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Li Clarence C William S. Middleton Veterans Hospital and Geriatric Research Education and Clinical Center, Madison, WI, U.S.A; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, - - 2014
6-[(18) F]-Fluoro-L-dopa (FDOPA) has been widely used as a biomarker for catecholamine synthesis, storage, and metabolism-its intense uptake in the striatum, and fainter uptake in other brain regions, is correlated with the symptoms and pathophysiology of Parkinson's disease (PD). 6-[(18) F]fluoro-m-tyrosine (FMT), which also targets L-amino acid decarboxylase, has potential ...
Morana Giovanni G Unità Operativa di Neuroradiologia, Istituto G. Gaslini, Genoa, - - 2014
Infiltrative astrocytomas (IAs) represent a group of astrocytic gliomas ranging from low-grade to highly malignant, characterized by diffuse invasion of the brain parenchyma. When compared with their adult counterpart, pediatric IAs may be considered biologically distinct entities; nevertheless, similarly to those in adults they represent a complex oncologic challenge. The ...
Godechal Q Q Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Avenue Mounier 73.40, 1200, Brussels, - - 2014
Melanoma is the most dangerous form of skin cancer and its incidence is rising each year. Because the current methods of diagnosis based on the visual aspect of the tumor show limitations, several new techniques are emerging to help in this diagnosis, amongst which are magnetic resonance imaging (MRI) and ...
Piccardo Arnoldo A Nuclear Medicine Unit, Galliera Hospital, Genoa, Italy, - - 2014
The aim of this study was to investigate the relationship between (123)I-metaiodobenzylguanidine (MIBG) scan semi-quantification and a new (18)F-DOPA positron emission tomography (PET)/CT score in patients with suspected or documented neuroblastoma (NB) relapse and to assess the association between these two parameters and progression-free survival (PFS)/overall survival (OS). We analysed ...
Magnaldi Silvia S Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna General Hospital, Waehringer Guertel 18-20, 1090 Vienna, Austria. - - 2014
Aim: To describe the (18)F-fluorodihydro-xyphenylalanine ((18)F-DOPA), positron emission tomography (PET) and magnetic resonance imaging (MRI) appearance of pheochromocytomas, with a focus on the presence or absence of typical MRI features. Eleven patients with histologically-verified pheochromocytoma [sporadic (n=9), multiple endocrine neoplasia (MEN) 2A syndrome (n=2)] were enrolled retrospectively. All patients underwent ...
Bacca Alessandra - - 2013
The objective of this study was to establish the clinical value of F-DOPA PET/CT in patients with adrenal and extra-adrenal paragangliomas (PGLs). Twenty-six consecutive patients with suspected or recurrent PGL underwent MR (and/or CT) and F-DOPA PET/CT. Histopathology confirmation was obtained in 20 cases. Genetic analysis on known susceptibility genes ...
Doong Ruey-An - - 2013
The effect of naturally occurring quinones including lawsone (LQ), ubiquinone (UQ), juglone (JQ), and 1,4-naphthoquinone (NQ) on the biotransformation of carbon tetrachloride (CT) in the presence of Geobacter sulfurreducens and ferrihydrite was investigated. AQDS was used as the model compound for comparison. The reductive dissolution of ferrihydrite by G. sulfurreducens ...
Piccardo Arnoldo - - 2013
Functional imaging plays a crucial role in the assessment of neuroblastoma. The evaluation of response to induction chemotherapy is a cornerstone in scheduling proper treatment management in patients affected by high-risk neuroblastoma. (123)I-metaiodobenzylguanidine has been recognized as the radiopharmaceutical of choice in neuroblastoma assessment. To date, the clinical role of ...
Chondrogiannis Sotirios - - 2013
Dihydroxyphenylalanine (DOPA) is a neutral amino acid that resembles natural L-dopa (dopamine precursor). It enters the catecholamine metabolic pathway of endogenous L-DOPA in the brain and peripheral tissues. It is amenable to labeling with fluorine-18 (F) for PET imaging and was originally used in patients with Parkinson's disease to assess ...
Shelton Trent - - 2013
A 58-year-old man with a history of stage IIIB melanoma of the right arm initially treated 4 years prior presented with new onset cough and hemoptysis. Bronchial washings were positive for melanoma. The PET/CT study showed a hypermetabolic nodule in the posterior mid-trachea. These findings indicate metastatic melanoma to the ...
Kroiss Alexander - - 2013
(18)F-Fluoro-L-dihydroxyphenylalanine ((18)F-DOPA) PET offers high sensitivity and specificity in the imaging of nonmetastatic extra-adrenal paragangliomas (PGL) but lower sensitivity in metastatic or multifocal disease. These tumours are of neuroendocrine origin and can be detected by (68)Ga-DOTA-Tyr(3)-octreotide ((68)Ga-DOTA-TOC) PET. Therefore, we compared (68)Ga-DOTA-TOC and (18)F-DOPA as radiolabels for PET/CT imaging for ...
Marzola Maria Cristina - - 2013
This study aims to evaluate the role of F-DOPA PET/CT in staging and follow-up of paraganglioma syndromes succinate dehydrogenase (SDH)-mutation-related patients, comparing F-DOPA PET/CT results with morphological imaging and biochemical results. We retrospectively studied 10 consecutive patients (3 F, 7 M, mean age 32 yrs), all with a genetically demonstrated ...
Meintjes Marguerite M Institute of Nuclear Medicine, University College London Hospital NHS Trust, London, - - 2013
Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycaemia in infants and children. Histologically, there are two subgroups, diffuse and focal. The aim of this study was to evaluate the accuracy of (18)F-fluoro-L-dihydroxyphenylalanine ((18)F-DOPA) PET/computed tomography (CT) and contrast-enhanced CT in distinguishing between focal and diffuse lesions in ...
Gramsch Carolin - - 2013
OBJECTIVE: While staging patients with malignant melanoma, cerebral susceptibility artefacts on T2*-weighted/susceptibility-weighted imaging (SWI) sequences without a correlate on contrast-enhanced T1-weighted images can be confusing. Without intravenous contrast enhancement, cavernomas, microhaemorrhages and melanin-containing metastases represent possible differential diagnoses for these findings. The purpose of this study was to find out, ...
Piccardo Arnoldo - - 2013
We report the case of a 6-year-old child with stage 4 neuroblastoma, previously treated with chemotherapy, which relapsed in the right mandibular branch, right submandibular lymph nodes, and bone marrow. These sites of recurrence were detected on diagnostic I-MIBG and confirmed by F-DOPA-PET/CT, which revealed the following 2 additional sites ...
Erro Roberto - - 2013
A 71-year-old man presented with a 6-month history of rest tremor and slowness in his left hand. Apart from mild left parkinsonism, neurologic examination was unremarkable. Because response to l-dopa, up to 600 mg/d, was lacking, [(123)I]FP-CIT ((123)I-N-ω-fluoropropyl-2β-carbomethoxy-3β-[4-iodophenyl]nortropane) SPECT was prescribed with unexpected results: transverse and coronal slices showed the ...
Qin Chunxia - - 2013
Development of reporter genes for multimodality molecular imaging is highly important. In contrast to the conventional strategies which have focused on fusing several reporter genes together to serve as multimodal reporters, human tyrosinase (TYR) - the key enzyme in melanin production - was evaluated in this study as a stand-alone ...
Treglia Giorgio - - 2013
A 40-year-old female patient with suspected multifocal extra-adrenal paraganglioma, on the basis of biochemical, genetic, and conventional imaging data, underwent F-FDG, F-DOPA and Ga DOTANOC PET/CT. FDOPA- and FDG-PET/CT detected a multifocal mediastinal and cervical paraganglioma. Ga-DOTANOC PET/CT detected 2 additional lesions compared to the other PET/CT methods. In our ...
Treglia Giorgio - - 2013
ABSTRACT: A 65-year-old woman with suspected insulinoma on the basis of clinical, biochemical, and conventional imaging data underwent F-dihydroxyphenylalanine (DOPA) PET/CT and Ga-DOTANOC PET/CT. F-DOPA PET/CT did not show any focal uptake in the pancreas, whereas Ga-DOTANOC PET/CT showed a focal area of intense uptake in the pancreatic tail. The ...
Yang Jigang - - 2013
OBJECTIVES: Studies have reported the applications of F-dihydroxyphenylalanine (F-DOPA) PET in patients with congenital hyperinsulinism (CHI). The aim of this study was to systematically review and perform a meta-analysis of published data on the diagnostic role of F-DOPA PET in patients with CHI. MATERIALS AND METHODS: A comprehensive computer literature ...
Hochhegger Bruno - - 2012
The aim of this study was to show the usefulness of chemical-shift MRI in the diagnosis of intranodular fat in seven patients with pulmonary hamartomas and indeterminate CT findings. In the setting of chemical-shift MRI, the average nodule signal intensity index of pulmonary hamartomas was 45.3% (SD = 25.5%). The ...
Kakinuma R - - 2012
The objective of this study was to compare the sensitivity of detection of lung nodules on low-dose screening CT images between radiologists and technologists. 11 radiologists and 10 technologists read the low-dose screening CT images of 78 subjects. On images with a slice thickness of 5 mm, there were 60 ...
Maruoka Yasuhiro - - 2012
A 26-year-old female who had had a hydatidiform mole at 20 years of age showed high levels of serum human chorionic gonadotropin. Because pelvic ultrasound did not show any gestational sac in her uterus, she was suspected to have had an extrauterine pregnancy and a spontaneous abortion. About 6 months later, a ...
Guo Wei - - 2012
Purpose: A key issue in current computer-aided diagnostic (CAD) schemes for nodule detection in CT is the large number of false positives, because current schemes use only global three-dimensional (3D) information to detect nodules and discard useful local two-dimensional (2D) information. Thus, the authors integrated local and global information to ...
Hoey Edward T D - - 2012
This article reviews the spectrum of disease processes that may involve the aortic root with particular emphasis on the role of cardiovascular MRI and MDCT angiography in their assessment. Key MRI and MDCT imaging findings are discussed and illustrated. Radiologists should be aware of the spectrum of disease processes that ...
Jeon Kyung Nyeo - - 2012
The aim of this study was to evaluate whether a computer-aided diagnosis (CAD) system improves interobserver agreement in the interpretation of lung nodules at low-dose computed tomography (CT) screening for lung cancer. Baseline low-dose screening CT examinations from 134 participants enrolled in the National Lung Screening Trial were reviewed by ...
Ahmed Sameer - - 2012
To determine the prevalence of unsuspected thyroid nodules on contrast enhanced 16- and 64-modified discrete cosine transform (MDCT) of the chest, in a population of adult outpatients imaged for indications other than thyroid disease. This retrospective study involved review of intravascular contrast-enhanced MDCT scans of the chest from 3077 consecutive ...
Zhao Yingru - - 2012
To evaluate performance of computer-aided detection (CAD) beyond double reading for pulmonary nodules on low-dose computed tomography (CT) by nodule volume. A total of 400 low-dose chest CT examinations were randomly selected from the NELSON lung cancer screening trial. CTs were evaluated by two independent readers and processed by CAD. ...
Matsuguma Haruhisa - - 2012
ABSTRACT OBJECTIVES: The positive results of screening computed tomography (CT) trial are likely to lead to an increase in the use of CT, and, consequently, an increase in the detection of subsolid nodules. Noninvasive methods including follow-up with CT, in order to determine which nodules require invasive diagnosis and surgical ...
Kim Young-Mo - - 2012
PURPOSE: To evaluate the reparability of the posterior horn of the medial meniscus with root ligament tear by measuring the actual pullout failure strength of a simple vertical suture of an arthroscopic subtotal meniscectomized posterior horn of the medial meniscus. METHODS: From November 2009 to May 2010, nine posterior horns ...
Xie Xueqian - - 2013
To assess the sensitivity of detection and accuracy of volumetry by manual and semi-automated quantification of artificial pulmonary nodules in an anthropomorphic thoracic phantom on low-dose CT. Fifteen artificial spherical nodules (diameter 3, 5, 8, 10 and 12 mm; CT densities -800, -630 and +100 HU) were randomly placed inside ...
Godoy Myrna C B - - 2012
A new classification of lung adenocarcinoma has been proposed recently-the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. Abundant information from recent lung cancer computed tomography (CT) screening programs has increased our understanding of the strong, although imperfect, correlation between histologic findings of lung adenocarcinoma ...
Prats-Galino A - - 2012
Cerebrospinal fluid (CSF) and nerve root volumes within the lumbosacral dural sac were estimated at various vertebral levels, in an attempt to determine any possible relevance to the incidence of nerve root trauma during lumbar puncture or spinal anaesthesia. Magnetic resonance images from seven patients were studied. Volumes were calculated ...
Donnelly Edwin F - - 2012
Lung cancer screening computed tomographies (CTs) differ from traditional chest CT scans in that they are performed at very low radiation doses, which allow the detection of small nodules but which have a much higher noise content than would be acceptable in a diagnostic chest CT. The technical parameters require ...
Lacson Ronilda - - 2012
In 2005, the Fleischner Society guidelines (FSG) for managing pulmonary nodules detected on CT scans were published. The aim of this study was to evaluate adherence to the FSG, adjusting for demographic and clinical variables that may contribute to adherence. Radiology reports were randomly obtained for 1,100 chest and abdominal ...
Chu Linda C - - 2012
Aortic root pseudoaneurysm is a rare but potentially lethal complication after cardiac surgery. The objective of this article is to review the CT appearance of postoperative aortic root pseudoaneurysms, with emphasis on imaging pearls and pitfalls. The most common location for postoperative aortic root pseudoaneurysm is the graft anastomosis site. ...
Trimba Roman - - 2012
BACKGROUND CONTEXT: Conjoined nerve roots are a relatively uncommon finding but are frequently undiagnosed on preoperative imaging studies. The presence of a conjoined root anomaly represents a significant potential for neurologic injury when nerve root mobilization is necessary during spinal procedures. PURPOSE: This comprehensive review of conjoined lumbar nerve roots ...
Cistaro Angela - - 2012
BACKGROUND: The principal aim of this study was to identify the lowest nodule diameter and the SUV(max) capable of characterizing lung nodules in pediatric patients with bone sarcoma. PROCEDURE: Eighteen consecutive bone sarcoma patients (M/F = 11:7; mean age 14 years) with suspicious lung lesions at CT were enrolled. Overall, 63 lung ...
Numburi Uma D - - 2012
To determine the optimal C-arm computed tomography (CT) protocol for transcatheter aortic valve implantation (TAVI) in swine. In 6 swine, C-arm CT was performed using 5-s ungated acquisition during sinus rhythm with aortic root (Method 1) or peripheral (Method 2) injection, and during rapid ventricular pacing with root injection (Method ...
Byun Woo Mok - - 2012
To investigate the role of lumbosacral radiculography using 3-dimentional (3D) magnetic resonance (MR) rendering for diagnostic information of symptomatic extraforaminal stenosis in lumbosacral transitional vertebra. The study population consisted of 18 patients with symptomatic (n = 10) and asymptomatic extraforaminal stenosis (n = 8) in lumbosacral transitional vertebra. Each patient ...
Teramoto Atsushi - - 2012
PURPOSE: Existing computer-aided detection schemes for lung nodule detection require a large number of calculations and tens of minutes per case; there is a large gap between image acquisition time and nodule detection time. In this study, we propose a fast detection scheme of lung nodule in chest CT images ...
Aydın Hasan - - 2012
Performance of proton magnetic resonance spectroscopy (H-MRS) and apparent diffusion coefficient (ADC) values in the diagnosis of malignant thyroid nodules. In a retrospective study with malignant nodules of 14 patients, H-MRS and diffusion-weighted MR imaging (DWI) were performed. Choline (Cho) peak, Cho/creatine (Cr) ratio, and ADC values of malignant nodules ...
Zhao Kui - - 2012
18-Fluoredeoxyglucose position emission tomography and computed tomography ((18)F-FDG PET/CT) scanning has been widely used in the assessment of malignancy. We report here an increased (18)F-FDG uptake in pleural nodules in the PET/CT scan images of a patient having recurrent fever and chest pain. Further studies with bacterial culture and histopathology ...
Saraya Takeshi - - 2012
Two cases of rheumatoid nodules evaluated by fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and video-assisted thoracic surgery (VATS) biopsy are reported. The first case was that of a 44-year-old woman who presented with a cavitated nodule with intense standardized uptake values (SUVs) both in the early (max 3.4) and ...
Jae Lee In - - 2012
PURPOSE: To evaluate accurate diagnosis and complication rates of percutaneous core needle biopsy (PCNB) with an automated gun for small lung nodules that are 10 mm or less in diameter. MATERIALS AND METHODS: Forty-two cases of small lung nodules with diameters ≤10 mm (mean diameter, 9 mm) that received a ...
Takayama Yukihisa - - 2012
PURPOSE: To investigate the predictive factors of malignant transformation of hypovascular hepatic nodule showing hypointensity in the hepatobiliary phase images of gadoxetic acid-enhanced MRI (HHN). MATERIALS AND METHODS: The clinical data and imaging findings of dynamic contrast-enhanced computed tomography (DCE-CT) and gadoxetic acid-enhanced MRI for a total of 103 HHNs ...
Goodsitt M - - 2012
Purpose: To investigate the effect of Model-Based Iterative Reconstruction (MBIR) on CT#s and noise (standard deviation, SD) of both nodules and homogeneous regions (heart and vertebra spongiosa) in an anthropomorphic chest phantom. Methods: A Lungman phantom (Kyoto-Kagaku Co. Japan) was imaged with a GE Discovery CT750 HD CT scanner using ...
Golfieri Rita - - 2012
PURPOSE: To investigate whether the malignancy of atypical nodules in cirrhosis can be identified at gadoxetic-acid-disodium(Gd-EOB-DTPA)-MRI by their hypointensity in the hepatobiliary(HB)-phase alone or combined with any other MR imaging features. MATERIALS AND METHODS: One hundred eleven atypical nodules detected in 77 consecutive Gd-EOB-DTPA-MRIs were divided, based on arterial-phase behavior, ...
Shan Fei - - 2012
PURPOSE: To evaluate the capability of first-pass volume perfusion computed tomography (PCT) for differentiation of solitary pulmonary nodules (SPNs) and to compare that of combination of PCT and routine CT with CT alone for the differentiation. MATERIALS AND METHODS: Our institutional review board approved this study and informed consent was ...
Godoy Myrna C B - - 2012
PURPOSE OF REVIEW: Given the higher rate of malignancy of subsolid pulmonary nodules and the considerably lower growth rate of ground-glass nodules (GGNs), dedicated standardized guidelines for management of these nodules have been proposed, including long-term low-dose computed tomography (CT) follow-up (≥3 years). Physicians must be familiar with the strategic ...
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