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Afshar-Oromieh Ali A Department of Nuclear Medicine, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany, - - 2014
Since the introduction of positron emission tomography (PET) imaging with (68)Ga-PSMA-HBED-CC (=(68)Ga-DKFZ-PSMA-11), this method has been regarded as a significant step forward in the diagnosis of recurrent prostate cancer (PCa). However, published data exist for small patient cohorts only. The aim of this evaluation was to analyse the diagnostic value ...
Loeffelbein Denys J - - 2014
To assess the diagnostic value of retrospective PET-MRI fusion and to compare the results with side-by-side analysis and single modality use of PET and of MRI alone for locoregional tumour and nodal staging of head-and-neck cancer. Thirty-three patients with head-and-neck cancer underwent preoperative contrast-enhanced MRI and PET/CT for staging. The ...
Abbas Ausami A Department of Cardiothoracic Radiology University Hospital Southampton Tremona Road, Southampton, United Kingdom. SO16 - - 2014
Cardiac myxomas are the most common benign primary cardiac tumour to present in adulthood. While most patients present with symptoms of cardiac obstruction, embolic phenomena or constitutional impairment, up to a fifth of patients remain asymptomatic and are incidentally diagnosed on imaging. Although echocardiography is usually the initial imaging modality ...
Sainz-Esteban Aurora A aDepartment of Nuclear Medicine, Hospital Clínico Universitario de Valladolid bInstitute of Endocrinology cDepartment of Endocrinology, Hospital Universitario Río Hortega de Valladolid, Valladolid, - - 2014
The aim of the study was to assess the contribution of In-pentetreotide single-photon emission computed tomography/computed tomography (SPECT/CT) imaging to conventional somatostatin receptor scintigraphy (SRS) in terms of lesion characterization and localization in the detection of neuroendocrine tumours (NETs). A total of 107 patients with suspected or confirmed NET underwent ...
Imperiale Alessio A Department of Biophysics and Nuclear Medicine, University Hospitals of Strasbourg, Strasbourg, - - 2014
(18)F-FDOPA PET imaging is increasingly used in the work-up of patients with neuroendocrine tumours. It has been shown to be of limited value in localizing pancreatic insulin-secreting tumours in adults with hyperinsulinaemic hypoglycaemia (HH) mainly due to (18)F-FDOPA uptake by the whole pancreatic gland. The objective of this study was ...
Alfieri Rita R Department of Surgical Oncology, Veneto Institute of Oncology-IRCCS, Padova, Italy, - - 2014
To investigate whether changes in tumour volume were predictive of histopathological response to neoadjuvant therapy for oesophageal cancer. Thirty-five consecutive patients with locally advanced oesophageal cancer were treated with chemoradiotherapy and surgery in responders from July 2007 to July 2009. Tumour volume (TV) was calculated using innovative tumour volume estimation ...
Freebody John J John Freebody, Eva A Wegner, Monica A Rossleigh, Department of Nuclear Medicine and PET, The Prince of Wales and Sydney Children's Hospitals, Randwick, NSW 2031, - - 2014
Positron emission tomography (PET) is a minimally invasive technique which has been well validated for the diagnosis, staging, monitoring of response to therapy, and disease surveillance of adult oncology patients. Traditionally the value of PET and PET/computed tomography (CT) hybrid imaging has been less clearly defined for paediatric oncology. However ...
Meerang Mayura M Division of Thoracic Surgery, University Hospital Zurich, Zurich, - - 2014
An orthotopic rat tumour recurrence model for malignant pleural mesothelioma (MPM) provides clinical similarity to patients and is useful for drug testing combined with surgical intervention. Importantly, a reliable imaging method is required allowing for noninvasive and repetitive evaluation of the tumour load. We compared the tumour load assessed by ...
Homedes Núria N University of Texas, School of Public Health, El Paso, Texas, - - 2014
To assess the potential role of clinical trial (CT) registries and other resources available to research ethics committees (RECs) in the evaluation of complex CT protocols in low-income and middle-income countries. Using a case study approach, the authors examined the decision-making process of a REC in Argentina and its efforts ...
Huang Yu-Ting YT aDepartment of Nuclear Medicine and Specialised PET Services Queensland, Royal Brisbane and Women's Hospital, Herston bDepartment of Medical Imaging, Gold Coast University Hospital cSchool of Medicine, Griffith University, Southport dSchool of Medicine, University of Queensland, St Lucia, Queensland, - - 2014
There is evidence that the status of human papilloma virus subtype 16 (HPV-p16) alters the prognosis of patients with oropharyngeal squamous cell cancer (OSCC). We sought to establish whether there is a relationship between HPV-p16 status and F-FDG uptake in the prognosis of OSCC. Patients with newly diagnosed OSCC at ...
Garnon J J Department of Interventional Radiology, Nouvel Hôpital Civil, Strasbourg, France, - - 2014
To determine whether MRI allows safe and accurate guidance for biopsies of renal masses. Between May 2010 and September 2013, 26 patients (15 men and 11 women) with 26 renal masses underwent MRI-guided percutaneous biopsy. For each patient, we retrospectively collected the epidemiological, procedural and histopathological data. Mean size of ...
Pont Elena E Servicio de Otorrinolaringología, Hospital General de Onteniente, Valencia, España. Electronic address: - - 2014
Congenital malformations and acquired lesions of the inner ear are characterised by small structural changes in this region. In recent decades, treatment options have improved considerably. At the same time, there has been a great advancement in diagnostic methods, obtaining high-resolution labyrinth images. Currently, we use a 64-multislice computed tomography ...
Pickhardt Perry J PJ Department of Radiology, University of Wisconsin School of Medicine & Public Health, E3/311 Clinical Science Center, 600 Highland Ave, Madison, WI, 53792-3252, USA, - - 2014
To assess the imaging features of primary hepatic angiosarcoma on multiphasic CT and MR. Multi-institutional review identified 35 adults (mean age, 57.1 years; 22M/13F) with pathologically proven hepatic angiosarcoma and pretreatment multiphasic CT (n = 33) and/or MR (n = 7). Multifocal hepatic involvement was seen in all 35 cases, with at least 10 lesions ...
Bliznakova Kristina K Department of Electronics and Microelectronics, Technical University of Varna, 9010, 1 Studentska 1, Varna, Bulgaria, - - 2014
Major hepatectomy causes a risk of postoperative liver dysfunction, failure, and infections like surgical site infection. Preoperative assessment of the liver volume and function of the remnant liver is a mandatory prerequisite before performing such surgery. The aim of this work is to develop and test a software application for ...
Fernandez O O Fundacion IMABIS, Hospital Universitario Carlos Haya, 29190 Malaga, - - 2014
The most relevant data presented at the 29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), held in October 2013 in Denmark, were summarised at the sixth edition of the Post-ECTRIMS Expert Meeting, held in Madrid in October 2013, resulting in this review, which is ...
Scharl M M Department of Oncology, University Hospital Zurich, Zurich, - - 2014
Primary sarcomas of the aorta are extremely uncommon. Depending on histomorphology and immunohistochemical pattern, intimal sarcomas can show angiosarcomatous differentiation. Here, we describe the case of a 60-year-old woman with a primary intimal sarcoma of the aortic arch and signs of cerebral metastatic disease as the initial manifestation. After the ...
Wang Hong-Kai - - 2014
To investigate whether visceral obesity is associated with certain histological subtypes of renal cell carcinoma (RCC) ina multicentre Chinese cohort. A kidney tumour database was created using three tertiary centres in China; 487 patients were enrolled presenting with localised RCC and complete computer tomography(CT)/magnetic resonance imaging (MRI) information. A single-slice ...
Just N N Centre d'Imagerie Biomédicale (CIBM) Animal Imaging and Technology Core, Ecole Polytechnique Fédérale de Lausanne, Lausanne, - - 2014
By definition, tumours are heterogeneous. They are defined by marked differences in cells, microenvironmental factors (oxygenation levels, pH, VEGF, VPF and TGF-α) metabolism, vasculature, structure and function that in turn translate into heterogeneous drug delivery and therapeutic outcome. Ways to estimate quantitatively tumour heterogeneity can improve drug discovery, treatment planning ...
Pereira Helcio Mendonça HM National Institute of Traumatology and Orthopedics, Rio de Janeiro, - - 2014
This study aimed to describe the magnetic resonance imaging (MRI) features of giant-cell tumours of bone. We analysed the clinical and MRI features of patients diagnosed with giant-cell tumours of bone confirmed by histopathology at our institution between 2010 and 2012. The peak incidence was between the second and third ...
Goda Jayant S JS Department of Radiation Oncology, Neuro-Oncology Disease Management Group, Tata Memorial Centre, Mumbai, - - 2014
Purpose: To study the impact of multiparametric MRI and (18)F-FDG-PET on the outcome of children with diffuse intrinsic pontine gliomas (DIPG). Materials and Methods: Imaging data from a phase-II prospective therapeutic study in children with newly diagnosed DIPG were considered for evaluation. They included baseline MRI with contrast enhancement before ...
Schartinger Volker H VH Department of Otorhinolaryngology, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria, - - 2014
PET/CT with (68)Ga-labelled [DOTA(0),Tyr(3)]-octreotide ((68)Ga-DOTA-TOC PET/CT) is a routinely used imaging modality for neuroendocrine tumours expressing somatostatin receptors (SSTR). Recent studies have shown SSTR expression in head and neck squamous cell carcinoma, albeit lower than in highly differentiated neuroendocrine tumours. We sought to determine whether nasopharyngeal carcinoma (NPC) positive for ...
Hephzibah Julie J Associate Professor, Department of Nuclear Medicine, Christian Medical College, Christian Medical College , Vellore, Ida Scudder Road, Vellore, India - - 2014
18 Fluorine-fluoro-2-deoxyglucose positron emis-sion tomography/computed tomography (18F- FDG-PET/CT) is of importance in assessing high-risk thymoma and thymic carcinomas. Detection of advanced thymoma versus thymic carcinoma by routine cross sectional anatomical imaging such as computed tomography (CT), magnetic resonance imaging (MRI) often poses a diagnostic dilemma. In this case series we ...
Zakaria Rasheed R Department of Neurosurgery, The Walton Centre NHS Foundation Trust; Liverpool, UK - Institute of Integrative Biology, University of Liverpool; Liverpool, UK - - - 2014
Brain metastases are increasingly common tumours but little is known about their biological mechanisms of local brain invasion in vivo. Samples across the leading edge are not easy to obtain using conventional neurosurgical methods as these tumours frequently show cysts, haemorrhage and necrosis. Apparent diffusion coefficient (ADC) maps were generated ...
d'Amico Andrea A Department of Diagnostic Positron Emission Tomography, Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology, ulica Wybrzeże Armii Krajowej 15, 44-101, Gliwice, Poland, - - 2014
Positron emission tomography, most commonly with 18F-fluorodeoxyglucose, is being used for evaluation of tumour response to therapy. Limitations of this method are associated with (1) fluorodeoxyglucose pharmacokinetic properties, (2) the detection system, (3) discrepancies between metabolic and anatomic images, and (4) acquisition standardization. Response to therapy may be evaluated with ...
Riley Garan T GT Department of General Radiology, North Tees & Hartlepool NHS Foundation Trust, University Hospital of North Tees, Hardwick Road, Stockton-on-Tees, Cleveland, TS19 8PE, UK, - - 2014
Paediatric diffuse intrinsic pontine glioma (DIPG) is noteworthy for its fibrillary infiltration through neuroparenchyma and its resultant irregular shape. Conventional volumetry methods aim to approximate such irregular tumours to a regular ellipse, which could be less accurate when assessing treatment response on surveillance MRI. Region-of-interest (ROI) volumetry methods, using manually ...
Tony G G Stafford General Hospital, Weston Road, Stafford, Staffordshire ST16 3SA, UK. Electronic address: - - 2014
Stress induced injuries affecting the physeal plate or cortical bone in children and adolescents, especially young athletes, have been well described. However, there are no reports in the current English language literature of stress injury affecting the incompletely ossified epiphyseal cartilage. We present four cases of stress related change to ...
Cicone Francesco F Unit of Nuclear Medicine, Sant'Andrea Hospital, Rome, Italy, - - 2014
We assessed the performance of 6-[(18)F]-fluoro-L-3,4-dihydroxyphenylalanine (F-DOPA) PET for differentiating radionecrosis (RN) from tumour progression (PD) in a population of patients with brain metastases, treated with stereotactic radiosurgery. The accuracy of F-DOPA PET was compared with that of perfusion-weighted magnetic resonance (perfusion-MR). In 42 patients with a total of 50 ...
Arumugam Thiruvengadam T Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, - - 2014
Early detection of pancreatic cancer could save many thousands of lives. Non-invasive diagnostic imaging, including PET with [(18)F]FDG, has inadequate resolution for detection of small (2-3mm) pancreatic tumours. We demonstrated the efficacy of PET imaging with an (18)F-labelled lactose derivative, [(18)F]FEDL, that targets HIP/PAP, a biomarker that is overexpressed in ...
Hodolic Marina M Department for nuclear medicine, University Medical Centre, Ljubljana, - - 2014
Positron emission tomography-computed tomography (PET/CT) with (18)F-fluorocholine (FCH) is routinely performed in patients with prostate cancer. In this clinical context, foci of FCH uptake in the head or in the neck were considered as incidentalomas, except for those suggestive of multiple bone metastases. In 8 patients the incidental focus corresponded ...
Scholtz L L Department of Radiology, Steve Biko Hospital, Pretoria, South Africa. - - 2014
Cardiovascular magnetic resonance (CMR) imaging is unsurpassed in the evaluation of myocardial anatomy, function and mass. Myocardial perfusion pre- and post-stress, as well as late enhancement is increasingly used in the work-up for ischaemic heart disease, especially in establishing the presence of myocardial viability. Late enhancement patterns can contribute substantially ...
Atay Musa - - 2014
A surgical sponge accidentally left in a surgical wound, called a textiloma or gossypiboma, is underreported in literature due to medicolegal consequences. Abdominal textiloma may be asymptomatic or present serious gastrointestinal complications such as bowel obstruction, perforation or fistula formation because of misdiagnosis. It may mimic abscess formation in early ...
Krähenbühl Barbara B Institute of Molecular Biology and Biophysics, ETH Zurich, 8093, Zurich, - - 2014
A fast, robust and reliable strategy for automated sequential resonance assignment for uniformly [(13)C, (15)N]-labeled RNA via its phosphodiester backbone is presented. It is based on a series of high-dimensional through-bond APSY experiments: a 5D HCP-CCH COSY, a 4D H1'C1'CH TOCSY for ribose resonances, a 5D HCNCH for ribose-to-base connection, ...
Wu Jun J Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.6 Tiantanxili, Dongcheng district, 100050, Beijing, - - 2014
The pathogenesis of cerebral arteriovenous malformations (cAVMs) is still not well understood. Generally, cAVMs are thought to be congenital lesions originating prenatally. We report a 7-year-old boy diagnosed with a de novo cAVM after 3 years of recurrent epileptic seizures. MR imaging at 4 years of age was normal. Follow-up MR imaging ...
Renthal William W Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, - - 2014
We present a developmentally appropriate adolescent boy who presented with upper and lower extremity glove-and-stocking paresthesias, distal weakness, vertigo, high-pitched voice, inattention, ataxia, and binocular diplopia after a voluntary 59-kg weight loss over 5 months. Extensive investigations revealed serum thiamine levels <2 nmol/L. Brain magnetic resonance imaging revealed symmetric abnormal T2 ...
Al Bunni Faise F Department of Medicine, Radiology, University of Padova, Padova, - - 2014
A phaeochromocytoma is a rare catecholamine-secreting tumour arising from the chromaffin cells. We describe a case of a child with Von Hippel-Lindau disease, with an adrenal phaeochromocytoma who presented with severe dilated cardiomyopathy driven by secondary hypertension. Contrast-enhanced ultrasound findings are described and compared with both magnetic resonance imaging and ...
Li Yuanpei Y 1] Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento, California 95817, USA - - 2014
Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nanoconstruct remains extremely challenging. Here we demonstrate the use of one single polymer to develop a smart 'all-in-one' nanoporphyrin platform that conveniently integrates ...
Suomalainen Piia P Division of Orthopaedics and Traumatology, Department of Trauma, Musculoskeletal Surgery and Rehabilitation, Tampere University Hospital, Tampere, - - 2014
The purpose of the study reported here was to find out if the clinical and magnetic resonance imaging (MRI) findings of a reconstructed anterior cruciate ligament (ACL) have an association. Our hypothesis, which was based on the different functions of the ACL bundles, was that the visibility of the anteromedial ...
Eyal Allon A Department of Internal Medicine H, Rambam Health Care Campus, Haifa, - - 2014
We describe the case of a 53-year-old man who presented with abdominal pain, diarrhoea and hypomagnesaemia. The hypomagnesaemia proved to be due to gastrointestinal loss as urinary fractional excretion was very low, suggesting non-renal loss. Common causes were discarded and the hypomagnesaemia was attributed to chronic use of the proton ...
Irving Benjamin - - 2014
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a powerful protocol for assessing tumour progression from changes in tissue contrast enhancement. Manual colorectal tumour delineation is a challenging and time consuming task due to the complex enhancement patterns in the 4D sequence. There is a need for a consistent approach to ...
Tan Teik Hin TH Nuclear Medicine Department, Hospital Putrajaya, Presint 7, 62250 Putrajaya, Wilayah Persekutuan - - 2014
In neuroendocrine liver metastases of unknown primary, a multimodality approach is usually adopted and consists of transabdominal ultrasound, endoscopic ultrasound (EUS), computed tomography (CT), magnetic resonance imaging (MRI), nuclear medicine techniques, endoscopy and exploratory surgery. The purpose of the study is to evaluate the diagnostic value of (68)Ga-DOTATATE positron emission ...
Streibelt Marco - - 2013
This study examined the effects of work-related multidisciplinary rehabilitation (MR) on occupational participation in patients with chronic musculoskeletal disorders. A randomized-controlled trial was carried out. The sample included patients with chronic musculoskeletal disorders and severe restrictions of work ability (n=222). Participants in the intervention group received a work-related rehabilitation programme ...
Patel Roma P - - 2011
A 60-year-old man presented with diplopia and neurocognitive deficits, which progressed rapidly over several months. Magnetic resonance imaging of the head revealed bilateral signal abnormalities and diffusion-weighted imaging restriction in bilateral basal ganglia, thalami, mesial temporal regions, and periaqueductal gray matter. Cerebrospinal fluid analysis was positive for 14-3-3 and tau ...
Siegel Nicole Hauptman - - 2011
PURPOSE:To compare topographically derived corneal wavefront aberrations between the NIDEK Magellan corneal topographer with built-in software (NIDEK Co Ltd) and VOL-CT software (Sarver and Associates) and determine their effects on intraocular lens (IOL) choice based on spherical aberration profiles. METHODS:Data were collected prospectively for 28 eyes without existing corneal disease ...
Turan Tanya N - - 2011
Studies in patients with extracranial carotid disease have shown that high-resolution magnetic resonance direct thrombus imaging (MRDTI) can reliably identify intraplaque hemorrhage, which may be a better predictor of clinical events than traditional radiographic methods such as percent stenosis. We present the use of high-resolution magnetic resonance imaging for the ...
Guarneri Valentina - - 2011
BACKGROUND: This study was designed to evaluate the accuracy of breast magnetic resonance imaging (MRI) and ultrasonography (US) in predicting the extent of breast residual disease after preoperative chemotherapy. METHODS: Patients with stage II-III invasive breast tumors who received preoperative chemotherapy and were imaged with post-treatment MRI were included. Histopathological ...
Langman Deborah A - - 2011
To assess the risk of RF-induced heating in pacemaker-attached and abandoned leads using in vitro temperature measurements at 1.5 Tesla as a function of lead length. Five custom lead lengths, 20-60 cm, were exposed to a uniform magnitude and phase radiofrequency electric field to examine the effect of lead length ...
Hiari Nadine N University of Cambridge, Addenbrooke's Hospital, England, - - 2011
The underlying pathologic mechanism of most acute coronary syndromes is atherosclerotic plaque rupture. One cause of rupture is plaque inflammation, leading to fibrous cap destabilization. Several imaging techniques, including x-ray coronary angiography and multislice CT, can be used for the detection of coronary atherosclerosis. However, these anatomical methods cannot measure ...
Pontifex Eliza K - - 2011
With the development of increasing numbers of potential therapeutic agents in inflammatory disease comes the need for effective biomarkers to help screen for drug efficacy and optimal dosing regimens early in the clinical trial process. This need has been recognized by the Outcome Measures in Rheumatology Clinical Trials (OMERACT) group, ...
Kwee Robert M - - 2010
To investigate the natural course of carotid plaque progression in transient ischemic attack/stroke patients by using serial multisequence magnetic resonance imaging (MRI). Forty transient ischemic attack/stroke patients with ipsilateral <70% carotid stenosis underwent MRI of the plaque ipsilateral to the symptomatic side at baseline and after 1 year. The MRI ...
Li Shuping - - 2010
Amyloid plaques are one of the hallmarks of Alzheimer's disease (AD). The lack of specific probes that can detect individual senile plaques in AD has prompted the development of magnetic resonance imaging (MRI) probes. In this study, based on DTPA-gadolinium (III) and congo red (CR), a novel specific MRI probe ...
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