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Shah N Jon NJ Institute of Neuroscience and Medicine-4, Research Centre Jülich, 52425, Jülich, Germany, - - 2014
The aim of this paper is twofold: firstly, to explore the potential of simultaneously acquiring multimodal MR-PET-EEG data in a human 9.4 T scanner to provide a platform for metabolic brain imaging. Secondly, to demonstrate that the three modalities are complementary, with MRI providing excellent structural and functional imaging, PET providing ...
Lohezic Maelene M Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, - - 2014
(i) To optimize an MR-compatible organ perfusion setup for the nondestructive investigation of isolated rat hearts by placing the radiofrequency (RF) coil inside the perfusion chamber; (ii) to characterize the benefit of this system for diffusion tensor imaging and proton ((1) H-) MR spectroscopy. Coil quality assessment was conducted both ...
Chai Toby C TC From the *Division of Urology, University of Maryland School of Medicine, Baltimore; †Cheaspeake Urology, Fulton; and ‡Department of Pathology, University of Maryland School of Medicine, Baltimore, - - 2014
The differential diagnoses for anterior wall vaginal prolapse (AWVP) include cystocele, enterocele, urethral diverticulum, and Gartner duct cyst. We present a case of a patient with a known solitary right kidney (congenital absence of a left kidney) presenting with lower urinary tract symptoms, absence of urinary incontinence, and feeling of ...
Patsikas M M Department of Clinical Sciences, School of Veterinary Medicine, Aristotle University of Thessaloniki, - - 2014
A seven-year-old, not-castrated male, Airedale Terrier presented with a history of ataxia and intention tremor of the head of three-week duration. Neurologic examination demonstrated severe hypermetria, intention tremor of the head and a bilateral menace response deficit. Magnetic resonance imaging revealed a well demarcated cerebellar vermis mass, hypointense on T1-weighted ...
Deelchand Dinesh K DK Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, - - 2014
To determine whether neurochemical concentrations obtained at two MRI sites using clinical 3T scanners can be pooled when a highly optimized, nonvendor short-echo, single-voxel proton MRS pulse sequence is used in conjunction with identical calibration and quantification procedures. A modified semi-LASER sequence (TE = 28 ms) was used to acquire ...
Li Yan Y Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, - - 2014
The purpose of this study was to evaluate the feasibility of using a short echo time, three-dimensional H-1 magnetic resonance spectroscopic imaging (MRSI) sequence at 7 Tesla (T) to assess the metabolic signature of lesions for patients with glioma. Twenty-nine patients with glioma were studied. MRSI data were obtained using ...
Furuta Akihiro A Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address: - - 2014
To compare monopolar (MP) and bipolar (BP) diffusion weighted imaging (DWI) in detecting small liver metastases. Eighty-eight patients underwent 3-T MRI. The signal-to-noise ratios (SNR) of the liver parenchyma and lesions, the lesion-to-liver contrast-to-noise ratios (CNR), and the detection sensitivities were compared. The lesion distortion was scored (LDS) from 4 ...
Cecil Kim M KM Department of Radiology, Imaging Research Center, Cincinnati Children's Hospital Medical Center, MLC 5033, 3333 Burnet Ave., Cincinnati, OH, 45229, USA, - - 2014
Atypical resonances on proton magnetic resonance spectroscopy (MRS) examinations are occasionally found in children undergoing a metabolic evaluation for neurological conditions. While a radiologist's first instinct is to suspect a pathological metabolite, usually the origin of the resonance arises from an exogenous source. We report the appearance of distinct resonances ...
Lecocq Angèle A Centre de Résonance Magnétique Biologique et Médicale, CRMBM, UMR 7339, CNRS, Faculté de Médecine de la Timone, Aix-Marseille Université, 23, Boulevard Jean Moulin, 13385, Marseille, Cedex 05, - - 2014
To propose a fast and robust acquisition and post-processing pipeline that is time-compatible with clinical explorations to obtain a proton density (ρ) map used as a reference for metabolic map normalization. This allows inter-subject and inter-group comparisons of magnetic resonance spectroscopic imaging (MRSI) data and longitudinal follow-up for single subjects. ...
Ramirez Marc S MS The Department of Imaging Physics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, - - 2014
There is great potential for real-time investigation of metabolism with MRS and hyperpolarized (HP) (13) C agents. Unfortunately, HP technology has high associated costs and efficiency limitations that may constrain in vivo studies involving many animals. To improve the throughput of preclinical investigations, we evaluate the feasibility of performing HP ...
Rivera Debra S DS Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, - - 2014
Neoadjuvant treatment response in lymph nodes predicts patient outcome, but existing methods do not track response during therapy accurately. In this study, specialized hardware was used to adapt high-field (7T) (31) P magnetic resonance spectroscopy (MRS), which has been shown to track treatment response in small breast tumors, to monitor ...
Grasso Daniela D Department of Imaging Diagnostics, University of Foggia; Foggia, Italy - - - 2014
We report a 33 year-old woman addicted to chronic unspecified solvents abuse with stupor, respiratory disorders, tetraplegia and severe metabolic acidosis. On admission an unenhanced cranial CT scan showed symmetrical hypodensities of both lentiform nuclei. MR imaging performed 12 hours after stupor demonstrates bilateral putaminal hemorrhagic necrosis, bilateral external capsule, ...
Pauliah Ss S Imperial College, London, - - 2014
Although cerebral metabolic changes during neonatal encephalopathy (NE) have been well characterised using magnetic resonance spectroscopy (MRS) in single-centre studies, the widespread effect of therapeutic hypothermia is less clear. To describe patterns of brain injury in a prospective multi-centre cohort of infants with NE who had rescue hypothermic neuroprotection. After ...
Lally Pj P Imperial College, London, - - 2014
Early cerebral proton magnetic resonance spectroscopy (MRS) predicts medium-term outcomes in neonatal encephalopathy (NE). Metabolite peak-area ratios are most commonly used for prognosis, but conflate pathological information from different metabolites. N-acetylaspartate (NAA) is predominantly neuronal and neuronal loss should result in reduced NAA absolute-concentration ([NAA]). Thus, thalamic [NAA] should offer ...
Linares I M P IM Department of Neuroscience and Behavior, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo - Brazil, and National Institute for Translational Medicine (INCT, CNPq) Brazil. Electronic address: - - 2014
There is a lack of consistent neuroimaging data on specific phobia (SP) and a need to assess volumetric and metabolic differences in structures implicated in this condition. To investigate possible metabolic (via (1)H-MRS) and cortical thickness abnormalities in spider-phobic patients compared to healthy volunteers. Participants were recruited via public advertisement ...
Prescot Andrew P AP Brain Institute, University of Utah, Salt Lake City, UT, USA; Department of Radiology, University of Utah School of Medicine, Salt Lake City, UT, - - 2014
The accuracy of metabolite concentrations measured using in vivo proton ((1) H) MRS is enhanced following correction for spin-spin (T2 ) relaxation effects. In addition, metabolite proton T2 relaxation times provide unique information regarding cellular environment and molecular mobility. Echo-time (TE) averaging (1) H MRS involves the collection and averaging ...
Suran Jantra N JN Sections of Radiology (J.S., J.R.) and Surgery (A.L.), Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA. - - 2014
A bronchopleural fistula (BPF) can lead to continuous pneumothorax and is rarely reported clinically in dogs. This report describes computed tomographic (CT) findings in two dogs with BPFs and subsequent continuous pneumothoraces that necessitated thoracotomy. Both dogs had a peripheral BPF in the right caudal lung lobe. The fistula in ...
Lee T-S TS From the Duke-National University of Singapore Graduate Medical School, Singapore. - - 2014
Molecular imaging is the visualization, characterization, and measurement of biologic processes at the molecular and cellular levels in humans and other living systems. Molecular imaging techniques such as MR spectroscopy and PET have been used to explore the molecular pathophysiology of depression and assess treatment responses. MR spectroscopy is a ...
Ramey Kelley K 1Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego (UCSD), Pharmaceutical Sciences Building (PSB), Dean's Suite, Room 1121, 9500 Gilman Drive, MC 0657, La Jolla, CA 92093-0657, - - 2014
Variability in imipramine and desipramine metabolism was evaluated using urinary excretion data from patients with pain. Liquid chromatography-tandem mass spectrometry was used to quantitate concentrations in urine specimens. Interpatient population contained 600 unique imipramine specimens, whereas intrapatient population had 137 patients with two or more specimens. Normal concentration ranges of ...
Apisarnthanarak Piyaporn - - 2014
To evaluate the computed tomographic (CT) appearances for differentiating of primary hepatic adenocarcinoma (peripheral, mass-forming cholangiocarcinoma) and secondary hepatic adenocarcinoma (liver metastases from colorectal carcinoma). Between January 2004 and December 2010, 45 patients with peripheral, mass-forming cholangiocarcinoma (Group 1) and 45 patients with liver metastases from colorectal adenocarcinoma (Group 2) ...
Kim Hyun Ok HO Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Republic of - - 2014
A primary gastrointestinal stromal tumor (GIST) arising in the liver is extremely rare. In our case of GIST, CT and MRI showed a well-defined, weakly enhancing mass with a cystic component in the left lateral segment of the liver that showed homogeneous and avid (18)F-fluorodeoxyglucose ((18)F-FDG) accumulation on positron emission ...
Bertolino Nicola N Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, - - 2014
We set out to investigate the potential confounding effect of variable concentration of N-acetyl-l-aspartate (NAA) and Glutamate (Glu) on measurement of the brain oncometabolite 2-hydroxyglutarate (2HG) using a standard MRS protocol. This issue may arise due to spectral overlap at clinical magnetic field strengths and thus complicate the usage of ...
Ding Xiao-Qi XQ Institute of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, - - 2014
A feasibility study of an echo-planar spectroscopic imaging (EPSI) using a short echo time (TE) that trades off sensitivity, compared with other short-TE methods, to achieve whole brain coverage using inversion recovery and spatial oversampling to control lipid bleeding. Twenty subjects were scanned to examine intersubject variance. One subject was ...
Neary Casey P CP Bush Veterinary Neurology Service, Leesburg, - - 2014
A 12 yr old castrated male mixed-breed dog presented with a 2 wk history of progressive tetraparesis. Neurologic deficits included a short-strided choppy gait in the thoracic limbs and a long-strided proprioceptive ataxia in the pelvic limbs. Withdrawal reflexes were decreased bilaterally in the thoracic limbs. Signs were consistent with ...
Lee Jae-Seung JS Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, NY 10016; Department of Chemistry, New York University, New York, NY - - 2014
The development of chemical exchange saturation transfer (CEST) and magnetization transfer (MT) contrast in MRI have enabled the enhanced detection of metabolites and biomarkers in vivo. In brain MRI, the separation between CEST and MT contrast has been particularly difficult due to overlaps in the frequency responses of the contrast ...
Ratcliffe Gregory E GE *From the Diagnostic Radiology, The Health Sciences Center, University of Manitoba, Winnipeg, Manitoba, Canada; †Diagnostic Radiology, MRI Department, St. Boniface General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada; ‡Division of Abdominal Imaging and Intervention, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and §Diagnostic Radiology, CT Department, St. Boniface General Hospital, University of Manitoba, Winnipeg, Manitoba, - - 2014
To determine if gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) cholangiography can detect and localize bile duct leaks in postcholecystectomy patients. Four blinded independent radiologists performed a retrospective review of 16 consecutive patients who underwent MR cholangiography with intravenous Gd-EOB-DTPA for the evaluation of possible biliary leak. Image quality, ductal ...
Zhang Xiaodong X Yerkes Imaging Center and Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, - - 2014
Automatic metabolite quantification with curve fitting is essential in analyzing large amount of in vivo magnetic resonance spectroscopic imaging (MRSI) data. However, such data analysis is usually hindered by distorted metabolite peaks and baselines normally seen in in vivo MRS. In the present study, a multiscale approach was utilized for ...
Tilbrook Linda K - - 2014
A 51-year-old man sustained an anterior shoulder dislocation during a motor vehicle accident. Radiographs and noncontrast magnetic images were obtained. resonance images were obtained.
Diercks Deborah B DB University of California Davis, Department of Emergency Medicine, Sacramento, - - 2014
Contrast-induced nephropathy is a result of injury to the proximal tubules caused by oxidative stress and ischemia. Metabolomics is a novel technique that has been used to identify renal damage from drug toxicities. The objective of this study is to analyze the metabolic changes in the urine after dosing with ...
Arita Junichi J Gastroenterological Surgery Department, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto-ku, Tokyo, 135-8550, Japan, - - 2014
Preoperative chemotherapy sometimes makes colorectal liver metastases disappear or diminish. Contrast-enhanced intraoperative ultrasound (CE-IOUS) using perflubutane may identify such metastases. Among 131 consecutive patients who underwent hepatic resection, 86 had received preoperative chemotherapy. Of these patients, 72 were examined using contrast-enhanced computed tomography (CE-CT), gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic ...
Stehouwer B L BL Department of Radiology, University Medical Center Utrecht, Room E01.132, PO Box 85500, 3508 GA, Utrecht, Netherlands, - - 2014
Phosphorus metabolite ratios are potential biomarkers in breast cancer diagnosis and treatment monitoring. Our purpose was to investigate the metabolite ratios phosphomonoester to phosphodiester, phosphoethanolamine (PE) to glycerophosphoethanolamine (GPE), and phosphocholine (PC) to glycerophosphocholine (GPC) in glandular breast tissue, and the potential effect of the menstrual cycle, using (31)P magnetic ...
Chmelik Marek M High Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, - - 2014
Phosphorus ((31) P) MRS is a powerful tool for the non-invasive investigation of human liver metabolism. Four in vivo (31) P localization approaches (single voxel image selected in vivo spectroscopy (3D-ISIS), slab selective 1D-ISIS, 2D chemical shift imaging (CSI), and 3D-CSI) with different voxel volumes and acquisition times were demonstrated ...
Dhull Varun Singh VS From the Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, - - 2014
Urinary bladder paragangliomas are exceedingly rare tumors. A 22-year-old woman with bladder paraganglioma underwent Ga DOTANOC PET/CT for proper localization of the primary tumor and to rule out locoregional and distant metastases. Ga DOTANOC-avid bladder mass was detected with no other abnormal site of radiotracer uptake elsewhere. Although radioactive urine ...
Ji Yuan Y Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, - - 2014
Citalopram (CT) and escitalopram (S-CT) are among the most widely prescribed serotonin reuptake inhibitors (SSRIs) used to treat Major Depressive Disorder (MDD). We applied a genome-wide association study (GWAS) to identify genetic factors that contribute to variation in plasma concentrations of CT or S-CT and their metabolites in MDD patients ...
Zhong Xiaomei X Department of Neurology, Guangzhou Brain Hospital, Affiliated Hospital of Guangzhou Medical University, Guangzhou, - - 2014
FDG-PET and SPECT studies suggest that hypometabolism and hypoperfusion in occipital lobe and posterior cingulate gyrus (PCG) are prominent features of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), respectively. Cerebral blood flow and glucose metabolism are tightly linked to brain energy metabolism. 1H-MRS is a useful tool to ...
Esmaeili Morteza M Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, - - 2014
To study cancer associated with abnormal metabolism of phospholipids, of which several have been proposed as biomarkers for malignancy or to monitor response to anticancer therapy. We explored 3D (31) P magnetic resonance spectroscopic imaging (MRSI) at high magnetic field for in vivo assessment of individual phospholipids in two patient-derived ...
Ogul Hayri H Department of Radiology, School of Medicine, Atatürk University, Erzurum, - - 2014
The aim of this study was to evaluate utility of gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance cholangiography (MRC) for the detection of biliary complications after living donor liver transplantation (LDLT). A total of 18 patients with suspected biliary complications underwent MRC. T2-weighted MRC and contrast-enhanced MRC (CE-MRC) were used to ...
Kato Yuji Y Department of Neurology and Cerebrovascular Medicine, Saitama International Medical Center, Saitama Medical University, Saitama. Electronic address: - - 2014
A 46-year-old man presented with right hemiparesis. Cranial magnetic resonance (MR) imaging revealed both an acute cerebral infarction in the territory of the left anterior cerebral artery (ACA) and a thin subarachnoid hemorrhage in the left superior frontal sulcus. MR angiography revealed stenosis at the A2 segment of the left ...
Zhang Huiming H Division of Cancer Treatment and Diagnosis, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD. Electronic address: - - 2014
Advances in genomics are enabling integration of various -omics to reveal the complexities underneath carcinogenesis. Multivariate signaling pathways are deregulated and evolve spatially and temporally depending on the tumor microenvironment. This finding shifts the focus of cancer research from "one disease-one target and drug" to "one disease-multiple pathway targets and ...
Kobus Thiele T Radboud University Medical Centre, Radiology Department, Nijmegen, The - - 2014
In (1) H MR spectroscopic imaging ((1) H-MRSI) of the prostate the spatial distribution of the signal levels of the metabolites choline, creatine, polyamines, and citrate are assessed. The ratio of choline (plus spermine as the main polyamine) plus creatine over citrate [(Cho+(Spm+)Cr)/Cit] is derived from these metabolites and is ...
Maudsley A A AA From the Departments of Radiology (A.A.M., S.S.) and Radiation Oncology (R.S., N.A.P.), University of Miami, Miami, Florida; Department of Radiology and Imaging (R.K.G., B.R.), Fortis Memorial Research Institute, Gurgaon, Haryana, India; Department of Pathology (N.H.), Ram Manohar Lohia, Institute of Medical Sciences, Lucknow, India; and Department of Neurosurgery (S.B.), Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, - - 2014
Increased glycine concentration in the brain is associated with altered metabolism in cancer and can be detected by using in vivo MR spectroscopy. This has been proposed as a marker for grade IV gliomas; however, little is known about the potential significance and frequency of in vivo glycine observation. The ...
Lee Donghoon D Department of Radiology, University of Washington, Seattle, Washington, - - 2014
To obtain robust estimates of (31) P metabolite content in mouse skeletal muscles using our recently developed MR absolute quantification method and a custom-built (1) H/(31) P dual tuned radiofrequency (RF) coil optimized for mouse leg. We designed and fabricated a probe consisting of two dual tuned (1) H/(31) P ...
Cakmakci Emin E Department of Radiology, Kelkit Government Hospital, Gumushane, Turkey. Electronic address: - - 2014
Our aim was to investigate whether there is a correlation between computerized tomography (CT) density measurements of the urinary bladder and urinalysis results. Patients were subdivided into three groups with respect to urinalysis results: Group 1, no leukocytes or erythrocytes detected in urine (n=25); Group 2, erythrocytes detected in urine ...
Sheng Ruo-Fan RF Department of Radiology, Zhongshan Hospital, Shanghai Medical School, Fudan, University, Shanghai Medical Imaging Institute, No. 180 Fenglin Road, Xuhui, District, Shanghai 200032, - - 2014
The objective was to identify the decision-making magnetic resonance (MR) features in differentiating small intrahepatic mass-forming cholangiocarcinoma (sIMCC) from atypical small hepatocellular carcinoma (sHCC) (≤3 cm) in patients with cirrhosis and chronic viral hepatitis. Signal features and relative contrast of sHCCs and sIMCCs in T2-weighted and dynamic enhanced imaging were ...
Kim Yi Kyung YK Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of - - 2014
To compare the diagnostic performance of the noncontrast MRI including DWI to the standard MRI for detecting hepatic malignancies in patients with chronic liver disease. We included 135 patients with 136 histologically-confirmed hepatocellular carcinomas (HCCs), 12 cholangiocarcinomas, and 34 benign lesions (≤ 2.0 cm), and 22 patients with cirrhosis but ...
Di Costanzo Alfonso A Dipartimento di Medicina e Scienze per la Salute, Università del Molise, Via De Sanctis snc, 86100, Campobasso, Italy, - - 2014
The discrimination between recurrent glioma and radiation injury is often a challenge on conventional magnetic resonance imaging (MRI). We verified whether adding and combining proton MR spectroscopic imaging ((1)H-MRSI), diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) information at 3 Tesla facilitate such discrimination. Twenty-nine patients with histologically verified high-grade gliomas, ...
Wiebenga Oliver T OT Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam and VU University Medical Center, Amsterdam, the Netherlands; Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam and VU University Medical Center, Amsterdam, the - - 2014
The purpose of this study was to evaluate quality parameters, metabolite concentrations and concentration ratios, and to investigate the reproducibility of quantitative proton magnetic resonance spectroscopic imaging ((1) H-MRSI) of selected white and gray matter regions of healthy adults. 2D-quantitative short-TE (1) H-MRSI spectra were obtained at 1.5T from the ...
Karandikar A - - 2014
Jacobson's nerve schwannoma is a rare middle ear tumour presenting as a mass along the cochlear promontory. It can be differentiated from other masses along the promontory based on clinical, computed tomography and magnetic resonance imaging features. For small-sized masses, it is possible to differentiate between the various middle ear ...
Koltz Michael T MT Department of Neurosurgery, Dean Clinic, Madison, Wisconsin, - - 2014
The authors present a case to illustrate the necessity and technical feasibility of C7 laminar screw placement for treatment of sub-axial cervical spondylitic myelopathy. The indications for C7 lateral mass screw placement was required internal fixation, with small lateral masses (8 mm) and pedicles (4 mm). A 67-year-old female with ...
Patel Tulpesh T Aston Brain Centre, School of Life and Health Sciences, Aston University Birmingham, - - 2014
Background: Proton Magnetic Resonance Spectroscopy ((1)H-MRS) is a non-invasive imaging technique that enables quantification of neurochemistry in vivo and thereby facilitates investigation of the biochemical underpinnings of human cognitive variability. Studies in the field of cognitive spectroscopy have commonly focused on relationships between measures of N-acetyl aspartate (NAA), a surrogate ...
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