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Egger Christine C Novartis Institutes for BioMedical Research, Analytical Sciences and Imaging, Basel, Switzerland; University of Basel, Biocenter, Basel, - - 2014
To assess whether hyaluronic acid, a building block of proteoglycans and extracellular matrix with hydrophilic characteristics, might contribute to magnetic resonance imaging (MRI)-detected proton signals elicited by bleomycin in the lung. To this end, hyaluronidase, which degrades hyaluronic acid, was administered to bleomycin-challenged animals. Fibrosis was induced by oropharyngeal aspiration ...
Ye Fei F Division of Experimental Cancer Medicine, Department of Laboratory Medicine (LABMED), Karolinska Institutet, SE-141 86 Stockholm, - - 2014
We have developed biodegradable polymeric vesicles as a nanocarrier system for multimodal bio-imaging and anticancer drug delivery. The poly(lactic-co-glycolic acid) (PLGA) vesicles were fabricated by encapsulating inorganic imaging agents of superparamagnetic iron oxide nanoparticles (SPION), manganese-doped zinc sulfide (Mn:ZnS) quantum dots (QDs) and the anticancer drug busulfan into PLGA nanoparticles ...
Bae Sungjun - - 2014
Experiments were conducted to investigate the effect of riboflavin on the reactivity of nanoscale zero-valent iron (NZVI) during three reaction cycles of carbon tetrachloride (CT) degradation. The degradation kinetics of CT by NZVI without riboflavin (0.556 ± 0.044 h-1) was 1.5 times higher than that with riboflavin (0.370 ± 0.012 ...
Suzuki Akira A Diagnostic Imaging Center, Japanese Red Cross Sendai Hospital, Miyagi, - - 2014
CT-based attenuation correction (CTAC) of myocardial SPECT images has been becoming more popular-and the application of SPECT/CT increasing-because it prevents attenuation-induced image degradation. However, CTAC can be affected by overestimation of counts caused by metals. It is possible that pacemaker, left ventricle (LV), and implantable cardioverter-defibrillator (ICD) leads have an ...
Narisawa Ayumi A Departments of - - 2014
The authors report on a 49-year-old man with a thoracic spinal dural arteriovenous shunt (dAVS) in which rupture of a varix caused intramedullary hemorrhage. In the literature, patients with a thoracic dAVS predominantly present with congestive myelopathy; however, the patient featured in this report presented without increased deep tendon reflexes ...
Goode Kevin M - - 2014
Abstract Background: The in vitro stability of a biomarker can determine whether it should be used in clinical practice where long delays between sampling and assay are common. We measured the in vitro stability of five novel biomarkers that are being evaluated for their diagnostic and/or prognostic utility in patients ...
Li Zhoubo Z Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota - - 2014
Purpose: To develop and evaluate an image-domain noise reduction method based on a modified nonlocal means (NLM) algorithm that is adaptive to local noise level of CT images and to implement this method in a time frame consistent with clinical workflow.Methods: A computationally efficient technique for local noise estimation directly ...
Landaluce Hugo H Deusto Institute of Technology (DeustoTech), University of Deusto, Bilbao 48007, Spain. - - 2014
Radio Frequency Identification (RFID) technology faces the problem of message collisions. The coexistence of tags sharing the communication channel degrades bandwidth, and increases the number of bits transmitted. The window methodology, which controls the number of bits transmitted by the tags, is applied to the collision tree (CT) protocol to ...
Vidal C M P CM Department of Restorative Dentistry, Dental Materials Area, Piracicaba Dental School, State University of Campinas, Piracicaba, - - 2013
Degradation of dentin matrix components within caries dentin has been correlated with the activity of host-derived proteases, such as matrix metalloproteases (MMPs) and cysteine cathepsins (CTs). Since this relationship has not been fully established, we hypothesized that the abundance of MMPs and CTs in caries-affected dentin must be higher than ...
Ventura Manuela M Department of Biomaterials, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The - - 2013
With biomimetic biomaterials, like calcium phosphate cements (CPCs), non-invasive assessment of tissue regeneration is challenging. This study describes a theranostic agent (TA) to simultaneously enhance both imaging and osteogenic properties of such a bone substitute material. For this purpose, mesoporous silica beads were produced containing an iron oxide core to ...
Lavdas Eleftherios E Technological Educational Institute of Athens, Radiology Department, Athens, - - 2013
The purpose of this retrospective clinical study was to identify and evaluate the presence and frequency of T2 FLAIR artifacts on brain MRI studies performed at 3 T. We reviewed axial T2 FLAIR images in 200 consecutive unremarkable brain MRI studies performed at 3 T. All studies were reviewed for ...
Schleyer Paul J - - 2013
Respiratory motion affects cardiac PET-computed tomography (CT) imaging by reducing attenuation correction (AC) accuracy and by introducing blur. The aim of this study was to compare three approaches for reducing motion-induced AC errors and evaluate the inclusion of respiratory motion correction. AC with a helical CT was compared with averaged ...
Glick Stephen J - - 2013
A number of research groups have been investigating the use of dedicated breast computerized tomography (CT). Preliminary results have been encouraging, suggesting an improved visualization of masses on breast CT as compared to conventional mammography. Nonetheless, there are many challenges to overcome before breast CT can become a routine clinical ...
Camenisch Colette C - - 2013
Macrolane is a biocompatible, biodegradable, injectable stabilized hyaluronic acid-based gel of nonanimal origin manufactured using the nonanimal stabilized hyaluronic acid technology. This was a substudy to evaluate localization, displacement, and degradation of the gel when used for volume restoration and shaping of the buttocks. Subjects aged 20 years or older ...
Tonkopi Elena - - 2013
OBJECTIVE. The objective of this study was to optimize CT protocols for whole-body PET/CT by reducing radiation dose while minimizing effects on image quality. MATERIALS AND METHODS. Before protocol optimization, a survey of 140 consecutive patients was conducted to establish the baseline dose from a whole-body PET/CT examination. Another sample ...
Nappi Carmela - - 2013
Simultaneous PET/MRI is an emerging technique combining two powerful imaging modalities in a single device. The wide variety of available tracers for perfusion and metabolic studies and the high sensitivity of positron emission tomography (PET) combined with the high spatial resolution and soft tissue contrast of magnetic resonance imaging (MRI) ...
Del Gaizo Andrew J - - 2013
Computed tomographic (CT) enterography is a diagnostic examination that is increasingly being used to evaluate disorders of the small bowel. An undesirable consequence of CT, however, is patient exposure to ionizing radiation. This is of particular concern with CT enterography because patients tend to be young and require numerous follow-up ...
Zhang Yunwan - - 2013
Ultra-low-dose x-ray computed tomography (CT) imaging is needed in CT fields. Through a scan protocol by lowering the milliampere-seconds (mAs) and reducing the number of projections per rotation around the body, we can realize low-dose CT imaging. However, the resulting noisy and insufficient measurements will unavoidably cause the degradation of ...
Kaplan Alex - - 2013
We present an optical mode solver for a whispering gallery resonator coupled to an adjacent arbitrary shaped nano-particle that breaks the axial symmetry of the resonator. Such a hybrid resonator-nanoparticle is similar to what was recently used for bio-detection and for field enhancement. We demonstrate our solver by parametrically studying ...
Di Gregorio Enza - - 2013
Commercial Gd-containing complexes are often used as MRI reporters in cellular labeling procedures as they are internalized into endosomes by pinocytosis. A methodology has been applied to assess the relative stability of three commercial Gd contrast agents following cellular uptake in fibroblasts and macrophages. It has been found that the ...
Yitta Silaja - - 2013
OBJECTIVE. This article will discuss routine 1.5 and 3 T MRI of the breast as well as illustrate several examples of patient-related and technical artifacts one might encounter. Suggestions to help eliminate these artifacts and optimize images will be provided. CONCLUSION. Artifacts seen on breast MR images can degrade image ...
Hani Ahmad Fadzil Mohd - - 2013
Osteoarthritis is a common joint disorder that is most prevalent in the knee joint. Knee osteoarthritis (OA) can be characterized by the gradual loss of articular cartilage (AC). Formation of lesion, fissures and cracks on the cartilage surface has been associated with degenerative AC and can be measured by morphological ...
Matsuki Mitsuru - - 2013
BACKGROUND: While CT is widely used in medical practice, a substantial source of radiation exposure is associated with an increased lifetime risk of cancer. Therefore, concerns to dose reduction in CT examinations are increasing and an iterative reconstruction algorithm, which allow for dose reduction by compensating image noise in the ...
Morsbach Fabian - - 2013
PURPOSE: To determine the value of a metal artefact reduction (MAR) algorithm with iterative reconstructions for dental hardware in carotid CT angiography. METHODS: Twenty-four patients (six of which were women; mean age 70 ± 12 years) with dental hardware undergoing carotid CT angiography were included. Datasets were reconstructed with filtered back projection (FBP) ...
Korn A - - 2013
PURPOSE: Iterative reconstruction has recently been revisited as a promising concept for substantial CT dose reduction. The purpose of this study was to assess the potential benefit of sinogram affirmed iterative reconstruction (SAFIRE) in head CT by comparing objective and subjective image quality at reduced tube current with standard dose ...
Hong Key Jo - - 2013
Purpose: The aim of this study was to develop a prototype magnetic resonance (MR)-compatible positron emission tomography (PET) that can be inserted into a MR imager and that allows simultaneous PET and MR imaging of the human brain. This paper reports the initial results of the authors' prototype brain PET ...
Rakoczy Megan M DLCSPM 4-5, National Defence, 101 Colonel By Dr., Ottawa, Canada, K1A 0K2. - - 2013
The accuracy of computer-aided diagnosis (CAD) for early detection and classification of breast cancer in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is dependent upon the features used by the CAD classifier. Here, we show that fast orthogonal search (FOS), which provides a more efficient iterative manner of computing stepwise regression ...
Kim Jongsik J University of Illinois at Urbana-Champaign, Beckman Institute for Advanced Science and Technology, 405 North Mathews Avenue, Urbana, Illinois 61801, - - 2013
Magnetomotive optical coherence tomography (MM-OCT) is a functional extension of OCT which utilizes magnetically responsive materials that are modulated by an external magnetic field for contrast enhancement and for elastography to assess the structural and viscoelastic properties of the surrounding tissues. Traditionally, magnetomotive contrast relies on the interaction between the ...
Coblentz W K - - 2013
Dairy cattle often make poor use of protein when offered diets comprising high proportions of alfalfa (Medicago sativa L.) hay or silage because nonprotein N formed during forage conservation and ruminal fermentation exceeds requirements for rumen microbial protein synthesis; however, condensed tannins (CT) may reduce proteolysis in the silo and ...
Lin Ching-Wen - - 2013
Chemically modified antisense RNA oligonucleotides (antagomir) offer promise for cancer therapies but suffer from poor therapeutic effect after systemic administration. Chemical modification or loading in degradable hydrogels can offer improvements in the accuracy and efficacy for sustained delivery at specific sites. In our approach, antagomir were entrapped with degradable poly(ethylene ...
Petibon Y Y Center for Advanced Medical Imaging Sciences, Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, - - 2013
Cardiac motion and partial volume effects (PVE) are two of the main causes of image degradation in cardiac PET. Motion generates artifacts and blurring while PVE lead to erroneous myocardial activity measurements. Newly available simultaneous PET-MR scanners offer new possibilities in cardiac imaging as MRI can assess wall contractility while ...
Pessis Eric - - 2013
With arthroplasty being increasingly used to relieve joint pain, imaging of patients with metal implants can represent a significant part of the clinical work load in the radiologist's daily practice. Computed tomography (CT) plays an important role in the postoperative evaluation of patients who are suspected of having metal prosthesis-related ...
Ali Syed H - - 2013
Voluntary patient motion is a common cause of image degradation during MRI and leads to repeated scanning, decreasing efficiency, and increasing costs. We hypothesized that providing an educational pamphlet to patients before their MRI examination could improve image quality and decrease the number of repeated sequences needed because of motion ...
Azuhnwi Blasius N - - 2013
BACKGROUND: To maximise the potential benefits to ruminants from sainfoin, plant breeding should focus on developing varieties with predictable condensed tannin (CT) profiles. Little is known about whether and to what extent accession and environment influence sainfoin CT structures. We sought to investigate the likely extent of accession and environment ...
Ye Mingzhou - - 2013
Highly sensitive and safe contrast agents (CAs) are essential for magnetic resonance imaging (MRI) to achieve accurate tumor detection and imaging. Dendrimer-based macromolecular MRI contrast agents are advantageous owing to their tumor-targeting ability, enhanced imaging contrast and enlarged imaging window. However, most of them have drawbacks of non-degradability and thereby ...
Song S - - 2013
To overcome the problems of limited needle inser-tion accuracy and human error in the use of a conventional nee-dle guide template in MRI-guided prostate intervention, we de-veloped a motorized MRI-compatible needle guide template that resembles a TRUS-guided prostate template. The motorized template allows automated, gapless needle guidance in a 3T ...
Chen Bailiang - - 2013
Non-invasive quantitative assessment of articular cartilage integrity is essential for early detection and evaluation of osteoarthritis (OA) and for the follow-up of stem-cell-driven cartilage engineering. In this study, we investigated the feasibility of exploiting diffusion tensor imaging (DTI) on porcine knee joints with a clinical magnetic resonance (MR) scanner to ...
Zhang Yu - - 2013
Brain magnetic resonance imaging (MRI) studies have demonstrated regional patterns of brain macrostructural atrophy and white matter microstructural alterations separately in the three major subtypes of frontotemporal lobar degeneration (FTLD), which includes behavioral variant frontotemporal dementia (bvFTD), semantic dementia (SD), and progressive nonfluent aphasia (PNFA). This study was to investigate ...
Anderla Andras - - 2013
For decades, computed tomography (CT) images have been widely used to discover valuable anatomical information. Metallic implants such as dental fillings cause severe streaking artifacts which significantly degrade the quality of CT images. In this paper, we propose a new method for metal-artifact reduction using complementary magnetic resonance (MR) images. ...
Glocker Ben B Microsoft Research, Cambridge, - - 2013
Accurate localization and identification of vertebrae in spinal imaging is crucial for the clinical tasks of diagnosis, surgical planning, and post-operative assessment. The main difficulties for automatic methods arise from the frequent presence of abnormal spine curvature, small field of view, and image artifacts caused by surgical implants. Many previous ...
Zerbi Valerio - - 2012
In patients with Alzheimer's disease (AD) the severity of white matter degeneration correlates with the clinical symptoms of the disease. In this study, we performed diffusion-tensor magnetic resonance imaging at ultra-high field in a mouse model for AD (APP(swe)/PS1(dE9)) in combination with a voxel-based approach and tractography to detect changes ...
Itatani R - - 2012
AIM: To optimize low-kilovoltage (kV) computed tomography (CT) protocols using a hybrid iterative reconstruction (HIR) algorithm at 256-detector-row body CT. MATERIALS AND METHODS: Based on preliminary phantom studies, three different tube voltage protocols with an equal contrast-to-noise ratio (CNR) were developed. They were a conventional 120 kV protocol with filtered back-projection ...
Kassamali Rahil Hussein - - 2012
PURPOSE: This feasibility study aimed to obtain initial data to assess the performance of a novel non-contrast ‡ow-spoiled magnetic resonance (MR) angiography technique (fresh-blood imaging [FBI]) compared to gadolinium-enhanced MR (Gd-MR) angiography for evaluation of the aorto-iliac and lower extremity arteries. MATERIALS AND METHODS: Thirteen patients with suspected lower extremity ...
Davenport Matthew S - - 2013
To determine whether acute transient dyspnea and/or arterial phase image degradation occurs more or less often after intravenous administration of gadoxetate disodium than with intravenous administration of gadobenate dimeglumine. Institutional review board approval and patient consent were obtained for this prospective observational study. One hundred ninety-eight gadolinium-based contrast media administrations ...
Krom Aaron J - - 2012
Reducing the radiation dose and scanning time of diagnostic tests is often desirable. One method uses image enhancement software such as Pixon, which processes lower-count scans and aims to produce high-quality images. However, it is essential that diagnostic accuracy is not compromised. We compared the level of agreement between clinicians ...
Balamoody Sharon - - 2012
OBJECTIVE: The transverse relaxation time (T2) in MR imaging has been identified as a potential biomarker of hyaline cartilage pathology. This study investigates whether MR assessments of T2 are comparable between 3-T scanners from three different vendors. DESIGN: Twelve subjects with symptoms of knee osteoarthritis and one or more risk ...
Sogur E - - 2012
The aim of this study was to determine (1) the effect of various scan delays on pixel intensity measurements and (2) the diagnostic accuracy of occlusal caries detection. 72 non-cavitated extracted human permanent molar teeth with sound and carious occlusal surfaces were radiographed using the DIGORA® storage phosphor plates (SPPs) ...
Langstaff Lorna Elizabeth - - 2012
A 47-year-old man is investigated in the ear, nose and throat department for a 6-month history of left submandibular swelling and pain. He underwent several investigations, before a large styloid process was found on CT imaging of the neck. The patient underwent surgical excision of the enlarged styloid process and ...
Irahara Kaori - - 2012
To detect the epileptogenic region causing epileptic spasms in an infant with tuberous sclerosis (TS). We applied a multiple band frequency analysis to video electroencephalographic (EEG) recordings of the infant's scalp. We also performed computed tomography (CT), magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), and magnetoencephalography (MEG) of ...
Casanova Ramon - - 2012
Machine learning neuroimaging researchers have often relied on regularization techniques when classifying MRI images. Although these were originally introduced to deal with "ill-posed" problems it is rare to find studies that evaluate the ill-posedness of MRI image classification problems. In addition, to avoid the effects of the "curse of dimensionality" ...
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