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Musto Alessandra A Nuclear Medicine Service, Ospedale Maggiore, Bologna, - - 2014
In the present review we reported the value of 18F-fluorodeoxyglucose (FDG) PET/CT in face of uterine cancer, in terms of sensitivity, specificity and accuracy. Moreover, we made a comparison with the other imaging techniques currently used to evacuate these tumors including contrast-enhanced CT, contrast enhanced-MRI and transvaginal ultrasonography. FDG PET/CT ...
Fu Chun C Department of Gynecology and Obstetrics, Second Xiangya Hospital, Central South University, Changsha, People's Republic of - - 2014
To investigate the changes to diffusion-weighted imaging (DWI) correlated with histopathology after neoadjuvant chemotherapy (NACT) in patients with locally advanced cervical cancer (LACC). Thirty-three patients with LACC were examined with 3T magnetic resonance imaging (MRI) with DWI and apparent diffusion coefficient (ADC) maps. MRIs were performed for each patient at ...
Knowles Scott M SM Department of Pharmacology, - - 2014
Purpose: Prostate stem cell antigen (PSCA) is highly expressed in local prostate cancers and prostate cancer bone metastases and its expression correlates with androgen receptor activation and a poor prognosis. In this study, we investigate the potential clinical applications of immunoPET with the anti-PSCA A11 minibody, an antibody fragment optimized ...
Chun Byung-Joon BJ Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, - - 2014
Background: We evaluated the use of FDG PET/CT for the identification of extracapsular spread (ECS) with supporting histologic correlations in laryngeal cancer. Methods: We reviewed the medical records of 89 laryngeal cancer patients who underwent FDG PET/CT before surgery. Results: ECS was present in 38.2% (18/47) of dissected necks and ...
Rubin Geoffrey D GD From the Duke Clinical Research Institute, Box 17969, 2400 Pratt St, Durham, NC 27715 (G.D.R., K.R.C.); Department of Radiology, Duke University School of Medicine, Durham, NC (G.D.R., J.E.R., M.T., B.H., S.B., D.M.S., L.M.H.); Department of Medical Imaging, University of Toronto, Toronto, ON, Canada (D.L.L.); and Department of Radiology, Stanford University School of Medicine, Stanford, Calif - - 2014
Purpose To determine the effectiveness of radiologists' search, recognition, and acceptance of lung nodules on computed tomographic (CT) images by using eye tracking. Materials and Methods This study was performed with a protocol approved by the institutional review board. All study subjects provided informed consent, and all private health information ...
Beheshti Mohsen M Department of Nuclear Medicine and Endocrinology, PET-CT Center Linz, St. Vincent's Hospital, Seilerstaette 4, Linz, 4020, Austria, - - 2014
(2RS,4S)-2-[(18)F]Fluoro-4-phosphonomethyl-pentanedioic acid (BAY1075553) shows increased uptake in prostate cancer cells. We compared the diagnostic potential of positron emission tomography (PET)-X-ray computed tomography (CT) imaging using BAY1075553 versus [(18)F]f luorocholine (FCH) PET-CT. Twelve prostate cancer patients (nine staging, three re-staging) were included. The mean prostate-specific antigen in the primary staging and ...
Shoji Sunao S Department of Urology, Tokai University Hachioji Hospital, Tokyo, - - 2014
To report our early experience with manually controlled targeted biopsy with real-time multiparametric magnetic resonance imaging and transrectal ultrasound fusion images for the diagnosis of prostate cancer. A total of 20 consecutive patients suspicious of prostate cancer at the multiparametric magnetic resonance imaging scan were recruited prospectively. Targeted biopsies were ...
Mukherjee Ankur A Core Surgical Trainee, Department of Urology, NHS Greater Glasgow and Clyde, - - 2014
Transperineal prostatic biopsy is firmly established as an important tool in the diagnosis of prostate cancer. The benefit of additional imaging (magnetic resonance imaging) to target biopsy remains to be fully addressed. Using a cohort of consecutive patients undergoing transperineal template mapping biopsies, we studied positive biopsies in the context ...
Hwang Sung Wook SW Sung Wook Hwang, Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 110-744, South - - 2014
The treatment option for gastric cancer is usually based on preoperative staging by imaging modalities. Endoscopic ultrasonography (EUS) and computed tomography (CT) have been used as the diagnostic modality of choice in preoperative staging of gastric cancer. Magnetic resonance imaging (MRI) has been employed in several studies, and ((18)F) 2-Fluoro-2-deoxyglucose ...
Goldstein Jeffrey J *Departments of Radiation Oncology, Nuclear Medicine, Medical Oncology, Urology, Chaim Sheba Medical Center †Department of Nuclear Medicine, Tel Aviv Sourasky Medical Center, both affiliated with the Sackler School of Medicine, Tel Aviv University, Israel ‡Mt Sinai School of Medicine, New York, - - 2014
The FDA approved C-11 choline PET/computed tomography (CT) for imaging patients with recurrent prostate cancer in 2012. Subsequently, the 2014 NCCN guidelines have introduced labeled choline PET/CT in the imaging algorithm of patients with suspected recurrent disease. However, there is only scarce data on the impact of labeled choline PET/CT ...
Chen Ming-Kai MK aDepartment of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut,USA bDivision of Nuclear Medicine and Molecular Imaging, Sidra Medical and Research Center, Doha, - - 2014
Pretreatment dosimetry prior to I-131 treatment for patients with advanced differentiated thyroid cancer will provide critical information for optimizing dosing regimen for effectiveness and safety. The review briefly summarizes relevant information and updates the current advances. I-124 positron emission tomography-computed tomography (PET-CT) with anatomical cross-section imaging provides a better assessment ...
Rodado-Marina Sonia S Nuclear Medicine Department., La Paz Universitary Hospital, Madrid - - 2014
This study evaluated the usefulness of 18F-fluorocholine PET/CT in restaging patients with a history of prostate adenocarcinoma who faced biochemical relapse after early radical treatment, and correlated the technique's disease detection rate with a set of variables and clinical and pathological parameters. This was a retrospective multicentre study which included ...
O'Neill A C AC Department of Cancer Imaging, Dana-Farber Cancer Institute, 450 Brookline Avenue, Brookline, MA 02215, USA. Electronic address: - - 2014
To study the differences in the imaging features of spread from the three cancer cell lines, namely epithelial, sarcomatoid, and lymphoid, resulting in peritoneal carcinomatosis, peritoneal sarcomatosis, and peritoneal lymphomatosis, respectively. In this institutional review board-approved Health Insurance Portability and Accountability Act (HIPAA)-compliant retrospective study, an electronic radiology database was ...
Hoang Jenny K JK aDepartment of Radiology bDepartment of Radiation Oncology, Duke University Medical Center, Durham, North Carolina cDepartment of Radiology, The Ohio State University Wexner Medical Center, Columbus, Ohio, - - 2014
To discuss the problem of incidental thyroid nodules (ITN) detected on imaging; summarize the literature for workup methods; and provide recommendations based on current evidence. ITN are a common problem, seen in 40-50% of ultrasound and 16% of computed tomography (CT) and MRI studies that include the thyroid. The personal ...
Nociti Viviana V Institute of Neurology, Department of Geriatrics, Neurosciences and Orthopedics, Catholic University, Rome, Italy Fondazione Don C. Gnocchi Onlus, Milan, - - 2014
Myoclonus consists of sudden, brief, involuntary jerky muscular contractions. Central and peripheral nervous system lesions are involved in the pathogenesis of this movement disorder. Symptomatic or secondary spinal myoclonus is the most common form. A 68-year-old woman was diagnosed with hemiabdominal spinal myoclonus. Occasional and very mild involuntary repetitive movements ...
Kubicki Shelby L SL Trinity University, San Antonio, TX, USA, - - 2014
To describe a benign focus of increased activity in the acetabular fossa (the acetabular fossa hot spot, AFHS) on (18) F-FDG PET/CT that can mimic a neoplasm. (18)F-FDG PET/CT images from four patient populations were examined. Group 1 (n = 13) was collected from a search of radiology reports and used to define ...
Kulik M M Department of Radiology, CHU Angers, 4 rue Larrey, 49100, Angers, France, - - 2014
Photodynamic therapy is a new focal therapy for prostate cancer. In this technique, a photosensitising agent is introduced intravenously, then activated by local laser illumination to induce tumour necrosis. Treatment efficacy is assessed by magnetic resonance imaging (MRI). We illustrate specific post-treatment MRI aspects at early and late follow-up with ...
Dite P P Academic Centre of Gastroenterology, Department of Internal Medicine of the University Hospitaland Faculty of Medicine of the University of - - 2014
Differential diagnosis between autoimmune pancreatitis /AIP/ and pancreatic cancer can be very difficult. The main clinical symptoms in patients with autoimmune pancreatitis are jaundice, weight loss, abdominal pain and new onset of diabetes mellitus. Unfortunately, the same symptoms could be observed in patients with pancreatic carcinoma too. Imaging methods as ...
Decker Georges G Department of Radiology, University of Bonn, Germany. Electronic address: - - 2014
Diffusion weighted imaging (DWI) as a functional MR technique allows for both qualitative and quantitative assessment of tumour cellularity and changes during therapy. The objective of this study was to evaluate changes of apparent diffusion coefficient (ADC) in biopsy proven prostate cancer (PCa) under intensity modulated radiotherapy (IMRT) at 3T. ...
Risko Rachel R Department of Industrial and Operations Engineering, University of Michigan, Ann Arbor, - - 2014
To identify clinical variables associated with a positive computed tomography (CT) scan and estimate the performance of imaging recommendations in patients from a diverse sample of urology practices. This study comprised 2380 men with newly diagnosed prostate cancer seen at 28 practices in the Michigan Urological Surgery Improvement Collaborative from ...
El Hammoumi Massine M Departamento de Cirugía Torácica, Centro Hospitalario Universitario Mohammed V, Rabat, Marruecos. Electronic address: - - 2014
The aim of our work is to promote the awareness about the development of sarcoidosis after antineoplastic therapy in order to avoid diagnostic errors with FDG-PET/CT findings. We report the observation of three women with breast, cervix and stomach treated cancers who developed a sarcoidosis after the end of anti-neoplastic ...
Yoo Shannon S SS Department of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta, - - 2014
Specific expression patterns of microRNA (miRNA) molecules have been linked to cancer initiation, progression, and metastasis. The accumulating evidence for the role of oncogenic or tumor-suppressing miRNAs identified the need for nano-scaled platform that can help deliver nucleotides to modulate miRNAs. Here we report the synthesis of novel layered gadolinium ...
Brook Olga R OR From the Departments of Radiology (O.R.B., A.B.) and Surgery (T.S.K., N.S.), Beth Israel Deaconess Medical Center, Boston, Mass; Department of Surgery, University of Pennsylvania, Philadelphia, Pa (C.M.V.); and Department of Radiology, University of Texas Southwestern Medical Center, 2201 Inwood Rd, 2nd Floor, Suite 202.Dallas, TX 75390-9085 - - 2014
Purpose To compare structured versus nonstructured reporting of multiphasic computed tomography (CT) for staging of pancreatic cancer and the effects of both types of reporting on subjective assessment of resectability. Materials and Methods This institutional review board-approved, HIPAA-compliant retrospective study with waiver of informed consent included all patients who were ...
Siva Shankar - - 2014
Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancers, and is the leading cause of cancer deaths. Radiation therapy (RT), alone or in combination with chemotherapy, is the standard of care for curative intent treatment of patients with locally advanced or inoperable NSCLC. The ability to intensify treatment ...
Cheng Gong G Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. - - 2014
The aim of the present study was to evaluate the value of systematic 12- and 13-core biopsies, guided by transrectal ultrasound (TRUS) or magnetic resonance imaging (MRI), with regard to the prostate cancer detection rate (PCDR). Between July 1999 and June 2012, 2,707 patients were recruited to the Department of ...
Frenk Nathan E NE 1 Instituto de Radiologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, Av Dr. Enéas Carvalho de Aguiar, s/n Rua 1, Cerqueira Césa, São Paulo, SP 05403-900, - - 2014
OBJECTIVE. The purpose of this article is to assess and describe the MRI findings after prostatic artery embolization for treatment of benign prostatic hyperplasia. MATERIALS AND METHODS. We retrospectively evaluated 17 patients who underwent prostatic artery embolization as part of different prospective studies to evaluate this alternative treatment of benign ...
Hilton Susan S Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address: - - 2014
Modern radiologic imaging is an aid to treatment planning for localized renal cancer, enabling characterization of mass lesions. For patients who present with advanced renal cancer, new imaging techniques enable a functional assessment of treatment response not possible using anatomic measurements alone. Multidetector CT urography permits simultaneous assessment of the ...
Gibson David A DA Centre for Health Services Research, School of Population Health, University of Western - - 2014
To explore the interaction of computed tomography (CT) use, dose and radiation risk of Australian Medicare-funded CT scanning and the impact on cancer incidence and mortality. This retrospective cohort study used records of Medicare subsidised CT scans in Australia (2006/07 to 2011/12) and Australian CT dosimetry. The annual number, rate ...
Backhus Leah M LM Surgery Service, VA Puget Sound Health Care System, Seattle, Washington; Division of Cardiothoracic Surgery, Department of Surgery, University of Washington, Seattle, Washington. Electronic address: - - 2014
Current guidelines recommend routine imaging surveillance for patients with non-small cell lung cancer (NSCLC) after treatment. Little is known about surveillance patterns for patients with surgically resected early-stage lung cancer in the community at large. We sought to characterize surveillance patterns in a national cohort. We conducted a retrospective study ...
Viswanathan Akila N AN Brigham & Women's Hospital/Dana-Farber Cancer Institute, Boston, Massachusetts. Electronic address: - - 2014
To create and compare consensus clinical target volume (CTV) contours for computed tomography (CT) and 3-Tesla (3-T) magnetic resonance (MR) image-based cervical-cancer brachytherapy. Twenty-three experts in gynecologic radiation oncology contoured the same 3 cervical cancer brachytherapy cases: 1 stage IIB near-complete response (CR) case with a tandem and ovoid, 1 ...
Martínez-Jiménez Santiago S From the Department of Radiology (S.M.J., M.L.R.d.C., C.M.W., J.R.K.), Department of Gynecology and Obstetrics, Division of Gynecologic Oncology (B.L.S.), and Department of Pathology (P.P.P.), Saint Luke's Hospital of Kansas City, University of Missouri in Kansas City, 4401 Wornall Rd, Kansas City, MO 64111; and Department of Radiology, MD Anderson Cancer Center, University of Texas, Houston, Tex - - 2014
Gynecologic malignancies are a heterogeneous group of common neoplasms and represent the fourth most common malignancy in women. Thoracic metastases exhibit various imaging patterns and are usually associated with locally invasive primary neoplasms with intra-abdominal spread. However, thoracic involvement may also occur many months to years after initial diagnosis or ...
Wu Haitao H Imaging Probe Development Center, National Heart, Lung, and Blood Institute, National Institutes of - - 2014
Nitroxides can ameliorate the toxic effects of radiation during cancer therapy. Nitroxides are paramagnetic and can be used in magnetic resonance imaging (MRI) and electron paramagnetic resonance imaging (EPRI) to monitor in vivo oxidative stress status. Compound 5 (3-(N-piperidinemethyl)-2, 2, 5, 5-tetramethyl-1-oxy-3-pyrroline) was found to be the most effective nitroxide ...
Urata Masakazu - - 2014
Axillary lymph node (ALN) status is an important prognostic factor for breast cancer. We retrospectively used contrast-enhanced computed tomography (CE-CT) to evaluate the presence of ALN, metastasis based on size, shape, and contrasting effects. Of 131 consecutive patients who underwent CE-CT followed by surgery for breast cancer between 2005 and ...
Strobel Kevin K From the Department of Diagnostic and Interventional Radiology, University Hospital of Aachen, RWTH, Pauwelsstrasse 30, 52074 Aachen, - - 2014
Purpose To investigate the utility of magnetic resonance (MR) imaging according to different types of Breast Imaging Reporting and Data System ( BI-RADS Breast Imaging Reporting and Data System ) category 4 findings from screening mammography and/or screening ultrasonography (US). Materials and Methods This institutional review board-approved prospective study included ...
Nguyen Phan P Department of Thoracic Medicine, The Royal Brisbane and Women's Hospital, Herston, Queensland, Australia; School of Medicine, Faculty of Health Sciences, University of Queensland, St Lucia, Queensland, - - 2014
There is widespread adoption of FDG-PET/CT in staging of lung cancer, but no universally accepted criteria for classifying thoracic nodes as malignant. Previous studies show high negative predictive values, but reporting criteria and positive predictive values varies. Using Endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) results as gold standard, we evaluated ...
Taneja Sangeeta S Department of Molecular Imaging and Nuclear Medicine, Indraprastha Apollo Hospitals, Sarita Vihar, Delhi-Mathura Road, New Delhi 110076, India. Electronic address: - - 2014
Accurate initial staging in breast carcinoma is important for treatment planning and for establishing the likely prognosis. The purpose of this study was to assess the utility of whole body simultaneous (18)F-FDG PET-MRI in initial staging of breast carcinoma. 36 patients with histologically confirmed invasive ductal carcinoma underwent simultaneous whole ...
Tilak Gaurie G Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, - - 2014
To demonstrate the utility of a robotic needle-guidance template device as compared to a manual template for in-bore 3T transperineal magnetic resonance imaging (MRI)-guided prostate biopsy. This two-arm mixed retrospective-prospective study included 99 cases of targeted transperineal prostate biopsies. The biopsy needles were aimed at suspicious foci noted on multiparametric ...
Haraldsen Ate A Nuclear medicine Department & PET Center, Department of Radiology, Department of Oncology, Aarhus University Hospital, Aarhus C, - - 2014
To evaluate and compare the diagnostic performance of whole-body planar bone scintigraphy (WBS), single photon emission computed tomography (SPECT), SPECT/low-dose computerized tomography (SPECT/ldCT) and SPECT/contrast enhanced diagnostic CT (SPECT/cdCT) in the staging of patients with advanced breast cancer. Seventy-eight patients with recurrence of biopsy-proven breast cancer and suspicion of disseminated disease ...
Veronesi Giulia G Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy Both authors contributed equally - - 2014
Low-dose computed tomography (CT) screening for lung cancer can reduce lung cancer mortality, but overdiagnosis, false positives and invasive procedures for benign nodules are worrying. We evaluated the utility of positron emission tomography (PET)-CT in characterising indeterminate screening-detected lung nodules. 383 nodules, examined by PET-CT over the first 6 years ...
Fuertes Jordi J Nuclear Medicine Department, Hospital Universitari Sant Joan, Reus, Tarragona, Spain. Electronic address: - - 2014
Unexpected focal colonic or rectal radiotracer activity is an usual finding in patients subjected to a PET study. The aim of this work has been to evaluate the clinical significance of this finding in the prediction of an existing colorectal malignancy. During the last three years, all patients studied with ...
Smith Haydan H Department of Chemistry, Clemson University, Clemson, South - - 2014
Magnetic resonance imaging (MRI) characteristics of Breast Imaging Reporting and Data System (BI-RADS) 4 and 5 lesions were evaluated to identify characteristics that may improve the positive predictive value (PPV) of a biopsy. MRI BI-RADS 4 or 5 breast findings in 101 women who underwent biopsy leading to a diagnosis ...
Salami Simpa S SS The Arthur Smith Institute for Urology, Hofstra North Shore-LIJ School of Medicine, New Hyde Park, NY - - 2014
To evaluate the performance of multiparametric MRI (MP-MRI) in predicting CaP on repeat biopsy; and to compare the cancer detection rates (CDR) of MRI/TRUS fusion-guided biopsy with standard 12-core biopsy in men with at least one previous negative biopsy. We prospectively enrolled men with elevated or rising PSA and/or abnormal ...
Ceci Francesco F From the *Service of Nuclear Medicine, and †Department of Urology, Policlinico S. Orsola-Malpighi, University of Bologna, Bologna, Italy; ‡Department of Radiology, University of Southern California, Los Angeles, CA; and §Department of Nuclear Medicine and PET/CT Centre, 'Santa Maria della Misericordia' Hospital, Rovigo, - - 2014
The aim of this study was to evaluate the potential role of C-choline-PET/CT in nodal assessment in patients with bladder cancer (BCa) using the pathological specimen as reference standard. Fifty-nine patients with proven BCa were retrospectively enrolled from April 2011 to January 2014 (mean [SD] age, 70.1 [9] years; range ...
Morisawa Nobuko N From the *Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, †Department of Diagnostic Pathology, Kyoto University Hospital, and ‡Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto, - - 2014
The purpose of the study was to investigate the magnetic resonance imaging findings of decidualized endometriotic cysts in comparison with endometriotic cysts associated with ovarian cancers. Eighteen decidualized endometriotic cysts and 24 ovarian cancers were retrospectively assessed on height, signal intensity of the solid component on T2- and diffusion-weighted imaging, ...
Patel Rikesh Kumar RK Academic Surgical Unit, Castle Hill Hospital, Cottingham, United Kingdom. Electronic address: - - 2014
In early rectal cancer, ERUS has a vital role in determining radical or local excision based on identification of T-stage. Transanal endoscopic microsurgery (TEMs) has a reduced morbidity and mortality compared with radical surgery. Correct identification of lesions that can be managed with TEMs is therefore imperative. Our aim was to assess ...
Yaparpalvi Ravindra R Department of Radiation Oncology, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York. Electronic address: - - 2014
To evaluate, in a gynecologic cancer setting, changes in bowel position, dose-volume parameters, and biological indices that arise between full-bladder (FB) and empty-bladder (EB) treatment situations; and to evaluate, using cone beam computed tomography (CT), the validity of FB treatment presumption. Seventeen gynecologic cancer patients were retrospectively analyzed. Empty-bladder and ...
Yap Timothy A TA Drug Development Unit and Division of Clinical Studies, Royal Marsden NHS Foundation Trust and The Institute of Cancer - - 2014
Purpose: Multiple cancers harbor genetic aberrations that impact AKT signaling. MK-2206 is a potent pan-AKT inhibitor with a maximum tolerated dose (MTD) previously established at 60mg on alternate days (QOD). Due to a long half-life (60-80h), a weekly (QW) MK-2206 schedule was pursued to compare intermittent QW and continuous QOD ...
Lee Jong Hoon JH Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Republic of Korea; Department of Radiation Oncology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of - - 2014
The reported overall accuracy of MRI in predicting the pathologic stage of nonirradiated rectal cancer is high. However, the role of MRI in restaging rectal tumors after neoadjuvant CRT is contentious. Thus, we evaluate the accuracy of restaging magnetic resonance imaging (MRI) for rectal cancer patients who receive preoperative chemoradiotherapy ...
Liu Alan J AJ Department of Radiation Oncology, City of Hope National Medical Center, Duarte, - - 2014
The objectives of the study were to evaluate the effect of intravenous contrast in the dosimetry of helical tomotherapy and RapidArc treatment for head and neck cancer and determine if it is acceptable during the computed tomography (CT) simulation to acquire only CT with contrast for treatment planning of head ...
Wani Sachin S Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Center, Aurora, Colorado; Division of Gastroenterology and Hepatology, Veterans Affairs Medical Center, Denver, - - 2014
The advantages of endoscopic ultrasound (EUS) and computed tomography (CT)-positron emission tomography (PET) with respect to survival for esophageal cancer patients are unclear. This study aimed to assess the effects of EUS, CT-PET, and their combination on overall survival with respect to cases not receiving these procedures. Patients who were ...
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