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Kim Hyun Ok HO Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Republic of - - 2014
A primary gastrointestinal stromal tumor (GIST) arising in the liver is extremely rare. In our case of GIST, CT and MRI showed a well-defined, weakly enhancing mass with a cystic component in the left lateral segment of the liver that showed homogeneous and avid (18)F-fluorodeoxyglucose ((18)F-FDG) accumulation on positron emission ...
Bertolino Nicola N Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, - - 2014
We set out to investigate the potential confounding effect of variable concentration of N-acetyl-l-aspartate (NAA) and Glutamate (Glu) on measurement of the brain oncometabolite 2-hydroxyglutarate (2HG) using a standard MRS protocol. This issue may arise due to spectral overlap at clinical magnetic field strengths and thus complicate the usage of ...
Ding Xiao-Qi XQ Institute of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, - - 2014
A feasibility study of an echo-planar spectroscopic imaging (EPSI) using a short echo time (TE) that trades off sensitivity, compared with other short-TE methods, to achieve whole brain coverage using inversion recovery and spatial oversampling to control lipid bleeding. Twenty subjects were scanned to examine intersubject variance. One subject was ...
Neary Casey P CP Bush Veterinary Neurology Service, Leesburg, - - 2014
A 12 yr old castrated male mixed-breed dog presented with a 2 wk history of progressive tetraparesis. Neurologic deficits included a short-strided choppy gait in the thoracic limbs and a long-strided proprioceptive ataxia in the pelvic limbs. Withdrawal reflexes were decreased bilaterally in the thoracic limbs. Signs were consistent with ...
Lee Jae-Seung JS Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, NY 10016; Department of Chemistry, New York University, New York, NY - - 2014
The development of chemical exchange saturation transfer (CEST) and magnetization transfer (MT) contrast in MRI have enabled the enhanced detection of metabolites and biomarkers in vivo. In brain MRI, the separation between CEST and MT contrast has been particularly difficult due to overlaps in the frequency responses of the contrast ...
Ratcliffe Gregory E GE *From the Diagnostic Radiology, The Health Sciences Center, University of Manitoba, Winnipeg, Manitoba, Canada; †Diagnostic Radiology, MRI Department, St. Boniface General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada; ‡Division of Abdominal Imaging and Intervention, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and §Diagnostic Radiology, CT Department, St. Boniface General Hospital, University of Manitoba, Winnipeg, Manitoba, - - 2014
To determine if gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) cholangiography can detect and localize bile duct leaks in postcholecystectomy patients. Four blinded independent radiologists performed a retrospective review of 16 consecutive patients who underwent MR cholangiography with intravenous Gd-EOB-DTPA for the evaluation of possible biliary leak. Image quality, ductal ...
Tilbrook Linda K - - 2014
A 51-year-old man sustained an anterior shoulder dislocation during a motor vehicle accident. Radiographs and noncontrast magnetic images were obtained. resonance images were obtained.
Diercks Deborah B DB University of California Davis, Department of Emergency Medicine, Sacramento, - - 2014
Contrast-induced nephropathy is a result of injury to the proximal tubules caused by oxidative stress and ischemia. Metabolomics is a novel technique that has been used to identify renal damage from drug toxicities. The objective of this study is to analyze the metabolic changes in the urine after dosing with ...
Arita Junichi J Gastroenterological Surgery Department, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto-ku, Tokyo, 135-8550, Japan, - - 2014
Preoperative chemotherapy sometimes makes colorectal liver metastases disappear or diminish. Contrast-enhanced intraoperative ultrasound (CE-IOUS) using perflubutane may identify such metastases. Among 131 consecutive patients who underwent hepatic resection, 86 had received preoperative chemotherapy. Of these patients, 72 were examined using contrast-enhanced computed tomography (CE-CT), gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic ...
Stehouwer B L BL Department of Radiology, University Medical Center Utrecht, Room E01.132, PO Box 85500, 3508 GA, Utrecht, Netherlands, - - 2014
Phosphorus metabolite ratios are potential biomarkers in breast cancer diagnosis and treatment monitoring. Our purpose was to investigate the metabolite ratios phosphomonoester to phosphodiester, phosphoethanolamine (PE) to glycerophosphoethanolamine (GPE), and phosphocholine (PC) to glycerophosphocholine (GPC) in glandular breast tissue, and the potential effect of the menstrual cycle, using (31)P magnetic ...
Chmelik Marek M High Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, - - 2014
Phosphorus ((31) P) MRS is a powerful tool for the non-invasive investigation of human liver metabolism. Four in vivo (31) P localization approaches (single voxel image selected in vivo spectroscopy (3D-ISIS), slab selective 1D-ISIS, 2D chemical shift imaging (CSI), and 3D-CSI) with different voxel volumes and acquisition times were demonstrated ...
Dhull Varun Singh VS From the Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, - - 2014
Urinary bladder paragangliomas are exceedingly rare tumors. A 22-year-old woman with bladder paraganglioma underwent Ga DOTANOC PET/CT for proper localization of the primary tumor and to rule out locoregional and distant metastases. Ga DOTANOC-avid bladder mass was detected with no other abnormal site of radiotracer uptake elsewhere. Although radioactive urine ...
Ji Yuan Y Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, - - 2014
Citalopram (CT) and escitalopram (S-CT) are among the most widely prescribed serotonin reuptake inhibitors (SSRIs) used to treat Major Depressive Disorder (MDD). We applied a genome-wide association study (GWAS) to identify genetic factors that contribute to variation in plasma concentrations of CT or S-CT and their metabolites in MDD patients ...
Zhong Xiaomei X Department of Neurology, Guangzhou Brain Hospital, Affiliated Hospital of Guangzhou Medical University, Guangzhou, - - 2014
FDG-PET and SPECT studies suggest that hypometabolism and hypoperfusion in occipital lobe and posterior cingulate gyrus (PCG) are prominent features of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), respectively. Cerebral blood flow and glucose metabolism are tightly linked to brain energy metabolism. 1H-MRS is a useful tool to ...
Esmaeili Morteza M Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, - - 2014
To study cancer associated with abnormal metabolism of phospholipids, of which several have been proposed as biomarkers for malignancy or to monitor response to anticancer therapy. We explored 3D (31) P magnetic resonance spectroscopic imaging (MRSI) at high magnetic field for in vivo assessment of individual phospholipids in two patient-derived ...
Ogul Hayri H Department of Radiology, School of Medicine, Atatürk University, Erzurum, - - 2014
The aim of this study was to evaluate utility of gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance cholangiography (MRC) for the detection of biliary complications after living donor liver transplantation (LDLT). A total of 18 patients with suspected biliary complications underwent MRC. T2-weighted MRC and contrast-enhanced MRC (CE-MRC) were used to ...
Kato Yuji Y Department of Neurology and Cerebrovascular Medicine, Saitama International Medical Center, Saitama Medical University, Saitama. Electronic address: - - 2014
A 46-year-old man presented with right hemiparesis. Cranial magnetic resonance (MR) imaging revealed both an acute cerebral infarction in the territory of the left anterior cerebral artery (ACA) and a thin subarachnoid hemorrhage in the left superior frontal sulcus. MR angiography revealed stenosis at the A2 segment of the left ...
Zhang Huiming H Division of Cancer Treatment and Diagnosis, Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD. Electronic address: - - 2014
Advances in genomics are enabling integration of various -omics to reveal the complexities underneath carcinogenesis. Multivariate signaling pathways are deregulated and evolve spatially and temporally depending on the tumor microenvironment. This finding shifts the focus of cancer research from "one disease-one target and drug" to "one disease-multiple pathway targets and ...
Kobus Thiele T Radboud University Medical Centre, Radiology Department, Nijmegen, The - - 2014
In (1) H MR spectroscopic imaging ((1) H-MRSI) of the prostate the spatial distribution of the signal levels of the metabolites choline, creatine, polyamines, and citrate are assessed. The ratio of choline (plus spermine as the main polyamine) plus creatine over citrate [(Cho+(Spm+)Cr)/Cit] is derived from these metabolites and is ...
Maudsley A A AA From the Departments of Radiology (A.A.M., S.S.) and Radiation Oncology (R.S., N.A.P.), University of Miami, Miami, Florida; Department of Radiology and Imaging (R.K.G., B.R.), Fortis Memorial Research Institute, Gurgaon, Haryana, India; Department of Pathology (N.H.), Ram Manohar Lohia, Institute of Medical Sciences, Lucknow, India; and Department of Neurosurgery (S.B.), Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, - - 2014
Increased glycine concentration in the brain is associated with altered metabolism in cancer and can be detected by using in vivo MR spectroscopy. This has been proposed as a marker for grade IV gliomas; however, little is known about the potential significance and frequency of in vivo glycine observation. The ...
Lee Donghoon D Department of Radiology, University of Washington, Seattle, Washington, - - 2014
To obtain robust estimates of (31) P metabolite content in mouse skeletal muscles using our recently developed MR absolute quantification method and a custom-built (1) H/(31) P dual tuned radiofrequency (RF) coil optimized for mouse leg. We designed and fabricated a probe consisting of two dual tuned (1) H/(31) P ...
Cakmakci Emin E Department of Radiology, Kelkit Government Hospital, Gumushane, Turkey. Electronic address: - - 2014
Our aim was to investigate whether there is a correlation between computerized tomography (CT) density measurements of the urinary bladder and urinalysis results. Patients were subdivided into three groups with respect to urinalysis results: Group 1, no leukocytes or erythrocytes detected in urine (n=25); Group 2, erythrocytes detected in urine ...
Sheng Ruo-Fan RF Department of Radiology, Zhongshan Hospital, Shanghai Medical School, Fudan, University, Shanghai Medical Imaging Institute, No. 180 Fenglin Road, Xuhui, District, Shanghai 200032, - - 2014
The objective was to identify the decision-making magnetic resonance (MR) features in differentiating small intrahepatic mass-forming cholangiocarcinoma (sIMCC) from atypical small hepatocellular carcinoma (sHCC) (≤3 cm) in patients with cirrhosis and chronic viral hepatitis. Signal features and relative contrast of sHCCs and sIMCCs in T2-weighted and dynamic enhanced imaging were ...
Kim Yi Kyung YK Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of - - 2014
To compare the diagnostic performance of the noncontrast MRI including DWI to the standard MRI for detecting hepatic malignancies in patients with chronic liver disease. We included 135 patients with 136 histologically-confirmed hepatocellular carcinomas (HCCs), 12 cholangiocarcinomas, and 34 benign lesions (≤ 2.0 cm), and 22 patients with cirrhosis but ...
Di Costanzo Alfonso A Dipartimento di Medicina e Scienze per la Salute, Università del Molise, Via De Sanctis snc, 86100, Campobasso, Italy, - - 2014
The discrimination between recurrent glioma and radiation injury is often a challenge on conventional magnetic resonance imaging (MRI). We verified whether adding and combining proton MR spectroscopic imaging ((1)H-MRSI), diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) information at 3 Tesla facilitate such discrimination. Twenty-nine patients with histologically verified high-grade gliomas, ...
Wiebenga Oliver T OT Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam and VU University Medical Center, Amsterdam, the Netherlands; Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam and VU University Medical Center, Amsterdam, the - - 2014
The purpose of this study was to evaluate quality parameters, metabolite concentrations and concentration ratios, and to investigate the reproducibility of quantitative proton magnetic resonance spectroscopic imaging ((1) H-MRSI) of selected white and gray matter regions of healthy adults. 2D-quantitative short-TE (1) H-MRSI spectra were obtained at 1.5T from the ...
Karandikar A - - 2014
Jacobson's nerve schwannoma is a rare middle ear tumour presenting as a mass along the cochlear promontory. It can be differentiated from other masses along the promontory based on clinical, computed tomography and magnetic resonance imaging features. For small-sized masses, it is possible to differentiate between the various middle ear ...
Koltz Michael T MT Department of Neurosurgery, Dean Clinic, Madison, Wisconsin, - - 2014
The authors present a case to illustrate the necessity and technical feasibility of C7 laminar screw placement for treatment of sub-axial cervical spondylitic myelopathy. The indications for C7 lateral mass screw placement was required internal fixation, with small lateral masses (8 mm) and pedicles (4 mm). A 67-year-old female with ...
Patel Tulpesh T Aston Brain Centre, School of Life and Health Sciences, Aston University Birmingham, - - 2014
Background: Proton Magnetic Resonance Spectroscopy ((1)H-MRS) is a non-invasive imaging technique that enables quantification of neurochemistry in vivo and thereby facilitates investigation of the biochemical underpinnings of human cognitive variability. Studies in the field of cognitive spectroscopy have commonly focused on relationships between measures of N-acetyl aspartate (NAA), a surrogate ...
Mickiewicz Beata B 1Bio-NMR-Centre, Department of Biological Sciences, University of Calgary, Calgary, AB, Canada. 2Critical Care Epidemiologic and Biologic Tissue Resource (CCEPTR), Department of Critical Care Medicine, University of Calgary, Calgary, AB, Canada. 3Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada. 4Department of Physiology and Biophysics, University of Calgary, Calgary, AB, - - 2013
To determine whether a nuclear magnetic resonance-based metabolomics approach can be useful for the early diagnosis and prognosis of septic shock in ICUs. Laboratory-based study. University research laboratory. Serum samples from septic shock patients and ICU controls (ICU patients with systemic inflammatory response syndrome but not suspected of having an ...
Duconseille Anne-Carole - - 2013
The magnetic resonance imaging features of a cauda equina paraganglioma in a 5-year-old dog are described. Imaging revealed a well-defined, strongly contrast-enhancing mass invading the adjacent vertebral body and infiltrating the intervertebral foramen bilaterally. Flow void, compatible with increased drainage veins around the mass, and macroscopically visible neovessels in contrast-enhanced ...
Weiduschat Nora - - 2013
Cerebral mitochondrial dysfunction has been observed in Parkinson's disease (PD). If mitochondrial dysfunction is an early event contributing to PD development, then noninvasive techniques that detect disturbed energy metabolism in vivo might be useful tools for early diagnosis and treatment monitoring. In the present study, we tested the hypothesis that ...
Harding Scott A SA Warnell School of Forestry and Natural Resources, University of Georgia, Athens, GA 30602, - - 2013
The partitioning of carbon for growth, storage and constitutive chemical defenses is widely framed in terms of a hypothetical sink-source differential that varies with nutrient supply. According to this framework, phenolics accrual is passive and occurs in source leaves when normal sink growth is not sustainable due to a nutrient ...
Kamisawa Terumi - - 2013
Pancreaticobiliary maljunction is a congenital malformation in which the pancreatic and bile ducts join anatomically outside the duodenal wall. The diagnostic criteria for pancreaticobiliary maljunction were proposed in 1987. The committee of The Japanese Study Group on Pancreaticobiliary Maljunction (JSGPM) for diagnostic criteria for pancreaticobiliary maljunction began to revise the ...
Yeh Yi-Chun - - 2013
ABSTRACT Background: Unawareness of deficits is common and is associated with poor outcomes in Alzheimer's disease (AD); however, little is known about correlated neurobiochemical changes. Methods: Proton magnetic resonance spectroscopy was used to examine neurobiochemical correlates of unawareness of deficits as assessed by the Dementia Deficit Scale in 36 patients ...
Novak Jan J School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom; Birmingham Children's Hospital, Birmingham, United Kingdom. Electronic address: - - 2013
In vivo (31)P Magnetic Resonance Spectroscopy (MRS) measures phosphorus-containing metabolites that play an essential role in many disease processes. An advantage over (1)H MRS is that total choline can be separated into phosphocholine and glycerophosphocholine which have opposite associations with tumour grade. We demonstrate (31)P MRS can provide robust metabolic ...
Verma Gaurav - - 2013
To evaluate the utility of two-dimensional (2D) Localized Correlated Spectroscopy (L-COSY) in metabolic profiling of the human brain at 7 Tesla (T). The 2D L-COSY sequence was implemented at 7T and its reliability was assessed by test-retest studies of a metabolite phantom and a healthy volunteer. L-COSY data were acquired ...
Larner Aj A Walton Centre for Neurology and Neurosurgery, Liverpool, - - 2013
Mrs Elizabeth Gaskell was a celebrated author of the Victorian era, a friend of both Charles Dickens and Charlotte Brontë and the latter's first biographer. References to headache in Mrs Gaskell's six major novels, published between 1848 and 1866 as well as some of her shorter fiction, have been collated. ...
Zaiss Moritz - - 2013
Chemical exchange saturation transfer (CEST) of metabolite protons that undergo exchange processes with the abundant water pool enables a specific contrast for magnetic resonance imaging (MRI). The CEST image contrast depends on physical and physiological parameters that characterize the microenvironment such as temperature, pH, and metabolite concentration. However, CEST imaging ...
Moy Katie V - - 2013
Meperidine (Demerol(®)) is a mu- and kappa-opiate receptor agonist used for moderate to severe pain. Overdose can result in respiratory depression, hypotension and coma, while accumulation of its toxic metabolite, normeperidine, can cause delirium and seizures. Little data exist examining the inter- and intrasubject variability of the normeperidine-to-meperidine metabolic ratio ...
Enkhbold Ch - - 2013
Background: Three-dimensional CT has become an essential tool for successful hepatic surgery. Up to now, efforts have been made to simultaneously visualize hepatic vasculature and bile ducts. Herein, we introduce a new one-stop shop approach to hepatic 3D-anatomy, using a standard enhanced MDCT alone.Methodology: A 3D-reconstruction of hepatic vasculature was ...
Warrington Christopher D - - 2013
Objective-To determine relative concentrations of selected major brain tissue metabolites and their ratios and lobar variations by use of 3-T proton (hydrogen 1 [(1)H]) magnetic resonance spectroscopy (MRS) of the brain of healthy dogs. Animals-10 healthy Beagles. Procedures-3-T (1)H MRS at echo times of 144 and 35 milliseconds was performed ...
Tripathi Madhavi M Department of Nuclear Medicine and PET, All India Institute of Medical Sciences, New Delhi, - - 2013
F-18 Fluorodeoxyglucose (FDG) Positron emission tomography/Computed Tomography (PET/CT) has come to play an increasingly important role for the pre-surgical evaluation of drug resistant epilepsy and complements Magnetic Resonance Imaging (MRI) in the evaluation of grey matter heterotopias. This case illustrates the characteristic pattern of metabolic abnormality in diffuse band heterotopia ...
Kızılgöz Volkan V Department of Radiology, Afyonkarahisar State Hospital, Afyonkarahisar, - - 2013
The purpose of this study was to diagnose the hypoxic impairment by Magnetic resonance spectroscopy (MRS), an advanced MR imaging technique, which could not be visualised by routine imaging methods in patients with obstructive sleep apnea (OSA). 20 OSA patients and 5 controls were included in this prospective research. MRS ...
Swiętaszczyk Cyprian C Department of Nuclear Medicine, The Dr. Władysław Biegański Regional Specialist Hospital in Grudziądz, Grudziądz, - - 2013
Although specificity of SPECT/CT examination using technetium-99m radiolabeled red blood cells (Tc-99m-RBC) for detection of liver hemangiomas is very high, it is still not perfect. It is possible to overlook a malignancy. Moreover, the difference in accumulation of RBCs between a hemangioma and uninvolved liver remains unknown. The aim of ...
Bibevski Jennifer Deck - - 2013
The clinical usefulness of computed tomography (CT) as a sole diagnostic modality in identifying disc lesion(s) in chondrodystrophic breeds presenting with acute signs of intervertebral disc disease (IVDD) is incompletely characterized. CT was used prospectively to determine the validity of this tool. Neurologic examinations and CT scans were performed on ...
Gallach Ricardo Guillem - - 2013
Veterinary cardiac MRI (cMRI) is a relatively new technique. A dog with recurrent pericardial effusion and a questionable right atrial mass lesion on echocardiography underwent cMRI. cMRI provided excellent anatomic information about the heart and surrounding structures and helped to rule out the presence of a focal mass. A diffuse ...
Weber-Fahr Wolfgang - - 2013
Phospholipid (PL) metabolism is investigated by in vivo 31P magnetic resonance spectroscopy (MRS). Inconsistent alterations of phosphocholine (PC), phosphoethanolamine (PE), glycerophosphocholine (GPC) and glycerophosphoethanolamine (GPE) have been described in schizophrenia, which might be overcome by specific editing techniques. The selective refocused insensitive nuclei-enhanced polarization transfer (RINEPT) technique was applied in ...
Natsubori Tatsunobu - - 2013
Changes in brain pathology as schizophrenia progresses have been repeatedly suggested by previous studies. Meta-analyses of previous proton magnetic resonance spectroscopy ((1)H MRS) studies at each clinical stage of schizophrenia indicate that the abnormalities of N-acetylaspartate (NAA) and glutamatergic metabolites change progressively. However, to our knowledge, no single study has ...
Andronesi Ovidiu C OC Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. - - 2013
The investigation of metabolic pathways disturbed in isocitrate dehydrogenase (IDH) mutant tumors revealed that the hallmark metabolic alteration is the production of D-2-hydroxyglutarate (D-2HG). The biological impact of D-2HG strongly suggests that high levels of this metabolite may play a central role in propagating downstream the effects of mutant IDH, ...
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