear Medicine, Shohada e Tajrish Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; - - 2014
The diagnostic usefulness of somatostatin receptor scintigraphy in the localization of tumors has been evaluated in several studies. Here, we present the case of a patient with a subserosal myoma diagnosed by (99m)Tc-labeled octreotide acetate scintigraphy. Oval and ring-shaped areas of hyperactivity in the pelvis were confirmed on MR imaging ...
Stoessl A Jon - - 2014
Positron emission tomography (PET) is a powerful technique to quantitatively assess brain function in vivo. In Parkinson's disease (PD), PET can assist in the identification of dopamine deficiency, the characterization of dopamine and other neurotransmitter receptors and transporters, serve as a biomarker and provide insights into motor and non-motor complications ...
Kuhn Felix P FP Department of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, Zurich 8091, Switzerland. - - 2014
Quantitative measures of 11C-raclopride receptor binding can be used as a correlate of postsynaptic D2 receptor density in the striatum, allowing 11C-raclopride positron emission tomography (PET) to be used for the differentiation of Parkinson's disease from atypical parkinsonian syndromes. Comparison with reference values is recommended to establish a reliable diagnosis. ...
Munro Kirsty I KI MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United - - 2014
There are no long-term medical treatments for uterine fibroids, and non-invasive biomarkers are needed to evaluate novel therapeutic interventions. The aim of this study was to determine whether serial dynamic contrast-enhanced MRI (DCE-MRI) and magnetization transfer MRI (MT-MRI) are able to detect changes that accompany volume reduction in patients administered ...
de Herder Wouter W WW Section of Endocrinology, Department of Internal Medicine, Erasmus MC, 's Gravendijkwal 230, 3015 CE Rotterdam, The - - 2014
For patients with neuroendocrine tumours (NETs) of the gastrointestinal tract and pancreas (GEP) (GEP-NETs), excellent care should ideally be provided by a multidisciplinary team of skilled health care professionals. In these patients, a combination of nuclear medicine imaging and conventional radiological imaging techniques is usually mandatory for primary tumour visualisation, ...
Choi Hongyoon H Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Molecular Medicine and Biopharmaceutical Science, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of - - 2014
Metabotropic glutamate receptor 5 (mGluR5) that regulates glutamatergic neurotransmission contributes to pathophysiology of epilepsy. In this study, we monitored the changes of mGluR5 in vivo using [11C]ABP688 PET during the epileptogenesis in a pilocarpine-induced epilepsy rat model. In vivo mGluR5 images were acquired using [11C]ABP688 microPET/CT in pilocarpine-induced chronic epilepsy ...
Sengoku Renpei R Department of Neurology, The Jikei University School of Medicine, - - 2014
We herein report that the clinical, laboratory, and radiographic features and positron emission tomography (PET) imaging may provide valuable clues to the pathogenesis of cerebral amyloid angiopathy (CAA)-associated encephalopathy, which currently remains unclear. We herein describe two cases of encephalopathy with CAA, with an emphasis on PET imaging with (11)C-Pittsburgh ...
Song Hong H University of Maryland School of Medicine, United - - 2013
'Classic' cardiotonic steroids (CTS) such as digoxin and ouabain selectively inhibit Na(+),K(+)-ATPase (the Na(+) pump) and, via Na/Ca exchange (NCX), exert cardiotonic and vasotonic effects. CTS action is more complex than previously thought: prolonged subcutaneous administration of ouabain, but not digoxin, induces hypertension, and digoxin antagonizes ouabain's hypertensinogenic effect. We ...
van Essen Martijn - - 2013
In patients with neuroendocrine tumours (NETs), a combination of morphological imaging and nuclear medicine techniques is mandatory for primary tumour visualization, staging and evaluation of somatostatin receptor status. CT and MRI are well-suited for discerning small lesions that might escape detection by single photon emission tomography (SPECT) or PET, as ...
Kota Gopi - - 2013
Intracranial hemangiopericytomas (HPCs) are rare tumors that closely mimic meningiomas. However, in contrast to meningiomas, HPCs have a relatively high incidence of local recurrence and distant metastases, manifesting the need for sensitive noninvasive methods of detection that efficiently image the entire body. We present a rare case of a right ...
Sharma Punit P 1 All authors: Department of Nuclear Medicine, All India Institute of Medical Sciences, E-81, Ansari Nagar (East), AIIMS Campus, New Delhi 110029, - - 2013
OBJECTIVE. Similar to neuroendocrine tumors (NETs) at other sites, a wide array of intracranial tumors also express somatostatin receptors (SSTRs). This expression can be exploited for both imaging and therapy. The introduction of (68)Ga-labeled tetraazacyclododecanetetraacetic acid (DOTA)-peptide PET/CT has given new dimension to SSTR-based imaging because of its improved sensitivity ...
Hori Katsuhito - - 2013
Prophylaxis of chemotherapy (CT)-induced nausea and vomiting (CINV) is important for patient's quality of life and adherence to CT. Neurokinin receptor antagonist (NK1 antagonist) was marketed in Japan in December 2009 and the first guideline for antiemetics for CINV was released in May 2010 from Japan Society of Clinical Oncology ...
Zou Jun - - 2013
Objectives. Polymorphisms in the Interleukin (IL)-1-related genes at the locations -889, -511, + 3962 and mspa1l 1100 have been investigated for possible association with Behçet's disease (BD). Methods. A literature-based search was conducted to identify all relevant studies. Five independent studies from Turkish population met the included criteria. Results. IL-1α ...
Bienvenu Laura A - - 2013
MR (mineralocorticoid receptor) activation in the heart plays a central role in the development of cardiovascular disease, including heart failure. The MR is present in many cell types within the myocardium, including cardiomyocytes, macrophages and the coronary vasculature. The specific role of the MR in each of these cell types in the ...
Poels E M P - - 2013
Currently, all treatments for schizophrenia (SCZ) function primarily by blocking D2-type dopamine receptors. Given the limitations of these medications, substantial efforts have been made to identify alternative neurochemical targets for treatment development in SCZ. One such target is brain glutamate. The objective of this article is to review and synthesize ...
Daya R P - - 2013
Functional imaging studies in schizophrenic patients have demonstrated metabolic brain abnormalities during cognitive tasks. This study aimed to 1) introduce a novel analysis of brain metabolic function in live animals to characterize the hypo- and hyperfrontality phenomena observed in schizophrenia and following NMDA antagonist exposure, and 2) identify a robust ...
Tago Tetsuro T Cyclotron and Radioisotope Center (CYRIC), Tohoku University, Sendai, 980-8578, - - 2014
Alzheimer's disease (AD) is the most common cause of dementia. Senile plaques, consisting of β-amyloid, and neurofibrillary tangles (NFTs), composed of tau protein, are representative pathological hallmarks of AD. It is believed that the accumulation of NFTs precedes the onset of clinical symptoms of AD and correlates with the progression ...
Lollert André - - 2013
To evaluate correlations between dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and clinicopathologic data as well as immunostaining of the markers of angiogenesis epidermal growth factor receptor (EGFR) and CXC-motif chemokine receptor 4 (CXCR4) in patients with rectal cancer. Presurgical DCE-MRI was performed in 41 patients according to a standardized protocol. ...
Li Chiang-Shan R - - 2013
Noradrenergic dysfunction is implicated in obesity. The norepinephrine transporter (NET) regulates the synaptic availability of norepinephrine. However, NET availability has not been previously characterized in vivo in obese people using Positron Emission Tomography (PET) imaging. Here we report findings evaluating NET availability in individuals with obesity and matched lean (i.e., ...
Taguchi Yoshiharu - - 2013
Reduced cortical benzodiazepine receptor binding potential in late images of I-iomazenil SPECT indicates neuronal damage in the cortex. We present the case of a 31-year-old woman with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) who had focal seizures in the right hand. FLAIR imaging in the ictal state ...
van Kruchten Michel - - 2013
Although the majority of endometrial stromal sarcomas (ESSs) express oestrogen receptor (ER), data on the efficacy of ER-targeted therapies are scarce. Using PubMed search engine we identified nine case reports and small series in a total of 25 patients reporting on the efficacy of palliative ER-targeted therapies. Literature supports the ...
Gottschalk Sven - - 2013
A series of magnetic resonance imaging probes has been evaluated to target selectively the metabotropic glutamate receptor subtype 5 (mGluR5). Eight imaging probes based on the contrast agent [Gd·DOTA], previously derived by linking it to a series of specific and selective mGluR5 antagonists, have been extensively tested for their functionality ...
Yang Jigang - - 2013
Gallium-68 somatostatin receptor positron emission tomography (PET) has been used in the diagnosis of neuroendocrine tumors (NETs). The compounds often used in molecular imaging of NETs with PET are 68Ga-DOTATOC, 68Ga-DOTATATE, and 68Ga-DOTANOC. There is varying affinity to different somatostatin receptors. To systematically review and perform a meta-analysis of published ...
Xie Xueqian - - 2013
Purpose: Coronary artery calcium score, traditionally based on electrocardiography (ECG)-triggered computed tomography (CT), predicts cardiovascular risk. However, nontriggered CT is extensively utilized. The study-purpose is to evaluate the in vitro agreement in coronary calcium score between nontriggered thoracic CT and ECG-triggered cardiac CT.Methods: Three artificial coronary arteries containing calcifications of ...
Baker Michael E ME Department of Medicine, 0693, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0693, United States. Electronic address: - - 2013
Mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) are descended from an ancestral corticoid receptor (CR). To date, the earliest CR have been found in lamprey and hagfish, two jawless fish (cyclostomes) that evolved at the base of the vertebrate line. Lamprey CR has both MR and GR activity. Distinct orthologs ...
Geijer Håkan - - 2013
Neuroendocrine tumours (NET) are uncommon and may be localized in many different places in the body. Traditional imaging has mainly been performed with CT and somatostatin receptor scintigraphy (SRS). Recently, it has become possible to use somatostatin receptor PET/CT (SMSR PET) instead, which might improve diagnostic quality. To evaluate the ...
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