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Zuhl Micah M Department of Health, Exercise, and Sport Science, University of New Mexico, Albuquerque, NM, 87131, USA, - - 2014
Chronic glutamine supplementation reduces exercise-induced intestinal permeability and inhibits the NF-κB pro-inflammatory pathway in human peripheral blood mononuclear cells. These effects were correlated with activation of HSP70. The purpose of this paper is to test if an acute dose of oral glutamine prior to exercise reduces intestinal permeability along with ...
Sandberg Camilla C Heart Centre and Department of Public Health and Clinical Medicine, Umeå University, - - 2014
Adults with congenital heart disease (ACHD) usually have reduced aerobic exercise capacity compared with controls. However, their skeletal muscle function is less studied. In this cross-sectional study, unilateral isotonic shoulder flexion, unilateral isotonic heel-lift, maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP) were tested in 85 patients with ACHD ...
Faulkner James J aSchool of Sport & Exercise bInstitute of Food, Nutrition and Human Health, Massey University cWellington Hospital, Wellington, New Zealand dYork Teaching Hospitals, NHS Foundation Trust, York, - - 2014
Exercise has beneficial effects on vascular risk factors in transient ischaemic attack (TIA) patients within the sub-acute phase. This study examined whether TIA patients randomized to an early exercise and education programme within 2 weeks of TIA diagnosis would demonstrate improvements in cardiovascular risk factors and aerobic fitness 12 months ...
Maeda Seiji S Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, - - 2014
Obesity and increased arterial stiffness are independent risk factors for cardiovascular disease. Arterial stiffness is increased in obese individuals than in age-matched non-obese individuals. We demonstrated that dietary modification and exercise training are effective in reducing arterial stiffness in obese persons. However, the differences in the effect on arterial stiffness ...
Ninaber Maarten K MK Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands - - 2014
Background Exercise intolerance (EI) in systemic sclerosis (SSc) is difficult to manage by the clinician. The peripheral chemoreflex drive compensates for metabolic acidosis during exercise and may be related to EI. Aim To assess the global peripheral chemoreflex drive (GPCD) in patients with SSc at rest and during exercise. Methods ...
Couto Mariana M Laboratory of Immunology, Basic and Clinical Immunology Unit, Faculty of Medicine, University of Porto, Portugal; Immunoallergology Department, Centro Hospitalar São João EPE, Porto, Portugal; Center for Research in Health Technologies and Information Systems (CINTESIS), Portugal; Instituto CUF & Hospital CUF Porto, Allergy Unit, Portugal. Electronic address: - - 2014
Dysautonomia has been independently associated with training and exercise-induced bronchoconstriction. In addition, neurogenic airway inflammation was recently associated with swimmers-asthma. We aimed to assess the relation between autonomic nervous system and airway responsiveness of asthmatic elite swimmers. Twenty-seven elite swimmers, 11 of whom had asthma, were enrolled in this exploratory ...
Guerra E E Department of Health, Movement and Human Sciences University of Rome "Foro Italico", Piazza Lauro de Bosis 15, Rome, Italy. Electronic address: - - 2014
There is growing evidence to show the effectiveness of physical exercise for multiple sclerosis (MS) patients. Aim of this study was to evaluate aerobic capacity, strength, balance, and the rate of perceived exertion (RPE) after exercise, in ambulatory patients with mild MS and matched control healthy participants. Seventeen MS patients ...
Sterrett Lauren E LE Pediatric Cardiology, Riley Hospital for Children at Indiana University School of Medicine, 705 Riley Hospital Drive, RR 127, Indianapolis, IN, 46202, USA, - - 2014
Optimal timing of pulmonary valve replacement (PVR) for pulmonary regurgitation is a debated topic. It is logical that maximal aerobic capacity (VO2peak) would decline when a PVR is needed, but a diminished VO2peak is not always present before PVR, and previous studies show no improvement in VO2peak after PVR. This ...
Fernandez-Gonzalo Rodrigo - - 2014
As spaceflight compromises skeletal muscle oxidative and aerobic work capacity, this study assessed the efficacy of resistance exercise (RE) to counteract muscle metabolic perturbations induced by 5 wk unilateral lower limb unloading (UL). There were 21 men and women (30-56 yr) who were randomly assigned to either UL with (Group, ...
Potus François F CRIUCPQ, medicine, quebec, Quebec, Canada ; - - 2014
Rationale: Pulmonary arterial hypertension (PAH) is characterized by a significant exercise intolerance, which is multifactorial and involves skeletal muscle alterations. There is growing evidence that microRNAs are involved in PAH pathogenesis. Objectives: We hypothesized that miR-126, an endothelial-specific pro-angiogenic microRNA, is downregulated in peripheral muscles of PAH patients, accounting for ...
Kondo Hiroyo H Department of Food Sciences and Nutrition, Nagoya Women's University, Nagoya, - - 2014
Introduction: This study determined the effects of low-intensity exercise on the 3-D capillary structure and associated angiogenic factors in the soleus muscle of Goto-Kakizaki (GK) diabetic rats. Methods: Four groups of male rats were studied: sedentary non-diabetic (Con), exercised non-diabetic control (Ex), sedentary GK, and exercised GK (GK+Ex). Rats in ...
E Lezi L Department of Physical Therapy and Rehabilitation Sciences, University of Kansas Medical Center, Kansas City, KS, - - 2014
In aged mice, we assessed how intensive exercise affects brain bioenergetics, inflammation, and neurogenesis-relevant parameters. After 8 weeks of a supra-lactate threshold treadmill exercise intervention, 21-month-old C57BL/6 mice showed increased brain peroxisome proliferator-activated receptor gamma coactivator-1α protein, mammalian target of rapamycin and phospho-mammalian target of rapamycin protein, citrate synthase messenger RNA, ...
Scholten Ralph R RR Radboud University Medical Center - - 2014
Introduction. Blood flow patterns in conduit arteries characterised by high levels of retrograde shear stress can be detrimental for vascular health. In this study we examined whether retrograde shear rate and endothelial function are related in healthy and formerly preeclamptic (PE) women and whether this relationship is altered by exercise ...
Hartmann Sara E - - 2014
COPD patients have decreased physical fitness, and have an increased risk of vascular disease. In the general population, fitness is positively associated with resting cerebral blood flow velocity, however, little is known about the cerebrovascular response during exercise particularly in COPD patients. We hypothesized that COPD patients would have lower ...
Zhu Li-Xia LX School of Nursing, The Hong Kong Polytechnic University, Kowloon, Hong Kong; Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, - - 2014
The preliminary effects of a transtheoretical model-based exercise stage-matched intervention on exercise behavior in sedentary patients with coronary heart disease were examined in this study. This was a pilot randomized, controlled trial. A total of 18 eligible patients with coronary heart disease were recruited and randomized to either a conventional ...
Lin Song - - 2014
Objectives: The objective of the present study was to investigate the effects of isometric handgrip induced physical ischemia training (PIT) on remote coronary recruitment and growth. Methods: Seventy-four CAD patients were randomly assigned to either isometric handgrip (IHG) or non-exercise groups (NEG). Patients in the IHG group performed isometric handgrip ...
Hill Kylie K School of Physiotherapy and Exercise Science, Faculty of Health Science, Curtin University, GPO Box U1987, Perth, Western Australia 6845, Australia; Lung Institute of Western Australia, Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, Hospital Avenue, Nedlands, Western Australia 6009, Australia; Physiotherapy Department, Royal Perth Hospital, Wellington Street, Perth, Western Australia 6000, Australia. Electronic address: - - 2014
Despite the well-established benefits of exercise training in people with chronic respiratory disease, there are a group of people in whom it confers minimal gains. Furthermore, there is increasing recognition of the prevalence of comorbid conditions among people with chronic obstructive pulmonary disease and other respiratory diseases, such as musculoskeletal ...
Andrianopoulos Vasileios V Department of Research & Education, CIRO+, Centre of Expertise for Chronic Organ Failure, Hornerheide 1, Horn 6085 NM, The Netherlands. Electronic address: - - 2014
Exercise training remains a cornerstone of pulmonary rehabilitation (PR) in patients with chronic respiratory disease. The choice of type of exercise training depends on the physiologic requirements and goals of the individual patient as well as the available equipment at the PR center. Current evidence suggests that, at ground walking ...
Kon Michihiro M Department of Sports Sciences, Japan Institute of Sports Sciences, 3-15-1 Nishigaoka, KitaTokyo, Japan Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, - - 2014
Hypoxia is an important modulator of endurance exercise-induced oxidative adaptations in skeletal muscle. However, whether hypoxia affects resistance exercise-induced muscle adaptations remains unknown. Here, we determined the effect of resistance exercise training under systemic hypoxia on muscular adaptations known to occur following both resistance and endurance exercise training, including muscle ...
Zavorsky Gerald S GS Department of Health and Sport Sciences, University of Louisville, Louisville, 40292, Kentucky Department of Physiology and Biophysics, University of Louisville, Louisville, 40292, - - 2014
The purpose of this study was to assess lung function in runners with marathon-induced lung edema. Thirty-six (24 males) healthy subjects, 34 (SD 9) years old, body mass index 23.7 (2.6) kg/m(2) had posterior/anterior (PA) radiographs taken 1 day before and 21 (6) minutes post marathon finish. Pulmonary function was ...
Tulppo Mikko P MP Verve Research - - 2014
Endothelin-1 (ET-1), a potent vasoconstrictor, interleukin-6 (IL-6), and catecholamines are increased and heart rate variability (SDNN) decreased during emotional excitement, but individual responses vary. We tested the hypothesis that exercise capacity is associated with physiological responses caused by real-life emotional excitement. We measured the plasma levels of ET-1, IL-6, catecholamines, ...
Ebersbach Georg G Fachkrankenhaus für Bewegungsstörungen/Parkinson, Paracelsusring 6a, 14547, Beelitz-Heilstätten, Germany, - - 2014
LSVT-BIG is an exercise for patients with Parkinson's disease (PD) comprising of 16 1-h sessions within 4 weeks. LSVT-BIG was compared with a 2-week short protocol (AOT-SP) consisting of 10 sessions with identical exercises in 42 patients with PD. UPDRS-III-score was reduced by -6.6 in LSVT-BIG and -5.7 in AOT-SP at ...
Seals Douglas R DR University of Colorado Boulder - - 2014
Cardiovascular diseases (CVD) remain the leading cause of morbidity and mortality in modern societies, and advancing age is the major risk factor for CVD. Arterial dysfunction, characterized by large elastic artery stiffening and endothelial dysfunction, is the key event leading to age-associated CVD. Our work shows that regular aerobic exercise ...
Richter Manuel Jonas MJ Department of Pneumology, Kerckhoff Heart and Thoracic Center, Bad Nauheim, - - 2014
Background: Patients with pulmonary arterial hypertension (PAH) present with an altered inspiratory capacity (IC) reflecting dynamic hyperinflation (DH) that leads to mechanical constraints and excessive ventilatory demand, particularly during exercise, resulting in exertional dyspnea. Objectives: Assessment of the long-term consequences of altered IC and DH in PAH. Methods: 50 patients ...
Boden William E WE Samuel S. Stratton VA Medical Center and Albany Medical College, Albany, NY. Electronic address: - - 2014
Treatment for stable ischemic heart disease may include guideline-directed pharmacologic therapy, coronary revascularization, and lifestyle and behavioral changes, including structured exercise. Of these, regular exercise is arguably one of the most cost-effective yet underutilized interventions. Most patients with stable ischemic heart disease are eligible for secondary prevention programs, which should ...
Schreuder Tim H A TH Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The - - 2014
Positive vascular effects of exercise training are mediated by acute increases in blood flow. Type 2 diabetes patients show attenuated exercise-induced increases in blood flow, possibly mediated by the endothelin pathway, preventing an optimal stimulus for vascular adaptation. We examined the impact of endothelin receptor blockade (bosentan) on exercise-induced blood flow ...
Kilicaslan Baris B Department of Cardiology, ─░zmir Tepecik Research and Training Hospital , Izmir , Turkey - - 2014
Abstract We aimed to evaluate the aortic elastic properties in subjects with hypertensive response to exercise stress test (HRE). Sixty-six patients were divided into two groups (33 patients in HRE group and 33 patients in normotensive group). Baseline demographic characteristics were similar. The mean aortic stiffness index (ASI) was significantly ...
Markworth James F JF The University of - - 2014
Cyclooxygenase (COX-1 and 2) pathway derived prostaglandins (PGs) have been implicated in adaptive muscle responses to exercise, but the role of PGs in contraction-induced muscle signalling has not been determined. We investigated the effect of inhibition of COX-1 and 2 activities with the NSAID ibuprofen on human muscle signalling responses ...
Pilz Magdalena M Department of Hospital Hygiene, Medical University of Vienna, Vienna, - - 2014
The classic symptom of peripheral arterial disease is the intermittent claudication (IC). Generally, endurance training is recommended to improve patients' walking performance. A potential benefit of the combination with strength training and the optimal duration of such an exercise program remain unclear. We evaluated the effects of a supervised exercise ...
Zhu Li-Xia LX Li-Xia Zhu, PhD, RN PhD Graduate, School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, China, and Postdoctoral researcher, Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore. Shuk-Ching Ho, PhD, RN Assistant Professor, School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, China. Janet Wing Hung Sit, PhD, RN Associate Professor, The Nethersole School of Nursing, The Chinese University of Hong Kong, Shatin, New Territories, China. Hong-Gu He, PhD, MD, RN Assistant Professor, Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of - - 2014
Angina is one of the most common complaints among patients with coronary heart disease (CHD). Evidence has shown that regular exercise is beneficial for angina management. However, poor adherence to exercise prescription may limit its effect on angina symptoms and rehabilitation outcomes. The transtheoretical model (TTM) is an effective model ...
Barrett-O'Keefe Zachary Z Department of Internal Medicine, Division of Geriatrics, University of Utah George E. Wahlen Department of Veterans Affairs Medical Center, Geriatric Research, Education, and Clinical Center, 500 Foothill Drive, Salt Lake City, UT 84148. - - 2014
The endothelin-1 vasoconstrictor pathway contributes to age-related elevations in resting peripheral vascular tone primarily through activation of the endothelin subtype A (ETA) receptor. However, the regulatory influence of ETA-mediated vasoconstriction during exercise in the elderly is unknown. Thus, in 17 healthy volunteers (n = 8 young, 24±2 years; n = ...
Vital Thays Martins TM Institute of Biosciences, UNESP - Univ Estadual Paulista, Physical Activity and Aging Lab (LAFE), Avenida 24 A, 1515 - Bela Vista, Rio Claro, SP CEP 13506-900, Brazil. Electronic address: - - 2014
The aim of this study was to conduct a systematic review of studies that verified the effects of physical exercise on vascular endothelial growth factor (VEGF) in elderly. The bibliographic search was conducted in five database, from 1990 to 2013, with the following keywords and boolean operators: physical exercise OR ...
Feairheller Deborah L DL Hypertension and Endothelial Function with Aerobic and Resistance Training (HEART) Laboratory, Health & Exercise Physiology Department, Ursinus College, Collegeville, PA; Hypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, Temple University, Philadelphia, - - 2014
As healthcare progresses toward individualized medicine, understanding how different racial groups respond to lifestyle interventions is valuable. It is established that African Americans have disproportionate levels of cardiovascular disease and impaired vascular health, and clinical practice guidelines suggest lifestyle interventions as the first line of treatment. Recently, the authors reported ...
Gonzales Joaquin U JU Department of Health, Exercise and Sport Sciences, Texas Tech University, Lubbock, Texas. Electronic address: - - 2014
Vascular aging as measured by central arterial stiffness contributes to slow walking speed in older adults, but the impact of age-related changes in peripheral vascular function on walking performance is unclear. The aim of this study was to test the hypothesis that calf muscle-specific vasodilator responses are associated with walking ...
Headley Samuel S Springfield College. Electronic address: - - 2014
The present study was designed to determine the effect of short-term moderate-intensity exercise training on arterial stiffness in patients with chronic kidney disease (CKD) stage 3. Randomized controlled trial with a parallel-group design. Testing and training sessions were performed at Springfield College. 46 (treatment group, n=25; control group, n=21) patients with ...
Scholten Ralph R RR Department of Obstetrics & Gynecology; Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen; The Netherlands. Electronic address: - - 2014
Formerly preeclamptic women demonstrate higher prevalence of metabolic syndrome (MetS), impaired vascular function and increased sympathetic activity and are at increased risk of cardiovascular disease. The aim of this study was to assess the effects of 12-weeks exercise training (70-80%VO2max) in formerly preeclamptic women on physical fitness, components of metabolic ...
Anand Ashima A Exertional Breathlessness Studies Laboratory, Vallabhbhai Patel Chest Institute, Delhi University, Delhi 110007, - - 2014
In Eisenmenger syndrome (ES), oral phosphodiesterase type-5 inhibitors, which are preferential pulmonary vasodilators, reduce the elevated pulmonary artery pressure and pulmonary vascular resistance index by increasing cyclic guanosine monophosphate (cGMP). However, no information is available as to how pulmonary vasodilatation alleviates the accompanying dyspnoea and improves patient's exercising ability. As ...
Durand Matthew J MJ Department of Medicine, Cardiology Division, and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, - - 2014
Exercise is a powerful therapy for preventing the onset of and slowing the progression of cardiovascular disease. Increased shear stress during exercise improves vascular homeostasis by both decreasing reactive oxygen species and increasing nitric oxide bioavailability in the endothelium. While these observations are well accepted as they apply to individuals ...
Moraes Cristiane C Graduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niterói, RJ, Brazil, - - 2014
Patients undergoing hemodialysis (HD) present persistent inflammation and protein-energy wasting (PEW), which contributes to high rates of mortality. This study aimed to assess the effects of a resistance exercise training program (RETP) on inflammation and PEW in HD patients. Thirty-seven patients (56.7 % men, 45.9 ± 14.1 years, 23.5 ± 3.9 kg/m(2)) performed 6 months of intradialytic RETP. ...
Nussbaumer M M Department of Sport, Exercise and Health, Division of Sports and Exercise Medicine, Medical Faculty, University of Basel, Birsstrasse 320B, 4052, Basel, - - 2014
Alterations of retinal vessel diameters are associated with increased cardiovascular risk. We aimed to investigate changes in retinal vessel diameters in response to acute dynamic exercise of different intensities and whether these changes are age dependent. Seventeen healthy seniors (median (IQR) age 68 (65, 69) years) and 15 healthy young ...
Delussu Anna Sofia - - 2014
Robotic-assisted walking after stroke provides intensive task-oriented training. But, despite the growing diffusion of robotic devices little information is available about cardiorespiratory and metabolic responses during electromechanically-assisted repetitive walking exercise. Aim of the study was to determine whether use of an end-effector gait training (GT) machine with body weight support ...
Ong Peter P Department of Cardiology, Robert Bosch Hospital, Stuttgart, - - 2014
The exercise electrocardiogram (ECG) is a standard examination in patients with suspected coronary artery disease. However, despite a pathologic result, many patients undergoing diagnostic coronary angiography do not have any significant epicardial stenosis. In this study, we assessed the relation between a pathologic exercise ECG and coronary microvascular dysfunction in ...
Kirkman Danielle L DL School of Sport, Health and Exercise Sciences, Bangor University, Bangor, Wales, UK, - - 2014
The anabolic response to progressive resistance exercise training (PRET) in haemodialysis patients is unclear. This pilot efficacy study aimed to determine whether high-intensity intradialytic PRET could reverse atrophy and consequently improve strength and physical function in haemodialysis patients. A second aim was to compare any anabolic response to that of ...
Weissmann Norbert N 1University of Giessen and Marburg Lung Center - - 2014
Pulmonary hypertension (PH) is a disease with a poor prognosis characterized by a vascular remodeling process and an increase in pulmonary vascular resistance. While a variety of reports demonstrated that exercise training exerts beneficial effects on exercise performance and quality of life in PH patients it is not known how ...
Geary Kate K *Anschutz Medical Campus, University of Colorado, 13001 E 17th Place, Aurora, CO 80045, - - 2014
Our translational research group focuses on addressing the problem of exercise defects in diabetes with basic research efforts in cell and rodent models and clinical research efforts in subjects with diabetes mellitus. CREB (cAMP-response-element-binding protein) regulates cellular differentiation of neurons, β-cells, adipocytes and smooth muscle cells; it is also a ...
Zagatina A A Cardiocenter "Medika" St. Petersburg, Russian Federation - - - 2014
Ischemic segments cannot develop a sufficient amount of strength during systole, so theoretically they begin to contract later in comparison with non-ischemic zones. There is a lack of information about methods that can detect dyssynchrony during exercise in patients with QRS not longer 100 ms. The aim of the study ...
Duttaroy Smita S Department of Molecular and Clinical Medicine/Cardiology, University of Gothenburg, - - 2014
In coronary artery disease (CAD), circulating angiogenic factors have been seen to increase, possibly as a response to ischaemia. Regular physical activity (PA) is recommended for prevention and treatment of CAD, but more research is needed to optimise PA regimes. We investigated the effect of home-based high frequency exercise (HFE) ...
Zhu Li-Xia LX School of Nursing, The Hong Kong Polytechnic University, Hong Kong; Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: - - 2014
To determine whether a transtheoretical model-based exercise stage-matched intervention (ESMI) has positive effects on the exercise behavior of sedentary patients with coronary heart disease (CHD). The study was a randomized controlled trial with a repeated measures design. Participants (N=196) were randomly allocated to either a conventional (C) group, a patient ...
Borland Maria M NärRehab Physiotherapy Unit, Primary Healt Care, , Alings8s, Sweden. - - 2014
Objective: To investigate how group-based exercise affects the levels of physical activity, physical fitness and health- related quality of life (HRQoL) in patients with chronic heart failure and comorbidities. Design: Randomized controlled trial. Patients: A total of 48 patients (10 women, 38 men), mean age 71 years (standard deviation 8 ...
Hirashiki Akihiro A Department of Advanced Medicine in Cardiopulmonary Disease, Nagoya University Graduate School of Medicine, Nagoya 466-8560, - - 2014
The 6-minute walking distance is often used for assessing the exercise capacity under the treatment with an endothelin receptor antagonist (ERA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). The cardiopulmonary exercise testing (CPX) was reported to be more useful for the patients with pulmonary arterial hypertension (PAH), however, few ...
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