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Westphal Saskia E - - 2012
For the past century, autopsy techniques in clinical pathology have not changed significantly, while autopsy rates are declining. Modern imaging techniques offer interesting prospects of supportive post-mortem diagnostic investigation. In a prospective study of 29 autopsy cases, complimentary virtual autopsy using unenhanced post-mortem computed tomography (pmCT) was performed. We analysed ...
Qiao Xiao-Fei - - 2012
Upconversion luminescent nanoparticles (UCNPs) have been widely used in many biochemical fields, due to their characteristic large anti-Stokes shifts, narrow emission bands, deep tissue penetration and minimal background interference. UCNPs-derived multifunctional materials that integrate the merits of UCNPs and other functional entities have also attracted extensive attention. Here in this ...
Zhen Mingming - - 2012
Macromolecular magnetic resonance imaging (MRI) contrast agent Gd-DTPA-HSA (DTPA: Diethylene Triamine Pentacetate Acid, HSA: Human Serum Albumin) as a model has been successfully conjugated with tri-malonic acid modified C60 for contrast enhancement at clinically used magnetic field strength. The Gd-DTPA-HSA-C60 conjugate exhibit maximal relaxivity (r1 = 86 mM-1s-1 at 0.5 ...
Trattnig Siegfried - - 2012
This article provides an overview of the initial clinical results of musculoskeletal studies performed at 7 Tesla, with special focus on sodium imaging, new techniques such as chemical exchange saturation transfer (CEST) and T2* imaging, and multinuclear MR spectroscopy. Sodium imaging was clinically used at 7 T in the evaluation of ...
Loubeyre Pierre - - 2012
Posterior deeply infiltrating endometriosis (PDIE) is an invalidating disorder that may involve the rectosigmoid colon. MRI with gel opacification after rectosigmoid colon cleansing improves visualization of rectosigmoid endometriosis. Nonetheless, the depth of bowel wall infiltration is still difficult to assess. In this regard, the use of high-frequency echoendoscope may be ...
Peroni Marta - - 2012
PURPOSE: The purpose of this work was to develop and validate an efficient and automatic strategy to generate online virtual computed tomography (CT) scans for adaptive radiation therapy (ART) in head-and-neck (HN) cancer treatment. METHOD: We retrospectively analyzed 20 patients, treated with intensity modulated radiation therapy (IMRT), for an HN ...
Lin Qin - - 2012
We used serial (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) to evaluate tumors' maximum standardized uptake value (SUV(max)) before, during, and after radiotherapy to explore the biological behavior of and response to radiation therapy in various subtypes of nasopharyngeal carcinoma (NPC). Sixty-one patients with pathologically diagnosed NPC were prospectively enrolled ...
Bailey John Kevin - - 2012
BACKGROUND: The pulsed-dye laser (PDL) is a potential adjunctive therapy for treatment of hyperemic and hypertrophic scars. OBJECTIVE: To compare the effects of early PDL treatment plus compression therapy (CT) with those of CT alone in patients undergoing burn scar reconstruction with split-thickness grafts on an extremity. METHODS: Laser treatments ...
Kemp J - - 2012
Purpose: Nucletron's Oncentra Brachy Applicator Modeling plugin (AMp) may facilitate HDR cervical brachytherapy treatment planning when image artifact inhibits dwell position localization. The AMp utilizes a 3D CAD rendering of the corresponding applicator to define possible source dwell positions. This study compares the equivalence of source localization within a CT/MR ...
Gerson Lauren B - - 2012
Obscure gastrointestinal haemorrhage is defined the presence of overt or occult bleeding in the setting of a normal endoscopic examination of the upper and lower gastrointestinal tracts. While obscure bleeding is not common, the evaluation and management of these patients often incurs considerable expense. Potential options for small bowel evaluation ...
S─ůsiadek Marek J - - 2012
We review the current knowledge concerning clinical applications of the advanced technique of magnetic resonance imaging (MRI): diffusion tensor imaging (DTI) of the spinal cord. Due to technical difficulties, DTI has rarely been used in spinal cord diseases. However, in our opinion it is potentially a very useful method in ...
Saidi Kevan - - 2012
The treatment of benign and malignant primary bone tumors has progressed over time from relatively simple practice to complex resection and reconstruction techniques. Recently, computer-assisted orthopaedic surgery (CAOS) has been used to assist surgeons to enhance surgical precision in order to achieve these goals. Initially, software developed for CT-based spinal ...
Cheng Phillip M - - 2012
This article reviews types of urinary calculi and their imaging appearances, presents direct and secondary imaging findings of urolithiasis, and provides an overview of treatment methods. Pertinent imaging findings that affect clinical management are highlighted. The implications of complex or variant genitourinary anatomy are reviewed. We outline a standard format ...
Vaseenon Tanawat - - 2012
Anterior ankle impingement results from an impingement of the ankle joint by a soft tissue or osteophyte formation at the anterior aspect of the distal tibia and talar neck. It often occurs secondary to direct trauma (impaction force) or repetitive ankle dorsiflexion (repetitive impaction and traction force). Chronic ankle pain, ...
Chang Z - - 2012
Recent developments in MRI have substantially improved its performance, making it a potentially powerful tool for not only diagnosis but also therapy. Treatment assessment using MR functional imaging is the process of using MR functional imaging before and/or during and/or after a course of radiation therapy (RT) to assess treatment ...
Bednarz B - - 2012
Purpose: The development of novel agents for targeted radionuclide therapy has led to an important need for accurate dosimetry characterization during pre-clinical trials. The purpose of this study is to discuss our progress in developing a fully automated Monte Carlo-based dosimetry platform for external and/or internal absorbed dose quantification in ...
DiFilippo Frank P - - 2012
Considering the high cost of dedicated small-animal positron emission tomography/computed tomography (PET/CT), an acceptable alternative in many situations might be clinical PET/CT. However, spatial resolution and image quality are of concern. The utility of clinical PET/CT for small-animal research and image quality improvements from super-resolution (spatial subsampling) were investigated. National ...
Chao M - - 2012
Purpose: A three-dimensional conformal radiotherapy (3DCRT) has been recently introduced to helical tomotherapy, allowing the user to plan and treat patients that do not require sophisticated IMRT planning and delivery. This study aims to test treatment planning on this modality and evaluate its performance by comparing to conventional LINAC-based 3DCRT ...
Ng Thomas S C - - 2012
Noninvasive methods are needed to explore the heterogeneous tumor microenvironment and its modulation by therapy. Hybrid PET/MRI systems are being developed for small-animal and clinical use. The advantage of these integrated systems depends on their ability to provide MR images that are spatially coincident with simultaneously acquired PET images, allowing ...
Abdoli Mehrsima - - 2012
Metallic implants are known to generate bright and dark streaking artifacts in x-ray computed tomography (CT) images, which in turn propagate to corresponding functional positron emission tomography (PET) images during the CT-based attenuation correction procedure commonly used on hybrid clinical PET/CT scanners. Therefore, visual artifacts and overestimation and/or underestimation of ...
Raaymakers B - - 2012
Purpose: We have developed and built a prototype ring based accelerator around a 1.5 T MRI system for MRI guided radiation therapy. Methods: The design is a closed bore cylindrical 1.5 T MRI with a ring mounted 6 MV accelerator in the transversal mid-plane with a 7 mm non-rotating MLC ...
Craciunescu O - - 2012
Image-guidance plays an important role in modern radiation therapy, predominantly in external beam planning and delivery. In contrast, brachytherapy is still largely based on systems originally developed in the early 20th century. In recent years, with the advent of high/pulsed dose rate (HDR/PDR) afterloading technology, advanced treatment planning systems and ...
Li H - - 2012
Purpose: To evaluate the effects of a CT on-board commercially available metal artifact reduction (MAR) algorithm for the use in radiation therapy treatment planning. Methods: Phantom and clinical data were used for evaluation. A CIRS electron density phantom (Model 062) was scanned with Philips Brilliance BigBore 16-slice CT simulator to ...
Lin Y - - 2012
Purpose: In this study, we developed a quantitative analysis tool based on patient's longitudinal MR images to 1) measure the radiation dose received by each subcortical structure, 2) follow the change of volume and shape of each structure longitudinally. This tool provides a systematic approach to study the radiation therapy ...
Milosevic M - - 2012
Human tumors are characterized by an abnormal vascular network that develops because of unregulated angiogenesis. This contributes to abnormalities of the tumor microenvironment like hypoxia, acidosis and high interstitial fluid pressure that influence treatment response and patient survival. There is an important clinical need to develop new minimally invasive tools ...
Beck Belinda R - - 2012
To examine the relationship between severity grade for radiography, triple-phase technetium 99m nuclear medicine bone scanning, magnetic resonance (MR) imaging, and computed tomography (CT); clinical severity; and recovery time from a tibial stress injury (TSI), as well as to evaluate interassessor grading reliability. This protocol was approved by the Griffith ...
Gordon Nicole M - - 2012
Failure of rotator cuff repair is a well-documented problem. Successful repair is impeded by muscle atrophy, fat infiltration, devascularization, and scar tissue formation throughout the fibrocartilagenous transition zone. This case study exemplifies a technique to biologically augment rotator cuff healing. Clinically, pain and function improved. Postoperative magnetic resonance imaging evaluation ...
Winter J - - 2012
Purpose: To develop the operational workflow and safety systems of a magnetic resonance-guided radiotherapy system (MRgRT™), which comprises an MR scanner on rails that travels between a linac vault, MR simulation room and brachytherapy suite. Methods: To develop a safe and streamlined clinical workflow, we conducted a comprehensive process review ...
Mills M - - 2012
Since AAPM Report No. 33 on Diagnostic Radiology Physics staffing is more than 20 years old, the Diagnostic Work and Workforce Study Subcommittee (DWWSS) of the Professional Council was formed to conduct a new study and update the data. The intent of the DWWSS study has two goals. First, it ...
Summers P - - 2012
Purpose: To detail and compare data collected during RPC onsite dosimetry review visits at proton therapy centers. Methods: The RPC has established a complete review process for proton therapy institutions wishing to participate in NCI-funded clinical trials that includes an on-site dosimetry review visit performed by the RPC. During the ...
Venkatesan Aradhana M - - 2012
To describe the preliminary safety and accuracy of a magnetic resonance (MR) imaging-guided high-intensity-focused ultrasound (HIFU) system employing new technical developments, including ablation control via volumetric thermal feedback, for the treatment of uterine leiomyomata with histopathologic correlation. In this phase I clinical trial, 11 women underwent MR-guided HIFU ablation (Sonalleve ...
Kircher Moritz F - - 2012
Molecular imaging, generally defined as noninvasive imaging of cellular and subcellular events, has gained tremendous depth and breadth as a research and clinical discipline in recent years. The coalescence of major advances in engineering, molecular biology, chemistry, immunology, and genetics has fueled multi- and interdisciplinary innovations with the goal of ...
Barbarisi Manlio - - 2012
Stereotactic radiosurgery is an emerging treatment option offered to patients with Glioblastoma multiforme (GBM). Radiosurgery is performed as an outpatient procedure and provides a safe and effective non invasive treatment for focal GBM. High energy beams originating from cobalt sources placed into an helmet (Gamma-Knife) or generated by a linear ...
Spinelli Antonino - - 2012
Anorectal involvement by in Crohns disease (CD) causes perianal lesions that vary from simple and asymptomatic skin tags, to complex and disabling fistulas and abscesses. Perianal CD affects approximately one-third of patients; its management is difficult challenging and may require combined medical and surgical treatment, which has provend to give ...
Desjardins Benoit - - 2012
Clinical palpation of a pulsating abdominal mass alerts the clinician to the presence of a possible abdominal aortic aneurysm (AAA). Generally an arterial aneurysm is defined as a localized arterial dilatation ≥50 % greater than the normal diameter. Imaging studies are important in diagnosing the cause of a pulsatile abdominal mass ...
Seña Arlene C - - 2012
Chlamydia trachomatis (CT), Mycoplasma genitalium (MG), and Trichomonas vaginalis (TV) are sexually transmitted infections (STIs) associated with nongonococcal urethritis (NGU). We assessed their predictors and persistence after treatment. We analyzed data from an NGU treatment trial among symptomatic heterosexual men aged 16-45 years from STI clinics. Nucleic acid amplification tests ...
Prestwich R J D - - 2012
Defining the target for head and neck radiotherapy is a critical issue with the introduction of steep dose gradients associated with intensity-modulated radiotherapy. Tumour delineation inaccuracies are a major source of error in radiotherapy planning. The integration of 18-fluoride fluorodeoxyglucose positron emission tomography ((18)FDG-PET) and magnetic resonance imaging directly into ...
Lammers Karin - - 2012
The aims of this systematic literature review were to assess whether the detection of pubovisceral avulsions using magnetic resonance (MR) imaging or perineal ultrasonography was clinically relevant in women with pelvic floor dysfunction and to evaluate the relation with anatomy, symptoms, and recurrence after surgery. We performed a systematic literature ...
Yeoh Kheng-Wei - - 2012
Fluorine-18 fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) has become indispensable for the clinical management of lymphomas. With consistent evidence that it is more accurate than anatomic imaging in the staging and response assessment of many lymphoma subtypes, its utility continues to increase. There have therefore been efforts to incorporate ...
Hoeffner E G - - 2012
SUMMARY:Although radiography of the spine began shortly after Roentgen's discovery in 1895, there was little written in the medical literature about spine imaging until nearly 25 years later with the development of myelography, first by using air and then a variety of positive contrast agents. The history of spine imaging ...
Jeon J Y JY Departments of Neuroradiology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY 10065, - - 2012
SIACI of bevacizumab has emerged as a promising novel therapy in the treatment of recurrent GB. This study assessed the potential of (1)H-MRS as an adjunctive technique in detecting metabolic changes reflective of antiproliferative effects of targeted infusion of bevacizumab in the treatment of GB. Eighteen patients enrolled in a ...
Leach M O MO Cancer Research UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research & Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey, SM2, 5PT, UK. - - 2012
Many therapeutic approaches to cancer affect the tumour vasculature, either indirectly or as a direct target. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has become an important means of investigating this action, both pre-clinically and in early stage clinical trials. For such trials, it is essential that the measurement process (i.e. ...
Burnley Mark - - 2012
Whether the transition in fatigue processes between "low-intensity" and "high-intensity" contractions occurs gradually, as the torque requirements are increased, or whether this transition occurs more suddenly at some identifiable "threshold", is not known. We hypothesized that the critical torque (CT; the asymptote of the torque-duration relationship) would demarcate distinct profiles ...
Weinberg Irving N - - 2012
A time-varying magnetic field can cause unpleasant peripheral nerve stimulation (PNS) when the maximum excursion of the magnetic field (ΔB) is above a frequency-dependent threshold level [P. Mansfield and P. R. Harvey, Magn. Reson. Med. 29, 746-758 (1993)]. Clinical and research magnetic resonance imaging (MRI) gradient systems have been designed ...
Seidenwurm David J - - 2012
Myelopathy is a problem that requires imaging to distinguish among numerous specifically treatable causes. The first priority is to determine mechanical stability after trauma. Next, it is crucial to distinguish intrinsic disease from extrinsic compression-for example, by epidural abscess. Osteophytes or disc extrusions and metastatic compression are the most common ...
Sanchez-Ros-Sanchez Alberto - - 2012
ABSTRACT: Castleman disease (CD) is a rare benign lymphoproliferative disorder commonly described as a hypervascular mass that causes progressive lymph node enlargement. Head and neck involvement occurs only in 15% to 20% of cases. The recommended treatment in solitary CD is radical resection. Few reports have described the use of ...
van der Kolk Anja G - - 2012
In this review, current (clinical) applications and possible future directions of ultrahigh-field (≥7 T) magnetic resonance (MR) imaging in the brain are discussed. Ultrahigh-field MR imaging can provide contrast-rich images of diverse pathologies and can be used for early diagnosis and treatment monitoring of brain disease. These images may provide ...
Goëb V V Section of Musculoskeletal Disease, Chapel Allerton Hospital, Leeds Institute of Molecular Medicine, University of Leeds, United Kingdom. - - 2012
Despite its advantages in diagnosis, treatment and research, the role of arthroscopy in the management of rheumatic diseases has diminished due to the development of other less invasive means of joint assessment including advances in imaging techniques, e.g. ultrasound and magnetic resonance imaging. However, arthroscopy still provides invaluable information. By ...
Baum Richard P - - 2012
Theranostics of neuroendocrine neoplasms (NENs) based on molecular imaging using receptor positron emission tomography/computed tomography (PET/CT) with (68)Ga-labeled somatostatin (SMS) analogs and molecular radiotherapy applying peptide receptor radionuclide therapy (PRRNT) with (90)Y- and/or (177)Lu-labeled peptides has paved the way to personalized medicine. SMS receptor PET/CT enables very accurate detection of ...
Yuan Chun C Department of Radiology, University of Washington, Seattle, WA 98109, USA. - - 2012
Manifestations of atherosclerotic plaque in different arterial beds range from perfusion deficits to overt ischemia such as stroke and myocardial infarction. Atherosclerotic plaque composition is associated with its propensity to rupture and cause vascular events. Magnetic resonance (MR) imaging of atherosclerotic plaque using clinical 1.5 T scanners can detect plaque ...
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