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Results 201 - 250 of 1314
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Jarratt Michael T MT DermResearch Inc., Austin, TX, USA. - - 2012
Topical combination therapy containing a retinoid and an antimicrobial is an effective treatment for acne vulgaris. To evaluate the efficacy and safety of a new topical formulation containing clindamycin phosphate 1.2% and tretinoin 0.025% solubilized in an aqueous-based gel (CT gel). 1,649 participants were randomized 2:2:2:1 to 12 weeks of ...
David F H - - 2012
To determine the effect of surgical implants on the depiction of canine stifle anatomy in magnetic resonance (MR) images, three canine cadaver limbs were imaged at 1.5 T before and after tibial plateau leveling osteotomy (TPLO), tibial tuberosity advancement (TTA), and extra-capsular stabilization (ECS), respectively. Susceptibility artifacts associated with implants ...
Gemmel Filip - - 2012
Prosthetic joint replacement surgery is performed with increasing frequency. Overall the incidence of prosthetic joint infection (PJI) and subsequently prosthesis revision failure is estimated to be between 1 and 3%. Differentiating infection from aseptic mechanical loosening, which is the most common cause of prosthetic failure, is especially important because of ...
Leblanc Amy K - - 2012
Palladia(TM) (toceranib phosphate-Pfizer Animal Health) is a novel orally administered receptor tyrosine kinase inhibitor (TKI) approved for treatment of canine mast cell tumors. Receptor tyrosine kinase dysregulation leads to tumor growth, progression, and metastasis. Toceranib's targets include vascular endothelial growth factor receptor (VEGFR-2/Flk-1/KDR), platelet-derived growth factor receptor, and kit. Positron ...
Temme Sebastian - - 2012
In this article, we review the use of (19) F MRI (magnetic resonance imaging) for in vivo tracking of monocytes and macrophages in the course of tissue inflammation. Emulsified perfluorocarbons (PFCs) are preferentially phagocytized by monocytes/macrophages and are readily detected by (19) F MRI. Because of the lack of any ...
Robbins Mike E - - 2012
Technological developments in radiation therapy and other cancer therapies have led to a progressive increase in five-year survival rates over the last few decades. Although acute effects have been largely minimized by both technical advances and medical interventions, late effects remain a concern. Indeed, the need to identify those individuals ...
Gauberti Maxime - - 2012
Background: The lack of a relevant stroke model in large nonhuman primates hinders the development of innova- tive diagnostic/therapeutic approaches concerned with this cerebrovascular disease. Our objective was to develop a novel and clinically relevant model of embolic stroke in the anesthetized monkey that incorporates readily available clinical imaging techniques ...
La Rocca Vieira Renata - - 2012
Improvement in both hardware and software has opened up new opportunities in magnetic resonance (MR) imaging of the shoulder. MR imaging at 3-T has become a reality, with the prospect of 7-T imaging on the horizon. The art of MR arthrography continues to improve, aided by the use of novel ...
Kuo Yen Lin - - 2012
We report a 16-year-old girl with suspected psychotic mania, who subsequently developed amnesia, catatonia, oro-lingual dyskinesia, consciousness disturbance, seizure and respiratory failure. Repeated studies of the cerebrospinal fluid (CSF), viral culture and serology, brain MRI, single photon emission CT scan, and autoimmune profiles were all normal. She was finally diagnosed ...
Caroline I - - 2012
High grade gliomas (HGG) frequently recur regardless of treatment. Radiological detection of progressive disease (PD) is challenging due to the possibility of therapy-related MRI changes including: pseudoprogression (PP) and radiation necrosis (RN). Both may mimic PD. We undertook a literature review to examine existing data regarding imaging modalities and their ...
Sharman M - - 2012
Objectives: Multiple topical treatments are often required for clinical cure of mycotic rhinosinusitis in dogs. The objective of this study was to describe the distribution and retention of enilconazole and clotrimazole solutions using a temporary trephination protocol. Methods: Nine client-owned dogs diagnosed with mycotic rhinosinusitis between March 2008 and December ...
De Rycke Lieve M - - 2012
Objective-To describe the anatomic features of dentition and surrounding structures of the head in rabbits assessed by use of a newly developed micro-computed tomography (CT) device. Sample-Cadavers of 7 clinically normal adult Dendermonde White domestic rabbits raised for human consumption. Procedures-The rabbits were slaughtered in a slaughterhouse, flayed, and decapitated; ...
Erbay Gürcan - - 2012
In the presented case, the radiologic, endoscopic and surgical findings of a gossypiboma that migrated into the stomach are presented. A 63-year-old woman presented with epigastric pain, and her clinical and laboratory findings were compatible with pancreatitis. Upper gastrointestinal endoscopy revealed a foreign body at the greater curvature of the ...
Tow Jonathan - - 2012
A 56-year-old man, recently diagnosed with non-Hodgkin lymphoma, was referred for a FDG PET/CT scan to stage disease. Unexpected large fluid collections with FDG-avid peripheries and central photopenia were demonstrated in the abdomen and pelvis on the FDG PET/CT study. The collections were urgently drained with subsequent resolution. After antibiotic ...
Marsac L - - 2012
This study aims to demonstrate, using human cadavers the feasibility of energy-based adaptive focusing of ultrasonic waves using magnetic resonance acoustic radiation force imaging (MR-ARFI) in the framework of non-invasive transcranial high intensity focused ultrasound (HIFU) therapy. Energy-based adaptive focusing techniques were recently proposed in order to achieve aberration correction. ...
Saeed Maythem M Maythem Saeed, Mark Wilson, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94107-5705, United - - 2012
In the past few years, there have been multiple advances in magnetic resonance (MR) instrumentation, in vivo devices, real-time imaging sequences and interventional procedures with new therapies. More recently, interventionists have started to use minimally invasive image-guided procedures and local therapies, which reduce the pain from conventional surgery and increase ...
Koyama Takayoshi - - 2012
Active targeting by monoclonal antibodies (mAbs) combined with nanosize superparamagnetic iron oxide (SPIO) is a promising technology for magnetic resonance imaging (MRI) diagnosis. However, the clinical applicability of this technology has not been investigated using appropriate controls. It is important to evaluate the targeting technology using widely used clinical 1.5-Tesla ...
Tunariu N N Section of Clinical Magnetic Resonance, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey SM2 5PT, UK. - - 2012
Key issues in early clinical trials of targeted agents include the determination of target inhibition, rational patient selection based on pre-treatment tumour characteristics, and assessment of tumour response in the absence of actual shrinkage. There is accumulating evidence that functional imaging using advanced techniques such as dynamic contrast enhanced (DCE)-magnetic ...
Zhao Zengxia - - 2012
Lanthanide-doped upconversion nanoparticles (UCNPs) have attracted considerable attention for their application in biomedicine. Here, silica-coated NaGdF(4) :Yb,Er/NaGdF(4) nanoparticles with a tetrasubstituted carboxy aluminum phthalocyanine (AlC(4) Pc) photosensitizer covalently incorporated inside the silica shells were prepared and applied in the photodynamic therapy (PDT) and magnetic resonance imaging (MRI) of cancer cells. ...
Nguyen Tan B - - 2012
To assess the diagnostic performance of distributed human intelligence for the classification of polyp candidates identified with computer-aided detection (CAD) for computed tomographic (CT) colonography. This study was approved by the institutional Office of Human Subjects Research. The requirement for informed consent was waived for this HIPAA-compliant study. CT images ...
Stoneham Grant - - 2012
INTRODUCTION: To assess the incidence and clinical significance of pneumoperitoneum after radiologic percutaneous gastrojejunostomy (PGJ) tube insertion. METHODS: Sixteen subjects were prospectively assessed after imaging-guided PGJ tube insertion to discern the incidence of pneumoperitoneum related to specific clinical signs and symptoms. Computed tomography of the abdomen and the pelvis was ...
Watson James C - - 2012
CTS is a clinically defined syndrome; however, there is value added by an evidence-based electrodiagnostic approach to (1) efficiently confirm the diagnosis (particularly before invasive interventions), (2) to identify neurogenic mimickers or superimposed processes that may influence the response to treatment, and (3) to stratify the degree of neurogenic injury ...
Kollewe Katja - - 2012
Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disorder which is incurable to date. As there are many ongoing studies with therapeutic candidates, it is of major interest to develop biomarkers not only to facilitate early diagnosis but also as a monitoring tool to predict disease progression and to ...
Takayama Yukihisa - - 2012
Purpose: We investigated the feasibility of performing chemical exchange saturation transfer (CEST) imaging using ytterbium-based paramagnetic CEST (PARACEST) agents on a clinical magnetic resonance (MR) scanner. Materials and Methods: We prepared solutions of 3 different ytterbium-based PARACEST agents at concentrations of 5, 10, 20, and 50 mM at a pH ...
Wang Ge - - 2012
We recently elevated interior tomography from its origin in computed tomography (CT) to a general tomographic principle, and proved its validity for other tomographic modalities including SPECT, MRI, and others. Here we propose "omni-tomography", a novel concept for the grand fusion of multiple tomographic modalities for simultaneous data acquisition in ...
Bohnert Julia - - 2012
Abstract Magnetic particle imaging, uses magnetic fields of frequencies in the kilo-hertz range. Little research has been carried out upon effects on excitable tissue caused by time-varying magnetic fields in that frequency range. To learn about magnetic stimulation thresholds, a system that is capable of generating a very focused magnetic ...
Wen Qian - - 2012
Osteonecrosis of the femoral head (ONFH) is generally characterized as an irreversible disease and tends to cause permanent disability. Therefore, understanding the pathogenesis and molecular mechanisms of ONFH and developing effective therapeutic methods is critical for slowing the progress of the disease. In this study, an experimental rabbit model of ...
Van Ryssen B B Ghent University, Faculty of Veterinary Medicine, Department of Veterinary Diagnostic Imaging and Small Animal Orthopaedics, Merelbeke, Belgium. - - 2012
To describe the radiographic, ultrasonographic, computed tomography (CT), magnetic resonance imaging (MRI), and arthroscopic findings in eight dogs with elbow lameness caused by primary flexor enthesopathy. Clinical study. Eight client-owned dogs. In all dogs, lameness was localized to the elbow by clinical examination. Radiographic examination, ultrasound, CT and MRI were ...
Panzer Stephanie - - 2012
Herniation pits (HPs) of the femoral neck were first described in a radiological publication in 1982 as round to oval radiolucencies in the proximal superior quadrant of the femoral neck on anteroposterior radiographs of adults. In following early clinical publications, HPs were generally recognized as an incidental finding. In contrast, ...
Thorwarth Daniela - - 2012
Hybrid imaging is beneficial for improved medical diagnosis and therapy planning today. Hybrid imaging describes the prospective correlation of two or more complementary sets of imaging information, such as functional and anatomical image volumes. Correlation can be performed through physically combined imaging modalities, such as PET/CT, SPECT/CT, or PET/MR. Here ...
Horakova Dana - - 2012
Traditionally, multiple sclerosis has been viewed as a disease predominantly affecting white matter. However, this view has lately been subject to numerous changes, as new evidence of anatomical and histological changes as well as of molecular targets within the grey matter has arisen. This advance was driven mainly by novel ...
Sörensen Jens - - 2012
Clinical molecular imaging by use of PET and PET/CT is increasingly important in routine oncological practice worldwide. A vast majority of clinical PET investigations are performed with [(18)F]-fluorodeoxyglucose (FDG), but there is a growing interest in novel molecular probes among scientists and clinicians. Beyond FDG, a small number of different ...
Bohnert Julia - - 2012
Abstract Magnetic particle imaging, uses magnetic fields of frequencies in the kilo-hertz range. Little research has been carried out upon effects on excitable tissue caused by time-varying magnetic fields in that frequency range. To learn about magnetic stimulation thresholds, a system that is capable of generating a very focused magnetic ...
Mohammadi A - - 2012
In computed tomography (CT) systems, it is desirable to know the X-ray energy spectra for various applications, including medical CT imaging, and diagnostic field and heavy ion therapy. However, because of the restricted space, the only practical solution is to use Compton spectroscopy, where the incident spectrum is inferred from ...
Chorny Michael - - 2012
Magnetic guidance is a physical targeting strategy with the potential to improve the safety and efficacy of a variety of therapeutic agents--including small-molecule pharmaceuticals, proteins, gene vectors, and cells--by enabling their site-specific delivery. The application of magnetic targeting for in-stent restenosis can address the need for safer and more efficient ...
Dahdal S - - 2012
Aim: To report a rare case of a spinal WHO grade I meningioma extending through intervertebral foramina C7 to D4 with an extensive mediastinal mass and infiltration of the vertebrae, and to discuss the malignant behavior of a tumor classified as benign. Methods (Clinical Presentation, Histology, and Imaging): A 54-year-old man ...
Tatsumi Daisaku - - 2012
Dose verification using radiochromic films may bring about moiré artifacts during the film scanning process using a flatbed scanner. A method for removing the moiré artifacts was already reported for reflective scanning. Recently, transmissive scanning using EBT2 films has played a major role for dose verification in intensity-modulated radiation therapy. ...
Hodaie Mojgan - - 2012
Focal radiosurgery is a common treatment modality for trigeminal neuralgia (TN), a neuropathic facial pain condition. Assessment of treatment effectiveness is primarily clinical, given the paucity of investigational tools to assess trigeminal nerve changes. Since diffusion tensor imaging (DTI) provides information on white matter microstructure, we explored the feasibility of ...
Hipp Elizabeth - - 2012
Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) is a noninvasive image-guided technique used to thermally ablate solid tumors. During treatment, ultrasound reflections from distal media interfaces can shift prescribed treatment locations. The purpose of this study was to investigate the effect of normal incidence reflections from air, acrylic (modeling bone), and ...
Lobatto Mark E ME Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, - - 2012
Nanomedicine can provide a potent alternative to current therapeutic strategies for atherosclerosis. For example, the encapsulation of anti-inflammatory drugs into liposomes improves their pharmacokinetics and biodistribution, thereby enhancing bioavailability to atherosclerotic plaques and improving therapeutic efficacy. The evaluation of this type of experimental therapeutics can greatly benefit from in vivo ...
Galbán Stefanie S Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, United States of - - 2012
The effectiveness of the radiosensitizer gemcitabine (GEM) was evaluated in a mouse glioma along with the imaging biomarker diffusion-weighted magnetic resonance imaging (DW-MRI) for early detection of treatment effects. A genetically engineered murine GBM model [Ink4a-Arf(-/-) Pten(loxP/loxP)/Ntv-a RCAS/PDGF(+)/Cre(+)] was treated with gemcitabine (GEM), temozolomide (TMZ) +/- ionizing radiation (IR). Therapeutic ...
Lee Percy - - 2012
Radiation therapy is an important component of cancer therapy for early stage as well as locally advanced lung cancer. The use of F18 FDG PET/CT has come to the forefront of lung cancer staging and overall treatment decision-making. FDG PET/CT parameters such as standard uptake value and metabolic tumor volume ...
van Heeswijk Ruud B - - 2012
[This corrects the article on p. e42236 in vol. 7.].
Yuan Jing - - 2012
The capability to image temperature is a very attractive feature of MRI and has been actively exploited for guiding minimally-invasive thermal therapies. Among many MR-based temperature-sensitive approaches, proton resonance frequency (PRF) thermometry provides the advantage of excellent linearity of signal with temperature over a large temperature range. Furthermore, the PRF ...
Ash Adam - - 2012
This is a case report of a superficial penile hematoma that was difficult to distinguish clinically from a penile fracture. Such cases occur with relative frequency, and because definitive treatment is an urgent surgery, timely diagnosis is essential to avoid complications. Typical imaging modalities such as cavernosonography and magnetic resonance ...
Eid Albert J - - 2012
Osteomyelitis can affect every bone and is heterogeneous in its pathophysiology and presentation. When the diagnosis is clinically suspected, further studies such as serum inflammatory markers and imaging studies should be performed. Magnetic resonance imaging can be very useful in establishing the diagnosis and determining the extent of infection. When ...
Wilson Emily - - 2012
Penetrating trauma to the thoraco-abdomen may cause diaphragmatic injury (DI). We present a case which highlights the difficulties of recognizing DI and the limited role of multimodal diagnostic imaging. A 19 year old male presented with stab wounds to his left lateral chest wall. CT was suspicious for diaphragmatic injury ...
De Decker Steven - - 2012
Disk-associated cervical spondylomyelopathy (DA-CSM) is a multifactorial neurological disorder in which progressive caudal cervical spinal cord compression is mainly caused by one or more intervertebral disk protrusions. The Doberman pinscher breed seems predisposed for this condition. The underlying cause and pathophysiology of DA-CSM are currently unknown. Recently, wider intervertebral disks ...
Muller Leah L Department of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Avenue, L-352, San Francisco, CA 94143-0628, USA. - - 2012
Image-guided endovascular interventions have gained increasing popularity in clinical practice, and magnetic resonance imaging (MRI) is emerging as an attractive alternative to X-ray fluoroscopy for guiding such interventions. Steering catheters by remote control under MRI guidance offers unique challenges and opportunities. In this review, the benefits and limitations of MRI-guided ...
O'Connor James P B - - 2012
About 100 early-phase clinical trials and investigator-led studies of targeted antivascular therapies-both anti-angiogenic and vascular-targeting agents-have reported data derived from T1-weighted dynamic contrast-enhanced (DCE)-MRI. However, the role of DCE-MRI for decision making during the drug-development process remains controversial. Despite well-documented guidelines on image acquisition and analysis, several key questions concerning ...
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