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Veskoukis Aristidis S - - 2008
The aim of this study was to examine the effect of allopurinol, a xanthine oxidase inhibitor, on oxidative stress and physical performance after swimming until exhaustion in rats. Blood and gastrocnemius muscle samples were collected before, immediately after, and 5 h after exercise and the respective timepoints after allopurinol administration. ...
Breckenridge Mark T - - 2009
To better understand the mechanism controlling nonmuscle myosin II (NM-II) assembly in mammalian cells, mutant NM-IIA constructs were created to allow tests in live cells of two widely studied models for filament assembly control. A GFP-NM-IIA construct lacking the RLC binding domain (DeltaIQ2) destabilizes the 10S sequestered monomer state and ...
Geusens B - - 2009
The aim of this work was to develop a system that can deliver siRNA into cells present in the human epidermis. More specifically, we wanted to block the expression of a specific Myosin Va exon F containing isoform that is physiologically involved in melanosome transport in human melanocytes. Therefore, we ...
Cole Russell - - 2008
The O(2) transport from mixtures of commercially produced hemoglobin-based O(2) carriers (HBOCs) and red blood cells (RBCs) flowing through arteriolar-sized (25-mum) conduits is simulated. A generalized treatment of extraluminal O(2) transport processes is used to reflect variations in physiological conditions, such as increased O(2) consumption. Of the HBOCs considered, polymerized ...
Skripchenko Andrey - - 2008
BACKGROUND: The activation marker CD40 ligand (CD40L) has recently been demonstrated to be released from the cytoplasm of platelets (PLTs) during storage. CD40L may be associated with some adverse transfusion reactions including febrile responses and transfusion-related acute lung injury. CD62P has been traditionally measured to assess PLT activation. This study ...
Caretti Anna - - 2008
Activation of the NO/cGMP pathway modulates smooth muscle cells relaxation and hence vasoconstriction, a major hindrance for the use of cell-free haemoglobin (Hb) as blood substitute, despite conjugation with 5-kDa maleimide poly(ethylene)-glycol (PEG) reduces vasoconstriction in vivo. We aimed at assessing how a recently developed PEGylated-Hb (Deoxy-PEGHb) and manipulation of ...
Votion, Dominique
At present, the relative severity of the bleeding in exercise-induced pulmonary hemorrhage (EIPH) is better evaluated using scoring methods based on tracheobronchoscopic assessment of bleeding or red blood cells (RBCs) count in broncho-alveolar lavage (BAL). However, misinterpretation might happen with tracheobronchoscopic examination when the hemorrhage is tiny as well as ...
Lukas J M - - 2008
The present study examines the relationship between the bulk tank somatic cell count (SCC) mean and sigma (an estimate of variation) and the probability of exceeding a SCC standard. Daily or every other day, bulk tank SCC data were collected for 24 mo from 1,501 herds. Mean and sigma were ...
Kramer Debora L - - 2008
Recent studies suggest that overexpression of the polyamine-acetylating enzyme spermidine/spermine N(1)-acetyltransferase (SSAT) significantly increases metabolic flux through the polyamine pathway. The concept derives from the observation that SSAT-induced acetylation of polyamines gives rise to a compensatory increase in biosynthesis and presumably to increased flow through the pathway. Despite the strength ...
Tripette Julien - - 2007
OBJECTIVE: To determine if the time courses of hemorheologic parameters are different between carriers of sickle cell trait (SCT) and subjects with normal hemoglobin in response to exercise. DESIGN: Observational and comparative study. SETTING: Testing was conducted in a laboratory of exercise physiology. PARTICIPANTS: Nine carriers of sickle cell trait ...
Craig S K - - 2008
The magnitude and pattern of the hematocrit (Hct), hemoglobin (Hb), and plasma volume (PV) responses during and upon recovery from two resistance training protocols based on either a ten-repetition maximum (10 RM) or five-repetition maximum (5 RM) resistance was examined. Twelve college-aged male resistance exercise trainers were equally divided between ...
Marlin Laurent - - 2008
This study investigated the cardioventilatory responses during heavy exercise in sickle cell trait carriers (SCTc) and subjects with normal hemoglobin (control group). Eight SCTc and six control subjects repeated three incremental exercise tests (Iet) separated by 10-min recoveries. Cardioventilatory parameters were analyzed at rest and during the first and third ...
Uzoaru, S C; ;
The aim of this work is to study the relevance of physiology and pathophysiology in blood rheology as effects of triphasic exercise. Regular exercise which has been established as life prolonging has led to decrease in both peripheral vascular and coronary morbidity that has been associated with certain improvements in ...
López-Domínguez Alejandra - - 2007
Cell swelling, regulatory volume decrease (RVD), volume-sensitive Cl(-) (Cl(-) (swell)) current and taurine efflux after exposure to high concentrations of urea were characterized in fibroblasts Swiss 3T3, and results compared to those elicited by hyposmotic (30%) swelling. Urea 70, 100, and 150 mM linearly increased cell volume (8.25%, 10.6%, and ...
Kohler Götz - - 2007
Intracellular/extracellular lactate (Lac) distribution has been determined before in human and animal erythrocytes (red blood cells [RBCs]) with various methods. However, all previous methods determine intra- and extracellular Lac separately or indirectly. Now, (13)C-NMR spectroscopy has been used to monitor intra- and extracellular Lac simultaneously in intact RBCs. Isolated human ...
Mocny Jeffrey C - - 2007
Colonization by Bordetella bronchiseptica results in a variety of inflammatory respiratory infections, including canine kennel cough, porcine atrophic rhinitis, and a whooping cough-like disease in humans. For successful colonization, B. bronchiseptica must acquire iron (Fe) from the infected host. A vast amount of Fe within the host is sequestered within ...
Lowe, Timothy Edward
Restricted Item. Print thesis available in the University of Auckland Library or available through Inter-Library Loan. Stress responses to exercise were compared for two tropical teleosts. The sweetlip emperor (Lethrinus chrysostomus), a relatively active species, increased plasma catecholamines after 1 min exercise. Exhaustive exercise increased hematocrit (Hct) and hemoglobin (Hb) ...
Iwaki Hiroshi - - 2007
Continuous monitoring of hematocrit with a CRIT-LINE monitor (CLM) is used to prevent excess ultrafiltration during hemodialysis and continuous renal replacement therapy. The presence of substances affecting the scattering and absorption rates of multiple wavelengths of near infrared rays of CLM in the blood may affect the measured values with ...
Sulowicz Wladyslaw - - 2007
BACKGROUND: C.E.R.A., a continuous erythropoietin receptor activator, is in development to provide anemia correction and stable maintenance of hemoglobin (Hb) levels at extended administration intervals in patients with chronic kidney disease (CKD). This study examined its efficacy and safety when administered up to once monthly in patients who have CKD ...
Jeong Hae Jin - - 2007
To explore the feeding ecology of the Pfiesteria-like dinoflagellate (PLD) Luciella masanensis (GenBank Accession no. AM050344, previously Lucy), we investigated the feeding behavior and the kinds of prey species that L. masanensis fed on and determined its growth and ingestion rates of L. masanensis when it fed on the dinoflagellate ...
Cinar Vedat - - 2007
The effects of magnesium supplementation on blood parameters were studied during a period of 4 wk in adult tae-kwon-do athletes at rest and exhaustion. Thirty healthy subjects of ages ranging in age from 18 to 22 yr were included in the study. The subjects were separated into three groups, as ...
Singbartl G - - 2007
AIM: To improve efficacy of preoperative autologous blood donation (i.e. increase in total RBC-mass) it is important to know those clinical parameters that are of decisive impact for it. METHODS: Prospective study in 704 patients scheduled for major orthopaedic surgery. Donation of either one or two separately collected RBC-units, and ...
Kalciene Virginija - - 2007
Elemental sulphur (as S0 and S8) is abundant in anaerobic sediments and soil, and is highly toxic in the Vibrio fischeri bioluminescence test. This mode of S0 action remains uncertain. The objective of this research was the analysis of the toxic effects of S0 on bioluminescence and respiration in V. ...
Bansal Ila - - 2007
BACKGROUND: Extracellular potassium concentration (K(+)) increases in the supernatant of whole and packed red blood cell units (pRBCs) with duration of refrigerated storage in citrate-phosphate-dextrose-adenine (CPDA-1) and additive solution (AS). Studies have shown that to avoid hyperkalemia, washed pRBCs are preferred if relatively fresh pRBCs are not available. To determine ...
Yusof Ashril - - 2007
Whether structural changes of the erythrocyte membrane increase the susceptibility to hemolysis particularly of the relatively older cell population during the early phase of a 216-km ultrarace was tested in six male runners (age 53.6 +/- 10.4 yr, height 175.8 +/- 11.1 cm, body mass 75.9 +/- 8.4 kg). Erythrocyte ...
A.K. Mohammed
Thirty-six <I>Bunaji</I> work bulls aged 4 to 6 years old, belonging to 18 agropastoral farmers in Kaduna State, Nigeria were used to investigate changes in haematological and serum biochemical parameters before and immediately after farmland ridging exercise. Significant (p< 0.01) elevations in Packed Cell Volume (PCV), Red Blood Cell (RBC), ...
A.K. Mohammed
Thirty-six &lt;I&gt;Bunaji&lt;/I&gt; work bulls aged 4 to 6 years old, belonging to 18 agropastoral farmers in Kaduna State, Nigeria were used to investigate changes in haematological and serum biochemical parameters before and immediately after farmland ridging exercise. Significant (p&lt; 0.01) elevations in Packed Cell Volume (PCV), Red Blood Cell (RBC), ...
Connes Philippe - - 2007
Exercise and lactate usually change blood rheology, particularly red blood cell (RBC) deformability. The effect of lactate on RBC aggregation is unknown. The present study tested the in vivo effects of exercise on both lactate and RBC aggregation and the in vitro effects of lactate on RBC aggregation. Thirteen well ...
Gotthardt M - - 2007
AIM: Ultrasound may be a cheap alternative to scintigraphic determination of splenic function. We directly compared nanocolloid scintigraphy (NS), scintigraphy with heat-altered erythrocytes (ES), and colour-coded Doppler sonography (DS) in patients with chronic inflammatory bowel disease (CIBD). PATIENTS, METHODS: 35 patients were included into the study. Clearance rates were determined ...
Rovira S - - 2007
This research assesses the relative contribution of splenic contraction and fluid shifts out of the vascular compartment to the increases in packed cell volume associated with Agility exercises. It also aims to evaluate the changes in the concentrations of electrolytes and markers of hydration state. Fifteen dogs of both sexes ...
Drouin Jacqueline S - - 2006
BACKGROUND: Erythrocyte changes from aerobic exercise training were examined during radiation treatment of breast cancer. METHODS: Twenty sedentary females with breast carcinoma who were ages 35 to 65 years were randomized to aerobic exercise (AE) of walking for 20 to 45 minutes, 3 to 5 times per week, at 50% ...
Richards Ross S - - 2007
BACKGROUND: It has been hypothesized that a link exists between erythrocyte metabolism (particularly redox metabolism) and erythrocyte shape and that both are related to erythrocyte deformability. The aim of this research is to confirm the results of earlier studies and to investigate a correlation between erythrocyte morphology and erythrocyte oxidative ...
Ferreira Leonardo F - - 2007
The aim of this study was to examine the effects of assuming constant reduced scattering coefficient (mu'(s)) on the muscle oxygenation response to incremental exercise and its recovery kinetics. Fifteen subjects (age: 24 +/- 5 yr) underwent incremental cycling exercise. Frequency domain near-infrared spectroscopy (NIRS) was used to estimate deoxyhemoglobin ...
Bayly W M - - 2006
REASONS FOR PERFORMING STUDY: Horses experience major perturbations in acid-base balance during supramaximal exercise. Ion movement in and out of erythrocytes (RBCs) is believed to be important in maintaining acid-base balance but it is unclear as to the extent to which this happens, nor how it affects single measurements of ...
Sterns Richard H - - 2006
Hyponatremia exerts most of its clinical effects on the brain. An acute onset (usually in <24 hours) of hyponatremia causes severe, and sometimes fatal, cerebral edema. Given time, the brain adapts to hyponatremia, permitting survival despite extraordinarily low serum sodium concentrations. Adaptation to severe hyponatremia is critically dependent on the ...
Grose Heather L - - 2006
BACKGROUND: An automated cell processing system (ACP 215, Haemonetics Corp.) can be used for the glycerolization and deglycerolization of RBC components, but the components must be 6 or fewer days old. Depending on the anticoagulant (CP2D)/additive solution (AS) used, deglycerolized RBCs can be stored at 1 to 6 degrees C ...
Madison Barry N - - 2006
Nitrite (NO2-) is a toxic intermediary of the bacterial oxidation of nitrogenous wastes (e.g. ammonia) in an aquatic environment. It becomes most lethal when oxygen becomes limited due to high fish densities or in the presence of high bacterial activity due to waste build-up-both situations commonly found in intensive aquaculture. ...
Connes Philippe - - 2006
This study compared the hemorheological profile at rest and in response to a short supramaximal exercise test between sickle cell trait (SCT) carriers and a control group. Eight SCT carriers and eight control subjects performed a ramp exercise test on a cycle ergometer conducted to maximal oxygen uptake (VO2max). One ...
Tsukanaka, Atsuko
TSUKANAKA, A, UMEMURA, Y, ISHIKO, T, and MATUI, N, Changes in Serum Haptoglobin Concentration by Treadmill-running and Ergometer-cycling. Adv. Exerc. Sports Physiol, Vol.6, No.1 pp.1-6, 2000. The purpose of this study was to investigate 1) whether footstrike impacts induce hemolysis, and 2) whether runner's erythricytes are more fragile than those ...
Bush Jill A - - 2006
This study was the first study to examine the three circulatory biocompartments (plasma, white blood cell layer (WBC) and red blood cell layer (RBC)) and determine PF concentrations before and after exercise. Proenkephalin peptide F (PF) is an enkephalin-containing peptide found predominantly within the adrenal medulla. PF is co-packaged with ...
Rodriguez-Proteau R - - 2006
The hypothesis tested was that specific flavonoids such as epicatechin gallate, epigallocatechin gallate, genistein, genistin, naringenin, naringin, quercetin and xanthohumol will modulate cellular uptake and permeability (P(e)) of multidrug-resistant substrates, cyclosporin A (CSA) and digoxin, across Caco-2 and MDCKII-MDR1 cell transport models. (3)H-CSA/(3)H-digoxin transport and uptake experiments were performed with ...
Petroianu G A - - 2006
Oximes are cholinesterase reactivators of use in poisoning with organophosphorus compounds. Pralidoxime (PRX) is used clinically as an adjunct to atropine in such exposure. Clinical experience with PRX (and other oximes) is, however, disappointing and routine use has been questioned. In addition it is known that oximes are not equally ...
Hess J R - - 2006
BACKGROUND: Red blood cell (RBC) storage solutions work in a narrow pH range between 7.2 and 6.4. While keeping RBC within that pH range, ATP production can be increased by buffering or dilution. STUDY DESIGN AND METHODS: In the first study, 12 units of packed CP2D RBCs were pooled in ...
Julian David - - 2005
Sulfide-tolerant marine invertebrates employ a variety of mechanisms to detoxify sulfide once it has entered their bodies, but their integumentary, respiratory epithelium and circulatory cells may still be exposed to toxic sulfide concentrations. To investigate whether sulfide exposure is toxic to mitochondria of a sulfide-tolerant invertebrate, we used the fluorescent ...
Temiz Artmann A - - 2006
Erythrocytes (RBC) from untrained male Wistar rats and rat glomerular endothelial cells (EC) were used to investigate the effects of acute exercise (speed: 20 m/min, slope: 0, duration: 1 hour) on RBC membrane protein oxidation and adhesion to cultured EC. Experimental animals were divided into juvenile (age 10 weeks) and ...
Beneke Ralph - - 2005
The pathophysiology of exercise related haemolysis is not thoroughly understood. We investigated whether exercise related haemolysis (1) is associated with alterations of red blood cell (RBC) membrane proteins similar to those found in inherited anaemic diseases, (2) can be induced with a non-running exercise mode, (3) is related to exercise ...
Petibois Cyril - - 2005
BACKGROUND: We tested the hypothesis that endurance training may reduce exercise oxidative stress damage on erythrocytes. METHODS: Fifteen subjects performed a standardized endurance exercise at 75% of maximal oxygen consumption weekly during a 19-week training period. Blood samples taken before and after exercise were analyzed by Fourier transform-infrared (FT-IR) spectrometry ...
Petibois Cyril - - 2005
We tested the hypothesis that usual exercise oxidative stress strongly affects erythrocytes viability. A 120-min physical exercise with progressive intensity was used as a model of oxidative stress. FT-IR spectrometry was used to determine structural changes in erythrocyte contents (phospholipids, proteins, lactate, and glucose) from blood samples taken every 20 ...
Monchanin Géraldine - - 2005
PURPOSE: This study investigated hemorheological parameters in response to exercise in sickle cell trait (SCT) athletes with or without alpha-thalassemia METHODS: Six athletes with SCT (HbAS), 7 athletes with SCT and alpha-thalassemia (HbASAT), and 10 control athletes (HbAA) performed a progressive and maximal exercise test on cycloergometer. Blood viscosity (etab), ...
Kayatekin Berkant Muammer - - 2005
This study aimed to determine whether high-dose antioxidant supplementation had an impact on the acute exercise effects related to erythrocyte membrane mechanics. Experimental animals (n=32) were divided into four groups as control, exercised, supplemented, and supplemented + exercise. Four-week antioxidant supplementation (vitamin C, vitamin E, and zinc) was applied to ...
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