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Ameli-Renani Seyed S From the Department of Radiology (S.A.R., F.R., A.N., L.R., A.W., H.K.S., A.D., I.V.) and Pulmonary Hypertension Unit (J.L.B., B.M.), St George's Hospital, Blackshaw Road, London SW17 0PZ, - - 2014
Computed tomography (CT) is routinely used in the evaluation of patients with pulmonary hypertension (PH) to assess vascular anatomy and parenchymal morphology. The introduction of dual-energy CT (DECT) enables additional qualitative and quantitative insights into pulmonary hemodynamics and the extent and variability of parenchymal enhancement. Lung perfusion assessed at pulmonary ...
Signorovitch James E JE Analysis Group, Inc., Boston, - - 2014
Abstract Background: Nilotinib and dasatinib have shown superior rates of molecular response (MR) compared to imatinib for the treatment of newly diagnosed chronic myeloid leukemia (CML) in chronic phase (CP). This study indirectly compares MR in patients taking nilotinib 300 mg bid with that in those taking dasatinib 100 mg ...
Ho Lin-Chen LC Department of Chemistry, National Taiwan University, Taipei, - - 2014
Developing novel multifunctional nanoparticles (NPs) with robust preparation, low cost, high stability, and flexible functionalizability is highly desirable. This study provides an innovative platform, termed unibody core-shell (UCS), for this purpose. UCS is comprised of two covalent-bonded polymers differed only by the functional groups at the core and the shell. ...
Ghalleb S S EXPERTOX Agency and Laboratory, 14 rue Godefroy Cavaignac, 75011, Paris, France; Ecole de Biologie Industrielle (EBI), 32 Bd du port, 95094, Cergy, - - 2014
Challenge test (CT) is essential to assure the efficiency of the preservative system in products. A previous study realized by our staff in 2012, carried out to evaluate the influence of three parameters (ethanol, pH and water) on the microbiological cosmetics products conservation. Following this work, a correlation between aw ...
Longstreth W T WT Jr Department of Neurology, University of Washington, Seattle, Washington; Department of Epidemiology, University of Washington, Seattle, - - 2014
To determine whether elderly people with different patterns of magnetic resonance imaging (MRI) findings have different long-term outcomes. Longitudinal cohort study. Cardiovascular Health Study. Individuals aged 65 and older were recruited (N = 5,888); 3,660 of these underwent MRI, and 3,230 without a stroke before MRI were included in these analyses. Cluster ...
Longo Dario L - - 2014
Chemical exchange saturation transfer (CEST) is a novel contrast mechanism for magnetic resonance imaging (MRI). CEST MRI selectively saturates exchangeable protons that are transferred to MRI detectable bulk water signal. MRI-CEST (pH)-responsive agents are probes able to map pH in the microenvironment where they distribute. To minimize confounding contrast agent ...
Jones Kyle M KM Biomedical Engineering Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ, - - 2014
A feed-forward loop involving lactic acid production may potentially occur during the formation of idiopathic pulmonary fibrosis. To provide evidence for this feed-forward loop, we used acidoCEST MRI to measure the extracellular pH (pHe), while also measuring percent uptake of the contrast agent, lesion size, and the apparent diffusion coefficient ...
Sehgal Nitasha N Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY, 14260, - - 2014
Despite decades of study of chromosome territories (CT) in the interphase nucleus of mammalian cells, our understanding of the global shape and 3-D organization of the individual CT remains very limited. Past microscopic analysis of CT suggested that while many of the CT appear to be very regular ellipsoid-like shapes, ...
Sebro Ronnie R Massachusetts General Hospital Imaging, 55 Fruit Street, Boston, MA, 02114, - - 2014
To investigate the threshold unenhanced CT density of adrenal nodules at which further evaluation with chemical shift MRI is unlikely to be definitive and therefore not helpful in further characterizing some indeterminate adrenal lesions. Retrospective evaluation of 44 adrenal lesions imaged with unenhanced CT and chemical shift MRI and followed ...
Bianchi Anthony - - 2014
Mild traumatic brain injury (mTBI) appears as low contrast lesions in magnetic resonance (MR) imaging. Standard automated detection approaches cannot detect the subtle changes caused by the lesions. The use of context has become integral for the detection of low contrast objects in images. Context is any information that can ...
Derlin Thorsten T Thorsten Derlin, Peter Bannas, Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, DE-20246 Hamburg, - - 2014
Medical imaging is of crucial importance for diagnosis and initial staging as well as for differentiation of multiple myeloma (MM) from other monoclonal plasma cell diseases. Conventional radiography represents the reference standard for diagnosis of MM due to its wide availability and low costs despite its known limitations such as ...
Aagaard-Kienitz B B Department of Radiology, University of Wisconsin, Madison, WI, - - 2014
Deep head and neck lesions are challenging to treat using conventional guidance, such as ultrasound (US) and fluoroscopy. High impedance structures prevent the use of US, while fluoroscopy lacks resolution of the targeted lesion. Recently developed tools allow the fusion of 3D MR images with low-dose DynaCT images of the ...
Swanberg J J Department of Radiology, Oncology and Radiation Sciences, Section of Radiology, Uppsala University Hospital, Uppsala, - - 2014
In patients with peripheral arterial occlusive disease, renal impairment is a common contraindication to iodine and gadolinium contrast media, which limits the utility of conventional computed tomography angiography (CTA) and magnetic resonance angiography (MRA). It is proposed that selective intra-arterial dual-energy CT-angiography (s-CTA), that is CTA with intra-arterial injection of ...
Yun Seong Jong SJ Department of Radiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, 149, Sangil-dong, Kangdong-gu, Seoul 134-727, - - 2014
Compared with 2-dimensional imaging, 3D-reformatted imaging is a valuable technique that offers improved anatomic accuracy with minimal flow artifact and thinner sections without gaps between slices. Our aim was to evaluate the usefulness of CE 3D T1-VISTA with fat suppression sequences compared with CE T1-TSE with fat suppression sequences in ...
Beiderwellen Karsten K Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany, - - 2014
To compare [(18) F]FDG PET/MRI with PET/CT for the assessment of bone lesions in oncologic patients. This prospective study included 67 patients with solid tumours scheduled for PET/CT with [(18) F]FDG who also underwent a whole-body PET/MRI scan. The datasets (PET/CT, PET/MRI) were rated by two readers regarding lesion conspicuity (four-point scale) ...
Millon Antoine A Department of Vascular Surgery, University Hospital of Lyon, 69000 Lyon, France CREATIS, UMR CNRS 5515, INSERM U630, Lyon University, 69000 Lyon, France - - 2014
Atherosclerosis, the main cause of heart attack and stroke, is the leading cause of death in most modern countries. Preventing clinical events depends on a better understanding of the mechanism of atherosclerotic plaque destabilization. Our knowledge on the characteristics of vulnerable plaques in humans has grown past decades. Histological studies ...
Kanazawa Ayumi A Department of Legal Medicine, Sapporo Medical University School of Medicine, - - 2014
An 80-year-old female was transferred to the hospital due to a traffic accident. Multiple cranial bone fractures with intracranial hemorrhage and intracranial air were detected. Despite treatment, the patient died after 6h. Twenty-one hours after the patient died, her whole body was scanned by postmortem CT, and a region of ...
Acar Yasemin Bahar YB a Resident, Department of Orthodontics, School of Dentistry, University of Marmara, Istanbul, - - 2014
Objective: To determine if density measurements of several maxillary regions in Hounsfield Units (HU) and outcomes of rapid maxillary expansion (RME) are correlated. Is correlation powerful enough to give us direct information about maxillary resistance to RME? Materials and Methods: Twenty-two computed tomographic (CT) scans (14 years) are used in ...
Gustafsson Björn B Center for Molecular Medicine, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, - - 2014
Maleylated bovine serum albumin is a known ligand for targeting macrophages and has potential as a carrier for molecular imaging purposes. We present a novel synthesis of glycolaldehyde-conjugated human serum albumin (GA-HSA) and maleylated human serum albumin (Mal-HSA). Seventeen modifications of fluorescently tagged GA-HSA and Mal-HSA molecules with different degrees ...
Kim Myeong-Hoon MH Department of Chemical and Biomolecular Engineering, College of Engineering, Yonsei University, Seoul, 120-749, Republic of - - 2014
Oleyl dextran-coated magnetic nanoclusters (ODMCs) are fabricated for the accurate detection of macrophage-rich atherosclerotic plaques using magnetic resonance (MR) imaging. Dextran is introduced to the cluster surface of magnetic nanocrystals (MNCs) through self-assembly using amphiphilic oleic acid-conjugated dextran (ODex) to provide not only hydrophilicity but also a high affinity to ...
Sigalov Alexander B AB SignaBlok Inc., Shrewsbury, MA, 01545, - - 2014
Magnetic resonance imaging (MRI) of macrophages in atherosclerosis requires the use of contrast-enhancing agents. Reconstituted lipoprotein particles that mimic native high-density lipoproteins (HDL) are a versatile delivery platform for Gd-based contrast agents (GBCA) but require targeting moieties to direct the particles to macrophages. In this study, a naturally occurring methionine ...
Wan Tao T Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio - - 2014
To develop a new spatio-temporal texture (SpTeT) based method for distinguishing vulnerable versus stable atherosclerotic plaques on DCE-MRI using a rabbit model of atherothrombosis. Aortic atherosclerosis was induced in 20 New Zealand White rabbits by cholesterol diet and endothelial denudation. MRI was performed before (pretrigger) and after (posttrigger) inducing plaque ...
Bradshaw Tyler J TJ Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin, Madison, - - 2014
In dose painting, in which functional imaging is used to define biological targets for radiation therapy dose escalation, changes in spatial distributions of biological properties during treatment can compromise the quality of therapy. The goal of this study was to assess the spatiotemporal stability of 2 potential dose painting targets-hypoxia ...
Dai Chun-Lai CL Chun-Lai Dai, Department of Radiology, the First Hospital of Jilin University, Changchun 130021, Jilin Province, - - 2014
To explore the characteristics of multi-slice computed tomography (CT) manifestations of hepatic epithelioid angiomyolipoma (HEA), improve the rate of accurate diagnosis, and reduce the misdiagnostic rate. The multi-slice CT manifestations in five patients who were diagnosed with HEA definitely by postoperative pathological examination were analysed retrospectively. Three female patients and ...
Whitesell Ryan T RT Department of Radiology and Imaging Sciences, Indiana University Health Methodist Hospital, 1701 N. Senate Blvd, Room AG-176, Indianapolis, IN, 46202, - - 2014
Intravascular thrombosis and thromboembolism are critical diagnoses which are frequently made on contrast-enhanced computed tomography (CECT) or Doppler ultrasound. For a variety of reasons, some patients with acute intravascular pathology are imaged using CT without intravenous contrast. In the acute setting, the increased Hounsfield unit (HU) density of the thrombus ...
Nguyen Tuyen H TH Translational and Molecular Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, New York, - - 2014
To determine if manganese (Mn) G8 dendrimers targeted to oxidation-specific epitopes (OSE) allow for in vivo detection of atherosclerotic lesions. OSE have been identified as key factors in atherosclerotic plaque progression and destabilization. Mn offers a potentially clinically translatable alternative to gadolinium-based agents when bioretention and potential toxicity of gadolinium ...
Moon Woo Kyung WK Department of Radiology, Seoul National University Hospital, Seoul, South - - 2014
A computational method was developed for the measurement of breast density using chest computed tomography (CT) images and the correlation between that and mammographic density. Sixty-nine asymptomatic Asian women (138 breasts) were studied. With the marked lung area and pectoralis muscle line in a template slice, demons algorithm was applied ...
Mohan Ravi Prakash Sasankoti RP Kothiwal Dental College and Research Centre, Moradabad, - - 2014
The incidence of multiple myeloma (MM) affecting the jaws is 30% and on rare occasions the oral involvement can be the first indication of the disease. Authors report a case of MM in a 40-year-old woman who presented with a multilocular radiolucent lesion in the left mandible initially mistaken as ...
Corcuera-Solano I I From the Department of Neuroradiology, The Mount Sinai Medical Center, New York, New - - 2014
Patients in the neurosurgical intensive care unit undergo multiple head CT scans, resulting in high cumulative radiation exposures. Our aim was to assess the acceptability of a dedicated, special-purpose sinogram-affirmed iterative reconstruction-based ultra-low-dose CT protocol for neurosurgical intensive care unit surveillance head CT examinations, comparing image quality with studies performed ...
Zheng Shaowei S Department of Radiology, the First Affiliated Hospital of Dalian Medical University, - - 2014
To assess the reliability of dual-energy CT (DECT) spectral imaging for the differentiation of bone metastases (BMs) from Schmorl's nodes (SNs) in the vertebrae of cancer patients. In this retrospective study, 102 cancer patients who underwent DECT (GE spectral CT Discovery CT750 HD scanner) had 110 low density vertebral lesions. ...
Zhao Q M QM Department of Cardiology, Beijing Anzhen Hospital Capital Medical University, Beijing, China - - - 2014
Aim: In vivo dynamic evaluation of atherosclerosis could be clinically significant in the prevention of cardiovascular events. We aimed to monitor Fluorine-18 fluorodeoxyglucose (18F-FDG) uptake in different stages of atherosclerosis, and investigate the feasibility of detecting vulnerable plaques using positron emission tomography/computed tomography (PET/CT) angiography. Methods: Twenty-two male NZW rabbits ...
Vesanen Panu T PT Department of Biomedical Engineering and Computational Science, Aalto University School of Science, P.O. Box 12200, FI-00076 AALTO, Finland. Electronic address: - - 2014
Electric current density can be measured noninvasively with magnetic resonance imaging (MRI). Determining all three components of the current density, however, requires physical rotation of the sample or current injection from several directions when done with conventional methods. However, the emerging technology of ultra-low-field (ULF) MRI, in which the signal ...
Milesi Gloria G Clinical Epileptology and Experimental Neurophysiology - - 2014
During development, the hippocampus undergoes numerous changes in its cell morphology and cyto- and myelo-architecture that begin during the fetal period and continue after birth. We investigated the developmental changes occurring in healthy fetal (20-32 gestational weeks) and post-natal human hippocampi (from 1 day to adulthood) by combining high-resolution 7T ...
Zhou Lixin - - 2014
Capsular warning syndrome (CWS) is rare (1.5% of TIA presentations) but has a poor prognosis (7-day stroke risk of 60%). Up to date, the exact pathogenic mechanism of CWS has not been fully understood. We report the clinical presentations and high-resolution MRI (HR MRI) findings of two cases with capsular ...
Li Jinghua J Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, People's Republic of - - 2014
A new fabrication protocol is described to obtain heparin and chitosan conjugated magnetic nanocomposite as a blood purification material for removal of low-density lipoprotein (LDL) from blood plasma. The adsorbent could be easily separated with an external magnet for recyclable use since it had a magnetic core. The LDL level ...
Beer Ambros J AJ Department of Nuclear Medicine, Technische Universität München, Munich, Germany. Electronic address: - - 2014
The goal of this study was to evaluate the feasibility of [(18)F]Galacto-RGD positron emission tomography (PET)/computed tomography (CT) imaging of αvβ3 expression in human carotid plaques. The integrin αvβ3 is expressed by macrophages and angiogenic endothelial cells in atherosclerotic lesions and thus is a marker of plaque inflammation and, potentially, ...
Pollack Daniel D Department of Podiatric Surgery, Wyckoff Heights Medical Center, Brooklyn, - - 2014
The purpose of this case study was to highlight a potential limitation of magnetic resonance imaging in diagnosing longitudinal tendon tears and to emphasize the importance of clinical examination for peroneal tendinopathy. We describe a 15-year-old female with lateral ankle pain, who was negative for peroneal tendon tear on magnetic ...
Aslam Anum A Division of Advanced Cardiovascular Imaging, Departments of Radiology and Cardiology, Stony Brook University Medical Center, Health Science Center, Level 4 Rm 120, Stony Brook, NY 11794, USA. Electronic address: - - 2014
The presence of calcified plaque in coronary arteries can be quantified by using 0.5-mm isotropic reconstructions from 320-row CT without increased radiation dose. Little is known about reclassification of patients with non-zero Agatston scores and quantitative measures of calcified plaque using 0.5-mm reconstructions. The aim was to compare proportions of ...
Brammen Lindsay L ISOTOPIX - Institute for Nuclear Medicine, Mariannengasse 30, A-1090, Vienna, Austria. - - 2014
Bural et al (2013), retrospectively investigated 143 subjects who received whole body fluorine-18-fluorodeoxyglucose- positron emission tomography ((18)F-FDG-PET) imaging for the assessment of non-cardiovascular diseases. They reported an increase of (18)F-FDG-positive lesions in various aortic segments, which increased with age, and were more pronounced in subjects being aged below 50 years ...
Winkel Leah C J - - 2014
The need for noninvasive imaging to distinguish stable from vulnerable atherosclerotic plaques is evident. Activated macrophages play a role in atherosclerosis and express folate receptor folate receptor β (FR-β). The feasibility of folate targeting to detect atherosclerosis was demonstrated in human and mouse plaques, and it was suggested that molecular ...
Parolini Cinzia - - 2014
AbstractThe aim of this study was to identify, by magnetic resonance imaging (MRI), the ability of the blood-pool contrast agent B22956/1 to detect atherosclerotic plaques developing at the brachiocephalic artery of apolipoprotein E knockout (apoE-KO) mice and to possibly identify vulnerable atherosclerotic lesions. After high-fat feeding for 8 or 12 ...
Chen Wei W Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, - - 2014
Specific morphologic features of hepatocellular carcinoma (HCC) on imaging have identifiable pathologic correlates as well as implications for altering surgical management and defining prognosis. In this study, we compared susceptibility-weighted imaging (SWI) to conventional techniques and correlated our findings with histopathology to determine the role of SWI in assessing morphologic ...
Chen H N HN Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou, - - 2014
This study aimed to verify the accuracy of low-field-intensity magnetic resonance imaging (MRI) in diagnosing meniscus tears. A total of 171 patients were examined through low-field-intensity MRI to detect meniscus injuries. These patients were then diagnosed through arthroscopy. Examination results were recorded and compared. The accuracy of the diagnosis for ...
Jung Caroline C 1Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf, Hamburg, - - 2013
-The aim of this study was to assess high density lipoprotein (HDL) labeled with superparamagnetic iron oxide nanoparticles (SPIOs) and quantum dots (QDs) for the detection of atherosclerotic lesions in mice after intravenous (iv) and intraperitoneal (ip) injection by multimodal imaging. -Nanoparticle labeled HDLs (NP-HDL) were characterized in vitro by ...
Jezovnik Mateja Kaja - - 2013
Inflammation plays a major pathogenetic role in the development of atherosclerotic plaques and related thromboembolic events. The identification of vulnerable plaques is of the utmost importance, as this may allow the implementation of more effective preventive and therapeutic interventions. Fluorodeoxyglucose positron emission tomography (FDG-PET) has been shown to be useful ...
Zheng Minwen M Department of Radiology, Xijing Hospital, Fourth Military Medical University, 127# West Changle Road, Xi'an 710032, Shaanxi Province, China. Electronic address: - - 2013
To assess the impact of low-concentration contrast medium on vascular enhancement, image quality and radiation dose of coronary CT angiography (cCTA) by using a combination of iterative reconstruction (IR) and low-tube-voltage technique. One hundred patients were prospectively randomized to two types of contrast medium and underwent prospective electrocardiogram-triggering cCTA (Definition ...
Ishino Seigo - - 2013
Intravascular ultrasonography (IVUS) and (18)F-FDG PET have been used to evaluate the efficacy of antiatherosclerosis drugs. These two modalities image different characteristics of atherosclerotic plaques, and a comparison of IVUS and PET images with histology has not been performed. The aim of this study was to align IVUS and PET ...
Spies Lothar - - 2013
A novel method is presented for fully automatic detection of candidate white matter (WM) T1 hypointense lesions in three-dimensional high-resolution T1-weighted magnetic resonance (MR) images. By definition, T1 hypointense lesions have similar intensity as gray matter (GM) and thus appear darker than surrounding normal WM in T1-weighted images. The novel ...
Xu Feng - - 2013
We present different findings on F-FDG PET/CT and F-NaF PET/CT images in 2 patients with multiple myeloma. In 1 case, F-FDG PET/CT showed intense uptake in the lesions in the axial skeleton where F-NaF PET/CT seemed normal. In addition, a sternal lesion showed FDG uptake only in the center but ...
Cerase Alfonso - - 2013
Evidence of areas of increased attenuation density within lateral ventricles at computed tomography (CT) of the brain is a finding of acute or subacute intraventricular hemorrhage. The purpose of this case report is to describe a 14-year-old female who presented with an episode of complicated migraine. Brain CT showed an ...
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