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Alatzoglou Ks K Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, London, - - 2014
Context: SOX3 is an early developmental transcription factor involved in pituitary development. In humans, over- and under-dosage of SOX3 is associated with X-linked hypopituitarism with variable phenotypes ranging from isolated growth hormone deficiency (GHD) to panhypopituitarism, with or without mental retardation and, in most cases with reported pituitary imaging, an ...
Kawabe Joji J From the Departments of *Nuclear Medicine and †Surgical Oncology, Graduate School of Medicine, Osaka City University, Osaka, - - 2014
After thyroid remnant ablation following total thyroidectomy for thyroid cancer, I SPECT/CT revealed I uptake, regarded as thyroid bed uptake on planar images, in the anterior cervical region. On SPECT/CT, the I uptake focus appeared at the esophagus, suggesting esophageal invasion. No esophageal invasion had been recognized intraoperatively, and no ...
Yazici Bulent B From the *Department of Nuclear Medicine, Ege University Medical Faculty, Izmir; and †Department of Pathology, Mugla University Hospital, Mugla, - - 2014
A 28-year-old woman underwent a near-total thyroidectomy for papillary carcinoma. Before radioiodine therapy, the serum thyroid-stimulating hormone level was 50 μIU/mL, the thyroglobulin level was 1 μg/L, and the antithyroglobulin was negative. She received 100 mCi of I for ablation of residual thyroid tissue. After therapy, I whole-body scan demonstrated ...
Treglia Giorgio G From the *Department of Nuclear Medicine and PET/CT Center, Oncology Institute of Southern Switzerland, Bellinzona; and †Institute of Pathology, Locarno, - - 2014
We describe a rare case of metastatic undifferentiated spindle cell sarcoma (USCS) of the thyroid gland evaluated by F-FDG PET/CT. A 63-year-old male patient with histological diagnosis of USCS of the thyroid gland underwent F-FDG PET/CT for staging. PET/CT revealed increased radiopharmaceutical uptake corresponding to a thyroid mass and mild ...
d'Amico Andrea A From the *Department of Diagnostic PET, †Department of Radiotherapy and Brachytherapy Planning, and ‡III Clinic of Radiotherapy, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, - - 2014
The images of a patient with acromegaly, who previously underwent operation for pituitary adenoma, were obtained. The MRI scan showed a mass in the right cavernous sinus, with biochemical test results positive for the presence of a hormonally active adenoma. The patient was scheduled for CyberKnife radiotherapy. Radiotherapy planning was ...
Ishida Masanori M Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan, - - 2014
We aimed to confirm whether postmortem adrenal volumetric changes occur by measuring adrenal volumes on computed tomography (CT). Fifty-five adrenal glands from 28 subjects who died were included. All subjects underwent antemortem CT (AMCT) and postmortem CT (PMCT) within 94-1,191 min after death, followed by conventional autopsy. CT volumetry was performed ...
Heinrich Angela A Departments of aCognitive and Clinical Neuroscience bBiostatistics cPsychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim dDepartment of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, - - 2014
Increasing field strengths in MRI necessitate the examination of potential side effects. Previously reported results have been contradictory, possibly caused by imbalanced samples. We aimed to examine whether special groups of people are more prone to develop side effects that might have led to contradictory results in previous studies. We ...
Pettinato Cinzia C From the *Department of Medical Physics, Sant'Orsola-Malpighi, Bologna, Italy; †Department of Medical Physics, Velindre Cancer Centre, Cardiff, United Kingdom; ‡Department of Nuclear Medicine, Sant'Orsola-Malpighi, Bologna; §Department of Nuclear Medicine, Santa Maria della Misericordia Hospital, Rovigo; and ¶Department of Radiotherapy, Sant'Orsola-Malpighi, Bologna, Italy; and ∥Department of Radiology, University of Southern California, Los Angeles, - - 2014
This study evaluates the use of sequential I PET/CT for predicting absorbed doses to metastatic lesions in patients with differentiated thyroid cancer undergoing I therapy. From July 2011 until July 2013, 30 patients with metastatic differentiated thyroid cancer were enrolled. Each participant underwent PET/CT at 4, 24, 48, and 72 ...
Isoda Takuro T From the *Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, †Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, - - 2014
Many cases of unexpected radioiodine uptake have been reported, including physiological uptake in healthy tissue and in both benign and malignant nonthyroidal lesions. However, iodine uptake in the uterus has not been well assessed. In this article, we systemically analyzed iodine uptake in the uterus and identified the site in ...
Giovanella Luca L Department of Nuclear Medicine and PET/CT Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; EOC Competence Centre for Thyroid Diseases, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland. Electronic address: - - 2014
Nuclear medicine techniques were first used in clinical practice for diagnosing and treating thyroid diseases in the 1950s, and are still an integral part of thyroid nodules work-up. Thyroid imaging with iodine or iodine-analogue isotopes is the only examination able to prove the presence of autonomously functioning thyroid tissue, which ...
Wickramarachchi Binula N BN Department of Surgery, Waikato Hospital, Hamilton, New - - 2014
Approximately 5% of all abdominal computed tomography (CT) and magnetic resonance imaging (MRI) scans reveal an adrenal incidentaloma. Although most adrenal incidentalomas are benign non-functioning adenomas, lesions may be hormonally active and/or malignant. The aim of this study was to determine adherence to recommended international guidelines and potential influencing factors ...
Maloney Ezekiel E From the Department of Radiology, University of Washington Medical Center, Seattle, - - 2014
Whole-body radioiodide scan is an essential procedure in the evaluation of radioiodine-avid metastatic foci in patients with differentiated thyroid carcinoma. Normal physiologic distribution of the radiotracer includes the stomach and colon, but the small intestine is not often seen. Gastrointestinal anatomic variants may be associated with atypical activity on I ...
Traub-Weidinger Tatjana T Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear - - 2014
Context: (99m)Tc-MIBI scintigraphy is a standard preoperative localisation imaging modality in patients with primary hyperparathyreoidism (pHPT). Its accuracy in localizing a hyperactive parathyroid gland after previous cervical surgery is limited. Recently, (11)C-Methionine has been introduced as a promising radiotracer for pHPT imaging. Yet, few data exist for this technique in ...
Palumbo B B Section of Nuclear Medicine and Medical Physics, Department of Surgical and Biomedical Sciences, University of Perugia, Italy - - - 2014
Patients with suspected recurrence of prostate cancer undergoing 18Fluoromethylcholine (18FCH) PET/CT were retrospectively evaluated to investigate the influence of hormonal therapy (HT) in 18FCH uptake. 18FCH PET/CT was performed in 102 surgically treated patients with suspected recurrence (PSA increase > 0.2 ng/ml) of prostate cancer, divided in two groups: under ...
Surov Alexey A Department of Radiology, Martin-Luther-University Halle-Wittenberg, Halle, Germany. Electronic address: - - 2014
From 1997 to 2013, 8849 patients with several disorders of the thyroid were treated in our surgical department. In nine patients (0.1%), primary thyroid sarcoma (PTS) was diagnosed. In eight patients, PTS manifested as a thyroid mass (range, 25-90mm). In one case, a global enlargement of the thyroid was seen. ...
Afshar-Oromieh Ali A Department of Nuclear Medicine, University Hospital of Heidelberg, Heidelberg, Germany (A.A.-O., C.K., F.L.G., U.H.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., M.B.W., R.G., M.C.R., H.P.S.); Clinical Cooperation Unit of Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.A.-O., A.D.-S.); Department of Radiation Oncology and Therapy, University Hospital of Heidelberg, Heidelberg, Germany - - 2014
(68)Ga-DOTATOC-PET/CT is a well-established method for detecting and targeting the volume definition of meningiomas prior to radiotherapy. Moreover, there is evidence that this method is able to detect meningiomas with higher sensitivity than the goldstandard MRI. Since the hybrid PET/MRI scanner became available in the past few years, the next ...
Lewis Maria M Medical Physics Department, Guy's & St. Thomas' NHS Foundation, Trust, London, - - 2014
To assess the cross-centre consistency of iodine enhancement, contrast-to-noise ratio and radiation dose in a multicentre perfusion CT trial of colorectal cancer. A cylindrical water phantom containing different iodine inserts was examined on seven CT models in 13 hospitals. The relationship between CT number (Hounsfield units, HU) and iodine concentration ...
Karanikas Georgios G Division of Nuclear Medicine, PET-PET/CT, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, Vienna A-1090, Austria. Electronic address: - - 2014
(11)C-acetate PET is used in the assessment of various cardiologic and oncologic diseases. This article describes the physiologic uptake of (11)C-acetate and presents the common benign findings in different anatomic parts of the body. Salivary glands, tonsils, thyroid, meningeal tuberculoma, meningiomas, and macroadenomas of pituitary gland are sites of mild ...
Bahl M M From the Departments of Radiology (M.B., R.C.N., J.K.H.), Radiation Oncology (J.K.H.), and Surgery, Duke Cancer Institute and Duke Clinical Research Institute (J.A.S.), Duke University Medical Center, Durham, North - - 2014
Incidental thyroid nodules are commonly seen on imaging, and their work-up can ultimately lead to surgery. We describe characteristics and pathology results of imaging-detected incidental thyroid nodules that underwent surgery. A retrospective review was performed of 303 patients who underwent thyroid surgery over a 1-year period to identify patients who ...
Olarescu Nicoleta Cristina NC Section of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital, - - 2014
Context Visceral adipose tissue (VAT) is established as a risk factor for type 2 diabetes and cardiovascular disease, but the radiation exposure and cost of computed tomography (CT) measurements limits its daily clinical use. Objective The main aim of this study was to compare the degree of agreement between VAT ...
Lee Minkyung M From the *Department of Nuclear Medicine, Gangnam Severance Hospital, and †Thyroid Cancer Center, Department of Surgery, Yonsei University College of Medicine, Seoul, South - - 2014
We report a case of unusual I uptake in the skull in a patient who received total thyroidectomy and cervical lymph node dissection for papillary thyroid carcinoma. This uptake mimicked a bone metastasis on posttherapeutic I whole-body scan. The lesion was further evaluated by I SPECT/CT and MRI, and it ...
Kist Jakob W - - 2014
After initial treatment of differentiated thyroid carcinoma (DTC) patients are followed with thyroglobulin (Tg) measurements to detect recurrences. In case of elevated levels of Tg and negative neck ultrasonography, patients are treated "blindly" with Iodine-131 (131I). However, in up to 50% of patients, the post-therapy scan reveals no 131I-targeting of ...
Chantadisai Maythinee M Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Chulalongkorn University, 1873 Rama 4 Rd Pathum Wan, Bangkok, 10330, Thailand, - - 2014
The aim of the study was to evaluate the usefulness of (99m)Tc-pertechnetate whole body scan (WBS) with neck and chest SPECT/CT for detection of post-surgical thyroid remnant and metastasis in differentiated thyroid cancer (DTC) patients. Fifty-six post total thyroidectomy patients were included. All patients were prospectively imaged with (99m)Tc-pertechnetate WBS ...
de Rotte Alexandra A J AA Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, Postbox 85500, 3508 GA, Utrecht, The Netherlands, - - 2014
Since the pituitary gland measures 3-8 mm, imaging with the highest possible spatial resolution is important for the detection of even smaller lesions such as those seen in Cushing's disease. In the current feasibility study, we tested a multi-sequence MRI protocol to visualize the pituitary gland in high resolution at 7.0 ...
Vriens D D dept. of Radiology and Nuclear - - 2014
Context: Patients with thyroid nodules of indeterminate cytology undergo diagnostic surgery according to current guidelines. In 75% of patients, the nodule is benign. In these patients, surgery was unnecessary and unbeneficial as complications may occur. Preoperative FDG-PET/CT was found to have a very high negative predictive value (96%) and might ...
Brindle R R North West Deanery, Manchester, - - 2014
Increasing use of 18F-Fluorodeoxy glucose (FDG) Positron Emission Tomography Computed Tomography (PET CT) has resulted in an increased frequency of incidentally discovered areas of focally increased FDG uptake within the thyroid gland - thyroid incidentalomas. We aimed to compare radiological characteristics of thyroid incidentalomas with cytology, histology and ultrasound findings. ...
Agrawal Kanhaiyalal K Department of Nuclear Medicine, Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital, Great Maze Pond, London, SE19RT, UK, - - 2014
The incidence of thyroid metastasis from other primary malignancy is rare. In this case, we present the findings of (18)F-FDG PET/CT in thyroid metastasis from underlying non-small cell carcinoma of the lung and highlight the importance of tracer uptake pattern recognition within the thyroid on (18)F-FDG PET/CT study.
Paladino Nunzia Cinzia NC Department of General and Endocrine Surgery, Hôpital de la Timone, 13385 Marseille - France. Electronic address: - - 2014
bilateral pheochromocytomas ( PHEO ) are rare, often hereditary and linked to a germline mutation of RET, VHL or SDHx. However they also occur sporadically. we report a case of a 76 year old female hospitalized for biological investigations following symptoms of abdominal discomfort with recurrent hypertensive episodes. The hormonal ...
Kneppo Carolin - - 2014
Abstract Aim: The aim of this study was to evaluate the morphology and elastic properties of the aorta in children and adolescents with Ullrich-Turner syndrome (UTS) treated with growth hormone, by using magnetic resonance imaging (MRI). Methods: Thirty-seven conscious UTS patients were examined using a 1.5-T whole-body MRI. Contrast-free three-dimensional ...
Colavolpe Cecile C Department of Nuclear Medicine, CHU Timone, Marseille, - - 2014
Intravascular large B-cell lymphoma (IVLBCL) remains a diagnostic challenge, because of non-specific findings on clinical, laboratory, and imaging studies. We present a case in which 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography was particularly useful to suspect the diagnosis, to detect unexpected locations, to guide contributive biopsy, and to assess the ...
Ma C C Department of Nuclear Medicine, Xinhua Hospital of Medical School Shanghai Jiaotong University, Shanghai, Republic of China - - - 2014
Aim of the present study was to investigate the usefulness of 18F-FDG SPECT/CT in differentiated thyroid cancer (DTC) with elevated serum thyroglobulin (Tg) but negative iodine-131 scan. This retrospective review of patients with DTC recurrence who had 18F-FDG SPECT/CT and 18F-FDG PET/CT for elevated serum Tg but negative iodine-131 scan ...
Cam Osman Halit OH Ear Nose Throat Department, Delta Hospital, Istanbul, Turkey ; Merdivenkoy Mah. Uyanıs Sok, No: 4/8 Kadıkoy, Istanbul, - - 2014
This study aimed to compare ultrasonography (US), contrast-enhanced computed tomography (CCT) of the neck, and diffusion-weigh magnetic resonance imaging (DW-MRI) in differentiating between benign and malignant nodules while approaching to thyroid nodules, and to estimate sensitivity and specificity of these methods. On thyroid US, echogenicity, calcification, presence/absence of halo, nodule ...
Buch Karen K From the *Department of Radiology, Boston Medical Center, Boston University School of Medicine, Boston, MA, †Boston University School of Medicine, Boston, MA, ‡Department of Medicine, and §Department of Otolaryngology - Head and Neck Surgery, Boston Medical Center, Boston University School of Medicine, Boston, - - 2014
Clinical manifestations of sickle cell disease (SCD) can affect the orbit with prior reports describing changes in the lacrimal gland potentially related to chronic vaso-occlusion. The purpose of this study was to evaluate lacrimal gland volumes and quantifiable shifts in MR-relaxation times in patients with SCD. Thirteen patients with SCD ...
De La Hoz Polo M M Unidad de Radiodiagnóstico, Hospital Universitario Mútua Terrassa, Barcelona, España. Electronic address: - - 2014
The term «juvenile idiopathic arthritis» (JIA) encompasses a group of arthritis of unknown cause with onset before the age of 16 years that last for at least 6 weeks. The prevalence of temporomandibular joint involvement in published series ranges from 17% to 87%. Temporomandibular joint involvement is difficult to detect ...
Agrawal Mukta D MD From the Department of Abdominal and Interventional Radiology, Massachusetts General Hospital, 55 Fruit St, White Building, Room 270, Boston, MA - - 2014
Dual-energy computed tomographic (DECT) technology offers enhanced capabilities that may benefit oncologic imaging in the abdomen. By using two different energies, dual-energy CT allows material decomposition on the basis of energy-dependent attenuation profiles of specific materials. Although image acquisition with dual-energy CT is similar to that with single-energy CT, comprehensive ...
Bukhari Amal A AA *Ophthalmology Department, and †Radiology department, King Abdulaziz University Hospital, Jeddah, Saudi - - 2014
Aimed to evaluate normal volume of the lacrimal gland in patients of different age groups and race. All MRI studies of the brain that were done between June 2012 and April 2013 were examined. Lacrimal glands were identified using fat-saturated fluid-attenuated inversion recovery (FLAIR) images, and the volumes were calculated ...
Kim Sang Soo SS Department of Internal Medicine, Pusan National University School of Medicine, Busan, - - 2014
We report a rare case of distant subcutaneous parathyroid carcinoma recurrence. A 50-year-old woman was referred to our hospital because of sustained hypercalcemia despite surgical removal of a parathyroid carcinoma. A focal uptake in the upper mediastinal area was detected in a (99m)Tc-sestamibi scan, and (18)F-fluorodeoxyglucose (FDG) positron-emission tomography (PET)/computed ...
Kim Dong Wook DW Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea. Electronic address: - - 2014
The aim of this study was to compare the diagnostic values of thyroid ultrasound (US) and neck computed tomography (CT) in incidentally detecting diffuse thyroid disease (DTD). A single radiologist made US and CT diagnoses of incidentally detected DTD in 130 consecutive patients before thyroidectomy for various malignancies. Histopathologic examinations ...
Nayan Smriti S Division of Otolaryngology-Head and Neck Surgery, McMaster University, Hamilton, Ontario, - - 2014
To evaluate through a systematic review and meta-analysis the malignancy rates of thyroid incidentalomas identified in adults by 18-fluorodeoxyglucose positron emission tomography, computed tomography (18-FDG PET-CT) imaging studies. The literature search was conducted using OVID Medline, EMBASE, the Cochrane Library, Google Scholar, Pubmed, and reference list review (inception to April ...
Freesmeyer Martin M Clinic of Nuclear Medicine, Jena University Hospital, Jena, Germany. Electronic address: - - 2014
A precise estimate of thyroid volume is necessary for making adequate therapeutic decisions and planning, as well as for monitoring therapy response. The goal of this study was to compare the precision of different volumetry methods. Thyroid-shaped phantoms were subjected to volumetry via 2-D and 3-D ultrasonography (US), computed tomography ...
Doruyter Alexander G AG Divisions of aNuclear Medicine bRadiology cNephrology, Tygerberg Hospital, Stellenbosch University, Cape Town, South - - 2014
Preoperative localization of parathyroid lesions is potentially beneficial in renal patients with hyperparathyroidism. The aim of this study was to determine the localizing value of hybrid single-photon emission computed tomography combined with low-dose x-ray computed tomography (SPECT/LDCT) compared with SPECT alone and whether the LDCT improved reader confidence. A retrospective ...
Lee Young Han YH Department of Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Republic of - - 2014
Dual-energy computed tomography (DECT) images may be underutilized for the evaluation of skeletal metastasis. Spectral parametric segmentation of DECT can produce bone-iodine separated images, which have the potential to detect bone metastases. To evaluate the potential of bone-iodine separation in the detection of bone metastasis with spectral parametric segmentation of ...
Deitz K K Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, 50011, - - 2014
To describe the computed tomography features of canine thyroid tumours. METHODS Retrospective study of records of dogs with a thyroid tumour and neck computed tomography. Neck computed tomographies were evaluated for tumour characteristics. Thoracic radiographs and computed tomographies were evaluated for lung nodules. Of 19 identified cases, 17 were carcinomas ...
Naswa Niraj N Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, - - 2014
Thyroid lymphoma is a rare disease entity of elderly females. Chronic lymphocytic thyroiditis is said to be the precursor of thyroid lymphoma, suggesting a role of chronic antigen stimulation in the development of the disease. We present a case of male with lymphocytic thyroiditis who presented with painless progressive neck ...
Agarwal Krishan Kant KK Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, - - 2014
Ectopic thyroid tissue (ETT) refers to the presence of thyroid tissue in locations other than the normal anterior neck region between the second and fourth tracheal cartilages. Multiple ectopia of the thyroid is extremely rare. Here we report a case of 10-year-old girl with anterior midline neck swelling and hypothyroidism ...
Miftari Ramë R Department of Nuclear Medicine, University Clinical Centre of Kosova, Prishtina, - - 2014
In cases of thyroid toxic autonomous nodule, anterior projection of Tc-99m pertechnetate image shows a hot nodule that occupies most, or the entire thyroid lobe with near-total or total suppression of the contra lateral lobe. In this case is very difficult to distinguish toxic nodule from lobe agenesis. Our interest ...
Bugalho Maria João MJ Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Serviço Endocrinologia, Lisboa, Portugal ; - - 2014
Background: Calcitonin (CT) is a useful pre and postoperative tumor marker for management of medullary thyroid cancer (MTC). A few cases of non-secreting carcinomas have been reported. Case presentation: A 55-yr-old man with multinodular goiter was diagnosed with MTC after a total thyroidectomy. Post operative basal and pentagastrin stimulated serum ...
Ranade Rohit R Rohit Ranade, Pradeep Thapa, Sandip Basu, Radiation Medicine Centre (B.A.R.C), Tata Memorial Centre Annexe, Mumbai 400012, - - 2014
Adrenal metastasis is an unusual site of disease involvement in the natural course of differentiated thyroid carcinoma (DTC). This paper discusses the clinical and imaging features of DTC with adrenal metastasis. An unusual case of unilateral solitary asymptomatic adrenal metastasis in the setting of DTC is described in this report ...
Fracassi Federico F Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy, Faculty of Veterinary Medicine, Utrecht University, The - - 2014
A 13 yr old castrated male vizsla was referred to the authors' institute because of polyuria, polydipsia, polyphagia, and weight loss. Pituitary-dependent hypercortisolism (PDH) was diagnosed by hormone testing and adrenal and pituitary imaging. Computed tomography (CT) revealed a pituitary mass measuring 21 mm in width. Medical therapy was initiated ...
De Filippis Elena A EA Division of Endocrinology, Diabetes and Metabolism Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston MA - - 2014
Context: Pemberton's sign is used to evaluate venous obstruction in patients with goiters. The sign is positive when bilateral arm elevation causes facial plethora. It has been attributed to a "cork effect" resulting from the thyroid obstructing the thoracic inlet thereby increasing pressure on the venous system. According to some ...
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