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Mykhaylyk Olga O Institute of Experimental Oncology, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, Munich, 81675, Germany, - - 2015
This chapter describes how to design and conduct experiments to deliver siRNA to adherent cell cultures in vitro by magnetic force-assisted transfection using self-assembled complexes of small interfering RNA (siRNA) and cationic lipids or polymers that are associated with magnetic nanoparticles (MNPs). These magnetic complexes are targeted to the cell ...
Kettenbach Joachim J Institute of Medical Radiology, Diagnostic, Intervention. Karl Landsteiner University of Health Science, University Hospital St. Poelten , St. Poelten , - - 2014
Abstract Several groups have developed robotic systems for invasive medical procedures. In this article we will focus on selected robotic systems for percutaneous needle-guided interventions using CT or MR imaging. We present six interventional robotic systems designed to work with imaging modalities such as CT, Cone-beam CT and MRI. The ...
Solivetti Francesco - - 2014
BackgroundOver the past several years the incidence of cutaneous melanoma has rapidly increased. This tumor develops often in-transit metastases that significantly reduce patient survival at 5 years. To improve prognosis and quality of life in patients with melanoma metastases, a mini invasive procedure like electrochemotherapy (ECT) is adopted to remove superficial ...
Thomas Karen E KE Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Avenue, Toronto, M5G 1X8, Canada, - - 2014
Optimal vascular and parenchymal enhancement for multi-region paediatric body computed tomography (CT) has many challenges. A variety of approaches are currently employed, associated with varying image quality and radiation dose implications. We present a dual bolus intravenous (DBI) contrast technique for single-acquisition imaging of the chest, abdomen and pelvis, with ...
Chen Fei F State Key Laboratory of Optoelectronic Materials and Technologies, School of Physics & Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China. - - 2014
Dual-modal lanthanide-doped gadolinium nanoparticles (NPs), which exhibit an excellent magnetic resonance imaging (MRI) spatial resolution and high fluorescence imaging (FI) sensitivity, have attracted tremendous attention in biotechnology and nanomedicine applications. In this paper, terbium (Tb) ion doped gadolinium oxide (Gd2O3:Tb) NPs with varied Tb concentrations were synthesized by a laser ...
van Atta Angela J AJ University of Utah School of Medicine, Salt Lake City, UT, - - 2014
The use of ultrasound to diagnose appendicitis in children is well-documented but not universally employed outside of pediatric academic centers, especially in the United States. Various obstacles make it difficult for institutions and radiologists to abandon a successful and accurate CT-based imaging protocol in favor of a US-based protocol. To ...
Romano Andrea A San Raffaele Foundation Rome, Rehabilitation Facility Ceglie Messapica, Merit Project RBNE08E8CZ, - - 2014
Objectives: In this preliminary report, we describe our experience with Time-Resolved Imaging of Contrast KineticS-Magnetic Resonance Angiography (TRICKS-MRA) in the assessment of Head-Neck Vascular Anomalies (HNVAs). Methods: We prospectively studied six consecutive patients with clinically suspected or diagnosed HNVAs. All of them underwent Time-resolved Imaging of contrast kinetics (TRICKS) Magnetic ...
Cieslak Matthew M Department of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, California, - - 2014
While simultaneous acquisition of electrocardiography (ECG) data during MRI is a widely used clinical technique, the effects of the MRI environment on impedance cardiography (ICG) data have not been characterized. We collected echo planar MRI scans while simultaneously recording ECG and thoracic impedance using carbon fiber electrodes and customized amplifiers. ...
Nakamura Tatsuya T Graduate School of Engineering, Osaka University, Yamadaoka 2-1, Suita, Osaka 565-0871 - - 2014
(19) F magnetic resonance imaging (MRI) probes that can detect biological phenomena such as cell dynamics, ion concentrations, and enzymatic activity have attracted significant attention. Although perfluorocarbon (PFC) encapsulated nanoparticles are of interest in molecular imaging owing to their high sensitivity, activatable PFC nanoparticles have not been developed. In this ...
Londoño Ana C AC Neurological Institute of Colombia-INDEC and Link Diagnostico Digital (A.C.L.), Medellín, Colombia; and Department of Neurology (C.A.M.), Georgetown Multiple Sclerosis Center, MedStar Georgetown University Hospital, Washington, - - 2014
To date, biomarkers based on nonconventional MRI have not been standardized for diagnosis and follow-up of patients with multiple sclerosis (MS). The sequential monitoring of pathogenesis in MS by imaging of the normal appearing brain tissue is an important research tool in understanding the early stages of MS. In this ...
Tao Qian Q LKEB - Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, The - - 2014
To develop and validate an objective and reproducible left ventricle (LV) segmentation method for late gadolinium enhanced (LGE) magnetic resonance imaging (MRI), which can facilitate accurate myocardial scar assessment. A cohort of 25 ischemic patients and 25 nonischemic patients were included. A four-step algorithm was proposed: first, the Cine-MRI and ...
Smith Iain M IM *Royal Centre for Defence Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK †202 (Midlands) Field Hospital, Roger Nutbeem House, Dawberry Fields Rd, Kings Heath, Birmingham, West Midlands, UK, and ‡NIHR Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital, Edgbaston, Birmingham, - - 2014
To determine utilization and accuracy of focused assessment with sonography for trauma (FAST) and computed tomography (CT) in a mature military trauma system to inform service provision for future conflicts. FAST and CT scans undertaken by attending radiologists contribute to surgical decision making for battlefield casualties at the Joint Force, ...
Roseau Gilles G Gilles Roseau, Department of Gastroenterology, Hôpital Cochin, 75014 Paris, - - 2014
Recto-sigmoid endoscopic ultrasonography (RS-EUS) has first been used in the staging of pelvic deep infiltrating endometriosis in the early 1990's. Since then, although publications have been sparse, RS-EUS is routinely used for this indication in few centers. In this paper, we focus on technical aspects and operating method of rectal ...
Drescher Robert R Clinic of Nuclear Medicine, Jena University Hospital, Bachstraße 18, 07743, Jena, - - 2014
Positron emission tomography (PET) angiography utilizes early dynamic PET acquisitions for depiction of the arterial vasculature. The aim of this study was to assess image quality and to evaluate feasibility of F-18 FDG PET angiography of the abdominal arteries. Twenty-seven patients were included in the study. Standard activities of 250-280 MBq ...
Edmund Jens M JM Department of Oncology, Radiotherapy Research Unit, Copenhagen University Hospital, Herlev, - - 2014
Radiotherapy (RT) based on magnetic resonance imaging (MRI) as the only modality, so-called MRI-only RT, would remove the systematic registration error between MR and computed tomography (CT), and provide co-registered MRI for assessment of treatment response and adaptive RT. Electron densities, however, need to be assigned to the MRI images ...
Xu Yang - - 2014
Magnetic resonance imaging (MRI) is used extensively for clinical diagnoses. It is critical to design and develop highly efficient MR contrast agents with simple preparation procedure, low toxicity, and high biocompatibility. Here, we report a carbon quantum dot (CQDs)-stabilized gadolinium hybrid nanoprobe (Gd-CQDs) prepared via a one-pot hydrothermal treatment of ...
Tahir Bilal A BA Academic Unit of Clinical Oncology, University of Sheffield, UK. Academic Unit of Academic Radiology, University of Sheffield, - - 2014
Hyperpolarized gas magnetic resonance imaging (MRI) generates highly detailed maps of lung ventilation and physiological function while CT provides corresponding anatomical and structural information. Fusion of such complementary images enables quantitative analysis of pulmonary structure-function. However, direct image registration of hyperpolarized gas MRI to CT is problematic, particularly in lungs ...
Chan Suk-Tak ST Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging - - 2014
Abstract Primary objective: To use breath-hold functional magnetic resonance imaging (fMRI) to localize the brain regions with impaired cerebrovascular reactivity (CVR) in a female patient diagnosed with mild traumatic brain injury (mTBI). The extent of impaired CVR was evaluated 2 months after concussion. Follow-up scan was performed 1 year post-mTBI ...
Fukumitsu Nobuyoshi N Department of Radiation Oncology, Ibaraki Prefectural Central Hospital, 6528, Koibuchi, Kasama, Ibaraki, 309-1793, Japan, - - 2014
To develop an objective and less invasive method for evaluating breath-hold status, and to investigate breath-hold reproducibility during voluntary breath-holding irradiation. We enrolled 20 patients who were treated using a voluntary breath-holding technique. Four or five sessions of cone beam computed tomography (CT) were performed during the radiotherapy session. An ...
Boros Eszter E Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. - - 2014
This perspective outlines strategies towards the development of MR imaging probes that our lab has explored over the last 15 years. Namely, we discuss methods to enhance the signal generating capacity of MR probes and how to achieve tissue specificity through protein targeting or probe activation within the tissue microenvironment.
Amiri Houshang H Department of Radiology, Radboud University Medical Center, Geert Grootplein 10, 6500 HB, Nijmegen, The Netherlands, - - 2014
(19)F MRI is emerging as a new imaging technique for cell tracking. It is particularly attractive because of its potential for direct and precise cell quantification. The most important challenge towards in vivo applications is the sensitivity of the technique, i.e. the detection limit in a reasonable imaging time. Optimal ...
Shapiro Benjamin B Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA; Institute for Systems Research, University of Maryland, College Park, MD, - - 2014
The principle of magnetic drug targeting, wherein therapy is attached to magnetically responsive carriers and magnetic fields are used to direct that therapy to disease locations, has been around for nearly two decades. Yet our ability to safely and effectively direct therapy to where it needs to go, for instance ...
Azarion Allan A AA Neurology, Perelman School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A; Penn Center for Neuroengineering and Therapeutics (CNT), Perelman School of Medicine, Philadelphia, Pennsylvania, - - 2014
Visualizing implanted subdural electrodes in three-dimensional (3D) space can greatly aid in planning, executing, and validating resection in epilepsy surgery. Coregistration software is available, but cost, complexity, insufficient accuracy, or validation limit adoption. We present a fully automated open-source application, based on a novel method using postimplant computerized tomography (CT) ...
Mirzadeh Zaman Z Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, - - 2014
Deep brain stimulation is typically performed with intraoperative microelectrode recording and test stimulation for target confirmation. Recent studies have shown accurate, clinically efficacious results after lead placement without microelectrode recording or test stimulation, using interventional magnetic resonance imaging (MRI) or intraoperative computed tomography (CT; iCT) for verification of accuracy. The ...
Kanayama Seisaku S Department of Neurosurgery, Toranomon Hospital, 2-2-2 Minatoku Toranomon, Tokyo, 105-8470, Japan, - - 2014
With the development of computed tomography (CT) and magnetic resonance imaging (MRI), the use of conventional X-ray angiography including digital subtraction angiography (DSA) for diagnosis has decreased, as it is an invasive technique with a risk of neurological complications. However, X-ray angiography imaging technologies have progressed markedly, along with the ...
Danhier Pierre P Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, - - 2014
The purpose of this paper is to describe some of the areas where electron paramagnetic resonance (EPR) has provided unique information to MRI developments. The field of application mainly encompasses the EPR characterization of MRI paramagnetic contrast agents (gadolinium and manganese chelates, nitroxides) and superparamagnetic agents (iron oxide particles). The ...
de Roos Albert A From the Department of Radiology, Leiden University Medical Center, C2-S, Albinusdreef 2, Leiden, South-Holland 2333 ZA, the Netherlands (A.d.R); and Department of Radiology, University of California-San Francisco, San Francisco, Calif - - 2014
During the past century, cardiac imaging technologies have revolutionized the diagnosis and treatment of acquired and congenital heart disease. Many important contributions to the field of cardiac imaging were initially reported in Radiology. The field developed from the early stages of cardiac imaging, including the use of coronary x-ray angiography ...
Chwen Ch'ng Chin M CC Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Email: - - 2014
The fact that this patient's rash was limited to his chest provided an important diagnostic clue.
Millischer Anne-Elodie AE Centre de Radiologie Bachaumont IMPC-Paris, - - 2014
Magnetic resonance imaging (MRI) and ultrasound (US) scanning complement each other in the screening and diagnosis of endometriosis. Real-time virtual sonography (RVS) is a new technique that uses magnetic navigation and computer software for the synchronized display of real-time US and multiplanar reconstruction MRI images. The purpose of this study ...
Cornwall Christopher E CE Institute for Marine and Antarctic Studies, University of Tasmania, Private Bag 129, Hobart, TAS, 7001, Australia. - - 2014
Understanding ecosystem responses to global and local anthropogenic impacts is paramount to predicting future ecosystem states. We used an ecosystem modeling approach to investigate the independent and cumulative effects of fishing, marine protection, and ocean acidification on a coastal ecosystem. To quantify the effects of ocean acidification at the ecosystem ...
Kortman H G J HG From the Department of Radiology and Nuclear Medicine, Radboud University Nijmegen Medical Center, Nijmegen, the - - 2014
CT angiography is a widely used technique for the noninvasive evaluation of neurovascular pathology. Because CTA is a snapshot of arterial contrast enhancement, information on flow dynamics is limited. Dynamic CTA techniques, also referred to as 4D-CTA, have become available for clinical practice in recent years. This article provides a ...
Poretti Dario D Dipartimento di Radiologia, IRCCS Istituto Clinico Humanitas, Via Alessandro Manzoni, 56, 20089, Rozzano, MI, - - 2014
This paper presents a new magnetic resonance angiography (MRA) protocol for the evaluation of thoracic outlet syndrome (TOS) that allows for a separate assessment of veins and arteries while using a single, simultaneous and bilateral (SB-MRA) single contrast injection, valid for both abduction and adduction acquisitions. From 2009 to 2013 ...
Kidambi Ananth - - 2014
Intramyocardial hemorrhage (IMH) identified by cardiovascular magnetic resonance (CMR) is an established prognostic marker following acute myocardial infarction (AMI). Detection of IMH by T2-weighted or T2 star CMR can be limited by long breath hold times and sensitivity to artefacts, especially at 3T. We compared the image quality and diagnostic ...
Shah Saqlain A SA Materials Science and Engineering, University of Washington , Seattle, Washington 98195, - - 2014
Magnetic Particle Imaging (MPI) is a new biomedical imaging technique that produces real-time, high-resolution tomographic images of superparamagnetic iron oxide nanoparticle tracers. Currently, 25 kHz and 20 mT/μ0 excitation fields are common in MPI, but lower field amplitudes may be necessary for patient safety in future designs. Here, we address fundamental questions ...
Goto M M Masami Goto, Department of Radiological Technology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan, E-mail: - - 2014
Objectives: To investigate whether reproducibility of gray matter volumetry is influenced by parameter settings for VBM 8 using Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra (DARTEL) with region-of-interest (ROI) analyses. Methods: We prepared three-dimensional T1-weighted magnetic resonance images (3D-T1WIs) of 21 healthy subjects. All subjects were imaged with each of ...
Cai Wenli - - 2014
Dual-energy CT provides a promising solution to identify tagged fecal materials in electronic cleansing (EC) for fecal-tagging CT colonography (CTC). In this study, we developed a new EC method based on virtual colon tagging (VCT) for minimizing EC artifacts by use of the material decomposition ability in dual-energy CTC images. ...
Mortensen Jonathan M JM http://orcid.org/0000-0002-7618-4796 Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, California, USA Biomedical Informatics Training Program, Stanford University, Stanford, California, - - 2014
The verification of biomedical ontologies is an arduous process that typically involves peer review by subject-matter experts. This work evaluated the ability of crowdsourcing methods to detect errors in SNOMED CT (Systematized Nomenclature of Medicine Clinical Terms) and to address the challenges of scalable ontology verification. We developed a methodology ...
Georgiadis Andrew G AG Department of Orthopaedic Surgery, Henry Ford Hospital, Detroit, MI, - - 2014
The terms "femoral anteversion" and "femoral torsion" have often been used interchangeably in the orthopaedic literature, yet they represent distinct anatomical entities. Anteversion refers to anterior tilt of the femoral neck, whereas torsion describes rotation of the femoral shaft. Together, these and other transverse plane differences describe what may be ...
Abedini-Nassab Roozbeh - - 2014
Cell manipulation is instrumental in most biological applications. One of the most promising methods in handling cells and other biological particles is the magnetic manipulation technique. In this technique, magnetic nanoparticles are employed to magnetize cells. Such cells then can be manipulated, sorted, or separated by applying an external magnetic ...
Rusak Grażyna G Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, ul. Skłodowskiej-Curie 9, 85-094, Bydgoszcz, - - 2014
MR elastography (MRE) is a recent non-invasive technique that provides in vivo data on the viscoelasticity of the liver. Since the method is not well established, several different protocols were proposed that differ in results. The aim of the study was to analyze the variability of stiffness measurements in different ...
van Slochteren F J FJ Department of Cardiology, University Medical Center Utrecht, E03.511, PO Box 85500, 3508 GA, Utrecht, the Netherlands, - - 2014
Intramyocardial cell injections in the context of cardiac regenerative therapy can currently be performed using electromechanical mapping (EMM) provided by the NOGA®XP catheter injection system. The gold standard technique to determine infarct size and location, however, is late gadolinium enhanced magnetic resonance imaging (LGE-MRI). In this article we describe a ...
Jin Xiulong X Shanghai Engineering Research Center of Medical Device and Technology at Med-X, School of Biomedical Engineering, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, 200030, China. - - 2014
With the increasing need for multi-purpose analysis in the biomedical field, traditional single diagnosis methods cannot meet the requirements. Therefore new multifunctional technologies and materials for the integration of sample collection, sensing and imaging are in great demand. Core-shell nanoparticles offer a unique platform to combine multifunctions in a single ...
Thrippleton Michael J MJ Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United - - 2014
The aim of our study was to develop a reliable technique for measuring volume of the fibroid uterus using Magnetic Resonance Imaging. We applied the Cavalieri method and standard calliper technique to measure the volume of the uterus and largest fibroid in 26 patients, and results were compared with "gold-standard" ...
Galland Sylvain - - 2014
A major limitation in the development of highly functional hybrid nanocomposites is brittleness and low tensile strength at high inorganic nanoparticle content. Herein, cellulose nanofibers were extracted from wood and individually decorated with cobalt-ferrite nanoparticles, and then for the first time molded at low temperature (< 120 oC) into magnetic ...
Diekhoff Torsten T From the *Department of Radiology, Charité - Universitätsmedizin Berlin Campus Mitte, Humboldt-Universität zu Berlin, Freie Universität Berlin; †Department of Medical Informatics, Biometry and Epidemiology, Free University Berlin, Berlin, Germany; ‡Toshiba Medical Systems Europe, BV, Zoetermeer, Netherlands; §Toshiba Medical Systems Corporation, Otawara-Shi, Tochigi, Japan; and ∥Central Pharmacy, Charité - Universitätsmedizin Berlin Campus Virchow-Klinikum, Humboldt-Universität zu Berlin, Freie Universität Berlin, Berlin, - - 2014
The aim of this study was to perform phantom measurements to prove the feasibility of single-source dual-energy computed tomography (DECT) of the extremities using a volume scan mode. In addition, we, for the first time, wanted to determine which concentrations of monosodium urate (MSU) in gout and calcium pyrophosphate (CP) ...
Lukas Vanessa A VA Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, - - 2014
To evaluate the sensitivity and specificity of classification of pathomimetically degraded bovine nasal cartilage at 3 Tesla and 37°C using univariate MRI measurements of both pure parameter values and intensities of parameter-weighted images. Pre- and posttrypsin degradation values of T1 , T2 , T2 *, magnetization transfer ratio (MTR), and ...
Gruner Christiane C Echocardiography Laboratory, University Hospital Zurich, Zurich, - - 2014
Echocardiographic quantification of mitral regurgitation (MR) can be challenging if the valve geometry is significantly altered. Our aim was to compare the quantification of MR by the recently developed real time three-dimensional (3D) volume color flow Doppler (RT-VCFD) method to the conventional two-dimensional (2D) echocardiographic methods during the MitraClip procedure. ...
Maritim Samuel S Department of Biomedical Engineering, Yale University, New Haven, CT, 06520, USA, - - 2014
Purposely designed magnetic resonance imaging (MRI) probes encapsulated in liposomes, which alter contrast by their paramagnetic effect on longitudinal (T1) and transverse (T2) relaxation times of tissue water, hold promise for molecular imaging. However, a challenge with liposomal MRI probes that are solely dependent on enhancement of water relaxation is ...
Xie Mei M University of Electronic Science and Technology of China, No. 2006, Xiyuan Ave, West Hi-Tech Zone, Chengdu, 611731, Sichuan, - - 2014
Markov random field (MRF) model is an effective method for brain tissue classification, which has been applied in MR image segmentation for decades. However, it falls short of the expected classification in MR images with intensity inhomogeneity for the bias field is not considered in the formulation. In this paper, ...
Ahlawat Shivani S The Russell H. Morgan Department of Radiology & Radiological Science, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD, 21287, USA, - - 2014
High-resolution multidetector computed tomography (MDCT) has played a pivotal role in assessing patients following trauma; however, recent advancements in technology including dual-energy CT, as well as multiplanar and three-dimensional (3D) capabilities, are expanding the potential clinical applications of CT to include nontraumatic pathologies. This article will review optimal technical parameters ...
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