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Ludlow Andrew T - - 2012
We evaluated the impact of long-term exercise on telomere dynamics in wild-derived short telomere mice (CAST/Ei) over 1 year. We observed significant telomere shortening in liver and cardiac tissues in sedentary 1-year-old mice compared with young (8 weeks) baseline mice that were attenuated in exercised 1-year-old animals. In contrast, skeletal ...
Tendera Michal - - 2012
BACKGROUND: Anti-ischaemic effect of A1 adenosine receptor agonists was shown in animal and preclinical studies. The present proof-of-concept study aimed at evaluation of the efficacy and safety of a new adenosine A1 receptor agonist capadenoson in patients with stable angina. METHODS: This was a randomized, double-blind, placebo-controlled, single dose-escalating, multicenter ...
Xiong Ruohong - - 2012
The female reproductive system is highly sensitive to physiological stress. However, the mechanism(s) involved in dysfunction of the ovaries induced by high intensity exercise training remain unknown. In the present study, we established a rat model of high intensity exercise training, and investigated the morphological and functional changes in ovaries. ...
Carroll Chad C - - 2012
Chronic consumption of acetaminophen (APAP) during exercise training leads to a reduction in tendon stiffness and modulus when compared to a placebo. We explored whether this effect could be due to a reduction in tendon collagen content or cross-linking. Ten-week-old male Wistar rats (n=50) were divided into placebo or APAP ...
Petkus Vytautas - - 2012
BACKGROUND AND OBJECTIVE. A novel noninvasive monitor is presented by demonstrating its capabilities to perform the real-time estimation of dynamics in cerebrovascular autoregulation in athletes during their training. The aim was to explore the characteristics of human cerebrovascular autoregulation by performing the monitoring of cerebrovascular autoregulation responses to resistance exercises ...
Laker Rhianna C - - 2012
We have previously shown that 4 wk of exercise training early in life normalizes the otherwise greatly reduced pancreatic β-cell mass in adult male rats born small. The aim of the current study was to determine whether a similar normalization in adulthood of reduced skeletal muscle mitochondrial biogenesis markers and ...
Bada A A - - 2012
In dogs, manipulation of heart rate has no effect on the exercise-induced increase in cardiac output. Whether these findings apply to humans remain uncertain, because of the large differences in cardiovascular anatomy and regulation. To investigate the role of heart rate and peripheral vasodilatation in the regulation of cardiac output ...
Borgenvik Marcus - - 2012
This investigation was designed to evaluate changes in plasma and muscle levels of free amino acids during an ultra-endurance exercise and following recovery. Nine male ultra-endurance trained athletes participated in a 24-h standardized endurance trial with controlled energy intake. The participants performed 12 sessions of running, kayaking and cycling (4 × each ...
Jamart Cécile - - 2012
In this study, the coordinated activation of ubiquitin-proteasome pathway (UPP), autophagy-lysosomal pathway (ALP), and mitochondrial remodeling including mitophagy was assessed by measuring protein markers during ultra-endurance running exercise in human skeletal muscle. Eleven male, experienced ultra-endurance athletes ran for 24 h on a treadmill. Muscle biopsy samples were taken from ...
Kyriazis Stephanie M - - 2012
PURPOSE: Prevention of the female athlete triad is essential to protect female athletes' health. The aim of this study was to investigate the knowledge, attitudes and behaviours of regularly exercising adult females towards eating patterns, menstrual cycles and bone health. METHODS: A total of 191 female exercisers, aged 18-40 y, ...
Banzet Sébastien - - 2012
The iron regulatory peptide hormone hepcidin has been proposed to participate in training-induced iron deficiency. Plasma and urinary hepcidin increase in response to one bout of prolonged exercise, a condition also known to increase plasma interleukin-6 (Il-6). Because Il-6 activates hepcidin transcription and expression during inflammation, our aim was to ...
Foncea Hermann Zbinden - - 2012
PURPOSE: Toll-like receptors 2 and 4 (TLR2, TLR4) are found in the membrane of skeletal muscle cells. A variety of molecular components can activate TLR2 and TLR4, amongst others long chain fatty acids. The subsequent downstream signalling triggers the MAPK and NF-κB pathways. Therefore, the purpose of this study was ...
Hautala Arto - - 2012
Abstract We hypothesised that habitual physical activity (PA) together with progressive endurance training contributes to the differences in training response (Δ[Vdot]O(2max)) in healthy and physically active male participants. Twenty volunteers (age 30±3 years and [Vdot]O(2max) 54±7 ml·kg(-1)·min(-1)) participated in an eight-week training program which included four to six heart rate-guided ...
Sawyer Brandon J - - 2012
PURPOSE: This study was designed to determine whether VO2 reaches a maximum, equivalent to that attained in an incremental exercise test to exhaustion, during "submaximal" fatigue-inducing constant-power exercise bouts above Critical Power (CP). METHODS: Nine males (age: 24.6 ± 3.6 yr.; ht: 182.8 ± 6.9 cm; wt: 77.8 ± 12.1 ...
Di Luigi Luigi - - 2012
Phosphodiesterase type 5 inhibitors may influence human physiology, health, and performance by also modulating endocrine pathways. We evaluated the effects of a 2-day tadalafil administration on adenohypophyseal and adrenal hormone adaptation to exercise in humans. Fourteen healthy males were included in a double-blind crossover trial. Each volunteer randomly received two ...
Zhou Zhichao - - 2012
A significant endothelium-dependent vasodilation persists after inhibition of nitric oxide synthase (NOS) and cyclo-oxygenase (COX) in the coronary vasculature, which has been linked to the activation of cytochrome P450 (CYP) epoxygenases expressed in endothelial cells, and subsequent generation of vasodilator epoxyeicosatrienoic acids (EETs). Here, we investigated the contribution of CYP ...
Caruso John F - - 2012
Caruso, JF, Lutz, BM, Davidson, ME, Wilson, K, Crane, CS, Craig, CE, Nissen, TE, Mason, ML, Coday, MA, Sheaff, RJ, and Potter, WT. Salivary hormonal values from high-speed resistive exercise workouts. J Strength Cond Res 26(3): 625-632, 2012-Our study purpose examined salivary hormonal responses to high-speed resistive exercise. Healthy subjects ...
Ekstrom Richard A - - 2012
Ekstrom, RA, MS, Osborn, RW, Goehner, HM, Moen, AC, Ommen, BM, Mefferd, MJ, Bergman, TR, Molencamp, TB, and Kelsey, SA. Electromyographic normalization procedures for determining exercise intensity of closed chain exercises for strengthening the quadriceps femoris muscles. J Strength Cond Res 26(3): 766-771, 2012-The purpose of this study was to ...
Li Gebin - - 2012
Continuous high intensity training may induce alterations to enzyme activities related to glucose and lipid metabolism in horses. In our study, five Thoroughbred race horses (3 male and 2 female, avg age = 5 yrs old) were compared against five riding horses (1 male, 1 female, 3 gelding, avg age = 13 yrs old) in terms ...
Yan Wen-Wen - - 2012
There is no research, either at home or abroad, focusing on assessing the cardiopulmonary functional reserve and exercise tolerance in patients with pulmonary embolism (PE), but the benefits of early exercise are well recognized. The goals of this study were to assess cardiopulmonary functional reserve in treated PE patients using ...
Roman-Campos Danilo - - 2012
Hypertension leads to electrophysiological changes in the heart. Chronic exercise induced by a treadmill-running programme (TRP) is considered a potential non-pharmacological treatment for hypertension and may have implications in heart remodelling. However, it is not known whether the TRP is able to improve the electrophysiological properties of the heart in ...
Li Lu - - 2012
Aim:To investigate the effects of exhaustive swimming exercise on P2X1 receptor- and α1-adrenoceptor-mediated vasoconstriction of different types of arteries in rats.Methods:Male Wistar rats were divided into 2 groups: the sedentary control group (SCG) and the exhaustive swimming exercise group (ESEG). The rats in the ESEG were subjected to a swim ...
Oliver Gretchen D - - 2012
The RAZOR curl has been introduced as a hamstring exercise. However, modifications to the exercise have been developed which are proposed to utilize some of the muscles of the lumbo-pelvic-hip complex. Thus, it was the purpose of this study to quantitatively examine the modified RAZOR curl using surface electromyography (sEMG), ...
Radom-Aizik Shlomit S Pediatric Exercise Research Center, Department of Pediatrics, University of California Irvine, - - 2012
MicroRNAs are increasingly seen as targets of drug discovery because they influence gene function acting both to silence and subtly modulate protein translation. Little is known about effects of dynamic physiological states on microRNA regulation in humans. We hypothesized that microRNA expression in peripheral blood mononuclear cells (PBMCs) would be ...
Marqueti R C - - 2012
The indiscriminate use of anabolic-androgenic steroids has been shown to induce left ventricular dysfunctions. The main objective of the present study was to investigate the effects of nandrolone decanoate on matrix metalloprotease (MMP-2) activity and protein level in the left ventricle (LV) of rats after 7 weeks of mechanical load ...
Molmen Harald Edvard - - 2012
Abstract Objectives: To study the effect of aerobic interval training (AIT) on myocardial function in sedentary seniors compared to Master athletes (MA) and young controls. Design: 16 seniors (72 ±1 years, 10 men) performed AIT (4x4minutes) at ∼90% of maximal heart rate 3 times/ week for 12 weeks. Results were ...
Kanarek Robin B - - 2012
Exercise is endorsed for its physiological and psychological benefits, and has been proposed to have positive effects on impression formation. To test this proposal, 62 female and 44 male college students read one of three brief descriptions of either a fictitious male or female "target" student. The descriptions varied only ...
Huang Chi-Chang - - 2012
Antrodia camphorata (AC) is an endemic mushroom that grows in Taiwan. We investigated the fatigue-alleviating effects of AC on endurance capacity in swim-exercised and weight-loading mice. Male Institute of Cancer Research (ICR) strain mice from 3 groups (n = 10 per group in each test) were orally administered AC fruiting ...
Brancaccio Paola - - 2012
Experimental studies suggest that mineral waters with high concentrations of calcium and bicarbonate can impact acid-base balance. The purpose of this study was to test the effect on acid-base balance and specific urine gravity, of a bicarbonate calcic mineral water (Acqua Lete®) compared to a minimally mineralized water. 88 amateur ...
Larson-Meyer D Enette - - 2012
Nine female runners and ten walkers completed a 60 min moderate-intensity (70% VO(2)max) run or walk, or 60 min rest in counterbalanced order. Plasma concentrations of the orexogenic peptide ghrelin, anorexogenic peptides peptide YY (PYY), glucagon-like peptide-1 (GLP-1), and appetite ratings were measured at 30 min interval for 120 min, followed by a free-choice ...
de Almeida Júlio C - - 2012
In this minireview we describe the involvement of the atrial natriuretic peptide (ANP) in cardiovascular pathophysiology and exercise. The ANP has a broad homeostatic role and exerts complex effects on the cardio-circulatory hemodynamics, it is produced by the left atrium and has a key role in regulating sodium and water ...
Ostojic Sergej M - - 2012
Evidence exists regarding the potential role of exogenous nucleotides as regulators of the immune function in physically active humans, yet the potential use of nucleotides has been hindered by their low bioavailability after oral administration. We conducted a double-blind, placebo-controlled, randomized trial to assess the effect of sublingual nucleotides (50 mg/day) ...
Spradley Brandon D - - 2012
The purpose of this study was to determine the effects of the pre-workout supplement Assault™ (MusclePharm, Denver, CO, USA) on upper and lower body muscular endurance, aerobic and anaerobic capacity, and choice reaction time in recreationally-trained males. Subjective feelings of energy, fatigue, alertness, and focus were measured to examine associations ...
Sugama Kaoru - - 2012
The T-cell subset Th17 is induced partly by interleukin (IL)-6 and activated by IL-23, and produces a proinflammatory cytokine IL-17. Since IL-6 increases dramatically following long-lasting endurance exercise, this response may also stimulate the induction of IL-17 and IL-23 after exercise. The aim of this study was to clarify the ...
Vegge Geir - - 2012
The effect on performance of protein ingestion during or after exercise is not clear. This has largely been attributed to the utilization of different scientific protocols and the neglection of accounting for factors such as differences in physical and chemical properties of protein supplements and differences in athletic performance level. ...
Pasławska U - - 2012
The duration of electrocardiographic (ECG) parameters: PQ, QT and R-R intervals change during long-term and short-term observation as the consequence of the fluctuations in autonomic nervous system activity among others dependent on the exercise and resting. There is no data of horse breed influence on these parameters. The aim of ...
Sakakima Harutoshi - - 2012
Stroke disability stems from insufficient neurorepair mechanisms. Improvement of functions has been achieved through rehabilitation or therapeutic agents. Therefore, we combined exercise with a neurovascular protective agent, S-nitrosoglutathione (GSNO), to accelerate functional recovery. Stroke was induced by middle cerebral artery occlusion for 60 min followed by reperfusion in adult male ...
Wan Zhongxiao - - 2012
Glyceroneogenesis is an important step in the control of fatty acid re-esterification with PEPCK and PDK4 being identified as key enzymes in this process. We have previously shown that glyceroneogenic enzymes such as PDK4 are rapidly induced in white adipose tissue during exercise. Recent studies have suggested that IL-6 regulates ...
Williams Paul T - - 2012
The guideline physical activity levels are prescribed in terms of time, frequency, and intensity (e.g., 30 minutes brisk walking, five days a week or its energy equivalence) and assume that different activities may be combined to meet targeted goals (exchangeability premise). Habitual runners and walkers may quantify exercise in terms ...
Gerecke Kim M - - 2012
Exercise has been demonstrated to potently protect substantia nigra pars compacta (SN) dopaminergic neurons from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. One mechanism proposed to account for this neuroprotection is the upregulation of neurotrophic factors. Several neurotrophic factors, including Brain Derived Neurotrophic Factor (BDNF), have been shown to upregulate in response to exercise. ...
Tian Ye - - 2012
It has been shown that a suppressive protein, acting as an immune suppressor, is generated in animals and humans under particular stresses. However, studies related to immunosuppressive factors in response to the stress resulting from acute exercise are limited. This study compares the effects of pre- and post-exercise human serum ...
Williams Paul T - - 2012
Current physical activity recommendations assume that different activities can be exchanged to produce the same weight-control benefits so long as total energy expended remains the same (exchangeability premise). To this end, they recommend calculating energy expenditure as the product of the time spent performing each activity and the activity's metabolic ...
Fomin Åsa - - 2012
Sex comparisons between girls and boys in response to exercise in trained adolescents are missing and we investigated similarities and differences as a basis for clinical interpretation and guidance. A total of 24 adolescent females and 27 adolescent males aged 13-19 years underwent a maximal bicycle exercise stress test with ...
Ogasawara Junetsu - - 2012
In adipose cells, adipose triglyceride lipase (ATGL) catalyzes the first step in adipocyte triacylglyceride hydrolysis, thereby regulating both basal and hormone-stimulated lipolysis. However, little is known about the molecular mechanism(s) underlying habitual exercise-induced adaptive modulation of ATGL in white adipocytes via alteration in transcription regulator and lipolytic cofactors. Male Wistar ...
Howatson Glyn G School of Life Sciences, Northumbria University, Newcastle upon Tyne, UK ; School of Environmental Sciences and Development, Northwest University, Potchefstroom, South - - 2012
It is well documented that exercise-induced muscle damage (EIMD) decreases muscle function and causes soreness and discomfort. Branched-chain amino acid (BCAA) supplementation has been shown to increase protein synthesis and decrease muscle protein breakdown, however, the effects of BCAAs on recovery from damaging resistance training are unclear. Therefore, the aim ...
Rowe Glenn C GC Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of - - 2012
Exercise confers numerous health benefits, many of which are thought to stem from exercise-induced mitochondrial biogenesis (EIMB) in skeletal muscle. The transcriptional coactivator PGC-1α, a potent regulator of metabolism in numerous tissues, is widely believed to be required for EIMB. We show here that this is not the case. Mice ...
Da Pureza Demilto Yamagushi - - 2011
Introduction: We evaluated the role of cardiovascular autonomic changes in hemodynamics at rest and in response to exercise in streptozotocin-induced diabetic rats. Methods: Male Wistar rats were divided into nondiabetic (ND, n = 8) and diabetic (D, n = 8) groups. Arterial pressure signals were recorded in the basal state ...
An Minjeong - - 2011
ABSTRACT: This review evaluated the effects of balance and/or gait exercise interventions for stroke survivors and summarized the available evidence on these exercise interventions. A search for studies published between January 2001 and January 2010 was performed using the keywords stroke, walking or balance, and physical activity or exercise. Seventeen ...
Fuchs Therese - - 2011
Sudden death in athletes can occur during sport activities and is presumably related to ventricular arrhythmias. There are no guidelines concerning athletes who develop ventricular arrhythmias during an exercise test. It is unclear whether they should be allowed to continue with their competitive activity or not. To investigate the long-term ...
Bhutkar Milind V - - 2011
The purpose of the present study was to evaluate effects of regular practice of sun salutation on muscle strength, general body endurance and body composition. Subjects (49 male and 30 female) performed 24 cycles of sun salutation, 6 days a week for 24 weeks. Upper body muscle strength was determined ...
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