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Brown Dawson S DS Departments of Orthopaedics and Rehabilitation (D.S.B. and D.C.C.) and Radiology (E.W.F. and J.S.), Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, Mail Code OP31, Portland, OR 97239. E-mail address for D.C. Crawford: - - 2014
Zonal T2 mapping and dGEMRIC (delayed gadolinium-enhanced magnetic resonance imaging of cartilage) are diagnostic quantitative techniques to evaluate the biochemical health of articular cartilage. We adapted these techniques to investigate the results of osteochondral allograft transplantation and correlated the findings with patient-reported outcomes. Nine patients with contained ICRS (International Cartilage ...
Popovich I I Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New - - 2014
Few imaging studies have investigated cartilage in gout. Magnetic resonance imaging (MRI) can image cartilage damage and also reveals other features of gouty arthropathy. The objective was to develop and validate a system for quantifying cartilage damage in gout. 3-T MRI scans of the wrist were obtained in 40 gout ...
Nakasa Tomoyuki T Hiroshima University, Hiroshima, - - 2014
Osteochondral lesions of the talar dome (OLT) involve the articular cartilage and/or subchondral bone. The subchondral bone plate plays an important role in cartilage metabolism. We hypothesized that the findings of subchondral bone on CT image would be related to the cartilage damage of OLT. The purpose of this study ...
Hesper Tobias T Department of Orthopaedics Medical Faculty, University Düsseldorf, Düsseldorf, - - 2014
With advances in joint preservation surgery that are intended to alter the course of osteoarthritis by early intervention, accurate and reliable assessment of the cartilage status is critical. Biochemically sensitive MRI techniques can add robust biomarkers for disease onset and progression, and therefore, could be meaningful assessment tools for the ...
Lattanzi Riccardo R The Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, 660 First Avenue, New York, NY 10016, USA; Department of Radiology, New York University Langone Medical Center, 550 First Avenue, New York 10016, NY, USA. Electronic address: - - 2014
This study aimed at identifying the optimal threshold value to detect cartilage lesions with Standardized dGEMRIC at 3T and evaluate intra- and inter-observer repeatability. We retrospectively reviewed 20 hips in 20 patients. dGEMRIC maps were acquired at 3T along radial imaging planes of the hip and standardized to remove the ...
Sutter Reto R 1 Department of Radiology, Orthopedic University Hospital Balgrist, Forchstrasse 340, 8008 Zurich, - - 2014
OBJECTIVE. The objective of our study was to prospectively compare the diagnostic performance of MR arthrography and conventional MRI with surgical correlation in the same patient for detecting labrum and articular cartilage defects. SUBJECTS AND METHODS. Twenty-eight patients (mean age, 31.8 years) underwent MR arthrography, conventional MRI, and subsequent hip ...
Challawar Nikhil Subhash NS Department of Orthopaedics, Kasturba Medical College, Manipal, Karnataka, - - 2014
Osteoid osteoma rarely presents in an intra-articular or juxta-articular location, leading to synovitis and flexion deformity, which can easily mislead the diagnosis. We present a case of an intra-articular osteoid osteoma of the distal humerus in a 19-year-old woman with pain and flexion deformity of the elbow. Although radiographs were ...
Stannus Oliver Patrick - - 2013
This study aims to assess mean signal intensity of cartilage on T1-weighted magnetic resonance imaging (MRI) images, and then examine whether mean signal intensity is associated with risk factors and measures of osteoarthritis in younger and older adults. A total of 50 younger adult subjects (mean age 41, range 29-57; ...
Li Hong - - 2013
To assess the cartilage status of the knee joints using magnetic resonance imaging at least 2 years after anterior cruciate ligament reconstruction (ACLR) in young adult men. Thirty young male patients with unilateral ACLR and 15 age-matched and body mass index-matched healthy men (controls) participated in this study. All participants ...
Kokkonen Harri T - - 2013
The aim of this study was to investigate the feasibility of delayed cone beam (CBCT) arthrography for clinical diagnostics of knee cartilage lesions. Knee joints with cartilage lesions were imaged using native radiography, MRI, and delayed CBCT arthrography techniques in vivo. The joints were imaged three times with CBCT, just ...
Peers Sebastian C - - 2013
To determine if T1ρ magnetic resonance imaging (T1ρ MRI) could assess early articular cartilage changes in knees of asymptomatic female collegiate athletes. It was hypothesized that impact cohort would demonstrate greater changes than nonimpact cohort. An institutional review board-approved prospective cohort study. Blinded MRI analyses. Participants from collegiate athletic program. ...
Rothman David J - - 2013
Epstein R. Overdose: how excessive government regulation stifles pharmaceutical innovation. New Haven, CT: Yale University Press, 2006. Stossel TP. Has the hunt for conflicts of interest gone too far? Brit Med J 2008;336:476. Weaver WD. President's page: disclosures, transparency, and firewalls protect integrity. Am Coll Cardiol 2008;52:964-5.
Cha Jang Gyu - - 2013
IDEAL technique is a robust fat-water separation method which is potentially useful in cartilage imaging with significant improvement in the cartilage signal-to-noise ratio (SNR). To identify whether iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) improved diagnostic performance for IDEAL 2D fast spin echo (FSE) ...
Spencer Brian A - - 2013
The purpose of this study was to assess the diagnostic sensitivity, specificity, accuracy, negative predictive value (NPV), positive predictive value (PPV), and test-retest reliability of magnetic resonance imaging (MRI) for detecting cartilage abnormalities of the glenohumeral joint in comparison with the gold standard of diagnostic arthroscopy. Forty-four patients with a ...
Crema Michel D - - 2013
To determine the association between changes in the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) index over 2 years as a measure of cartilage proteoglycan concentration, with changes in cartilage thickness in the medial tibiofemoral compartment of knees in middle-aged women. One hundred and forty-eight women (one knee for each subject) ...
Feldman Rebecca E - - 2013
Sodium signal strength in MRI is low when compared with (1)H. Thus, image voxel volumes must be relatively large in order to produce a sufficient signal-to-noise ratio (SNR). The measurement of sodium in cartilage is hindered by conflation with signal from the adjacent fluid spaces. Inversion recovery can be used ...
Ho-Fung Victor M - - 2013
Evaluation of hyaline cartilage in pediatric patients requires in-depth understanding of normal physiologic changes in the developing skeleton. Magnetic resonance (MR) imaging is a powerful tool for morphologic and functional imaging of the cartilage. In this review article, current imaging indications for cartilage evaluation pertinent to the pediatric population are ...
Garnov Nikita - - 2013
Signal intensities of T2 -weighted magnetic resonance images depend on the local fiber arrangement in hyaline cartilage. The aims of this study were to determine whether angle-sensitive MRI at 7 T can be used to quantify the cartilage ultrastructure of the knee in vivo and to assess potential differences with age. ...
Garnov Nikita - - 2013
PURPOSE: To demonstrate the feasibility of a novel experimental method to quantitatively analyze fiber-network deformation in compressed cartilage by angle-sensitive magnetic resonance imaging (MRI) of cartilage. METHODS: Three knee cartilage samples of an adult sheep were imaged in a high-resolution MRI scanner at 7 T. Main fiber orientation and its ...
Fontaine Pascal - - 2013
Osteochondrosis dissecans (OCD) is a focal failure of endochondral ossification of the epiphysis characterized by the presence of cartilage flaps and osteochondral fragments. The objective of this study was to image epiphyseal development in the equine pelvic limb to determine whether there was a variation in site maturation that could ...
Gallo Robert A - - 2013
Current high-field magnetic resonance imaging (MRI) techniques provide a sensitive and reliable diagnostic tool for the evaluation of cartilage and osteochondral injury. This article summarizes technical factors for optimal MRI evaluation of articular cartilage of the knee. There is emphasis on the important correlation of the MRI signal to the ...
Bekkers Joris E J - - 2013
OBJECTIVE: Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) facilitates non-invasive evaluation of the glycosaminoglycan content in articular cartilage. The primary aim of this study was to show that the dGEMRIC technique is able to monitor cartilage repair following regenerative cartilage treatment. DESIGN: Thirty-one patients with a focal cartilage lesion underwent ...
Lepage-Saucier Marianne - - 2013
OBJECTIVE. This study evaluates the impact of toe traction and direct MR arthrography on the assessment of articular cartilage and plantar plates of the first and second metatarsophalangeal joints. MRI of five cadaveric feet was obtained utilizing four techniques: before arthrography without and with traction and after arthrography without and ...
Boutsikou Konstantina - - 2013
OBJECTIVES: In the present work, we aim to identify changes in the cartilage texture of the injured knee in young, physically active, patients by computer analysis of MRI images based on 3.0T morphological sequences. METHODS: Fifty-three young patients with training injury or trauma in one knee underwent MRI and arthroscopy. ...
Shepherd Suzanne M - - 2013
We investigated the efficacy of axial traction of the fingers combined with magnetic resonance (MR) arthrography in assessing the metacarpophalangeal (MCP) joint cartilage in cadavers. Cartilage was imaged and graded before/after MR arthrography, with/without traction, then correlated with cadaveric sectioning. The application of traction with MR arthrography is a promising ...
Illingworth Kenneth David - - 2013
PURPOSE: The purpose of this study was to determine the correlation between the Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC) and Knee Injury Osteoarthritis Outcomes scores (KOOS) and the degree of tibiofemoral cartilage loss on plain radiography and 3T magnetic resonance imaging (MRI). We hypothesize that these subjective outcome ...
Campbell Andrew B - - 2013
BACKGROUND:Magnetic resonance imaging (MRI) is widely used as a preoperative tool to estimate the size of articular cartilage defects to optimize treatment selection. However, the reliability of MRI sizing of cartilage defects is not well understood.Hypothesis/ PURPOSE:The purpose of this investigation was to compare the size of knee articular cartilage ...
Kijowski Richard - - 2013
Purpose:To determine whether the addition of a T2 mapping sequence to a routine magnetic resonance (MR) imaging protocol could improve diagnostic performance in the detection of surgically confirmed cartilage lesions within the knee joint at 3.0 T.Materials and Methods:This prospective study was approved by the institutional review board, and the ...
Cluzel C - - 2013
Adult articular cartilage (AC) has a well described multizonal collagen structure. Knowledge of foetal AC organisation and development may provide a prototype for cartilage repair strategies, and improve understanding of structural changes in developmental diseases such as osteochondrosis (OC). The objective of this study was to describe normal development of ...
Lizarbe Blanca - - 2013
We review the role of neuroglial compartmentation and transcellular neurotransmitter cycling during hypothalamic appetite regulation as detected by Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) methods. We address first the neurochemical basis of neuroendocrine regulation in the hypothalamus and the orexigenic and anorexigenic feed-back loops that control appetite. Then we ...
Shan Liang L Department of Computer Science, University of North Carolina, Chapel Hill, NC, - - 2012
In this paper, we propose a multi-atlas-based method to automatically segment the femoral and tibial cartilage from T1 weighted magnetic resonance (MR) knee images. The segmentation result is a joint decision of the spatial priors from a multi-atlas registration and the local likelihoods within a Bayesian framework. The cartilage likelihoods ...
Zilkens Christoph - - 2012
OBJECTIVE: To compare morphologically normal appearing cartilage in two age groups with delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and correlate magnetic resonance imaging (MRI) findings with histology. MATERIALS AND METHODS: Twenty femoral head specimens collected from ten lambs (group I) and ten young adult sheep (group II) underwent ...
Carstens Ann - - 2012
The purpose of this study was to determine whether delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and T2 mapping are accurate techniques for measuring cartilage thickness in the metacarpus3/metatarsus3 (Mc3/Mt3) of Thoroughbred racehorses. Twenty-four Mc3/Mt3 cadaver specimens were acquired from six healthy racehorses. Cartilage thickness was measured from postintra-articular ...
Garrett K S - - 2012
REASONS FOR PERFORMING STUDY: Laryngeal ultrasonography can provide valuable information when considering a diagnosis of arytenoid chondritis, but specific ultrasonographic parameters have not been defined. OBJECTIVES: To compare ultrasonographic findings of the arytenoid cartilages in horses with endoscopically diagnosed arytenoid chondritis with ultrasonographic findings of the arytenoid cartilages in normal ...
Raya José G - - 2012
Purpose:To assess the use of diffusion-tensor (DT) imaging of articular cartilage to detect and grade early cartilage damage in human specimens with early signs of cartilage damage.Materials and Methods:This study was approved by the institutional review board. Forty-three cartilage-on-bone samples drilled from 21 human patellae were examined with 17.6-T magnetic ...
Kim Hyungsuk - - 2012
BACKGROUND: There are several methods that may be used to confirm the status of rib cartilage, such as physical examinations or chest radiography, for subjects with microtia. However, these methods are limited because of clinicians' inability to gain accurate information about the rib cartilage. We performed 3-dimensional chest computed tomography ...
Choi Young Rak - - 2012
PURPOSE: The menisci play a critical protective role for the knee joint through shock absorption and load distribution. We hypothesized that cartilage degeneration will be abruptly progressed if meniscal subluxation exceeds a critical point. METHODS: Of 56 cases that showed medial meniscal subluxation without cartilage degeneration of ipsilateral medial femoral ...
Giers Morgan B - - 2012
Management of orthopaedic infections relies on débridement and local delivery of antimicrobials; however, the distribution and concentration of locally delivered antimicrobials in postdébridement surgical sites is unknown. Gadolinium-DTPA (Gd-DTPA) has been proposed as an imaging surrogate for antimicrobials because it is similar in size and diffusion coefficient to gentamicin. Is ...
Theodoropoulos John S - - 2012
: The purpose of this study was to evaluate the usefulness of magnetic resonance imaging (MRI) in detecting elbow articular cartilage injuries through comparison of preoperative MRI and magnetic resonance arthrography (MRA) with arthroscopic findings. : Retrospective case analysis. : Tertiary care orthopedic private practice. : Consecutive series of 31 ...
Cheng Jie-Jun - - 2012
BackgroundMRI is of increasing importance in the diagnostic evaluation of gastrointestinal diseases, with depiction of mucosal enhancement obtained with conventional intravenous contrast. Routine clinical use of contrast agents has been carried out using intravenous injection for mucosal imaging. Contrast agents that specifically target the intestinal mucosa are therefore needed to ...
Pentlicky Sara S University of Pennsylvania, Philadelphia, PA 19104, - - 2013
Microbicide gels studied for HIV prevention often are delivered via a single-use vaginal applicator. Using a contraceptive diaphragm such as the SILCS diaphragm for gel delivery could have advantages, including lower cost and additional pregnancy prevention. We performed an exploratory, nonblinded, randomized, crossover study among healthy, sexually active, nonpregnant women. ...
Xu Wenlong - - 2012
There is no doubt that magnetic resonance imaging contrast agents (MRI CAs) can play a vital role in diagnosing diseases. Therefore, demand for new MRI CAs with an enhanced sensitivity and advanced functionalities is very high. Here, paramagnetic nanoparticles (NPs) are reviewed as new potential candidates for either T(1) or ...
Park Hyun Soon - - 2012
Nanostructured magnetic materials play an important role in increasing miniaturized devices. For the studies of their magnetic properties and behaviors, nanoscale imaging of magnetic field is indispensible. Here, using electron holography, the magnetization distribution of a TMR spin valve head of commercial design is investigated without and with a magnetic ...
Guillaume Olivier - - 2012
The clinical advantage of MRI visualization of prostheses in soft tissue prolapses is very appealing as over 1 000 000 MRI-transparent synthetic meshes are implanted annually, and postoperative complications such as mesh shrinkage and migration are frequent. Here, the synthesis of a new material composed of a DTPA-Gd complex grafted onto a ...
Li Feifei - - 2012
Monodisperse water-soluble hexagonal phase Ln(3+) -doped NaGdF(4) upconverting nanocrystals (UCNCs) have been successfully fabricated by means of a fast, facile, and environmentally friendly microwave-assisted route with polyethylenimine as the surfactant. Fine-tuning of the UC emission from visible to near-IR and finally to white light has been achieved. Furthermore, studies of ...
Moliner-Martínez Yolanda - - 2012
We report a new in tube solid phase microextraction approach named magnetic in tube solid phase microextraction, magnetic-IT-SPME. Magnetic-IT-SPME has been developed taking advantage of magnetic microfluidic principles with the aim to improve extraction efficiency of IT-SPME systems. Firstly, a magnetic hybrid material formed by Fe3O4 nanoparticles supported on SiO2 ...
Torres Andrew S - - 2012
OBJECTIVES: Metal-containing nanoparticles show great promise as x-ray contrast media and could enable reduced radiation dose, increased contrast, and the visualization of smaller anatomic features. In this study, we report progress toward these goals using a size-fractionated core-shell tantalum oxide nanoparticle contrast agent. MATERIALS AND METHODS: A core-shell tantalum oxide ...
Yang Fang - - 2012
It is found that Prussian Blue nanoparticles (PBNPs) possess a catalase-like activity to catalyse the breakdown of H(2) O(2) into oxygen (O(2) ) molecules under the neutral conditions (pH = 7.4). Based on this finding, we have developed a new strategy in which PBNPs can be excellent ultrasound (US) and ...
Béalle Gaelle - - 2012
Magnetic liposomes offer opportunities as theranostic systems. The prerequisite for efficient imaging, tissue targeting or hyperthermia is high magnetic load of these vesicles. Here we describe the preparation of Ultra Magnetic Liposomes (UMLs), which may encapsulate iron oxide nanoparticles in a volume fraction of up to 30%. This remarkable magnetic ...
Writer Michele J MJ Molecular Immunology Unit, UCL Institute of Child Health, London WC1N 1EH, - - 2012
Gadolinium-labelled nanocomplexes offer prospects for the development of real-time, non-invasive imaging strategies to visualise the location of gene delivery by MRI. In this study, targeted nanoparticle formulations were prepared comprising a cationic liposome (L) containing a Gd-chelated lipid at 10, 15 and 20% by weight of total lipid, a receptor-targeted, ...
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