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Adams Hugo J A HJ Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The - - 2014
This study aimed to investigate whether visual and quantitative 18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT)-based bone marrow assessment can replace blind bone marrow biopsy (BMB) in newly diagnosed diffuse large B-cell lymphoma (DLBCL). This retrospective study included 78 patients with newly diagnosed DLBCL who had undergone both FDG-PET/CT and BMB. ...
Bonar S Fiona SF Douglass Hanly Moir Pathology, 14 Giffnock Avenue, Macquarie Park, NSW, 2113, Australia, - - 2014
To describe the imaging and histopathological findings and provide an overview of a recently described and rare cause of bone sclerosis. Five cases of intra-osseous hibernoma of bone that presented over the last year. The imaging and histopathology is reviewed. All cases were identified in asymptomatic middle-aged to elderly adults ...
Lu Yu-Yu YY aDepartment of Nuclear Medicine, Taichung Veterans General Hospital bDepartment of Radiation Oncology cDepartment of Nuclear Medicine and PET Center, China Medical University Hospital dSchool of Medicine, China Medical University, Taichung eSchool of Public Health, Taipei Medical University, Taipei, Taiwan fSchool of Biological Sciences, University of California, Irvine, California, - - 2014
The purpose of this study was to conduct a systematic review and meta-analysis of the published literature to evaluate the diagnostic accuracy of fluorine-18 2-fluoro-2-deoxy-D-glucose (F-FDG) PET or PET/computed tomography (CT) in the pretherapeutic staging of patients with small-cell lung cancer (SCLC). The authors conducted a systematic MEDLINE search of ...
Ho Chi-Lai CL Department of Nuclear Medicine and PET, Hong Kong Sanatorium and Hospital, Hong - - 2014
We prospectively compared (11)C-acetate with (18)F-FDG in a PET/CT evaluation of multiple myeloma (MM), specifically on diagnostic accuracy, identification of high-risk patients, and monitoring of treatment response. Dual-tracer PET/CT was performed on 35 pathologically and clinically confirmed and untreated patients (26 with symptomatic MM, 5 with smoldering MM, and 4 ...
Pinna Audrey E AE From the *Department of PET and Nuclear Medicine, Royal Prince Alfred Hospital, and †Sydney Medical School, University of Sydney, Camperdown, New South Wales, - - 2014
Physical activity before F-FDG PET/CT can cause increased muscle glucose metabolism. We report markedly increased glucose metabolism in the masseter and temporalis muscles of a 53-year-old man who was clenching his teeth before the scan, and then resolution of this increased metabolism on a second scan 12 weeks later. SUVmax ...
Treglia G G Department of Nuclear Medicine and PET/CT Center, Oncology Institute of Southern Switzerland, via Ospedale, 12, 6500, Bellinzona, Switzerland, - - 2014
Fluorine-18-fluorodeoxyglucose (F-18-FDG) is the most used positron emitter radiopharmaceutical worldwide. This glucose analogue allows to study the glucose metabolism which is often increased in many tumors. Nowadays the diagnostic performance of positron emission tomography/computed tomography (PET/CT) using F-18-FDG in different tumors is well known. On the other hand, to date, ...
Zimny Anna A Department of General and Interventional Radiology and Neuroradiology, Wroclaw Medical University, Wroclaw, - - 2014
Background: The posterior cingulate region is an area of the earliest pathological changes in amnestic mild cognitive impairment (aMCI). The utility of FDG-PET imaging in dementia is already well established. Objectives: The aim of the study was to compare FDG-PET with advanced MR measurements: MR spectroscopy (MRS), perfusion weighted imaging ...
Demetriades Andreas K AK Department of Neurosurgery, King's College Hospital, Denmark Hill, London SE5 9RS, UK. Electronic address: - - 2014
The field of neuro-oncology is concerned with some of the most challenging and difficult to treat conditions in medicine. Despite modern therapies patients diagnosed with primary brain tumours often have a poor prognosis. Imaging can play an important role in evaluating the disease status of such patients. In addition to ...
Poulin Eric E Centre d'imagerie moléculaire de Sherbrooke, Département de médecine nucléaire et radiobiologie, Université de Sherbrooke, Sherbrooke, - - 2014
The combination of MRI and positron emission tomography (PET) offers new possibilities for the development of novel methodologies. In pharmacokinetic image analysis, the blood concentration of the imaging compound as a function of time, [i.e., the arterial input function (AIF)] is required for MRI and PET. In this study, we ...
Queiroz Marcelo A MA Department of Medical Radiology, Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland, - - 2014
Positron emission tomography (PET)/MRI combines the functional ability of PET and the high soft tissue contrast of MRI. The aim of this study was to assess contrast-enhanced (ce)PET/MRI compared to cePET/CT in patients with suspected recurrence of head and neck cancer (HNC). Eighty-seven patients underwent sequential cePET/CT and cePET/MRI using ...
An Li L National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, - - 2014
To achieve detection of glutamate (Glu), glutamine (Gln), and glutathione (GSH) by minimizing the N-acetyl-aspartate (NAA) multiplet signals at 2.49 ppm using a echo time (TE) -optimized PRESS pulse sequence and a novel J-suppression radiofrequency pulse. Using density matrix simulations, a PRESS sequence with (TE1 , TE2 ) = (69, 37) ms ...
Tripathi Madhavi M AIIMS, All India Institute of Medical Sciences; New Delhi, Delhi, India - - - 2014
Positron emission tomography (PET) imaging with F-18 fluorodeoxyglucose (FDG) can be used as a downstream marker of neuronal injury, a hallmark of neurodegenerative dementias. Characteristic patterns of regional glucose metabolism have been used to classify the dementia subtypes, namely Alzheimer's dementia (AD), frontotemporal dementia (FTD), diffuse Lewy body (DLBD) and ...
Skoura Evangelia E Nuclear Medicine Department, Evangelismos General Hospital, Ipsilantou 45-47, 10676 Athens, Greece. - - 2014
Neuroblastoma is the most common extracranial solid malignancy in children, but is rare in adults. We report the case of a 33 year old man with recurrence of neuroblastoma, 2 years after the excision of the primary tumor in the right adrenal gland. The iodine-123-radioiodinated metaiodobenzylguanidine ((123)I-MIBG) and (99m)Tc-methylene diphosphonate ...
Guy Matthew S MS From the Kettering Medical Center, Dayton, - - 2014
A 29-year-old female patient exhibited a solitary neck mass, severe hypercalcemia, and multiple skeletal lytic lesions consistent with metastatic neoplastic disease. Fine-needle aspiration (FNA) cytology of the neck lesion indicated a follicular thyroid neoplasm. CT-guided bone biopsy was non-diagnostic. Subsequent F-FDG PET/CT examination demonstrated avid glucose uptake within the neck ...
Coakley Fergus V FV Oregon Health and Sciences University. Electronic address: - - 2014
Imaging findings in a patient with invasive thymoma in the costophrenic recess are presented, in whom computed tomography (CT) and MRI revealed lateral arcuate ligament thickening. Increased fluoro-deoxy-glucose (FDG) uptake on subsequent positron emission tomography (PET)/CT was helpful in suggesting the correct diagnosis. A second patient with much more obvious ...
Hess Søren S Department of Nuclear Medicine, Odense University Hospital, Soender Boulevard 29, 5000 Odense, Denmark. Electronic address: - - 2014
The technology behind positron emission tomography (PET) and the most widely used tracer, 2-deoxy-2-[18F]fluoro-D-glucose (FDG), were both conceived in the 1970s, but the latest decade has witnessed a rapid emergence of FDG-PET as an effective imaging technique. This is not least due to the emergence of hybrid scanners combining PET ...
Nogami Yuya Y Department of Obstetrics and Gynecology, School of Medicine, Keio University, Shinanomachi 35 Shinjuku-ku, Tokyo 160-8582, Japan. - - 2014
Positron-emission tomography (PET), a diagnostic imaging technique using an agent labeled with a positron-emitting radionuclide, may facilitate improved diagnosis and treatment in gynecological fields. A combined PET/computerized tomography (CT) scan can identify the precise anatomical location of a lesion based on accumulation of (18)F-fluoro-D-glucose (FDG). FDG-PET and PET/CT have been ...
Lohrmann C C Molecular Imaging and Therapy Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United - - 2014
The noninvasive diagnostic workup of solitary pulmonary nodules (SPNs) continues to be a challenge for radiologists and nuclear medicine physicians. Morphological evaluation is useful to differentiate between benign and malignant SPNs, but there is a considerable overlap between the benign and the malignant features, resulting in a large fraction of ...
Alan Selçuk Nalan N Yeditepe University Hospital, Department of Nuclear Medicine, İstanbul, - - 2014
Positron Emission Tomography with 2-deoxy-[F-18]-fluoro-D-glucose (FDG-PET) has become a reliable diagnostic tool in clinical practice similar to Magnetic Resonance (MR) imaging and Computed Tomography (CT). FDG-PET has especially been used to differentiate malignant from benign lesions, and for staging and follow- up malignant tumors. However, FDG-PET has some pitfalls in ...
Choi Yun Jung YJ Department of Nuclear Medicine, Hallym University Medical Center, Hallym University College of Medicine, Seoul, - - 2014
The purpose of this study was to evaluate the diagnostic performance of (18)F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) as a single imaging agent in neuroblastoma in comparison with other imaging modalities. A total of 30 patients with pathologically proven neuroblastoma who underwent FDG PET for staging were enrolled. Diagnostic performance ...
Alf Malte F MF Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Switzerland; Center for Radiopharmaceutical Sciences of ETH Zurich, PSI and USZ, - - 2014
Although numerous positron emission tomography (PET) studies with ((8) F-fluoro-deoxyglucose) FDG have reported quantitative results on cerebral glucose kinetics and consumption, there is a large variation between the absolute values found in the literature. One of the underlying causes is the inconsistent use of the lumped constants (LCs), the derivation ...
Ohtomo Ryo R From the Graduate School of Medicine, The University of Tokyo, - - 2014
A 75-year-old man undergoing chemotherapy for prostate cancer for 3 months presented with headache after having blisters in his left ear canal and auricle. His body temperature at presentation was 38°C. Neurologic examination revealed nuchal stiffness and left peripheral facial palsy. We also noted leukocytopenia (2,000/µL) and elevated serum C-reactive ...
Baştuğ Funda F Department of Pediatric Nephrology, Kayseri Educational and Research Hospital , Kayseri , Turkey - - 2014
Abstract Background: Original peritoneal equilibration test (PET) is an implementation that requires hard work for peritoneal dialysis (PD) staff. Therefore, several authors have attempted to validate short and fast PET protocols, with controversial results. The aim of this study was to evaluate the concordance between the mini-PET and original PET ...
Kim So Yeon SY From the Departments of Radiology (S.Y.K., K.H.L., Y.H.K., H.S.K.), Pathology (H.K.), Surgery (J.Y.C., J.H.K., Y.S.Y., H.S.H.), and Internal Medicine (S.L.), Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Korea; and Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pa - - 2014
Purpose To assess the relationship between computed tomographic (CT) indexes and histologically measured pancreatic fat in surgical specimens and to evaluate patients with impaired glucose metabolism in a clinical setting. Materials and Methods This retrospective study was institutional review board approved and informed consent was waived. The hospital database was ...
Shyn P B PB Abdominal Imaging and Intervention, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: - - 2014
To determine whether a single 20 s breath-hold positron-emission tomography (PET) acquisition obtained during combined PET/computed tomography (CT)-guided percutaneous liver biopsy or ablation procedures has the potential to target 2-[(18)F]-fluoro-2-deoxy-d-glucose (FDG)-avid liver masses as accurately as up to 180 s breath-hold PET acquisitions. This retrospective study included 10 adult patients with 13 ...
Huovinen Ville V Turku PET Centre, University of Turku, PO Box 52, FI-20521 Turku, Finland; Department of Radiology, Turku University, Medical Imaging Centre of Southwest Finland and Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, - - 2014
Diabetes induces osteoporosis and during osteoporosis, vertebral bone marrow (VBM) adipose tissue amount increases. The association between this adiposity and bone marrow metabolism is unclear. Here, we compared VBM glucose metabolism and fat content in healthy and diabetic pigs, in vivo, using positron emission tomography (PET), in-phase and out-of-phase magnetic ...
Nakajima Nobuhito N Department of Neurology, Kitamurayama Public Hospital, Japan. Electronic address: - - 2014
We report an 89-year-old woman who developed consciousness disturbance associated with marked hypoglycemia, and showed involuntary movements manifested as spontaneous quick-jerking flexion followed by slow relaxation, in the right leg. Diffusion-weighted imaging revealed bilateral hyperintensities in the posterior limbs of the internal capsule (P-IC). She was treated with intravenous glucose ...
Keu Khun Visith - - 2014
Positron emission tomography combined with computed tomography (PET/CT) has emerged in the last decade as a dominant imaging modality used for staging, monitoring response and surveillance of various cancers, including melanoma. Using 2-deoxy-2-((18)F)fluoro-D-glucose ((18)F-FDG) as the radiopharmaceutical, PET/CT has demonstrated its efficacy and its utility in the management of patients ...
Byrnes Kimberly R KR Department of Anatomy, Physiology and Genetics, Uniformed Services University Bethesda, MD, USA ; Neuroscience Program, Department of Neuroscience, Uniformed Services University Bethesda, MD, USA ; Center for Neuroscience and Regenerative Medicine Bethesda, MD, - - 2014
Traumatic brain injury (TBI) affects an estimated 1.7 million people in the United States and is a contributing factor to one third of all injury related deaths annually. According to the CDC, approximately 75% of all reported TBIs are concussions or considered mild in form, although the number of unreported ...
Rilling James K - - 2014
Comparative neuroimaging can identify unique features of the human brain and teach us about human brain evolution. Comparisons with chimpanzees, our closest living primate relative, are critical in this endeavor. Structural magnetic resonance imaging (MRI) has been used to compare brain size development, brain structure proportions and brain aging. Positron ...
Rissanen Eero E Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland ; Division of Clinical Neurosciences, University of Turku and Turku University Hospital, Turku, - - 2014
Here, we present a patient with Creutzfeldt-Jakob disease (CJD) who developed initial symptoms mimicking progressive supranuclear palsy (PSP). Before the development of typical CJD symptoms, functional imaging supported a diagnosis of PSP when [(123)I]-FP-CIT-SPECT showed a defect in striatal dopamine transporter binding, while [(18)F]-fluorodeoxyglucose PET showed cortical hypometabolism suggestive of ...
Caobelli Federico F Department of Nuclear Medicine, Fondazione Poliambulanza, Brescia, Italy. - - 2014
Although 18F-fluoro-deoxy-glucose (FDG) positron emission tomography (PET) has been widely validated and extensively used in the latest years in clinical practice, interpretation of PET/CT images can be affected by several pitfalls. We here present a case of intense lung uptake in a patient without a corresponding finding on CT images, ...
Fülöp András A 1st Department of Surgery, Semmelweis University, Budapest, - - 2014
In the early recognition of portal vein ligation (PVL) induced tumor progression, positron emission tomography and magnetic resonance imaging (PET/MRI) could improve diagnostic accuracy of conventionally used methods. It is unknown how PVL affects metabolic patterns of tumor free hepatic tissues. The aim of this preliminary study is to evaluate ...
Probst Sonja - - 2014
AbstractIn this study, simultaneous positron emission tomography (PET)/magnetic resonance (MR) imaging was employed to evaluate the feasibility of the PET tracers 2-deoxy-2-18F-fluoro-d-glucose (18F-FDG), 11C-choline, and 18F-fluorothymidine (18F-FLT) to detect papillomavirus-induced tumors in an established rabbit model system. The combined PET/MR allowed the analysis of tracer uptake of the tumors using ...
Zhang Jiuquan J Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, - - 2014
To prospectively examine the relation between tumor vascularity and glucose metabolism in adenocarcinoma (AC) and squamous cell carcinoma(SCC) of the lung by using positron emission tomography/computed tomography (PET/CT) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). Forty-one consecutive patients with histologically confirmed untreated NSCLC underwent routine diagnostic work-up, including DCE-MRI ...
Sahin Ertan E Namik Kemal University Hospital, Department of Nuclear Medicine,Tekirdag, - - 2014
Purpose: Due to the fact that fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT) and technetium-99m-methylenediphosphonate ((99m)Tc-MDP) whole body scans identify bone metastases by different mechanisms, i.e. by using glucose metabolism and osteoblastic response in the bone, respectively, it can be expected that there may be some differences between these two methods ...
Ibrahim Ramez R Royal Hallamshire Hospital Sheffield - - 2014
A 30-year-old female presented with a history of secondary amenorrhoea, acromegalic features and progressive visual deterioration. She had elevated serum IGF1 levels and unsuppressed GH levels after an oral glucose tolerance test. Magnetic resonance imaging revealed a heterogeneously enhancing space-occupying lesion with atypical extensive calcification within the sellar and suprasellar ...
Jokinen Tarja S TS Department of Equine and Small Animal Medicine, University of Helsinki, Helsinki, - - 2013
Regional cerebral metabolism and blood flow can be measured noninvasively with positron emission tomography (PET). 2-[(18) F]fluoro-2-deoxy-D-glucose (FDG) widely serves as a PET tracer in human patients with epilepsy to identify the seizure focus. The goal of this prospective study was to determine whether juvenile or adult dogs with focal-onset ...
Kekelidze Maka M Maka Kekelidze, Luigia D'Errico, Michele Pansini, Anthony Tyndall, Joachim Hohmann, Clinic of Radiology and Nuclear Medicine, University Hospital Basel, University of Basel, 4031 Basel, - - 2013
In the last 10 years the mortality rate of colorectal cancer (CRC) has decreased by more than 20% due to the rising developments in diagnostic techniques and optimization of surgical, neoadjuvant and palliative therapies. Diagnostic methods currently used in the evaluation of CRC are heterogeneous and can vary within the ...
Coman Daniel D Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520, USA; Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT 06520, USA; Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA. Electronic address: - - 2013
(19)F magnetic resonance spectroscopy (MRS) studies of 2-fluoro-2-deoxy-d-glucose (FDG) and 2-fluoro-2-deoxy-d-glucose-6-phosphate (FDG-6P) can be used for directly assessing total glucose metabolism in vivo. To date, (19)F MRS measurements of FDG phosphorylation in the brain have either been achieved ex vivo from extracted tissue or in vivo by unusually long acquisition ...
Tahari Abdel K - - 2013
Tertiary care institutions often deal with patients who have had a baseline positron emission tomography (PET)/computed tomography (CT) scan performed elsewhere. Little data exist regarding the quality of these PET/CT scans and whether they are fully suitable for qualitative or quantitative interpretation. We evaluated outside PET/CT scans from cancer patients ...
Bernsdorf M - - 2013
Positron emission tomography (PET)/computed tomography (CT) is not suited for primary diagnostics of breast tumours and it cannot replace sentinel lymph node technique in determining metastases to the axilla. PET/CT has a high sensitivity and specificity regarding the detection of loco-regional recurrence and metastases to mediastinal and internal mammary lymph ...
Bucerius Jan - - 2013
(18)F-FDG PET is increasingly used for imaging of vessel wall inflammation. However, limited data are available on the impact of methodological variables, i.e. prescan fasting glucose, FDG circulation time and injected FDG dose, and of different FDG uptake parameters, in vascular FDG PET imaging. Included in the study were 195 ...
Topakian R - - 2013
Sporadic hemiplegic migraine (SHM) is defined as migraine attacks associated with some degree of motor weakness during the aura phase and where no first-degree relative has identical attacks. SHM has a wide inter- and intraindividual clinical spectrum and, in case of prolonged aura symptoms and disturbed consciousness, can mimic several ...
Rae Caroline D - - 2013
The current knowledge of the normal biochemistry of compounds that give rise to resonances in human brain proton magnetic resonance spectra measureable at readily available field strengths (i.e. ≤3 T) is reviewed. Molecules covered include myo- and scyllo-inositol, glycerophospho- and phospho-choline and choline, creatine and phosphocreatine, N-acetylaspartate, N-acetylaspartylglutamate, glutamate, glutamine, γ-aminobutyrate, ...
Izquierdo-García José L - - 2013
Global metabolic profiling using quantitative nuclear magnetic resonance spectroscopy (MRS) and mass spectrometry (MS) is useful for biomarker discovery. The objective of this study was to discover biomarkers of acute lung injury induced by mechanical ventilation (ventilator-induced lung injury [VILI]), by using MRS and MS. Male Sprague-Dawley rats were subjected ...
Banzo Ignacio - - 2013
The objective of this study was to evaluate the contribution of amyloid imaging with C-Pittsburgh compound B (C-PIB) and of glucose metabolism on F-fluorodeoxyglucose (F-FDG) PET/CT to the study of cognitive impairment in the clinical setting. Thirty-four patients (15 male, 19 female) were enrolled in the study. They were classified ...
Bjurberg Maria - - 2013
The superiority of positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro-D-glucose (FDG) over computed tomography and magnetic resonance imaging in detecting recurrent cervical cancer and determining the extent of the disease has been demonstrated in several clinical trials. However, there is a lack of data concerning the clinical impact of the extra ...
Pan Bo - - 2013
Primary malignant lymphoma of the prostate is exceedingly rare. Here we report a case of a 65-year-old man who presented with increased urinary frequency, urinary urgency, and urinary incontinence for two years. Benign prostatic hypertrophy was suspected at primary impression. Ultrasound revealed a hypoechoic lesion of the prostate. The total ...
Weijenberg Amerins - - 2013
A 50-year-old man presented with progressive tetraparesis and loss of vision. Inflammation and malignancy were considered based on diffuse meningeal enhancement on MRI (figure 1) and CSF content (very high protein, mild pleocytosis, and low to normal glucose). CSF cultures and cytologic examinations, including flow cytometry, were normal. FDG-PET showed ...
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