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Chen Aidong A University of Ottawa Heart Institute, Ottawa, ON, K1Y 4W7, - - 2014
Circulating Ang II activates an aldosterone-mineralocorticoid receptor (MR) - angiotensin II (Ang II) - angiotensin type 1 receptor (AT1R) pathway in the hypothalamus. To obtain insights into the actual neuronal projections involved, adeno-associated virus carrying small interfering RNA against either AT1aR (AAV-AT1aR-siRNA) or MR (AAV-MR-siRNA) were infused into the paraventricular ...
Fukunaga Naoto - - 2013
A 67-year-old man underwent surgical repair for a Crawford extent V thoracoabdominal aortic aneurysm under cerebrospinal fluid drainage and motor evoked potential monitor on distal aortic perfusion. Postoperatively, weakness of right-sided leg graded 2/5 and bladder disorder were recognized. Magnetic resonance imaging revealed hyperintensity between Th11 and L1 on T2-weighted ...
Jung Carla S - - 2013
OBJECTIVES: Monomethylated L-arginine (L-NMMA) has been proven to be a strong inhibitor of nitric oxide synthase (NOS) and has been used as an exogenous tool in experimental evaluation of cerebrovascular reactivity leading to vasoconstriction. However, L-NMMA is also produced endogenously and belongs, as does asymmetric dimethylated L-arginine (ADMA), to a ...
Binanti D - - 2012
An 8-day-old female Holstein Friesian calf was examined because of congenital spastic paresis of the hind limbs. Myelography revealed deviation and thinning of subarachnoid contrast medium columns in the lumbar segment. Upon magnetic resonance imaging, the 'hour-glass' subdural compression appeared as a T1-hypointense, T2-hyperintense ovoidal area suggestive of cerebral spinal ...
Mouraviev Vladimir - - 2012
In this study, we investigated the potential of a new class of therapeutic Mn porphyrins as molecular MRI probes for prostate cancer imaging. Two compounds of different bioavailibility were investigated: Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin (MnTE-2-PyP(5+)) and Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin (MnTnHex-2-PyP(5+)). These compounds have previously been shown to have adjunctive antineoplastic activity through their ...
Sugimoto Yoshihisa - - 2012
The diagnostic performance of helical computed tomography (CT) is excellent. However, some artifacts have been reported, such as motion, beam hardening and scatter artifacts. We herein report a case of motion-induced artifact mimicking cervical dens fracture. A 60-year-old man was involved in a motorcycle accident that resulted in cervical spinal ...
Kapanen Mika - - 2012
In radiotherapy, target tissues are defined best on MR images due to their superior soft tissue contrast. Computed tomography imaging is geometrically accurate and it is needed for dose calculation and generation of reference images for treatment localization. Co-registration errors between MR and computed tomography images can be eliminated using ...
Vees Hasnsjörg - - 2012
ABSTRACT: BACKGROUND: To assess the influence of sentinel lymph nodes (SNs) SPECT/CT and 18F-choline (18F-FCH) PET/CT in radiotherapy (RT) treatment planning for prostate cancer patients with a high-risk for lymph node (LN) involvement. METHODS: Twenty high-risk prostate cancer patients underwent a pelvic SPECT acquisition following a transrectal ultrasound guided injection ...
Chandra S - - 2012
Accurate localisation of the prostate and its surrounding tissue is essential in the treatment of prostate cancer. This paper presents a novel approach to fully automatically segment the prostate, including its seminal vesicles, within a few minutes of a Magnetic Resonance (MR) scan acquired without an endorectal coil. Such MR ...
Rud Erik - - 2012
Transrectal ultrasound (TRUS)-guided random biopsies is the gold standard when diagnosing prostate cancer. A new 3D system with organ tracking, allows accurate targeted biopsies using magnetic resonance imaging (MRI) and TRUS soft image fusion. The aim of the study was to evaluate the accuracy of targeted biopsies. Retrospective study of ...
Wassberg Cecilia - - 2012
The purpose of this study is to retrospectively assess the incremental value of contrast-enhanced MRI (CE-MRI) to T2-weighted MRI in the detection of postsurgical local recurrence of prostate cancer by readers of different experience levels, using biopsy as the reference standard. Fifty-two men with biochemical recurrence after prostatectomy underwent 1.5-T ...
Wu Xueming X Department of Biomedical Engineering, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, - - 2012
Tumor extracellular matrix has an abundance of cancer related proteins that can be used as biomarkers for cancer molecular imaging. Innovative design and development of safe and effective targeted contrast agents to these biomarkers would allow effective MR cancer molecular imaging with high spatial resolution. In this study, we synthesized ...
De Brabandere Marisol - - 2012
AIM: Reliable post-implant evaluation of prostate seed implants requires optimal seed identification and accurate delineation of anatomical structures. In this study the GEC-ESTRO groups BRAPHYQS and PROBATE investigated the interobserver variability in post-implant prostate contouring, seed reconstruction and image fusion and its impact on the dose-volume parameters. MATERIALS: Post-implant T2-TSE, ...
Kobus Thiele - - 2012
To determine the individual and combined performance of magnetic resonance (MR) spectroscopic imaging and diffusion-weighted (DW) imaging at 3 T in the in vivo assessment of prostate cancer aggressiveness by using histopathologically defined regions of interest on radical prostatectomy specimens to define the prostate cancer regions to be investigated. The ...
Miano Roberto - - 2012
Introduction: Previous measurement of the male external urethral sphincter complex (EUSC) length by magnetic resonance imaging and urethral pressure profilometry did not consider the intraprostatic portion, although its role for urinary continence has been demonstrated. The aim of our study was to verify the feasibility of a morphological evaluation of ...
Rybalov Maxim - - 2012
PURPOSE: To evaluate the effect of total PSA (tPSA) and PSA kinetics on the detection rates of (11)C-Choline PET in patients with biochemical recurrence (BCR) after radical prostatectomy (RP) or external beam radiotherapy (EBRT). METHODS: We included 185 patients with BCR after RP (PSA >0.2 ng/ml) or after EBRT (ASTRO definition). After ...
Góra Joanna - - 2012
PURPOSE: To investigate robust margin strategies in intensity modulated proton therapy to account for interfractional organ motion in prostate cancer. METHODS AND MATERIALS: For 9 patients, one planning computed tomography (CT) scan and daily and weekly cone beam CTs (CBCTs) were acquired and coregistered. The following planning target volume (PTV) ...
Porcaro Antonio B - - 2012
OBJECTIVES: To assess the accuracy of intra-rectal coil magnetic resonance imaging (ER-MRI) for staging early prostate cancer (EPC). MATERIALS AND METHODS: ER-MRI was performed with the Magnetom Symphony 1.5 Tesla system. ER-MRI and pathology findings were statistically correlated. RESULTS: One hundred and fifty-four consecutive patients underwent radical prostatectomy (RRP) for ...
Battista J - - 2012
On-line CT imaging in the radiotherapy room has become the norm for targeted intensity-modulated radiotherapy (IMRT), enabling precise adjustments of the daily patient setup based on soft tissue visualization. Corrections for plasticity of the anatomy and dose deformation are within technological reach but will require more on-line resources. We have ...
Marcu Loredana G - - 2012
Purpose: The roles of postimplant dosimetry (PID) after permanent I-125 implant are to identify and rectify inadequate implants, assess the dosimetric quality indicators, and evaluate dose to the organs at risk. The aim of the current work was to assess the progress of prostate implant quality via postimplant dosimetry over ...
N'djin William Apoutou - - 2012
The feasibility and safety of magnetic resonance imaging (MRI)-controlled transurethral ultrasound therapy were demonstrated recently in a preliminary human study in which a small subvolume of prostate tissue was treated prior to radical prostatectomy. Translation of this technology to full clinical use, however, requires the capability to generate thermal coagulation ...
Jadvar Hossein - - 2012
This study aimed to perform a prospective evaluation of 18F-NaF and 18F-FDG PET/CT in the detection of occult metastatic disease in men with prostate cancer and biochemical relapse. Thirty-seven men with prostate-specific antigen (PSA) relapse (median, 3.2 ng/mL; range, 0.5-40.2 ng/mL) after definitive therapy for localized prostate cancer [26 radical ...
Quentin M - - 2012
Purpose: Functional prostate MR is performed in varying combinations of T2-weighted images with diffusion-weighted imaging (DWI), dynamic contrast-enhanced MRI (DCE-MRI), and spectroscopic imaging (MRSI). Recently, a European consensus meeting proposed the use of a simple 5-point scale for estimating the probability of a lesion being malignant. The aim of the ...
Ghose Soumya - - 2012
Prostate segmentation is a challenging task, and the challenges significantly differ from one imaging modality to another. Low contrast, speckle, micro-calcifications and imaging artifacts like shadow poses serious challenges to accurate prostate segmentation in transrectal ultrasound (TRUS) images. However in magnetic resonance (MR) images, superior soft tissue contrast highlights large ...
Petrik David - - 2012
PURPOSE: Postplan quality assurance using CT shows considerable interobserver contour variability. We examined CT postplans of four experienced brachytherapists for comparison with MR-determined prostate volumes. METHODS AND MATERIALS: Seventy-five patients had CT and MR scans 1 month post-(125)I prostate brachytherapy. CT scans were contoured by the treating physician and dosimetry ...
Bowes David - - 2012
PURPOSE: Postplan evaluation is essential for quality assurance in prostate brachytherapy. MRI has demonstrated greater interobserver consistency in prostate contouring compared with CT. Although a valuable tool in postimplant assessment, MRI is costly and not always available. Our purpose is to compare dosimetry obtained using fusion of postimplant CT with ...
Albert Jeffrey M - - 2013
Transrectal ultrasound (TRUS) is the standard imaging modality for planning prostate brachytherapy. However, magnetic resonance imaging (MRI) provides greater anatomic detail than TRUS. We compared treatment plans generated using TRUS, endorectal coil MRI (erMRI), and standard body array coil MRI (sMRI). Treatment plans were used from patients treated with permanent, ...
Stroup Sean P - - 2012
Sentinel lymph node (SLN) identification with preoperative image guidance may improve pathological staging of prostate cancer by identifying nodes outside the standard template of dissection. Four anesthetized male dogs received an intra-prostatic injection of Ga-68-labeled tilmanocept. Every 20 min the pelvic lymph nodes were imaged using PET/CT fusion imaging. At 90 min ...
Chen Yu-Jen - - 2012
PURPOSE: To investigate the associations between dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) parameters and the Gleason score (GS) for prostate cancer (PCA) with localization information provided by concurrent apparent diffusion coefficient (ADC) maps. MATERIALS AND METHODS: Forty-three male patients received MR scans, including diffusion tensor imaging (DTI) and DCE ...
Liauw Stanley L - - 2012
PURPOSE: To summarize the results of a 4-year period in which endorectal magnetic resonance imaging (MRI) was considered for all men referred for salvage radiation therapy (RT) at a single academic center; to describe the incidence and location of locally recurrent disease in a contemporary cohort of men with biochemical ...
Moore Caroline M - - 2012
CONTEXT: Technical improvements in prostate magnetic resonance imaging (MRI) have resulted in the use of MRI to target prostate biopsies. OBJECTIVE: To systematically review the literature to compare the accuracy of MRI-targeted biopsy with standard transrectal biopsy in the detection of clinically significant prostate cancer. EVIDENCE ACQUISITION: The PubMed, Embase, ...
Wilkinson Christopher - - 2012
We present a case of granulomatous prostatitis that presented in a rare way as an incidentally discovered focus of increased FDG activity within the prostate on PET-CT in a patient who had previously undergone intravesical bacille Calmette-Guérin treatment for bladder cancer. FDG uptake is commonly discovered in organs distant from ...
Tokuda Junichi - - 2012
To evaluate the targeting accuracy of a small profile MRI-compatible pneumatic robot for needle placement that can angulate a needle insertion path into a large accessible target volume. We extended our MRI-compatible pneumatic robot for needle placement to utilize its four degrees-of-freedom (4-DOF) mechanism with two parallel triangular structures and ...
Gu Chris N - - 2012
We present the case of a 74-year-old male with biochemical recurrence of prostate cancer who underwent [(11)C]choline PET/CT. The PET/CT demonstrated an intense focus of uptake within the skull base that was initially felt to potentially represent metastatic disease. Subsequent evaluation with MRI and dedicated thin-section CT revealed this area ...
Quentin M - - 2012
Background: Functional magnetic resonance imaging (MRI) seems to be a useful tool for prostate cancer (PCa) detection in patients with a previous negative biopsy but persistently increased prostate-specific antigen (PSA) values. Additionally, it enables correct cancer localization in patients with known PCa under active surveillance to avoid misclassification on repeat ...
Bloch B Nicolas - - 2012
To assess the value of dynamic contrast-enhanced (DCE) combined with T2-weighted (T2W) endorectal coil (ERC) magnetic resonance imaging (MRI) at 3 T for determining extracapsular extension (ECE) of prostate cancer. In this IRB-approved study, ERC 3-T MRI of the prostate was performed in 108 patients before radical prostatectomy. T2W fast spin-echo ...
Guo Y - - 2012
Purpose: To develop a new method for automatic localization of prostate cancer using multispectral MRI data. Methods: Multispectral MRI including MR spectroscopic imaging (MRSI), T2 weighted MRI, diffusion weighted imaging (DWI) and dynamic contrast-enhanced (DCE) MRI, has been used for cancer target localization. The combination of multiple MRI imaging technologies ...
Hossain M - - 2012
Purpose: Magnetic Resonance Spectroscopy (MRS) of the prostate is not used in radiotherapy departments on a regular basis due to a number of issues. The indication and severity of prostate cancer is related to the presence of choline in the prostate, in particular, the ratio of choline (plus creatine) to ...
Chen Y - - 2012
Purpose: To investigate dosimetric consequences of patient metal prosthesis in prostate radiotherapy, considering the body heterogeneity, metal artifacts, prostate daily displacements and target delineation. Methods: Three prostate patients with metal prosthesis were simulated with CT images and 3D ultrasound images. Conformal RT treatment plans were generated based on target volumes ...
Li W - - 2012
Purpose: Anatomy delineation is a major time consuming task to correct for inter-fractional changes in anatomy. Atlas-based auto-segmentation (ABAS) was developed to expedite this process. This study aims to evaluate the performance of ABAS applying to high quality verification CT-imaging acquired using a CT-on-rail system for prostate cancer. Methods: The ...
Xu Z - - 2012
Purpose: To report the inter-fractional prostate bed motion (PBM) during post-prostatectomy radiotherapy using cone-beam CT (CBCT). The correlations between PBM, anterior rectal wall and posterior bladder wall shifts were also investigated. Methods: Seventy CBCT and 8 planning CT scans from 8 patients treated with prostate bed radiotherapy were retrospectively analyzed. ...
Liu F - - 2012
Purpose: To demonstrate the dosimetric benefits of using an online adaptive replanning scheme to address interfractional variations in radiotherapy of prostate bed. Methods: We have previously developed an online adaptive replanning tool (RealART, Prowess Inc.) aiming to address interfractional variations including organ deformation and rotation. Using this tool, we analyzed ...
Fatemi-Ardekani A - - 2012
Purpose: Conventionally, post-implant CT scans are used for identification of prostate brachytherapy implant seed locations. The dosimetric quality of the seed implant in our institution is evaluated based on CT/MRI fusion and contouring of prostate and rectal wall on MRI. Post-implant evaluation of prostate brachytherapy using MRI alone is generally ...
Xue J - - 2012
Purpose: The accuracy of CT-MR imaging fusion plays an important role in both accurate delineation (using MR data) and dose calculation (using CT data) for image-guided radiotherapy (IGRT) of prostate cancer. The purpose of this study was to investigate the accuracy of CT-MRI fusion in target delineation/localization for prostate IGRT. ...
Mocikova Ingrid - - 2012
Background. This article reviews the potential of magnetic resonance imaging (MRI) in prostate cancer diagnosis. Methods. Systematic scan of Pubmed, Ovid, Medline, Elsevier search engines was used, additional information was found through bibliographic review of relevant articles. Results. Substantial progress has been made in the imaging of prostate cancer in ...
Koedooder C - - 2012
Purpose: Estimation of deviations between planned and delivered dose in Pulsed Doserate (PDR) brachytherapy for prostate cancer. Methods: A boost of 28.8 Gy is given with PDR brachytherapy in addition to 46 Gy delivered with External Beam RT. Brachytherapy is given in 24 pulses of 120 cGy, with an interpulse ...
Jeong Chang Wook - - 2012
To evaluate conventional magnetic resonance imaging (MRI), prostate needle biopsy (PBx), and the combination of both tests in predicting the laterality of final specimen pathology after radical prostatectomy. A total of 574 radical prostatectomy cases that had PBx with at least 12 cores and preoperative prostate MRI with pelvic coil ...
Mapelli Paola - - 2012
ABSTRACT: Positron emission tomography/computed tomography (PET/CT) with C-choline is an established diagnostic tool for restaging prostate cancer patients with biochemical failure after primary treatment. In the present case, C-choline PET/CT was performed in a prostate cancer patient with skeletal metastases, treated with hormonal therapy. In addition to the detection of ...
Song H - - 2012
Purpose: To study prostate-bed motion after prostatectomy using the surgical clips as a surrogate. Methods: On the treatment planning CT, surgical clips within the PTV are identified and contoured. They are also identified and contoured in each daily CBCT. The center of mass (COM) coordinates for each clip within the ...
Ma C - - 2012
Purpose: Advanced imaging techniques have been developed to facilitate patient setup and target localization for advanced prostate radiotherapy. These techniques work well for translational, interfractional organ motion but may Result in poor target coverage for some cases where the effects of rotational motion and organ deformation are not corrected. This ...
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