We have measured the endogenous TRH concentration in the pineal and 9 brain regions of a seasonal hibernator, the golden-mantled ground squirrel, during euthermia and hibernation in order to investigate the possibility that changes in TRH concentration might occur in association with naturally-occurring changes in CNS-mediated physiological and behavioral processes. ...

Interpretation of data on the possible relationship between changes in endogenous putative transmitters and neuropsychiatric disorders may be altered by the use of neuroleptic agents. As one approach to this problem, we attempted to simulate the situation in man by measuring the changes in dopamine in basal ganglia of monkeys ...

The fingernails of a woman with pachyonychia congenita were ablated by several different methods. The most effective, most rapidly performed, and most acceptable method was vigorous curettage and electrofulguration of the matrices and beds of the nails. The responses to treatment suggest that the matrix, rather than the bed, is ...

The biological aspects of cobalamin were studied in autopsy brains of eight elderly subjects who had lacked marked neurologic symptoms. Separation of the gray and white matter of the frontal and temporal lobes, and subsequently, subcellular fractionation of each matter were attempted. The contents of cobalamin and its binders and ...

The lining of the intestinal tract is constantly renewed in a brisk but orderly fashion. Further acceleration of cell renewal is elicited by various stimuli, notably surgical shortening of the intestine and hyperphagia, which lead to prompt but persistent increases in mucosal mass. Progressive hypoplasia ensues when the small and ...

The 1982 edition of the Laboratory Workload Recording Method manual will reflect a reduction in unit values assigned to some clinical chemistry procedures. In this article, the author explains why the changes have been made, what they mean, and offers guidelines on coping with the ever changing but valuable Workload ...

Prostaglandins E and F (PGE, PGF) and their 13,14-dihydro-15-keto metabolites were measured by radioimmunoassay in myometrium obtained from 27 women during abdominal hysterectomy for benign gynecologic conditions at defined stages of the menstrual cycle. Excepting the late secretory phase, when myometrial PGF concentrations were highest, the myometrial PGE concentration exceeded ...

Five obsessive-compulsive patients were treated for intrusive thoughts by three sessions of repetition of the thought. Within- and between-session changes in both frequency and subjective distress lent only partial support to the habituation and conditioned inhibition models which have been used to account for the effects of prolonged repetition. Alternative ...

Results of the studies reviewed suggest that hair represents a promising biopsy material to study trace element redistribution and changes in trace-element status during early infancy. Caution must be exercised in sampling and only proximal, recently-grown hair collected. Appropriate standard washing procedures must also be employed and sensitive analytical techniques ...

An experiment was conducted to determine if improvement in resolution acuity due to exercise was based on changes in sensory discrimination or decision criterion. Two subjects participated in 15 exercise sessions of 1100 kpm per min. On a bicycle ergometer and 5 control sessions. After each exercise and non-exercise condition, ...

Electrical stimulation of the crossed olivo-cochlear bundle (COCB) increases both the cochlear microphonic and the acoustically synchronized changing resistance (CR) and it causes a decrease in the electrical impedance of scala media of the guinea pig. The similarity between the change in CR due to COCB stimulation and the change ...

The exponential-relaxation rates (rate constant k) of relatively slow (ms) chemical reactions may change with applied potential. Three general cases are described which, by their dependencies on an externally applied voltage, should be experimentally separable. They are processes due to (1) permanent dipoles entirely in the field - - (d ...

We reviewed speech, language, and biographical data on 144 asphasic patients who had suffered left hemisphere cerebral vascular accidents. Using a step-wise multiple regression procedure, we attempted to predict change in severity of aphasia at three, six, and 12 months postonset based on performance at one, three, and six months ...

A tristimulus reflectance spectrophotometer was used to examine the color changes of nystatin during accelerated stability studies, and a relationship was observed between the loss of microbiological potency and the change in color during thermal degradation. By substitution of the measured tristimulus values in the Kubelka-Munk equation, the remission function ...

A colitis-like state induced in Guinea Pigs fed degraded carrageenan orally. By means of a combined semimacroscopic and histologic technique the course of the disease was followed during 28 days. The changes were primarily seen and became most prominent in the caecum. The first lesions were observed following 24 hours ...

The exercise stress test is evaluated in terms of epidemiological criteria including validity, reliability, safety, rapidity, cost, yield, and acceptability. Rigid criteria for the diagnosis of abnormality allow a high specificity and sensitivity. It is one of the safer medical examinations, and can be completed in three to nine minutes. ...

Twenty-one schizophrenic subjects, who had been neuroleptic-free, were tested for responsiveness to dopaminergic agonists: Apomorphine emesis threshold was determined and change in psychopathology after 0.5 mg/kg d-amphetamine orally was rated. The subjects' subsequent response to neuroleptic treatment were also determined. Sensitivity to apomorphine emesis was also determined in a nonschizophrenic ...

The effects of levonorgestrel-loaded plastic intrauterine devices on endometrial morphology were investigated in 15 rhesus monkeys for 14 weeks. The devices were designed to release 25 microgram of the hormone per day and were inserted in the uterus by hysterotomy. Control animals were sham operated or received inert placebo devices. ...

Diphenylhydantoin (DPH) induced changes in distal colon motility in the 37 subjects investigated. In subjects with sigmoidal hyperactivity plus rectal hypoactivity, DPH suppressed or reduced sigmoidal phasic activity. In subjects showing no sigmoidal activity predominance, DPH induced increases of sigmoidal and/or rectal motility. Sulpiride (an "atypical" dopaminergic blocking agent) antagonized ...

A unit is discussed which employs a pair of matched silicon diode detectors to check the constancy of the output, beam quality, field flatness, and symmetry of teletherapy equipment. The unit has proven useful, but the long-term stability of the diode-amplifier system must be considered, because two years of experience ...

Pattern-reversal VERs were studied during the visual impairment provoked by exercise in 2 patients with demyelinating optic neuritis. It was found that the transient reduction in visual acuity was correlated to a transient decrease in the amplitude of the major positive component of the VER, whereas no significant changes could ...

The main parameters of the vestibulo-ocular reflex (i.e. the gain or reflectivity, the long-time constant of the semicircular canals, the time constant of the mechano-neural transduction, and that of the central leaky integrator) were computed from the post-rotational nystagmic responses of unilateral Meniere's patients. Comparison with normal subjects showed a ...

Exercise-induced changes in hemostatic measurements were studied in 25 women. Twelve of the subjects were not using oral contraceptives and the remainder were using Demulen (ethynodiol diacetate (1 mg) and ethinyl estradiol (0.05 mg)). Exercise on a treadmill induced similar changes in both groups, but during the use of Demulen ...

The validity of probe tube microphone measurements in providing data indicative of the magnitude of the change in subjects' threshold resulting from changes in earmold configuration was investigated. The relationship between these measures in the real ear canal and the changes observed in 2-cm3 and Zwislocki couplers under similar circumstances ...

Isozyme profiles of lactic dehydrogenase (LDH) and creatine phosphokinase (CPK) were determined in cardiac tissue of mice during postnatal development. LDH isozymes 1 and 5 showed a definite developmental change, achieving the adult values by 20 days of age, while the other three isozymes showed no change. During the first ...

The pathological findings in tissues obtained from 6 patients with idiopathic neurotrophic feet are described. The salient features were those of a neuropathy characterized by gross demyelinization and marked changes in the distal blood vessels. The vascular changes included medial and intimal hypertrophy with luminal narrowing. It is proposed that ...

Alanine, starting from alanine-adenylate, has been polymerized in the presence of non-swelling Al-montmorillonite. The yield of polymerization is much lower than that obtained in the presence of swelling Na-montmorillonite. The possibility that the changing interlayer spacing in Na-montmorillonite might be responsible for its catalytic properties, is discussed.

The changes of the juxtaglomerular index values in the superficial, deep and whole cortical areas of rat kidneys after unilateral papillectomy were analyzed. On the papillectomized side the JGI values showed an increase in the deep, and a decrease in the superficial cortical zone. The changes proved to be significant ...

Electrically augmented acupuncture stimulation was applied to two volunteer subjects who presented with a variety of symptoms. The subjects were given osteopathic musculoskeletal examinations immediately before and after acupuncture stimulation. Prior to stimulation, both subjects were found to have musculoskeletal dysfunctions affecting a number of body regions. After acupuncture had ...

1. Nine healthy volunteers participated in a comparative study of the effects of nomifensine, nomifensine plus alcohol, and placebo plus alcohol, on aspects of psychomotor performance. 2. The study was carried out according to a Latin square design and each treatment was separated from the preceding treatment by 7 days. ...

Changes of the "representative" maximum spatial cardiac vector were followed daily from the 1st till the 3th postnatal day of life in a group of 70 guinea-pigs. This vector representing the spatial vectorcardiographic loop shifted gradually during the observation period from the right caudal quadrant to the left caudal quadrant ...

Etorphine and xylazine were found to be a safe and reliable drug combination for the immobilization of Père David's deer, whether excited or unexcited. Excited deer had a longer preimmobilization period, when compared with unexcited deer at comparable dosages. Generally, the acid-base status of Père David's deer during immobilization was ...

Investigations of serum total protein, albumin, alpha-1, alpha-2, alpha-2M, beta- and gamma-globulin changes are reported in 48 patients with craniocerebral trauma. Only alpha-2 and alpha-2M globulins showed important variations, the first rising to three to four times normal values (112% on average) and directly correlating with the amount of tissue ...

A total of 96, dated pregnant, New Zealand white rabbits were studied. In 58 animals the intrauterine pressure (IUP) of the unstimulated and PGF2alpha-stimulated myometrium was recorded, by the extraovular microballoon technique, before, during and after parturition. In the remaining 38 the concentrations of PGE and PGF and progesterone (P) ...

With gray scale ultrasonics echography, it is possible to identify changes in placental anatomy which formerly have been recognized only by examination of the placenta after delivery. By serial examinations these changes can be detected as they occur. The significance of the changes is discussed and an association between the ...

It has been proposed that the notable capacity for epileptogenesis in the hippocampus may be related to potassium accumulation in extracellular spaces. To investigate this hypothesis more directly, we measured changes in extracellular potassium concentration ([K+]o) during focal hippocampal epilepsy using potassium-sensitive microelectrodes. Interictal and ictal electroencephalographic events were accompanied ...

Mecholyl-stimulated flow from the excretory duct of the rabbit lacrimal gland in vivo was recorded continuously and samples of Mecholyl-stimulated fluid were collected before, during, and after 30 min of local intra-arterial infusion of 2,4-dinitrophenol (DNP). Compared with the control period, Mecholyl-stimulated flow during the DNP infusion was 60-70% less; ...

Swine adipose tissue was not responsive to glucagon at any age and only marginally to adrenocorticotropin (ACTH). The latter response could be greatly magnified and the sensitivity increased by addition of theophylline (Theo). The maximal lipolytic activity (MAX) obtained with ACTH plus Theo was minimal in the newborn, greatly increased ...

A review is given of the literature concerning the physiological and pathophysiological changes in humans, caused by sustained acceleration. After definition of the acting forces and an introduction into terminology, circulatory and respiratory mechanisms are described which are active under sustained acceleration. The origin of visual disturbances associated with acceleration ...

A method is described for automatic compensation of changes in geometry during monitoring of 133Xe-washout curves from subcutaneous depots. A 99mTc source is placed on the skin over the 133Xe depot, and both isotopes are counted simultaneously. Variations in the 99mTc activity (corrected for radioactive decay) reflects changes in counting ...

Pathological, histochemical and ultrastructural studies on 3 siblings with GM1 gangliosidosis type II are reported. These studies support a biochemical defect with profound deficiency of beta-galactosidases which results in widespread accumulation of the GM1 ganglioside and its asialo derivative in brain and to a lesser extent in viscera, as well ...

The modifications induced by the intrauterine release of copper in the macromolecular and glycoprotein composition of the proliferative and secretory human endometrium were studied. In addition, the endometrial changes produced in women users of copper-T intrauterine devices in the polysome pattern and in the content of ribonucleoprotein particles were determined ...

This study sought to determine whether changes in disfluency characteristics accompany biological and emotional changes during the menstrual cycle. Four extemporaneous speech samples were collected from each of 12 women, one at ovulation (when the average woman experiences her greatest feelings of self-esteem and self-confidence) and one at premenstruation (when ...

Physical: measurements of third-octave clicks (produced by ringing a commercial third-octave filter having a rejection rate of 50 dB in the first octave) show that waveform and spectral shape of the clicks remain the same through the range of audiometric frequencies. Auditory: relations between click and tonal thresholds are developed ...

Malabsorption of bile salts plays a major role in the pathogenesis of diarrhea after resection of the ileum, but the diarrhea usually improves with the passage of time. To test the hypothesis that this improvement may occur as a result of increased absorptive capacity for bile salts in the jejunal ...

The influence of postural changes on renal function was determined in 13 patients with nephroptosis and in 5 normal subjects by measuring GFR in the erect and supine positions. The results indicate that GFR was reduced in the erect position in 10 of 13 patients with either unilateral or bilateral ...

1. A statistical analysis has been made of the changes in the binomial parameters n and p during transmitter release from motor-nerve terminals when synapses are forming in either regenerating or reinnervated mammalian muscle.2. The amplitude-frequency distribution of e.p.p.s evoked by a single impulse was well predicted by binomial statistics ...

A growing colony of a mutant strain of Neurospora crassa had two morphologically distinct areas which were formed as a result of a rhythmic spore-forming (conidiation) process. The total pyridine nucleotide content of these two areas was the same, but the levels of NADH, NADPH, and NADP were lower in ...

Five asthmatics aged 25-30 were studied during bicycle ergometer and treadmill exercise. Metabolic and ventilatory changes during exercise were compared with the degree of bronchoconstriction which followed exercise. In all patients bronchoconstriction was greater after treadmill exercise. Contrary to previous suggestions, exercise-induced bronchoconstriction did not seem to be caused by ...

1. To obtain evidence on the relative importance of exercise and emotion in the cardiovascular changes of fighting in the cat, the changes during fighting were compared with changes during a mild non-emotional exercise (walking on a treadmill at low speed), and during confrontation without fighting (preparation for fighting), an ...