During the past several years, Jerapan Krungkrai, H. Kyle Webster and Yongyuth Yuthavong have characterized the metabolic pathway of folate biosynthesis and folate-dependent reactions, including the cobalamin-dependent activity of methionine synthase, in P. falciparum grown in vitro. In this review, they discuss the implications of this work for understanding the ...

The suitability of 75 sunglasses for use by patients receiving 8-methoxypsoralen photochemotherapy (PUVA) was assessed by measuring their ultraviolet radiation (UVR) transmission spectra and comparing the results with some published proposed spectral limits. The sunglasses were classified according to whether their lenses were polarised, photochromic, reflective, graduated tint or of ...

Three times daily administration of isosorbide dinitrate may avoid much of the tolerance seen with more frequent dosing. To determine the daylong pattern of the antianginal effect of three times daily isosorbide dinitrate, eight men with stable exertional angina and a positive exercise test were studied. The subjects had demonstrated ...

Kinetic aspects of threonine (Thr) metabolism were examined in eight pigs fed hourly with a diet containing either 0.68% (LT group) or 0.81% (HT group) of Thr (wt/wt), corresponding to 10 and 30% Thr excess, respectively, compared with an "ideal" diet. Primary production (PR) and disposal (DR) rates were obtained ...

A 9 year old boy with intractable postprandial reflex vomiting was taught a self hypnotherapy technique incorporating relaxation exercises, mental imagery, and suggestions of symptom relief. The sequence was recorded on a personal stereo cassette tape. Vomiting was completely eliminated within four weeks. At 12 month review vomiting had not ...

Tissue factor activity (TFA) of leukemic cells (1 x 10(8) cells/mL) was measured in 44 patients with acute nonlymphoid leukemia (ANLL) by the one-stage assay using factor-IX deficient plasma (OSA-dIX) and two-stage assay (TSA). According to the preventative heparin dose schedule based on the TFA measured by the TSA, all ...

Diurnal effects on periodic exercise were examined in 8 male divers wearing passive thermal protection during whole body immersions in 5 degrees C water for periods of up to 6 h. Studies were done during the course of 5-day air saturation dives at a depth of 1.61 ATA, with immersions ...

The luminol-enhanced chemiluminescence of zymosan-stimulated polymorphonuclear leukocytes is continuously diminished in the presence of increasing amounts of human serum albumin (from 1 to 30 mg/ml). HSA competes with luminol for hypochlorite as shown by adding sodium hypochlorite to luminol solutions containing HSA. Titration of HSA with NaOCl affects firstly the ...

This study finds no significant differences between deaf and hearing readers' sensitivity to contextual build-up as evaluated in a cumulative cloze exercise measured by a 2 X 5 X 2 factorial design using readers at the eighth, tenth and twelfth grade levels. Differences favoring hearing readers have been documented at ...

1. Monosynaptic excitatory postsynaptic potentials (EPSPs) were elicited in lumbosacral motoneurones of pentobarbitone anaesthetized cats by stimulating group Ia muscle afferents with most of the dorsal roots severed. In some experiments Ia EPSPs were recorded together with monosynaptic EPSPs elicited by stimulating the ipsilateral ventral quadrants (VQ) of the thoracic ...

In a series of 11 melancholic patients who received both right unilateral and bilateral ECT during a single course of treatment, mean and minimum postictal heart rates were greater after bilateral ECT. Greater catecholamine release during bilateral ECT is the most likely explanation for these effects. These differences complement other ...

Melanization and encapsulation of invading foreign organisms observed during the immune response in insects is known to be due to the action of activated phenoloxidase. Phenoloxidase-generated quinones are deposited either directly or after self-polymerization on foreign objects accounting for the observed reactions. Since the reactions of quinones are nonenzymatic, they ...

Subjects searched for target letters and symbols in VDT displays produced with green, amber, yellow, red, blue, and white phosphors. The green was rated more highly than yellow, and blue was rated worst. There were no significant differences in search time, but there were significant differences in the number of ...

A sensitive method for the determination of retinyl esters, including their geometric isomers, by isocratic adsorption HPLC is described. The development of a special recycling system allows the separation of all-trans-, 13-cis, 11-cis- and 9-cis-retinyl palmitate, -stearate, -oleate, -palmitoleate and -linoleate with short retention times and high sensitivity. Extraction of ...

Phospholipase A (PLA) and Sepsis Severity Score (SSS) were measured regularly in 28 patients with sepsis (n = 11), pancreatic operations (n = 7), or multitrauma combined with contused abdominal trauma (n = 10). No linear correlation was found between these two parameters. A statistical correlation could be shown for ...

During the 25 years between 1959 and 1984, the suicide rate in the United States increased from 10.5/100,000 to 12.4/100,000. The increase was confined to those suicides using a firearm, which had reached 58.5% of the total by the end of the period. At the same time, there was a ...

An experiment was carried out on 30 spider-fearful and 30 snake-fearful subjects in an attempt to replicate the finding of a correlation between the rapid reduction of fear and the reduced likelihood of significant fear returning after an interval (low return of fear). It was also hoped to observe and ...

This bibliography is the seventeenth annual supplement to the comprehensive bibliography on the same subject which was published in Space Life Sci. 2(1970), 225-295; 3(1972), 293-304; 4(1973), 309-329 and in Origins of Life 5(1974), 505-527; 6(1975), 285-300; 7(1976), 75-85; 8(1977), 59-66; 9(1978), 67-74; 10(1980), 69-87; 10(1980), 379-404; 11(1981), 273-288; 12(1982), ...

Evaluation of a family in which males were clinically euthyroid despite having low serum total T4 (TT4) and free T4 index (FT4I) values revealed the presence of a new inherited T4-binding globulin (TBG) variant (TBG-San Diego). Two brothers had low TT4 (39 and 49 nmol/L; normal range, 64-154 nmol/L) and ...

The sequence selectivity of methylation at the O6 and N7 position of guanine by N-methyl-N'-nitrosourea (MNU) and the rate of removal of O6-methylguanine by O6alkylguanine-DNA alkyltransferase (AGT) was determined using dodecadeoxynucleotides of defined structure. The extent of guanine adduct formed in self-complementary dodecamers, 5'-TATACGCGTATA-3', 5'-TATACCGGTATA-3' and 5'-TATAGGCCTATA-3', after methylation with ...

The kinetics of inactivation of mitochondrial monoamine oxidase type B (MAO-B) by a series of 18 stereoisomers of tertiary alpha-allenic amines have been investigated in detail. The chirality of the allene group in N-methyl-N-aralkylpenta-2,3-dienamines was found to have a profound effect on the inactivation rate, with the (R)-allenes being up ...

In a randomized controlled trial, 58 subjects were treated for Pediculus humanus var capitis with either pyrethrins combined with piperonyl butoxide (RID, Pfizer Inc, New York) or 1% permethrin (NIX, Burroughs Wellcome Co, Research Triangle Park, NC); 31 subjects received RID and 27 subjects received NIX. Both products were applied ...

The kinetics of tubulin assembly were examined in the absence and presence of dimethyl sulfoxide at 37 degrees C. Inclusion of 1.4 M (10%) dimethyl sulfoxide lowered the critical protein concentration about 8-10-fold, from 9.4 microM in the absence of the organic solvent to 1.1 microM in its presence. This ...

The dissociation constants, partition coefficients, and solubility of carbenoxolone (1) were determined using tritium-labeled drug. The partition and solubility methods were used to assess the dissociation constants of carbenoxolone, while the pKa of the structurally related triterpenoid, enoxolone (2) was determined using a spectrophotometric method. The true partition coefficient (TPC) ...

Interresponse intervals (IRIs) were recorded as 8 right-handed male subjects tapped a key separately with the index finger of each hand as fast as possible for twenty 10-s runs. Frequency distributions of the IRIs produced by each hand showed that the shorter mean IRI that is usually reported for preferred-hand ...

This paper reports the results of a revised replication of the von Stockert/Bader constituent ordering study (1976) with German agrammatics. Part 1 describes why such a replication was necessary. In part 2, the original study is summarized and the weaknesses are identified which caused a revision. Part 3 reports the ...

Seven severely nonfluent aphasics and one relative or close friend were investigated in an interview situation. The conversation was videotaped and analyzed for the use of nonverbal communication between aphasic and partner. The results indicate that the group of aphasics used significantly more frequently and for a significantly longer period ...

The purpose of this study was to determine the effects of police enforcement and the use of signs and posters in promoting seat belt use by nighttime tavern patrons. Ten taverns in two cities served as sites. Data were collected on the nighttime seat belt use of tavern patrons and ...

The purpose of this study is to provide a thorough and comprehensive description of the late onset manifestations of poliomyelitis (PM). In addition, unusual findings, seen in the post-poliomyelitis period, have been presented to further increase awareness of the potential diversity of the problem. The scope of PM sequelae is ...

The nephrotoxicity of the aminoglycoside amikacin sulfate was evaluated in an open, controlled study of newborns with presumed neonatal sepsis. One hundred twelve neonates were randomly allocated to receive either amikacin-ampicillin or mezlocillin, a semisynthetic penicillin. Neonates receiving amikacin, in contrast to those receiving mezlocillin, showed significant nephrotoxicity as evidenced ...

Effects of advancing forage maturity and drought-induced summer dormancy on site and extent of digestion and microbial protein synthesis in beef steers grazing native blue grama rangeland were evaluated in four sampling periods. Five steers (avg initial wt 227 kg) fitted with ruminal, duodenal and ileal cannulae and three steers ...

The levels of complement components (C1q, C4, C3 and C3d) were measured in the sera of nine azoospermic Nigerian men and compared with those of 12 oligospermic and 19 normospermic Nigerian men. The mean values of C1q, C4, C3 and C3d for azoospermic men showed no significant difference from those ...

Interaural attenuation of pure tone and speech signals was evaluated for a new audiometric insert earphone, the ER-3A tubephone, and a conventional TDH-49P supra-aural earphone in seven unilaterally deaf adult subjects. These results validate and extend the interaural attenuation data reported by the manufacturer of the ER-3A and his associates. ...

According to I. P. Pavlov's theory of higher nervous activity, the establishment and dissolution of conditional reflexes enhances the higher organism's adaptation to the external environment. Pavlov asserted that, ontogenetically, conditional reflexes are based upon innate, unconditional reflexes (UR) or instincts. Pavlov did not distinguish between URs and instincts, but ...

The ability of phosphatidylinositol-specific phospholipase C (PIPLC) to solubilize acetylcholinesterase (AChE) in the electromotor system of adult Torpedo ocellata and in the developing electric organ was examined. PIPLC solubilizes significant amounts of the membrane-bound G2 form of AChE throughout embryonic development of the electric organ, as it does in the ...

Exercise is commonly listed as a remedy for the premenstrual syndrome (PMS), although no study has proven that it is an effective therapy. Numerous reports have suggested that exercise is associated with improved mood and symptoms. In those reports, however, the diagnosis of PMS was not clearly documented, nor was ...

We used phosphorus NMR spectroscopy to study 16 patients with muscular enzyme deficiencies affecting glycogenolysis and glycolysis. Study of phosphomonoester (Pm) kinetics and intracellular pH during exercise and recovery provided criteria for the distinction of these metabolic myopathies by NMR spectroscopy. The Pm peak was undetectable in patients lacking debrancher ...

Eight well-trained speed skaters performed three all-out tests during ice speed skating, board skating and cycling. Compared to speed skating, cycling produced significantly higher values of oxygen consumption (57.2 +/- 4.9 vs. 53.9 +/- 4.2 ml/(kg X min], ventilation (111.3 +/- 10.2 vs. 98.8 +/- 7.3 l/min) and respiratory exchange ...

Hamster cheek pouches were treated with the topical carcinogen DMBA for 8 weeks. 2 episodes of cryosurgery, located within the area of previous carcinogen application enhanced the neoplastic process by comparison with matched controls. Comparison with previous studies suggests that the 2 episodes of cryosurgery may have a greater effect ...

The aim of the study was to investigate CRF- and neurophysin-immunoreactive neurocytes in hypothalamo-pituitary system of the hamster. CRF-immunoreactive nerve fibers were observed mainly in the outer layer of the median eminence and pituitary stalk and also in the neurohypophysis. On the contrary, neither intermediate lobe nor anterior pituitary contained ...

Previous studies have shown that the "synaptic" bodies of mammalian pinealocytes are a heterogeneous group of organelles. Whereas "synaptic" ribbons (SR) exhibit a day/night rhythm with small numbers during daytime and high numbers at night, the so-called "synaptic" spherules (SS) show species-specific differences in their rhythmicity. In the present study ...

In order to improve the rate of recovery of mature ova over those previously reported, we evaluated a new hormonal regimen for induction of follicular growth in the squirrel monkey. This regimen, which consisted of 50 IU pregnant mare's serum (PMS) per day for 4 days followed by 50 IU ...

In a study of the intradialytic behaviour of l-ascorbatemia during acetate and bicarbonate dialysis we noted the paradoxical increase in l-ascorbatemia during the first hour of acetate dialysis. During biofiltration, the intradialytic curve of l-ascorbatemia is similar to that in bicarbonate dialysis, even though an acetate dialysis bath is used. ...

It has been reported that there is a certain rhythm in the appearance of Fm theta. In the present study, round-the-clock changes in the appearance of Fm theta were analyzed. The Uchida-Kraepelin test was conducted for 5 minutes a day over a period of 3 days on 18 university students. ...

The definition, classification, proposed etiologies, diagnosis, and treatment of the premenstrual syndrome (PMS) are discussed, and guidelines for the clinical management of PMS are presented. PMS encompasses a cluster of physical and psychosocial symptoms that recur during each menstrual cycle. Proposed etiologies for the syndrome include a hormonal imbalance between ...

Male eastern red-spotted newts (Notophthalmus viridescens) under controlled laboratory conditions exhibit unimodal magnetic compass orientation either in a trained compass direction or in the direction of their home pond. If the vertical component of the magnetic field is inverted, newts exhibiting the simple-compass response undergo a 180 degree reversal in ...

Gallbladder sludge during total parenteral nutrition may be related to abnormal gallbladder motility. To test this hypothesis, gallbladder motility was assessed in 15 parenterally fed patients and in 22 controls using ultrasonography. Parenteral infusion was continuous in 10 cases and cyclic in 5 cases (6 PM to 10 AM). Gallbladder ...

Methylene blue, used as an external marker for bronchoalveolar lavage (BAL) in a concentration of 1 microgram/ml, reduced the functional activity of BAL alpha 1-protease inhibitor (alpha 1-PI) in 2 healing nonsmokers who each had 2 BAL done, one with and the other without methylene blue. Inactivation of alpha 1-PI ...

Dehydrogenase activity assay of activated sludge using the redox dye 2-(p-iodophenyl)-3-(p-nitrophenyl)-5-phenyltetrazolium chloride (INT) was investigated. INT-dehydrogenase activity (INT-DHA) was directly proportional to INT dosage and inversely proportional to bio-mass concentration over limited ranges. INT dosages exceeding 2.5m/M were toxic to dilute activated sludge suspensions. INT-DHA was greatest near pH 9, ...

The effect of ketoconazole on the kinetics of antipyrine was investigated. The antipyrine Vd showed an overall difference among the 4 trials, but the magnitude of the differences was small. Antipyrine half-life was slightly but not significantly shortened and the antipyrine clearance was essentially identical in the whole study. The ...