The effect of ketoconazole on the kinetics of antipyrine was investigated. The antipyrine Vd showed an overall difference among the 4 trials, but the magnitude of the differences was small. Antipyrine half-life was slightly but not significantly shortened and the antipyrine clearance was essentially identical in the whole study. The ...

The chemical and mutagenic properties of a series of chloromethylbenzo[a]pyrenes (chloromethyl-BaP) (chloromethyl groups in position 1-, 4-, 5-, 6-, 10-, 11- or 12-) were studied in order to address the question of the importance of arylmethyl carbocations as possible ultimate carcinogens of methylated polycyclic aromatic hydrocarbons (PAH). The rates of ...

Clathrin was isolated from detergent-solubilized, biosynthetically radiolabeled cells by immunoprecipitation with anti-clathrin monoclonal antibodies. Immunoprecipitates obtained after pulse-chase labeling demonstrated that after biosynthesis the LCa light chain of clathrin could be found either complexed to heavy chain or in a free pool (not associated with heavy chain) which decreased steadily ...

Among 50 patients with phenytoin intoxication, 14 had seizures during the episode. Seizures in 9 of these 14 patients probably resulted from poor seizure control despite high phenytoin levels, but in 5 cases, attacks were attributed to phenytoin toxicity. The only factor that seemed to correlate with seizures was a ...

Human complement receptor type 2 (CR2) was biosynthetically labeled by pulsing SB B lymphoblastoid cells for 25 min with [35S]methionine followed by chase in the presence of excess unlabeled methionine. An Mr 134,000 polypeptide represented the major form of the receptor at the end of the pulse period, and within ...

Bronchomotor tone after deep inspiration and bronchial responsiveness to methacholine were studied at 4:00 A.M. and 4:00 P.M. in 14 normal and 13 asthmatic subjects. Bronchomotor tone was assessed with respiratory resistance (Rrs) measured by the forced oscillation method. Bronchial responsiveness to methacholine and baseline Rrs were higher at 4:00 ...

To minimize the risk of adverse side effects from mydriatics during binocular indirect ophthalmoscopy, a procedure was developed which intentionally starts with a dose significantly less than an ED99. Using a clinically effective diameter of greater than 7 mm as a criterion, I found that 1 drop of 0.5% tropicamide ...

A prospective, randomized study was undertaken to compare the efficacy and safety of ceftazidime with those of a combination of ticarcillin and tobramycin in the treatment of 40 nonneutropenic patients with pneumonia or bacteremia. Altogether, 93% of the patients receiving ceftazidime for pneumonia were cured, and 87% of those with ...

Chinese NiTi wire was studied by means of a bending test to determine wire stiffness, springback, and maximum bending moments. Chinese NiTi wire has an unusual deactivation curve (unlike steel and nitinol wires) in which relatively constant forces are produced over a long range of action. The characteristic flexural stiffness ...

A mailed questionnaire was sent to 2712 subjects asking about respiratory symptoms, and a raffle for three prizes of 50 pounds, 30 pounds, and 20 pounds was organised. The response rate in the 1762 who were told about the raffle was no higher than for 950 subjects who served as ...

The 10 hole (Adult Version) Tactile Performance Test (TPT) or Form Board is too difficult for patients with moderate to severe brain damage. A series of studies were done to enable an examiner to substitute the simpler 6 hole board (TPT 6 - Child's Version) for such patients. Eighty subjects ...

The detection of simulated pulmonary nodules was measured in three different situations that required: (1) reports of all significant chest findings (Free Search), (2) only reports of possible nodules (Nodule Search), or (3) evaluation of particular film locations as nodules (Specified Location). ROC curves from these conditions compared how accurately ...

We used aminoethyldextran (AED) as a secretagogue for the simultaneous exocytosis of a great proportion of secretory organelles (trichocysts) from Paramecium tetraurelia cells and we applied freeze-fracturing and ultrathin sectioning for a quantitative analysis of the re-arrangement of ultrastructural details within the cell membrane during re-insertion of new trichocysts. Characteristic ...

Consecutive screenings by the same examiner (the author) disclosed among 380 white North Europeans (Copenhagen, Denmark) pigmentation of the plica semilunaris and/or lacrymal caruncle in 2%, among 189 Mongols (Kyoto, Japan) in 4%, and among 257 Eskimos (East Greenland) in 45% (P less than 0.001). In Eskimos the phenomenon was ...

Hydroxylamine was evaluated and found to be a highly effective agent for the in vitro prevention of penicillin inactivation of tobramycin. This inactivation reaction resulted in an underestimation of tobramycin concentrations and was dependent on time, temperature, amount and type of penicillin, and amount of tobramycin. Plasma samples containing tobramycin ...

Minoxidil, a potent peripheral vasodilator used orally for refractory hypertension, has produced hypertrichosis. To determine the efficacy and safety of 1% or 5% topical minoxidil for the stimulation of scalp hair regrowth, we studied fifteen normotensive patients, five with androgenic alopecia and ten with alopecia areata diagnosed clinically and by ...

How does one begin to approximate the inner experience of another? Empathic exploration demands of the investigator the creative capacity to suspend closure. The founders of phenomenology and psychoanalysis developed methods to facilitate a process of not-concluding, ways of keeping the mind open to new possibilities. Moreover, Husserl's phenomenological reduction ...

The presence of a groove in the lateral wall of the human orbit (Royle, 1973) was found in 45 of 100 orbits examined (45%). In 15 skulls the groove was present bilaterally. The groove probably lodges an anastomosis between the middle meningeal and infraorbital blood vessels. No reference to this ...

Threshold values of interaural differences of time (delta IDTs ) were measured for trains of dichotic clicks whose levels were 20, 40, or 60 dB SPL. All clicks were bandpass filtered at 4 kHz, and the number of clicks in the train (n) was 1, 2, 4, 8, 16, or ...

The effect of addition of lanolin and Span 60 to white vaseline and of their concentration on the pharmaceutical availability of monoethanolamine , diethanolamine and morpholine was investigated. The emulsifier type and its concentration exercise an influence on constant release rates. The liberation of the investigated amines proceeds at almost ...

The occurrence of wet dog shakes (WDS) was studied during hippocampal kindling and amygdala kindling. Many WDS were observed after the first stimulation of the dorsal and ventral hippocampus. Their number rapidly increased to a maximal value (after five to six stimulations) and then progressively decreased during the development of ...

Continuous recording of body postures (standing or lying) using photocells connected to an event recorder was carried out on 125 pregnant sows tethered either by a thoracic girth or by a neck harness in six different farms, at different times of the year. Standing activity occupied an average of 250 ...

A nonlinear least-squares fitting procedure has been used to derive absolute intensities for lines in the P, R, and Q branches of the (11(1)0)II <-- 00(0)0 band of 12Cl602 (band center = 1932 cm(-1)) from long-path 0.01-cm(-1) resolution laboratory spectra. The spectral data were recorded at room temperature and low ...

To exercise leadership, boards need information that is exclusively prepared to help them fulfill their unique responsibilities. This article examines, in view of our changing economic environment, what kind of information the board needs to receive, how often it should be forthcoming, in what format, and how to assess it.

The primary purpose of this study was to determine list equivalency of Harris' revision of the CID Everyday Sentence Lists under three signal-to-noise ratios: O dB, --3 dB, and --6 dB. On the basis of list means, nonsignificant groupings of lists were found at each noise level; however, lists were ...

The role of hypothalamic and limbic aminergic systems in neuroendocrine control in the rat has been investigated by measuring the temporal changes in serotonergic and noradrenergic neuronal uptake in a model of the estrous cycle. Using the pregnant mare serum (PMS) model of induced ovulation and an in vitro uptake ...

4-Hydroxycyclophosphamide (4-HCY) is generated spontaneously in cryoprecipitated plasma from synthesized 4-hydroperoxycyclophosphamide (4-HPCY); its immunosuppressive and cytotoxic effects seem to depend on milieu, temperature, time, and dosage. Our preliminary results suggest that prolonged canine renal allograft survival can be achieved with grafts exposed to CY metabolites (4-HPCY and PM) in vitro ...

The progress of incorporation of radioactive glucosamine into the O-acetylated and non-O-acetylated sub-units of the insoluble peptidoglycan of growing Neisseria gonorrhoeae was examined. More than 80% of the final degree of cross-linking was achieved within 3 min; the remainder of the process took much longer. Rapid O-acetylation occupied up to ...

Oxazepam and diazepam were compared in healthy elderly volunteers. Absorption of diazepam was faster than oxazepam and onset of clinical effects were more profound. Diazepam accumulation was extensive, washout was slow and active compounds were present two weeks after the last dose. Oxazepam accumulation was significantly less and elimination significantly ...

Studies were performed to compare the cytotoxicity for human alveolar macrophages of a naturally occurring short-fiber chrysotile asbestos (RG 144) to that of a standard reference mixed-fiber (long and short) chrysotile asbestos (UICC chrysotile A. Rhodesian). Parallel studies were also performed with quartz (Min-U-Sil 15), a known macrophage toxin. On ...

Mentally retarded adults were presented with size and number discriminations using four stimulus conditions. In Condition 1, the S+ circles faded from large (Size 10) to smaller (Size 6) while the S- circles remained at Size 5 and number of circles varied randomly. In Condition 2, the S- squares faded ...

An "in vivo" study of metaphase degeneration in the murine plasmacytoma (MPC 11) over 8.5 h after mitotic arrest with vincristine sulphate and labelling with 3H-TdR is described. The main points to emerge were that: (1) Metaphase degeneration becomes apparent from the decline in the unlabelled metaphase collection function after ...

The results of the determination of total bilirubin in neonatal sera using the Compur kit and miniphotometer are reported. The kit method was modified somewhat by halving the volume of serum. This smaller volume (10 microliters) minimizes the interference of haemoglobin and turbidity. In a study of 68 neonatal sera, ...

The possible antagonism between silybin and phalloidin an F-actin has been examined in vitro. Phalloidin protects F-actin against denaturation by potassium iodine, cytochalasin B, DNase and pronase. Silybin does not counteract the effect of phalloidin on F-actin. However, silybin alone slowed the rate of polymerization of actin, but this effect ...

Sixty paired venous and capillary total neutrophil counts (TNCs) were obtained from 30 healthy, term neonates on days 1 and 2 of life. Day 1 venous TNC (8,200 +/-- 3,800/cu mm) and capillary TNC (10,400 +/- 4,400/cu mm) were significantly different when examined by the paired t test as were ...

Four fit, healthy young men (aged 20) volunteered for the experiment. After a 5 day control period, they marched for 6 consecutive days (from 09:00 h to 17:00 h) for 34 km/day at a speed of 6 km/h, with an energy expenditure of 35% of individual VO2 max. A recovery ...

The clear zones seen around microtubules in transverse sections of nutritive tubes vary in size depending on whether a microtubule is bordered by ribosomes or by another microtubule. We consider that such a finding is not consistent with the current view, that the clear zone is maintained by microtubule-associated material. ...

In the present study pineal glands of rats aged 69-71 days were studied in vivo and in vitro with respect to day/night changes of "synaptic" ribbons and spherules. It was found that ribbons outnumber spherules by a factor of 3. In vivo, both ribbons and spherules show a roughly 3-fold ...

Lactose, magnesium carbonate, phenacetin, microcrystalline cellulose and directly compressible starch compacts were repeatedly compressed in a tablet press, the tablets not being ejected from the die between compressions. When the interval between compressions was 1.3 s, all substances showed a decrease in the maximum force exerted by the tablet press, ...

Two experiments were carried out. In the first, three groups of lambs were inoculated subcutaneously with 3 X 10(6) schizonts of different passages (3, 30 and 63) of Theileria hirci propagated in tissue culture. Severe reactions were observed in lambs inoculated with organisms derived from the 3rd passage. In the ...

The kinetic parameters describing the dissociation of GDP from the elongation factor Tu (EF-Tu) . GDP complex in the absence and presence of elongation factor Ts (EF-Ts) have been characterized using an equilibrium isotope exchange technique. The rate constant for dissociation of GDP from EF-tu was found to be 1.7 ...

This brief communication reports the results of 24-ambulatory cardiac monitoring of a Bering Strait Eskimo population and compares the findings with 3 other populations. Similar heart rate rhythmicity and almost identical acrophases are found in the Eskimo, Aymara Indian and French populations. However, the Alaskan Eskimo and Aymara Indian 24-h ...

Previous studies indicate that the hamster fasted for 16 h fails to demonstrate a significant phosphaturic response to parathyroid hormone (PTH). However, when hamsters were infused with ammonium chloride, a phosphaturic response to PTH was observed. The present studies evaluate the respective roles of acidemia and the ammonium ion in ...

We have utilized sodium butyrate to inhibit histone deacetylases in order to study the rates of histone acetylation in hepatoma tissue culture cells. In this manner, we have been able to observe two rates of hypermodification of acetylated core histone. By selectively radolabeling acetylated histone fractions based upon differences in ...

Six fit men, aged 20, participated in the 16 day experiment. After a 5 day control period, the subjects marched on 6 consecutive days (from 09:00 h to 17:00 h) for 34 km/day at a speed of 6 km/h, with a backpack adjusted to complete a 35% of individual VO2 ...

Trials were conducted to evaluate the efficacy of permethrin and fenvalerate, two synthetic pyrethroid compounds, for the control of the northern fowl mite, Ornithonyssus sylviarum (Canestrini and Fanzago), on White Leghorn hens. Fenvalerate at .0125%, .025%, and .05% active ingredient (ai) were as effective as carbaryl at .5% ai for ...

1. The cerebral giant cells (CGCs) of Lymnaea have a tonic, modulatory effect on the intensity of output from feeding motoneurones in the buccal ganglia. 2. Short latency, excitatory and probably monosynaptic connexions occur between the CGCs and three identified feeding motoneurones. Unitary excitatory postsynaptic potentials in these motoneurones, following ...

Lethal dieldrin concentrations were found in the brains of dead gray bats (Myotis grisescens) collected during 1976 and 1977 beneath a maternity roost in a Missouri cave. In addition, residues of heptachlor epoxide, oxychlordane, cis-chlordane, and trans-nonachlor increased significantly in both brains and carcasses of bats collected during 1977. These ...

A study was undertaken to determine whether the antiesterase activity of echothiophate iodide would prevent the conversion of dipivefrin to epinephrine. Dipivefrin was administered singly and in combination with echothiophate to 24 adult rabbits. Administration of dipivefrin lowered the intraocular pressure (IOP) 8 +/- 1 mm Hg (P less than ...

"Encéphale isolé" cats were implanted with three push-pull cannulae. The two caudate nuclei (CN) were superfused continuously with 3H-tyrosine to measure the release of 3H-DA in serially collected fractions. Three hours after the beginning of the experiment, d,l-baclofen, d- or l-baclofen or gamma-hydroxybaclofen were introduced for 15 min in the ...