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Results 551 - 600 of 880
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Tisdale J E - - 1996
The primary objective of this study was to determine the effect of esmolol, administered alone and in combination with lidocaine, on ventricular fibrillation threshold (VFT) in pigs. A secondary objective was to determine the relationship between blood esmolol concentrations and VFT. We determined VFT using a train of electrical stimuli ...
Petty R - - 1996
BACKGROUND AND OBJECTIVES: Epidural air bubbles are known to persist for more than 24 hours after injection. Nitrous oxide may cause expansion of these bubbles. METHODS: Nine dogs were anesthetized. Ten mL air and 9 mL of iophendylate were injected into the lumbar epidural space. Control animals (n = 3) ...
Storella R J - - 1996
PURPOSE: These studies were intended to resolve the conflict between the reasonable inference from the scientific literature that atropine might alter neuromuscular fade and the expectation from informal clinical experience that it does not. METHODS: We examined the effect of a high concentration of atropine (20 microM) on moderate neuromuscular ...
Marx T - - 1996
BACKGROUND: Improvement of working conditions and anaesthesia with closed systems includes reduction of gas leaks during anaesthesia. One source of contamination is the permeation of gases through plastic materials. The volume of gas permeating through a polymer depends on its molecular structure, the solubility and the diffusion coefficient. METHODS: We ...
Hans P - - 1996
We studied the time-course of action of atracurium 0.5 mg kg-1 and rocuronium 0.6 mg kg-1 in 24 healthy adult patients. Anesthesia was induced with thiopentone and sufentanil, and maintained with 50% nitrous oxide and 1% enflurane in oxygen. Neuromuscular transmission was monitored by stimulating the ulnar nerve at the ...
Rödig G - - 1996
We have examined the dose-related effects of sevoflurane and isoflurane on systemic vascular resistance (SVR) during cardiopulmonary bypass (CPB) in patients undergoing elective coronary artery surgery. Fifty-two patients were allocated randomly to one of six groups to receive 1.0, 2.0 or 3.0 vol% (inspiratory) sevoflurane or 0.6, 1.2 or 1.8 ...
Liu J - - 1996
BACKGROUND: The electroencephalogram (EEG) has been used to study the effects of anesthetic and analgesic drugs on central nervous system function. A prospective study was designed to evaluate the accuracy of various EEG parameters for assessing midazolam-induced sedation during regional anesthesia. METHODS: Twenty-six consenting adult patients were administered 4.5-20 mg ...
Li S - - 1996
Anesthesia was induced with intravenous thiopental, fentanyl, and succinylcholine, and maintained with isoflurane, N2O-O2 and atracurium after denitrogenation in 20 adult patients. Inspired and end-tidal concentrations of O2, N2O, CO2, isoflurane and oxygen saturation of pulse oximeter (SpO2) were monitored. After intubation, N2O (750 ml/min) and O2 (250 ml/min) were ...
Brunner M D - - 1996
We have studied the arousal effect of suxamethonium on the auditory evoked response (AER) of the electroencephalogram (EEG) in 40 ASA I and II patients during isoflurane anaesthesia. After induction of anaesthesia, the patient's lungs were ventilated for 20 min with 0.6 MAC end-expiratory isoflurane (0.59-0.77% depending on the age ...
Walker T J - - 1996
The amount of desflurane required to maintain an end-expired concentration of 8% was measured in 30 ASA 1 and 2 patients undergoing elective spinal surgery. The anaesthetic was administered using a computer-controlled closed circle system. After an initial period during which the expired concentration of desflurane was stabilised (4 min) ...
Saitoh Y - - 1995
The purpose of this study was to compare the pattern of recovery from vecuronium 0.07 mg.kg-1 induced neuromuscular blockade using post-tetanic burst count (PTBC)-(three short tetanic bursts of 0.2 msec duration every 20 msec given every second following a tetanus), and post-tetanic count (PTC)-(0.2 msec single twitch stimuli given every ...
Rundshagen I - - 1995
Median nerve somatosensory evoked responses (MnSSER) were recorded in 15 healthy adult patients, ASA I-II, before and during orthopaedic surgery. After induction of anaesthesia with fentanyl 0.1-0.15 mg, etomidate 0.3 mg kg-1 and vecuronium 0.1 mg kg-1, anaesthesia was maintained with 0.6% isoflurane (end-tidal) and 66% nitrous oxide in oxygen. ...
Belant J L - - 1995
The effectiveness of isoflurane as an inhalation anesthetic for muskrats (Ondatra zibethicus) was evaluated. Thirty muskrats were anesthetized in an enclosed chamber using 10 ml of isoflurane in Carlton County, Minnesota (USA), from 27 September to 24 October 1994. Mean (+/- SE) induction time for adults, juveniles, and kits was ...
Antognini J F - - 1995
We investigated the ability of isoflurane to ablate cardiovascular responses to a noxious stimulus (dew-claw clamp) in 10 goats during isoflurane delivery throughout the body and with selective delivery to either the head or torso. Whole-body minimum alveolar anesthetic concentration (MAC) and the concentration blocking autonomic responses (MAC-BAR) were determined. ...
Das S K - - 1995
In pedius anaesthesia system, oxygen enriched air and air are generated through an electrically driven oxygen generator 'Permox', obviating the need of compressed gas cylinder or pipe line. Effect of anaesthesia with pedius A anaesthesia system using ketamine or halothane with muscle relaxant in 2 groups of patients had been ...
Fang Z X - - 1995
Carbon dioxide absorbents, such as soda lime and Baralyme brand absorbent, convert sevoflurane to CF2 = C(CF3)OCH2F, a vinyl ether called "Compound A," whose toxicity raises concerns regarding the safety of sevoflurane in rebreathing circuits. Because an increased inflow rate to an anesthetic circuit decreases rebreathing, we assumed that an ...
Loan P B - - 1995
We studied 50 ASA I-II patients, aged 18-65 yr, undergoing elective orofacial surgery. Anaesthesia was induced with fentanyl and propofol, and maintained with 66% nitrous oxide in oxygen and either desflurane or isoflurane to compare recovery characteristics and cardiovascular stability. Cardiovascular responses to induction, intubation and incision were similar with ...
Kirkegaard-Nielsen H - - 1995
During general anesthesia, different modes of nerve stimulation are used for estimation of the degree of neuromuscular blockade. When switching between the different modes, it is important to know whether the preceding mode influences the responses to the succeeding mode, and if so, for how long. The object of our ...
McMurphy R M - - 1995
Eight adult cats, 4 male and 4 female, (3.5 +/- 0.9 [SD] kg) were used to determine the minimum alveolar concentration (MAC) of desflurane. Desflurane (DES) anesthesia was induced in a 20 L chamber with an oxygen inflow of 10 L/min and the DES vaporizer set at 18%. After 3.5 ...
Masuda A - - 1995
Although the depressive effect of sevoflurane on ventilation has been reported, its potency and mode of action on the neural respiratory activity is still unclear. Therefore, the effects of sevoflurane on the phrenic nerve discharge and the respiratory timing were compared with those of halothane. The efferent activity of the ...
Wing D A - - 1995
OBJECTIVE: Our purpose was to compare the safety and efficacy of intravaginal misoprostol versus intracervical prostaglandin E2 gel (dinoprostone) for preinduction cervical ripening and induction of labor. STUDY DESIGN: Two hundred seventy-six patients with indications for induction of labor and unfavorable cervices were randomly assigned to receive either intravaginal misoprostol ...
Cervin A - - 1995
The effect of halothane on mucociliary activity in the rabbit maxillary sinus in vivo was recorded photoelectrically. Administration of halothane (1%, 2% or 4%) into the maxillary sinus induced a temporary acceleration of mucociliary activity. The peak increase (39.1% +/- 9.1%, p < 0.05, n = 5) was seen after ...
Andress J L - - 1995
This study investigated the potential for multiple exposures of propofol to induce oxidative injury, in the form of Heinz body production, to feline red blood cells. Anesthesia was induced in six healthy cats with propofol (6 mg/kg, intravenous [IV]) and maintained for 30 minutes with a propofol infusion (0.20 to ...
Brattebø G - - 1995
Reports have indicated that there are less postoperative complaints after the use of pencil pointed spinal needles. We compared a 24G Sprotte needle with a 27G Quincke needle in a randomised study of 200 healthy patients (49% females), aged 15-46 years. Four patients (2%) reported postdural puncture headache, three with ...
Hinrichs J E - - 1995
A small laser doppler probe with an outside diameter comparable to a conventional periodontal probe (0.5 mm) was developed. The objectives of this investigation were to determine if intrasulcular laser doppler readings (LDR): 1) are reproducible; 2) can detect vascular changes associated with trauma from probe placement; 3) were reproducible ...
Lukas S E - - 1995
The present study was conducted to determine if there is a neurophysiological correlate of marihuana-induced good effects or euphoria. Three groups of 6 male occasional marihuana smokers were prepared for electroencephalographic (EEG) recording and smoked either placebo or marihuana cigarettes containing 1.26% or 2.53% delta 9-tetrahydrocannabinol (delta 9-THC) in a ...
Imai M - - 1995
STUDY OBJECTIVES: To evaluate the circulatory effects of fiberoptic intubation with a newly developed mask adapter and to compare these effects with those obtained with a conventional laryngoscope and laryngeal mask airway with general anesthesia. DESIGN: Randomized study. SETTING: Operating room at a university hospital. PATIENTS: 30 ASA physical status ...
Kalman S H - - 1995
The azeotropic mixture of halothane and diethyl-ether has been claimed to be a suitable anaesthetic agent for use during difficult conditions because of its negligible effect on circulation and ventilation. The purpose was to evaluate the effect of halothane-diethyl-ether azeotrope (HE) and isoflurane (ISO) on ventilation. 12 patients scheduled to ...
Donaldson D - - 1995
This investigation compared the use of a 5% eutectic mixture of local anesthetics (EMLA) cream to a "standard" intraoral topical anesthetic (5% lidocaine) as a means of anesthetizing the gingival sulcus in a double-blind, split-mouth study with human volunteers. A 5-min application of EMLA in a customized intraoral splint resulted ...
Giunta F - - 1995
The breath-by-breath monitoring of anesthetic gases can provide information, beyond the usual safety control. The study of the decay and concentration effects along the circuit can be useful to evaluate their kinetics. The presence of unexpected gases coming from the patient's tissues is another important topic. By means of gas ...
Schneider L J - - 1995
Intraspinal air has been described in patients undergoing diagnostic lumbar puncture and epidural analgesia, as a manifestation of degenerative disk disease, and after less common mechanisms, such as blunt trauma [1], strenuous exercise [2], and pelvic trauma [3]. We report a case of spinal epidural emphysema incidentally noted on CT ...
Kirkegaard-Nielsen H - - 1995
With double burst stimulation (DBS) it is possible to monitor more profound degrees of neuromuscular blockade than with train-of-four stimulation (TOF). It may therefore be indicated to change between DBS and TOF stimulation during moderate to profound degrees of neuromuscular blockade. Consequently, the aim of the study was to evaluate ...
McCoy E P - - 1994
The use of rocuronium (Org 9426) as a single bolus followed by an infusion was assessed in 50 patients under anaesthesia with nitrous oxide-oxygen and halothane. Neuromuscular block was monitored using train-of-four stimulation and recording the force of contraction of the adductor pollicis muscle. Rocuronium was administered in an initial ...
Newman P J - - 1994
Sevoflurane, a new volatile inhalational agent, undergoes biotransformation to fluoride which is potentially nephrotoxic. We compared the effects of sevoflurane or isoflurane anaesthesia on hepatorenal function and serum fluoride concentrations in 50 ASA 1-3 patients undergoing major intra-abdominal surgery. No patient developed renal or hepatic dysfunction. Mean (SEM) peak fluoride ...
Carl P - - 1994
Eltanolone, a new intravenous steroid anaesthetic agent was administered intravenously in a dose of 0.6 mg.kg-1 over 45 s to eight healthy male volunteers to evaluate some of its pharmacokinetic and pharmacodynamic effects. Drug concentration-time data were analysed by PCNONLIN, a non-linear regression programme, showing data consistent with a three-compartment ...
Sepúlveda M S - - 1994
During November and December of 1988, 1990, and 1991, a total of 22 free-ranging Juan Fernández fur seal (Arctocephalus philippii) females from Alejandro Selkirk Island, Juan Fernández Archipelago, Chile, were immobilized with a combination of ketamine and diazepam. Atropine sulphate was used to decrease respiratory secretions. The mean (+/- SD) ...
Gin T - - 1994
BACKGROUND: Minimum alveolar concentration (MAC) is decreased in pregnant animals, but this change has not been demonstrated in humans, probably because of ethical considerations. It is less problematic to determine MAC in pregnant women undergoing termination of pregnancy, however, and therefore we compared the MAC of isoflurane in these women ...
Marini R P - - 1994
Effects of isoflurane on the CBC in ferrets were studied. There was rapid decrease in all hematologic variables after induction of anesthesia. Percentage reductions in indices of the erythron (hematocrit, RBC count, hemoglobin concentration) exceeded those of plasma protein concentration and WBC count at the first postinduction time point. There ...
van den Elsen M J - - 1994
BACKGROUND: Differences in results studying the effects of subanesthetic concentrations of volatile agents on the hypoxic ventilatory response may be related to the conditions under which the subjects were tested. In this study we investigated the effects of 0.1 minimum alveolar concentration (MAC) of isoflurane on the hypoxic ventilatory response ...
Smith D C - - 1994
We have examined the correlation between serum concentrations of catecholamines and the evoked electromyographic (EEMG) response from the first dorsal interosseous muscle of the hand in 20 patients during minor surgery under propofol or enflurane anaesthesia without neuromuscular blocking drugs. The supinated forearm, with the wrist fully extended, was strapped ...
Naguib M - - 1994
BACKGROUND: Rocuronium is a new nondepolarizing neuromuscular blocking agent with a rapid onset but with intermediate duration of action. Mivacurium, on the other hand, is a new short-acting nondepolarizing neuromuscular relaxant, but of slower onset of action. The current study was undertaken to characterize the interaction between rocuronium and mivacurium. ...
Kimura T - - 1994
The purpose of this study was to determine both the concentration of sevoflurane required for tracheal intubation (MACEI) and its minimum alveolar anesthetic concentration (MAC) in adults. The study group consisted of 86 elective surgical patients, ASA physical status I or II, aged 16-59 yr. There was no premedication administered. ...
Hood J R - - 1994
Tubocurare (0.125 mg.kg-1 or 0.25 mg.kg-1) was injected 10 s before 1 mg.kg-1 suxamethonium in patients anaesthetised with enflurane 1-1.5%. Measurement of electromyographic response was recorded using a 0.2 Hz train-of-four every 20 s. The modified blocks were slower in onset, of lesser intensity, and of shorter duration than that ...
Ozaki M - - 1994
BACKGROUND: There are significant physiologic differences between spinal and epidural anesthesia. Consequently, these two types of regional anesthesia may influence thermoregulatory processing differently. Accordingly, in volunteers and in patients, we tested the null hypothesis that the core-temperature thresholds triggering thermoregulatory sweating, vasoconstriction, and shivering are similar during epidural and spinal ...
Deutschman C S - - 1994
We propose to study the bradycardia associated with propofol anesthesia. Ten women undergoing laparoscopy for benign disease were studied using ambulatory electrocardiogram monitoring. Anesthesia was induced with an intravenous bolus of propofol and maintained with an infusion. After ventilation using positive pressure via a mask for 5 min, relaxants (succinylcholine ...
Lee J G - - 1994
The effects of volatile anesthetics on red blood cell flow in the cerebral microcirculation have not been compared. We used laser-Doppler flowmetry, which measures red blood cell flow in the microcirculation to compare the effects of differing concentrations of isoflurane and halothane on cerebrocortical microcirculation. Sprague-Dawley rats were anesthetized with ...
Oshita S - - 1994
To gain a better understanding of the direct actions of halothane on myocardial function in ischaemia, we studied the effects of increasing extracellular potassium concentration and decreasing extracellular pH (acidosis), alone or in combination with halothane, on the contractile force and resting tension in isolated atria. Guinea pig left atria ...
Morita T - - 1994
We have examined the interactions of 1 MAC of isoflurane and sevoflurane (and 66% nitrous oxide in oxygen) with vecuronium, using the EMG response of the abductor digiti minimi to train-of-four (TOF) stimulation of the ulnar nerve. We constructed dose-response curves for vecuronium in 54 patients. The curves for both ...
Schaefer H G - - 1994
One hundred ASA grade 1 and 2 patients requiring orotracheal intubation for various general surgical procedures were randomly assigned to receive either expert rigid laryngoscopic or novice fibreoptic orotracheal intubation under total intravenous anaesthesia. Five anaesthesia residents in the 4th year, with no prior experience in fibreoptic laryngoscopy, participated in ...
Achenbach-Ng J - - 1994
There are few data in the EEG literature describing the time course of hyperventilation-(HV) induced changes in blood gases, despite this being a routine activating procedure. We studied changes in blood gases and EEG in nine normal adult subjects before, during, and after HV. The mean PCO2 fell 18 mm ...
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