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Leyton Jeffrey V JV Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, - - 2014
Engraftment of primary human acute myeloid leukemia (AML) specimens into the bone marrow (BM) of NOD/SCID mice has been used to study leukemia biology and new treatments for the disease. CSL360 is a chimeric IgG1 monoclonal antibody that recognizes CD123 (IL-3 receptor α-subchain) expressed in the absence of CD131 (β-subchain), ...
Kim Rihyeon R Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-Gu, Seoul, 110-744, - - 2014
To investigate magnetic resonance (MR) findings of angiomyolipoma (AML) on gadoxetic acid-enhanced MR imaging, and to identify features that differentiate AML from hepatocellular carcinoma (HCC) in patients with a low risk of HCC development. This retrospective study was institutional review board approved, and the requirement for informed consent was waived. ...
Kubota Kazuo K Department of Pediatrics, Gifu University Graduate School of Medicine, Gifu, - - 2014
Extramedullary infiltration is common in acute myeloid leukemia (AML) patients. Although AML can cause neurological symptoms, especially when associated with extramedullary infiltration, a presenting manifestation of facial palsy is rare. We report on a 1-year-old boy who developed right facial palsy. Detailed examination led to a diagnosis of AML (French-American-British ...
Meyer Jan-Philip JP School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB, Wales, UK; Wales Research & Diagnostic PET Imaging Centre (PETIC), Institute for Translation, Innovation, Methodology & Engagement (TIME), School of Medicine, Heath Park, Cardiff University, Cardiff, CF14 4XN, Wales, - - 2014
This review article considers 2'-labelled and 3'-labelled nucleosides, which are of great importance as positron emission tomography (PET) probes in clinical diagnostics and PET research. Although the radiochemical preparation of several [(18) F]-labelled nucleosides such as [(18) F]fluorothymidine or [(18) F](fluoroarabinofuranosyl)cytosine has been accomplished within the last two decades, a ...
Eyre Toby A TA Department of Haematology, Oxford University Hospitals NHS Trust, Churchill Hospital, Oxford, OX3 7EJ, UK, - - 2014
Gemcitabine is a nucleoside analogue used widely across haemato-oncology. Side effects are generally predictable, and typically consist of cytopenia, nausea, and infection. As the present case clearly demonstrates, gemcitabine is in rare cases associated with life-threatening large vessel vasculitis, which can involve the aorta. It is important to consider gemcitabine-induced ...
Zhang Chun-Yu CY Chun-Yu Zhang, Hai-Shan Yang, Department of Radiology, China-Japan Union Hospital Affiliated to Jilin University, Changchun 130033, Jilin Province, - - 2014
To investigate the utility of phosphorus-31 (31P) magnetic resonance spectroscopy (MRS) as a noninvasive test for assessment of response to interferon and ribavirin treatment in patients with different severities of hepatitis C virus infection. Sixty chronic hepatitis C patients undergoing antiviral therapy with interferon and ribavirin underwent 31P MRS at ...
Miyauchi Kenjyo - - 2012
N(6)-threonylcarbamoyladenosine (t(6)A) is a universally conserved, essential modified nucleoside found in transfer RNAs (tRNAs) responsible for ANN codons in all three domains of life. t(6)A has a crucial role in maintaining decoding accuracy during protein synthesis. The presence of t(6)A in cellular tRNAs has been well documented for more than ...
Wu Juefei - - 2011
Purpose: To evaluate whether microbubbles targeted to vascular cell adhesion molecule-1 (VCAM-1) (CD106) coupled with a magnetic guidance system could improve the efficacy of contrast-enhanced molecular ultrasonography (US) of atherosclerosis in the aorta. Materials and Methods: The animal research committee at Southern Medical University approved all experiments. Adherence of magnetic ...
Kshatriya Shilpa - - 2011
A 55 year old Caucasian male with history of hypertension, diabetes mellitus, protein C deficiency and deep vein thrombosis presented with typical angina. Both computed tomography and transesophageal echocardiography identified a mobile mass in left atrium, but could not differentiate between thrombus and myxoma. A cardiac catheterization with coronary angiography ...
Arai Motomi - - 2011
A 19-year-old university student with no personal or family history of neurologic disorders developed convulsions and was administered phenytoin. Two months later, he developed lower limb-dominant acute demyelinating polyneuropathy, from which he recovered within 2 months. At age 20, he rapidly developed visual disturbances and paraplegia from phenytoin intoxication. Cranial magnetic ...
Bertram Stefan - - 2011
PURPOSE: To estimate in patients with temporomandibular joint (TMJ) arthralgia whether magnetic resonance (MR) imaging findings of bilateral TMJ disc displacement without reduction (DDwoR) and/or osteoarthrosis (OA) are determinants of horizontal mandibular and vertical ramus deficiencies. PATIENTS AND METHODS: Bilateral MR imaging of the TMJ was performed in 68 consecutive ...
Pelosi Paolo - - 2011
PURPOSE OF REVIEW: We discuss the possible role of computed tomography (CT) to guide protective mechanical ventilation in acute lung injury/acute respiratory distress syndrome (ALI/ARDS), especially tidal volume (VT) and positive-end expiratory pressure (PEEP) settings and recruitment manoeuvres. RECENT FINDINGS: CT should be used as early as possible after the ...
Rathore Yashpal S - - 2011
Transsellar transsphenoidal encephalocele is the least common type of basal encephalocele. We present a series of four cases of transsellar transsphenoidal encephalocele. Clinical findings, imaging reviews, surgical repair techniques and postoperative morbidity are discussed with the relevant literature. Non contrast CT scan head with 3D reconstruction and magnetic resonance imaging ...
Chung Jin - - 2011
To describe imaging features in giant phyllodes tumors (GPTs) with radiology-pathologic correlations. Surgically confirmed 14 GPTs of the breast were retrospectively reviewed with ultrasound, mammograms, computed tomography, magnetic resonance imaging, and positron emission tomography. The most GPTs showed circumscribed and lobulated masses with cystic necrosis. Five cases of core needle ...
Karajanagi Sandeep S - - 2011
Most cases of irresolvable hoarseness are due to deficiencies in the pliability and volume of the superficial lamina propria of the phonatory mucosa. By using a US Food and Drug Administration-approved polymer, polyethylene glycol (PEG), we created a novel hydrogel (PEG30) and investigated its effects on multiple vocal fold structural ...
Weininger Markus - - 2011
Over the last decade, rapid technologic evolution in CT has resulted in improved spatial and temporal resolution and acquisition speed, enabling cardiothoracic CT angiography to become a viable and effective noninvasive alternative in the diagnostic algorithm. These new technologic advances have imposed new challenges for the optimization of contrast medium ...
Arnaiz Javier - - 2011
The objective of this article is to present a comprehensive review of apophysitis of the lower limb regarding anatomy, physiopathology, clinical findings, differential diagnosis, and imaging features with special emphasis on MRI. Apophysitis, which is inflammation of the traction epiphysis resulting from chronic trauma, is a common abnormality that affects ...
Gujjar Arunodaya - - 2011
ABSTRACT MRI is an essential investigation in epilepsy and status epilepticus (SE) for determining the underlying cause. However, SE or prolonged seizures may themselves induce changes in the MRI resulting in difficulty in interpretation. This case report illustrates a patient who recovered completely from prolonged generalized idiopathic SE lasting more ...
Miyanohara Ikuyo - - 2011
OBJECTIVE:: To describe a case of cochlear nerve deficiency (CND) with unique otologic findings. PATIENT:: A 6-year-old girl. MAIN OUTCOME MEASURES:: Magnetic resonance imaging, pure tone audiometry, distortion product otoacoustic emissions, and auditory brainstem response. RESULTS:: The patient showed moderate sensorineural hearing impairment limited to high frequency in the right ...
Ragetly Chantal A - - 2011
Objectives: To determine the combination of conformation characteristics of the pelvic limbs of Labrador Retrievers that best discriminates between limb at risk to develop cranial cruciate ligament (CCL) disease and limbs at low risk using radiographs, computerized tomography (CT) images, and dual-energy X-ray absorptiometry (DEXA). Study Design: Cross-sectional clinical study. ...
Ansede Gonzalo - - 2011
Groin pain is a common problem in the elite athlete and may lead to prolonged inactivity if inadequately treated. Groin pain, arising from injuries to the hip and pelvis, accounts for 5 to 6% of athletic injuries in adults and 10 to 24% of these injuries in children. Lower limb-dominated ...
Steinert Hans C - - 2011
Accurate staging is essential to offer the patient the most effective available treatment and the best estimate of prognosis. In non-small cell lung cancer (NSCLC), surgical resection offers the best chance of cure in the early stages, either alone or in combination with chemo- or radiotherapy at the more advanced ...
Kuramoto Alan - - 2011
A 71-year-old male with lumbar spinal stenosis developed exacerbation of lower back pain and leg paresthesias while attempting to undergo a spinal magnetic resonance imaging (MRI) scan in the supine position. After undergoing sedation for the MRI, he developed an acute cauda equina syndrome that required surgical decompression. MRI may ...
Saouab R - - 2011
Sandhoff disease is a rare and severe lysosomal storage disorder representing 7% of GM2 gangliosidoses. Bilateral thalamic involvement has been suggested as a diagnostic marker of Sandhoff disease. A case of an 18-month-old infant admitted for psychomotor regression and drug resistant myoclonic epilepsy is presented. Cerebral CT scan showed bilateral ...
Keeling Aoife N - - 2011
Multidetector computed tomography (MDCT) enables imaging of the entire arterial tree non-invasively. Optimal technical considerations for performing MDCT angiography (MDCTA) are essential for accurate diagnosis and atherosclerotic disease stratification. This review article focuses on the various technical aspects necessary for peripheral computed tomographic angiography (CTA) acquisition. Common clinical indications for ...
Ergül Yakup - - 2010
Kearns-Sayre syndrome (KSS) is a rare mitochondrial disease in which neuromuscular structures, endocrine glands, and cardiac conduction systems are most commonly involved. An 11-year-old boy was admitted with blurred consciousness, respiratory instability, and bradycardia of two-hour onset. He was immediately intubated. His medical history included growth retardation and myopic refractive ...
Okada Midori - - 2010
To characterize clinical signs and findings from magnetic resonance imaging (MRI) and CSF analysis for dogs with progressive myelomalacia (PM) diagnosed on the basis of clinical and histologic features. Retrospective case series. 5 dogs with confirmed PM and 7 with presumptive PM evaluated from 1997 through 2008. Medical records of ...
Flegel Thomas T Department of Small Animal Medicine, University of Leipzig, Leipzig, - - 2011
To report slot morphometry, degree of spinal decompression, and factors influencing decompression after partial lateral corpectomy (PLC) of the thoracolumbar spine in dogs with intervertebral disc disease. Case series. Dogs (n=51) with predominantly ventrally located spinal cord compression. PLC (n=60) were performed. Spinal cord compression was determined by computed tomographic ...
Wong S - - 2010
Propriospinal myoclonus is a rare movement disorder characterised by axial flexion or extension myoclonic jerks, produced by activation of spinal segments spreading rostrally or caudally. We present a 54-year-old man with propriospinal myoclonus confirmed on multimodal surface electromyography. Magnetic resonance imaging of his spinal cord was normal. He has a ...
Kim Hana - - 2010
Scoliosis is defined as a lateral spinal curvature with a Cobb angle of 10° or more. This abnormal curvature may be the result of an underlying congenital or developmental osseous or neurologic abnormality, but in most cases the cause is unknown. Imaging modalities such as radiography, computed tomography (CT), and ...
Freund Patrick A B - - 2010
To investigate whether a 3D-modified driven equilibrium Fourier transform (MDEFT)-based acquisition protocol established for brain morphometry also yields reliable information about the cross-sectional spinal cord area (SCA). Images of brain and cervical cord of 10 controls and eight subjects with spinal cord injury (SCI) were acquired with the 3D-MDEFT-based imaging ...
Klawiter Eric C EC Department of Neurology, Washington University, St Louis, Missouri, USA. - - 2010
To describe the clinical and imaging characteristics of spinal cord ring enhancement in multiple sclerosis (MS). Clinical case series. Academic referral center. Twenty patients with MS who had spinal cord ring enhancement were retrospectively identified from 322 cervical and thoracic spinal cord magnetic resonance imaging studies during a 3-year period. ...
Cui Jiao-Long - - 2011
The present study utilized diffusion MR imaging and fractional anisotropy (FA) mapping to delineate the microstructure of spinal cord. The concept of Shannon entropy was introduced to analyze the complex microstructure of healthy and injured spinal cords based on FA map. A total of 30 volunteers were recruited in this ...
Shuster Anatoly - - 2011
Surfer's myelopathy is an emergent medical condition, representing a rare type of nontraumatic injury of the spinal cord, triggered by continued hyperextension of the back in inexperienced surfers. Subsequent acute spinal cord ischemia is the main pathological "substrate" for extensive cord myelopathy, determining potential neurological damage and thus predicting a ...
Rajasekaran Shanmughanathan - - 2010
The authors report the utility of diffusion tensor tractography in demonstrating the partially severed spinal cord tracts on one side with normal, intact, distally traceable tracts on the opposite side in a patient with posttraumatic Brown Sequard syndrome. A 30-year-old man presented with typical clinical features of a hemisection injury ...
Rabo Carter S - - 2010
We report the case of a 28-year-old man who presented with the sole complaint of lumbago. Spinal magnetic resonance imaging (MRI) revealed a solitary, well-defined intramedullary mass at the L1-L2 level typical of a primary spinal cord germinoma. However, cranial magnetic resonance imaging (MRI) showed a concomitant lesion in the ...
Mitera Gunita - - 2011
To correlate computed tomography (CT) imaging features of spinal metastases with pain relief after radiotherapy (RT). Thirty-three patients receiving computed tomography (CT)-simulated RT for spinal metastases in an outpatient palliative RT clinic from January 2007 to October 2008 were retrospectively reviewed. Forty spinal metastases were evaluated. Pain response was rated ...
Byrnes Kimberly R KR Department of Neuroscience, Georgetown University Medical Center, Washington, DC, - - 2010
To investigate the utility of noninvasive magnetic resonance imaging (MRI) protocols to demonstrate pathological differences between rats and mice after spinal cord injury (SCI). Rats and mice are commonly used to model SCI; however, histology and immunohistochemistry have shown differences in neuropathology between the two species, including cavity formation and ...
Ciceri Elisa F - - 2010
The objective of this study is to discuss the possible role of cervical posterior epidural plexus engorgement during cervical flexion in the pathogenesis of Hirayama myelopathy. In Hirayama disease, MRI during neck flexion often shows that the posterior dura detaches from the posterior arches compressing the spinal cord. Autopsies demonstrated ...
Li Peng - - 2011
We report a 24-year-old male with pseudohypoparathyroidism and a 6-month history of sensory disturbance in both legs which was associated with difficulty in walking. His physical signs included a short stature, a thick neck, short fourth metacarpals and metatarsals, a spastic paraparesis and sphincteric disturbance. His serum electrolytes included low ...
Drolet Beth A - - 2010
OBJECTIVE: To prospectively evaluate a cohort of patients with infantile hemangioma in the midline lumbosacral region for spinal anomalies to determine the positive predictive value of infantile hemangioma for occult spinal anomalies and to make evidence-based recommendations for screening. STUDY DESIGN: A multicenter prospective cohort study was performed at 9 ...
Sakushima Ken - - 2011
Spinal cord sarcoidosis is a rare manifestation of sarcoidosis. Magnetic resonance imaging (MRI) of spinal cord sarcoidosis sometimes resembles that of the non-inflammatory spinal cord lesion. (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) is an effective method to detect both systemic and central nervous system lesions in sarcoidosis. This study compared the ...
Bagley Rodney S - - 2010
Tumors arising from or involving the spinal cord are important considerations in animals presented for pain and limb dysfunction. Clinical signs of spinal cord dysfunction, however, are not pathognomic for neoplastic disease in most instances. Advanced magnetic resonance imaging (MRI) often accurately identifies the location and extent of abnormalities. Although ...
da Costa Ronaldo C - - 2010
Computed tomography (CT) and magnetic resonance imaging (MRI) are extremely valuable techniques in the diagnosis of spinal disorders. This article reviews the fundamentals, indications, key technical aspects, and advantages and disadvantages of each modality. The CT and MRI features of common spinal diseases are discussed and illustrated. Comparative studies using ...
De Risio Luisa - - 2010
Fibrocartilaginous embolic myelopathy (FCEM) typically results in peracute onset of nonpainful, nonprogressive (after the first 24 hours), and often asymmetric neurologic deficits. Definitive diagnosis can be reached only through histologic examination of the affected spinal cord segments. Although MRI is the preferred diagnostic imaging modality for the antemortem diagnosis of ...
Wang Hanjie - - 2010
Due to the existence of the blood-spinal cord barrier (BSCB), many therapeutic macromolecular agents, such as drugs, protein and gene, cannot pass through this barrier to reach the site of injury, all of which restricts the treatment of spinal cord injuries (SCI). In this study, TAT-conjugated PEGlated Magnetic polymeric liposomes ...
Chung Sung-Kyun - - 2010
Capillary hemangiomas are common soft tissue tumors on the skin or mucosa of the head and neck in the early childhood, but very rare in the neuraxis. A 47-year-old man presented with one month history of back pain on the lower thoracic area, radiating pain to both legs, and hypesthesia ...
Tidwell Vanessa K VK Department of Electrical and Systems Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, USA. - - 2010
MRI, is a key tool for noninvasive spinal cord lesion analysis; however, accurate, quantitative methods for this analysis are lacking. A new, multistep, multidimensional approach, utilizing the classification expectation maximization algorithm, is proposed for MRI segmentation of spinal cord tissues. Diffusion tensor imaging is used to generate multiple images of ...
Bozzo Anthony - - 2011
Magnetic resonance imaging (MRI) has become the gold standard for imaging neurological tissues including the spinal cord. The use of MRI for imaging in the acute management of patients with spinal cord injury has increased significantly. This paper used a vigorous literature review with Downs and Black scoring, followed by ...
Verhey Leonard H - - 2010
Spinal cord lesions in adults with multiple sclerosis (MS) are thought to contribute to disability. The magnetic resonance imaging (MRI) appearance and clinical correlates of spinal cord lesions in children with MS have not been reported. T1-weighted pre- and post-gadolinium and T2-weighted TSE/FSE spine MR images of 36 children (age, ...
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