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Furuyama Jon K JK Department of Radiological Sciences, University of California, Los Angeles, CA, - - 2014
A current limitation of MR spectroscopic imaging of multiple skeletal muscles is prolonged scan duration. A significant reduction in the total scan duration using the echo-planar correlated spectroscopic imaging (EP-COSI) sequence was accomplished using two bipolar readout trains with different phase-encoded echoes for one of two spatial dimensions within a ...
Schieda N N Department of Radiology, The Ottawa Hospital, The University of Ottawa, Civic Campus C1 1053 Carling Avenue, Ottawa, Ontario, Canada, K1Y 4E9. Electronic address: - - 2014
Chemical shift (CS) MRI of the adrenal glands exploits the different precessional frequencies of fat and water protons to differentiate the intracytoplasmic lipid-containing adrenal adenoma from other adrenal lesions. The purpose of this review is to illustrate both technical and interpretive pitfalls of adrenal imaging with CS MRI and emphasize ...
Bye Nicole - - 2014
The purpose of this work was to synthesize and screen, for their effectiveness to act as T1 enhancing magnetic resonance imaging (MRI) contrast agents, a small library of nitroxide lipids incorporated into cubic phase lipid nanoparticles (cubosomes™). The most effective nitroxide lipid was then formulated into lower toxicity lipid nanoparticles ...
Boer Vincent O VO Department of Radiology, University Medical Center Utrecht, The - - 2014
Lipid suppression in MR brain imaging and spectroscopy has been a long-standing problem for which various techniques have been developed. Most methods are based on inversion recovery or spatially or spectrally selective excitation of the lipid signal followed by dephasing. All techniques require additional RF pulses, gradient crushers and delays, ...
Boussel Loic L Department of Radiology, CREATIS, UMR CNRS 5515, INSERM U1044, Croix-Rousse Hospital, 103 Grande Rue de la Croix-Rousse, 69004 Lyon, - - 2014
Objectives. To evaluate the capabilities of Photon Counting Spectral CT to differentiate components of coronary atherosclerotic plaque based on differences in spectral attenuation and iodine-based contrast agent concentration. Methods. 10 calcified and 13 lipid-rich atheromatous plaques from postmortem human coronary arteries were scanned with a Photon Counting Spectral CT scanner. ...
Helck A A Institute for Clinical Radiology, University of Munich, Grosshadern Campus, Marchioninistr. 15, 81377, Munich, Germany, - - 2014
To evaluate whether single-phase dual-energy-CT-based attenuation measurements can reliably differentiate lipid-rich adrenal adenomas from malignant adrenal lesions. We retrospectively identified 51 patients with adrenal masses who had undergone contrast-enhanced dual-energy-CT (140/100 or 140/80 kVp). Virtual non-contrast and colour-coded iodine images were generated, allowing for measurement of pre- and post-contrast density on ...
Lu Jianhua J Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, - - 2014
To investigate the characteristics of nuclear Overhauser enhancement (NOE) imaging signals in the brain at 7T. Fresh hen eggs, as well as six healthy, and six C6 glioma-bearing Wistar rats were scanned using chemical exchange saturation transfer-magnetic resonance imaging (CEST-MRI) and chemical exchange saturation transfer-magnetic resonance spectroscopy (CEST-MRS) sequences (saturation ...
Seo Jung Min JM 1 All authors: Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong Kangnam-ku, Seoul, Korea - - 2014
OBJECTIVE. The purpose of this article is to retrospectively compare the accuracy of MRI and CT in characterizing lipid-poor adrenal adenomas with respect to lesion-attenuation values measured on unenhanced CT. MATERIALS AND METHODS. Fifty-two lipid-poor adrenal masses measuring greater than 10 HU on unenhanced CT were identified in 52 patients ...
de Fatima Vasco Aragao M M From the Departments of Radiology (M.d.F.V.A., D.B.d.A., B.D., A.S.B., M.P.) and Pathology (M.F.), Mount Sinai School of Medicine, New York, New York; Centro Diagnóstico Multimagem (M.d.F.V.A.), Recife, Brazil; Department of Neuropsychiatry and Behavioral Studies (M.d.F.V.A., M.M.V.), Federal University of Pernambuco, Recife, Brazil; Department of Radiology (M.L.), University of Southern California, Los Angeles, California; Department of Radiology (G.F.), New York University Langone Medical Center, New York, New York; and Department of Pathology (R.V.d.M.), Federal University of Pernambuco, Recife, - - 2014
The differentiation of pilocytic astrocytomas and high-grade astrocytomas is sometimes difficult. There are limited comparisons in the literature of the advanced MR imaging findings of pilocytic astrocytomas versus high-grade astrocytomas. The purpose of this study was to assess the MR imaging, PWI, DWI, and MR spectroscopy characteristics of pilocytic astrocytomas ...
Zavodni Anna E H AE From the Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada (A.E.H.Z.); Departments of Radiology (B.A.W., J.A.C.L.) and Medicine (J.A.C.L.), Johns Hopkins University, Baltimore, Md; Collaborative Health Studies Coordinating Center, University of Washington, Seattle, Wash (R.L.M.); Department of Radiology, University of California-Los Angeles School of Medicine, Los Angeles, Calif (A.S.G.); Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minn (A.R.F.); Department of Radiology, Tufts Medical Center, Boston, Mass (J.F.P.); and Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bldg 10/1C355, Bethesda, MD 20892 - - 2014
Purpose To determine if carotid plaque morphology and composition with magnetic resonance (MR) imaging can be used to identify asymptomatic subjects at risk for cardiovascular events. Materials and Methods Institutional review boards at each site approved the study, and all sites were Health Insurance Portability and Accountability Act (HIPAA) compliant. ...
Zheng Jiahe J 1 Department of Radiology, Shengjing Hospital of China Medical University, 36 Sanhao St, Heping District, Shenyang, Liaoning, 110004, - - 2014
OBJECTIVE. There is a need for a simple, rapid, and repeatable noninvasive imaging method to accurately assess carotid atherosclerotic plaque. The purpose of this study was to explore the utility of MDCT and carotid artery plaque analysis software for detecting and identifying atherosclerotic plaque in a rabbit model of carotid ...
Boekhoven Renate W RW Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands. Electronic address: - - 2014
In this study, an experimental framework is described that allows pressurization of intact, human atherosclerotic carotid samples (inflation testing), in combination with ultrasound imaging. Eight fresh human carotid endarterectomy samples were successfully pressurized and tested. About 36 2-D (+t) ultrasound datasets were acquired by rotating the vessel in 10° steps ...
Weis Jan J Department of Radiology, Uppsala University Hospital, Uppsala, - - 2014
This study exploits the speed benefits of echo-planar spectroscopic imaging (EPSI) to acquire lipid spectra of skeletal muscle. The main purpose was to develop a high-resolution EPSI technique for clinical MR scanner, to visualise the bulk magnetic susceptibility (BMS) shifts of extra-myocellular lipid (EMCL) spectral lines, and to investigate the ...
Nakamura Taro T Institute of Medicinal Chemistry, Hoshi - - 2014
To enhance tumor magnetic resonance imaging (MRI) signals via the selective accumulation of contrast agents, we prepared folate-modified gadolinium-lipid-based nanoparticles as MRI contrast agents. Folate-modified nanoparticles were comprised of polyethylene glycol (PEG)-lipid, gadolinium diethylenetriamine pentaacetic acid lipid, cationic cholesterol derivatives, folate-conjugated PEG-lipid, and Cy7-PEG-lipid. Folate receptor-mediated cellular nanoparticle association was ...
Tak Sandeep S Department of Medicine, Dr SN Medical College, Jodhpur, Rajasthan, - - 2014
A 65-year-old man presented with a history of acute onset pain in toes of the right foot immediately after an abdominal massage by a 'local healer'. General physical examination and systemic examination were normal except for discolouration of the fourth and fifth toes and cold toes. Investigations including complete blood ...
Lei-Xing Xie X Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing, - - 2013
To assess the correlations between atherosclerotic plaque characteristics and inflammatory activity by combined use of (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI). Patients underwent (18)F-FDG PET/CT and MRI. Target/background ratios (TBR) of axial sections were determined from mean standard uptake values (SUV). Correlations between TBR ...
Kim Hee Kyung - - 2013
Various skeletal muscle diseases result in fatty infiltration, making it important to develop noninvasive biomarkers to objectively measure muscular fat. We compared T2 relaxation time mapping (T2 maps) and magnetic resonance spectroscopy (MRS) with physical characteristics previously correlated with intramuscular fat to validate T2 maps and MRS as objective measures ...
Kim Young Jun - - 2013
We evaluated the feasibility of automatic computer-aided analysis (CAA) compared with semi-automatic CAA for differentiating lipid-rich from fibrous plaques based on coronary CT angiography (CCTA) imaging. Seventy-four coronary plaques in 57 patients were evaluated by CCTA using 64-slice dual-source CT. Quantitative analysis of coronary artery plaques was performed by measuring ...
Khan Mansoor - - 2013
Oncocytic adrenal neoplasms (OANs) are rare, but are an important subtype of adrenal tumors that is being diagnosed with increasing frequency. Unfortunately, the imaging characteristics of this tumor have not been well described. Our purpose was to identify CT features to differentiate OANs from adrenocortical carcinomas (ACC). From 1991 to ...
Woo Sungmin - - 2013
Chemical-shift magnetic resonance imaging (MRI) has been known to successfully differentiate adenomas from metastases. However, there has been concern that metastasis from extra-adrenal primary malignancies which contain high lipid content such as clear cell renal cell carcinoma (RCC) could mimic adrenal adenomas. To evaluate the ability of MR to differentiate ...
Morgan Desiree E - - 2013
This study aimed to determine if a single-source rapid kilovolt (peak)-switching dual-energy (RSDE) multidetector computed tomography (CT) can differentiate high lipid content (HLC) from low lipid content (LLC) incidental adrenal lesions. A retrospective intrapatient study of 40 consecutive adults with known hepatic or pancreatic pathology who underwent multiphasic abdominal RSDE ...
Narumi S - - 2013
BACKGROUND AND PURPOSE:MR plaque imaging is used to evaluate the risk of embolic complications during carotid endarterectomy and carotid artery stent placement. However, its performance for characterizing intraplaque components has varied across studies and is generally suboptimal. Hence, we correlated MR imaging results with histologic findings to determine whether a ...
Faller Kiterie M E KM Department of Cardiovascular Medicine, British Heart Foundation Experimental Magnetic Resonance Unit (BMRU), Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, - - 2013
Magnetic resonance spectroscopy (MRS) is the only non-invasive, non-radiation-based technique for investigating the metabolism of living tissue. MRS of protons (1H-MRS), which provides the highest sensitivity of all MR-visible nuclei, is a method capable of detecting and quantifying specific cardiac biomolecules, such as lipids and creatine in normal and diseased ...
Shi Jiang Wei - - 2013
Application of dual-energy CT in characterization of adrenal nodules has not been well evaluated. To evaluate the ability of dual-energy CT scan to differentiate an adrenal adenoma from a metastasis. Fifty-five patients presenting 63 adrenal nodules underwent dual-energy CT scan at tube voltages of 80 kVp and 140 kVp. Mean attenuation values ...
Lu S-S - - 2013
BACKGROUND AND PURPOSE:It may be challenging to differentiate primary CNS lymphomas, especially primary CNS lymphomas with atypical MR features, from tumefactive demyelinating lesions by the use of conventional MR. This study aimed to investigate the usefulness of (1)H-MR spectroscopy for making this discrimination.MATERIALS AND METHODS:Forty-four patients with primary CNS lymphomas ...
Rosenbohm Angela - - 2013
Introduction: Glutaric aciduria type II (GAII) is a rare autosomal recessive disorder with variable clinical course. The disorder is caused by a defect in the mitochondrial electron transfer flavoprotein or the electron transfer flavoprotein dehydrogenase (ETFDH). Methods: We performed clinical characterization, brain and whole body MRI, muscle histopathology, and genetic ...
Rolla Gabriele A - - 2013
Highly efficient magnetic resonance imaging (MRI) probes have been prepared by loading Gd(III) complexes on the surface of solid lipid nanoparticles (pSLNs). Applicability as molecular imaging probes is demonstrated by an in vitro model study with targeted pSLNs.
Patel Jeet - - 2013
OBJECTIVE. The purpose of this article is to determine the proportion of pheochromocytomas that mimic adrenal adenoma using established CT washout and attenuation criteria. MATERIALS AND METHODS. The CT characteristics of pheochromocytomas confirmed by histologic analysis (n = 46) and (131)I-metaiodobenzylguanidine (n = 1) were compared with those of 98 ...
Ahn So Yoon - - 2013
This study was performed to determine the accuracy of proton magnetic spectroscopy ((1)H-MRS) lipid peak as a noninvasive tool for quantitative in vivo detection of brain cell death. Seven day-old Sprague Dawley rats were subjected to 8% oxygen following a unilateral carotid artery ligation. For treatment, cycloheximide was given immediately ...
Liao Ai-Ho - - 2013
In our previous studies we explored the potential of using a combined US/magnetic resonance (MR) multimodality contrast agent, albumin-gadolinium-diethylenetriaminepentacetate (Gd-DTPA) MBs, to induce BBB opening and for distinguishing between FUS-induced BBB opening and intracerebral hemorrhage in MR T1-weighted contrast imaging. According to the previous study in the literature, 1-2 µm ...
Sopelana P - - 2013
In this work, (1)H Nuclear Magnetic Resonance ((1)H NMR) has been used to study the lipidic fraction of margarines of different compositions, determining simultaneously both major components, which is to say triglycerides, and other minor ones, such as 1- and 2-monoglycerides, 1,2-diglycerides, vegetable stanols and sterols, and sorbic acid. The ...
Bolacchi Francesca - - 2013
OBJECTIVE: To evaluate whether bone marrow proton magnetic resonance spectroscopy (MRS) might provide a quantitative parameter able to assess disease activity in acute Charcot neuro-osteoarthropathy (CN). METHODS: Ten diabetic patients with stage 0 CN were prospectively evaluated at clinical onset and during treatment follow-up. The MRS lipid spectrum was analysed ...
Takeuchi Mayumi - - 2013
OBJECTIVE: To retrospectively evaluate the clinical significance of the lipid peak in in vivo proton magnetic resonance spectroscopy (MRS) for the diagnosis of high-grade uterine sarcomas. METHODS: MRS was performed in patients with 38 pathologically diagnosed uterine corpus tumours (26 leiomyomas and 12 sarcomas) at 3 T. Single-voxel MRS data were ...
Borisjuk Ljudmilla - - 2013
This review highlights technological developments in magnetic resonance imaging (MRI), which are creating opportunities for the three dimensional visualization and quantification of lipids in plant materials. A major feature of MRI is that it is a non-invasive platform, and thus can be used for the analysis of living organisms. An ...
Zhao Xue-Cheng - - 2013
Noninvasive detection of vulnerable plaque has a significant implication for prevention and treatment of atherosclerotic diseases. The aim of this study is to investigate the difference between vulnerable plaques and stable plaques in magnetic resonance (MR) images. Atherosclerosis was induced in twenty male New Zealand white rabbits by high cholesterol ...
Forbes Sean C SC Department of Physical Therapy, Department of Physiology and Functional Genomics, and Department of Pediatrics and Molecular Genetics and Microbiology, Powell Gene Therapy Center, University of Florida, Box 100154, UFHSC, Gainesville, FL 32610; Advanced Imaging Research Center, Oregon Health and Science University, Portland, Ore; Division of Neurology and Department of Radiology, the Children's Hospital of Philadelphia, Philadelphia, Pa; Section of Integrative Biology, Division of Statistics and Scientific Computation, the University of Texas at Austin, Austin, Tex; Departments of Pediatrics and Neurology, Oregon Health and Science University, Shriners Hospital for Children, Portland, Ore; Nemours Children's Hospital, University of Central Florida College of Medicine, Orlando, - - 2013
To validate a multicenter protocol that examines lower extremity skeletal muscles of children with Duchenne muscular dystrophy (DMD) by using magnetic resonance (MR) imaging and MR spectroscopy in terms of reproducibility of these measurements within and across centers. This HIPAA-compliant study was approved by the institutional review boards of all ...
Schlett Christopher L - - 2013
AIMS: To compare the accuracy of two plaque delineation methods for coronary computed tomographic angiography (CTA) to identify lipid-core plaque (LCP) using histology as the reference standard. METHODS AND RESULTS: Five ex vivo hearts were analysed by CTA and histology. LCP was defined by histology as fibroatheroma with core diameter/circumference ...
Takahashi Kentaro - - 2013
iMAP™ has recently been introduced as a new tissue characterization method using the 40-MHz intravascular ultrasound (IVUS). However, few data have been published on the comparative findings of other imaging modalities in vivo. We examined 108 matched lesions from 70 patients (35 with stable angina and 35 with acute coronary ...
Emoto Miho C - - 2013
Nitroxides have recently been used as redox-sensitive contrast agents for both MRI and EPR imaging. However, the rapid in vivo reduction in paramagnetism of nitroxides due to reductants such as ascorbic acid (AsA) has limited their use as contrast agents. This study developed a formulation of a newly synthesized AsA-resistive ...
Saito Hisayasu - - 2013
Background: Vulnerable and inflamed plaques in the carotid artery are at high risk of ischemic stroke, suggesting the importance of diagnostic modalities to detect them in patients with carotid stenosis with high sensitivity and specificity. Although many investigators have reported that magnetic resonance imaging (MRI) is a useful tool to ...
Clark M H - - 2013
(1)H magnetic resonance spectroscopy ((1)H MRS) is the preferred technique for noninvasive quantification of hepatic triglyceride in humans. Domestic cats are subject to liver lipid accumulation, but MRS has not been investigated for quantification of liver fat in cats. The purpose of this project was to explore a technique for ...
Pudhiavan Arunachalam - - 2013
Cerebrotendinous xanthomatosis (CTX), also known as Van Bogaert-Scherer-Epstein disease is a rare autosomal recessive genetic disorder of the lipid metabolism. To date, there are less than 300 cases reported worldwide. We present a case of a 30 year old male who presented with mental retardation and swelling of ankles, with ...
Korivi Brinda Rao BR Brinda Rao Korivi, Khaled M Elsayes, Department of Radiology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, United - - 2013
Advances in medical imaging with current cross-section modalities enable non-invasive characterization of adrenal lesions. Computed tomography (CT) provides characterization with its non-contrast and wash-out features. Magnetic resonance imaging (MRI) is helpful in further characterization using chemical shift imaging (CSI) and MR spectroscopy. For differentiating between benign and malignant masses, positron ...
Sun Jie - - 2013
Purpose:To use magnetic resonance (MR) imaging to examine the short-term (6 months) natural history of the lipid-rich necrotic core (LRNC) in carotid artery plaques by examining the placebo group of a multicenter clinical trial.Materials and Methods:Study procedures and consent forms were approved by the institutional review board for this HIPAA-compliant ...
Károlyi Mihály M Cardiac MR/PET/CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, - - 2013
This study sought to determine whether the classification of human coronary atherosclerotic plaques with T1, T2, and ultrashort echo time (UTE) cardiac magnetic resonance (CMR) would correlate well with atherosclerotic plaque classification by histology. CMR has been extensively used to classify carotid plaque, but its ability to characterize coronary plaque ...
de Graaf Robin A - - 2013
PURPOSE: Intramolecular zero-quantum-coherences (ZQCs) are intrinsically insensitive toward magnetic field inhomogeneity. This fact is used to quantify and characterize lipid signals in the human breast at 7 T despite the presence of severe magnetic field inhomogeneity caused by water-lipid susceptibility boundaries. METHODS: A novel 3D localized 2D ZQC method is ...
Crisi Girolamo - - 2013
OBJECTIVE: The differentiation between solitary metastasis (MET) and glioblastoma (GBM) is difficult using only magnetic resonance imaging techniques. Magnetic resonance spectroscopy (MRS) lipid signal indicates cellular necrosis both in GBMs and METs. The purpose of this prospective study was to determine whether a class of lipids and/or macromolecules (MMs), able ...
Naim Cyrille C Department of Radiology, University of Montreal Hospital Center (CHUM), Montréal, Québec, Canada. - - 2013
To evaluate the ability of ultrasound non-invasive vascular elastography (NIVE) strain analysis to characterise carotid plaque composition and vulnerability as determined by high-resolution magnetic resonance imaging (MRI). Thirty-one subjects with 50 % or greater carotid stenosis underwent NIVE and high-resolution MRI of internal carotid arteries. Time-varying strain images (elastograms) of ...
Kim Yi Kyung - - 2013
Purpose:To determine the diagnostic performance of dual-energy computed tomography (CT) by using virtual unenhanced CT to characterize adrenal masses.Materials and Methods:This study is retrospective, HIPAA-compliant, and approved by the institutional review board. Between December 2009 and June 2010, 49 patients with 49 adrenal masses underwent 120-kVp unenhanced CT and 80-kVp ...
Kristanto Wisnumurti - - 2013
Computed tomography (CT) may characterize lipid-rich and presumably rupture-prone non-calcified coronary atherosclerotic plaque based on its Hounsfield-Unit (HU), but still inconclusively. This study aimed to evaluate factors influencing the HU-value of non-calcified plaque using software simulation. Several realistic virtual plaqueburdened coronary phantoms were constructed at 5 μm resolution. CT scanning was ...
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