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Segal R - - 1983
In the present investigation, the hemolytic properties of T-2 toxin were examined. Tests with different concentrations of T-2 toxin showed that essentially complete hemolysis of rat erythrocytes commenced after a lag period, the length of which depended on the concentration of toxin. Comparison of the characteristics of hemolysis caused by ...
Charache S - - 1983
Although sickle cells have increased intracellular viscosity, the viscosity of patient's blood is usually not increased, because of the low hematocrit typically found in such patients. When patients receive transfusions, their exercise capacity increases, but it is unclear whether the change is due primarily to increased hemoglobin concentration, or also ...
Werstiuk E S - - 1983
Combined treatment with haloperidol and lithium is a frequently employed strategy for the treatment of acute psychoses. Although this combination regime is safe in most clinical situations, under certain circumstances it has resulted in neurotoxicity, with organic brain syndrome, and ultimately, in some patients, irreversible brain damage and death. Plasma ...
White J C - - 1983
Computer modeling has been a valuable tool for clarifying the mechanism of action of antifolates. Some consequences of folyl and antifolyl polyglutamate synthesis can be addressed by adaptation of a network thermodynamic computer model of methotrexate action. Reversal or prevention of methotrexate cytotoxicity by 5-formyltetrahydrofolate has widely been assumed to ...
Butler W M - - 1982
Five members of a new family with hemoglobin Osler are described. Exercise studies were performed before and after phlebotomy in one patient. These studies demonstrated that anaerobic threshold was directly related to hematocrit. Our data suggest that the elevation of red cell mass seen with this high oxygen affinity hemoglobin ...
Fassett R G - - 1982
Midstream urine samples were examined by phase-contrast microscopy before and immediately after 48 subjects participated in a long-distance run. Minor abnormalities were found in six samples before exercise. Eighteen subjects developed proteinuria and five haematuria on dipstick testing after exercise. Forty-four subjects had increased urinary red-cell counts after exercise; of ...
Rotstein A - - 1982
The influence of a short, supramaximal task of 30 s duration on plasma volume (PV) was tested in 14 female physical education students. Hemoglobin (Hb), hematocrit (Hct), and osmolality (Osm) were tested pre- and post-exercise. Performance of the exercise test, consisting of 30 s all-out pedaling against a load of ...
Konstam M A - - 1982
We studied the effect of exercise on blood radiotracer concentration after technetium-99m in vivo red blood cell labeling. After red blood cell labeling, 13 subjects underwent maximal supine bicycle exercise. Radioactivity, analyzed with a well counter, was measured in heparinized venous blood samples drawn at rest and during peak exercise. ...
Tomasik M - - 1982
Glucose utilization by the erythrocytes, lactic acid concentration in the blood and erythrocytes, and haematocrit value were determined before exercise and during one hour rest following maximal exercise in 97 individuals of either sex differing in physical efficiency. In the investigations reported by the author individuals with strikingly high physical ...
Coombe D R - - 1982
Haemolymph was collected from colonies of Botrylloides leachii killed at various times after injection with sheep or chicken erythrocytes and the agglutination titre for sheep, chicken and guinea-pig erythrocytes was determined. Controls included haemolymph from groups of uninjected colonies and from others injected with balanced salt solution. Animals given a ...
Platt O S - - 1982
We describe a steady-state patient with sickle cell anemia (SS disease) who developed sporadic hemoglobinuria, historically related to vigorous exercise. We studied him and four other patients with SS disease and demonstrated exercise-induced hemoglobinemia. To see if SS erythrocytes were abnormally fragile when exposed to shear forces that could be ...
Vial H J - - 1982
The metabolism of phospholipids in synchronous Plasmodium falciparum-infected erythrocytes was studied over one cycle of 48 h by the incorporation of labeled palmitate, serine, choline, and myo-inositol into cellular lipids. The rates of incorporation of palmitate and serine into total phospholipids and of choline into phosphatidylcholine (PC) were linear with ...
Klein H G - - 1982
Eighteen subjects with sickle cell disease underwent automated partial red cell exchanges while hospitalized as part of a research protocol. Using either a discontinuous-flow or a continuous-flow cell separator, we were able to accomplish a 50% exchange in an adult in approximately two hours. Transfusion of blood with an antigenic ...
Vieira H F - - 1982
1. Hemoglobin from terrestrial and an aquatic amphibia Bufo paracnemis and Pipa pipae respectively both living in the same region (Belém, Pará) were compared. 2. The number of hemolysate components were determined by starch-gel electrophoresis and CMC-chromatography. P. pipae hemoglobin presented 4 components and B. paracnemis 2, all of anodic ...
Thiriot C - - 1982
In this work, we studied the influence of whole-body gamma irradiation (8 Gy) upon oxygen transport by erythrocytes, through the erythrocyte count and related parameters, and through the factors affecting the oxygen affinity of hemoglobin. The oxygen affinity of hemoglobin is increased from day D + 5 after irradiation, and ...
de Boisfleury Chevance A - - 1982
We report the case of a 5 1/2-year-old Congolese girl with homozygous sickle cell anemia and hereditary persistence of fetal hemoglobin (Hemoglobin S 88%, Hemoglobin A2 2%, Hemoglobin F 10%). She presented marked enlargement of the spleen, descending into the left iliac fossa and producing significant hypersplenism with thrombocytopenia as ...
DeSimone J - - 1981
Previous studies have shown that the magnitude of the fetal haemoglobin (Hb F) response to haemolytic anaemia and hypobaric hypoxia in the baboon is specific to an animal ('high and low Hb F responders'), suggesting that the Hb F response is under genetic control. In this study Hb F levels ...
Latman N S - - 1981
A literature survey revealed many reports implicating the microclimate and seasonal changes in arthritic diseases. Therefore, a retrospective study of the erythrocyte sedimentation rate (ESR) and the C-reactive protein (CRP) concentration of 2,802 rheumatoid arthritis (RA) was performed. No statistically significant fluctuation was found when analyzed according to the month ...
Platt O S - - 1981
A patient with xerocytosis was found to have swimming-induced intravascular hemolysis and shortening of erythrocyte life-span. In a microviscometer, xerocytes were more susceptible than normal erythrocytes to hemolysis by shear stress. Fractionation of normal and abnormal cells on discontinuous Stractan density gradients revealed that increasingly dehydrated cells were increasingly more ...
Boucher J H - - 1981
The erythrocytes of 14 conditioned horses participating in a 157-km endurance ride (requiring 14-21 h) were examined before the ride, immediately upon entering the 44-91-, and 130-km rest stops, and at the finish. At the first rest stop (44 km), the mean erythrocyte count increased 41% (P less than 0.001), ...
Giampieri M P - - 1981
A quantitative analysis of lipocytes (fat-storing cells, Ito cells) has been conducted on needle liver biopsies of 8 subjects without hepatic impairment. The mean volume density of lipocytes was 1.88 +/- 0.25% of parenchymal volume, and the number of lipocytes per 1,000 hepatocytes (Ito cell index) was 63.45 +/- 19.18. ...
Meen H D - - 1981
Previous studies of the influence of physical exercise on erythrocyte 2,3-DPG have shown conflicting results, including that exercise induces increase, decrease or no changes in 2,3-DPG. Assuming that the interplay between the factors governing 2,3-DPG metabolism may change considerably during the early phase of recovery after exercise, the level of ...
Ataullakhanov F I - - 1981
The mathematical modelling of human erythrocyte energy metabolism has shown that stabilization of ATP concentration can be achieved if the curve representing the relation between glycolysis rate and ATP concentration (glycolysis characteristic) is bell-shaped with steeply descending part at physiologically normal ATP concentration. The glycolysis characteristic of human erythrocytes has ...
Chao T L - - 1981
The contribution of the high molecular weight hemoglobin (HMW Hb) to the antisickling effect produced by treatment of sickle cell erythrocytes with methyl acetimidate (MAI) was investigated. Erythrocytes obtained from sickle cell anemia and normal individuals were incubated with varying concentrations of MAI. The presence of intermolecularly crosslinked HMW Hb ...
Miller D M - - 1980
Ten patients with sickle cell anemia underwent partial exchange transfusion with hemoglobin-A-containing cells using a technique that allowed hemoglobin concentration and blood volume to remain constant. The mean fraction of hemoglobin-A in these patients increased from 9% to 55%, but the mean hemoglobin concentration increased by only 1.44 g/dl. The ...
Fisher D D - - 1980
The objective of this study was to determine the effects of certain environmental and genetic factors on selected hematologic characteristics of beef cows under wintering and grazing conditions in the Northeast. Packed cell volume PCV, hemoglobin concentration (Hb), RBC count, and WBC count were determined in serial blood samples collected ...
Buckley D E - - 1980
Erythrocyte and leucocyte numbers and cyclic AMP content were monitored weekly in a mentally defective short-cycle manic-depressive woman. The erythrocyte count remained relatively constant but cyclic AMP content when manic was significantly higher than when depressed, and the mood and biochemical data appeared to have the same periodicity, with coincident ...
Markiewicz K - - 1980
The reported investigations were carried out in 6 young (20 years old) healthy males who performed a 10-minute exercise on a Monark cycle ergometer at workloads increasing the heart rate to 170/minute. Before the exercise, after its termination, and after 30 minutes of restitution the concentrations of adenosine-5' triphosphate, adenosine-5' ...
Klein J P - - 1980
We assessed hemoglobin affinity for oxygen (standard P50: pH 7.40, PCO2 40 Torr, temperature 37 degrees C) in 3 series of studies of 16 male subjects who performed exhaustive treadmill exercise of 10 min duration. Standard P50 was significantly elevated (0.7--2.5 Torr) during the last minute of and for 30 ...
Nagata H - - 1980
The present study was designed to examine the osmotic resistance of erythrocytes measured by a new method-Coil Planet Centrifuge under the glutaraldehyde incubation, and to determine free cholesterol and adenine nucleotide contents of glutaraldehyde-treated erythrocytes compared with that of control erythrocytes. Glutaraldehyde increased the osmotic resistance of erythrocytes. Hemolysis end ...
Gazenko O G - - 1980
Four experiments were carried out with mammals (white laboratory rats) in Kosmos biosatellites. The experimental results indicate that rather prolonged weightlessness does not cause pathological changes in internal organs. Changes were discovered in the metabolic and hormonal status of the organisms, allowing us to consider an 18-22-day space flight as ...
Haralambie G - - 1980
Sixteen young adults were investigated before, immediately after and 24 h after swimming 5,200 +/- 618 m in 90 min. Mean pulse rate at the end of exercise was 151.3 min-1; skin and rectal temperature both slightly increased. Except for a marked leukocytosis, no changes were observed in other blood ...
Honig C R - - 1980
Erythrocyte-containing capillaries were counted in dog gracilis muscles freeze-clamped at rest and after twitch contraction at 4/s. In each of 21 muscles, 6--8 blocks were examined at -70 degrees C without fixation or staining; 15 fields were counted per block. Frequency analysis of capillaries per field based on the negative ...
Böswart J - - 1980
The effect of physical exercise on erythrocyte 2,3-diphosphoglycerate (2,3-DPG) content was studied in eight trained speed canoeists aged 15-25 years. One-stage-4-min load on a paddling ergometer corresponding to a 1 km race was observed. During the test, the following cardiorespiratory parameters were recorded: V, VO2, VO2/kg, HR, VO2/HR, R. Blood ...
Ockelford P A - - 1980
Hb Volga (beta 27 Ala replaced by Asp) on the basis of physical tests is only a mildly unstable hemoglobin yet it is associated with a gross reticulocytosis. This is partly explicable by an increased oxygen affinity with a compensating erythrocytosis but there is also brisk hemolysis. It is not ...
Radomski M W - - 1980
Hematological changes were studied in physically fit young soldiers who marched 35 km/d for 6 d, working at 35% of their Vo2 max. Four days of marching produced decreases in numbers of erythrocytes (RBC) and in hematocrit (Hct). This "sports anemia" persisted beyond day 6 into the post-march period and ...
Remes K - - 1979
A statistically significant 10% increase (p less than 0.005) in mean red cell 2,3-diphosphoglycerate (2,3-DPG) concentration, concomitantly with a mean 16% increase (p less than 0.001) in the predicted maximal oxygen uptake (VO2max) was observed in 29 recruits, who were studied during 6 months of physical training in military service. ...
Talstad I - - 1979
The relationship between the erythrocyte sedimentation rate (ESR) and plasma proteins was studied within homogenous clinical material and in vitro models. In acute phase reactions, fibrinogen was the likely cause of the ESR-elevation, but there were significant associations between the ESR and the concentrations of alpha 1-antitrypsin, C3, haptoglobin and ...
Karsh J - - 1979
Four patients with active, severe rheumatoid arthritis were subjected to the removal of circulating lymphocytes (lymphapheresis) for a 6-week period by use of a continuous flow cell centrifuge. Repetitive venous access was gained through forearm arteriovenous fistulae. In all patients the Ritchie-Camp articular index declined rapidly in the first week ...
Tomasik M - - 1979
A group of 27 canoeists from the national team and 35 subjects beginning training in a sports discipline were subjected to investigations for determination of glucose utilization by erythrocytes, and the level of lactic acid in these cells and in serum. Furthermore, erythrocyte count and haematocrit value were determined in ...
Walsh L - - 1979
Serum C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) were compared in 241 patients with rheumatoid arthritis (RA). There was a positive linear correlation between the 2 measurements with a high degree of variability. Neither age nor duration of RA had a detectable influence. The relationship between CRP and ...
Ramsey J M - - 1979
Since increases of erythrocytic 2,3-diphosphoglycerate (2,3-DPG) have been shown to enhance the release of oxygen from hemoglobin, experiments were designed to evaluate the response of 2,3-DPG to two different work-loads in 13 fasted human subjects. No signficant mean change in 2.3-DPG was found following 16 min of strenuous exercise on ...
Charache S - - 1978
Blood from carriers of hemoglobin Osler (Hb Osler) had almost the same oxygen affinity as that of carriers of Hb McKees Rocks (Hb MR) (P50 10-11 mm Hg), but Hb concentrations were higher in male carriers of the former (21.6 versus 17.2 g/dl). Two carriers of each Hb were studied ...
D'Addamio G H - - 1978
Hematologic parameters were determined at capture and during captivity for nine-banded armadillos. Compared to the time of capture, the mean erythrocyte counts were significantly lower after 6 months in captivity. After 1 year in captivity, the mean hematocrit was significantly higher and the mean neutrophil count in males was significantly ...
McKinney R J - - 1978
The linearity and repeatability of measurements of total haemoglobin concentration ([Hb]) and oxygen saturation (So2) by the OSM2 oximeter have been studied. Standard deviations (SD) of measurements from linearity were as follows: [Hb], 4.2 g . litre-1; So2, 1.14 to 1.08% between zero and 100% saturation. Reproducibility by a single ...
Fishbein W N - - 1978
Five cases of a new disease presented with muscular weakness or cramping after exercise; three of the cases also had an elevated serum creatine phosphokinase. Muscle biopsies were histologically normal but lacked adenylate deaminase by stain and solution assay, while the erythrocyte isozyme was normal. A clinical diagnostic test has ...
Sztobryn M - - 1978
In 79 swimmers aged 13--15 years the concentration of 2,3-DPG was determined in the erythrocytes at rest and 1 minute after the end of 7 minutes of submaximal exercise on an arm ergometer. In the examined subjects no significant changes were found in 2,3-DPG concentration in the erythrocytes. A non-significant ...
Kraan W J - - 1978
Determination of the dog's splenic storage volume without surgical procedures requires measurement of both circulating and total red cell volumes. The estimation of circulating red cell volume by radioisotope techniques is impeded by the rapid uptake of tagged cells in the spleen. The circulating cell volume might be calculated from ...
Carney M W - - 1978
Serum folate and B12 estimations were carried out on 272 admissions to a psychiatric unit during 1972 and 1973. 21.3% had serum folate below 2 ng/ml and 26.1% serum B12 below 150 pg/ml. The organic psychosis patients had a significantly lower mean B12 than the others, and were over-represented among ...
Assoku R K - - 1978
The possibility that the extreme refractoriness of the chicken to injected endotoxin would permit the buildup of sufficient free endotoxin in the circulation to immunologically modify the erythrocytes in vivo and thereby cause them to be eliminated from the circulation was investigated. It was shown that a moderately severe immunohaemolytic ...
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