Micropuncture studies of single nephrons have shown that macula densa solute reabsorption via a furosemide-sensitive pathway activates nitric oxide (NO) generation via neuronal NO synthase (nNOS). This pathway is enhanced during salt loading. We investigated the hypothesis that changes in NO generation via nNOS in the macula densa contribute to ...

OBJECTIVE: Experimental evidence suggests that cardiopulmonary bypass (CPB) associated inflammatory response leads to endothelial injury and increased permeability, but this has been difficult to show clinically. We have investigated the use of von Willebrand factor (vWF), and urinary albumin excretion, as measured by the urinary albumin creatinine ratio (ACR), to ...

In the past 15 years, research on the effect of pelvic muscle exercise on urinary stress incontinence has contributed substantially to the understanding of the function of the pelvic muscles and the role of pelvic muscle exercise in management of stress urinary incontinence. This literature review addresses pelvic muscle function, ...

PURPOSE: The Abrams-Griffiths and linear passive urethral relationship (PURR) nomograms are commonly used to diagnose bladder outlet obstruction. To the best of our knowledge there are no clinical studies comparing these 2 evaluations to determine if they similarly predict the findings of bladder outlet obstruction. MATERIALS AND METHODS: From October ...

Urea production rate (Ra) is commonly measured using a primed continuous tracer urea infusion, but the accuracy of this method has not been clearly established in humans. We used intravenous infusions of unlabeled urea to assess the accuracy of this technique in normal, postabsorptive men under the following four different ...

BACKGROUND: To evaluate the results of anti-incontinence operations and Kegel exercises in patients with pure type II anatomic stress incontinence. METHODS: After evaluation by physical, genitourinary and urologically oriented neurological examinations, urogynecologic tests, perineal ultrasonography and cystometry, pure type II anatomic stress incontinence was diagnosed in 98 patients. Modified Pereyra ...

OBJECTIVE: To compare pelvic floor exercises and vaginal weight cones in the treatment of genuine stress incontinence. STUDY DESIGN: Randomised controlled trial. METHODS: Sixty ambulatory and fit white women (mean age 56 years) with urinary stress incontinence, treated by a single physiotherapist as outpatients during twelve weeks. Thirty women were ...

BACKGROUND: Nitric oxide is a major neurotransmitter in non-adrenergic, non-cholinergic (NANC) pathways. NANC inhibitory innervation has been shown in human gall bladder muscle in vitro; the role of nitric oxide in human gall bladder emptying however is undefined. AIMS: To study the effect of glyceryl trinitrate, a nitric oxide donor, ...

OBJECTIVES: To review the role of biofeedback in the management of community-dwelling individuals with urge urinary incontinence (UUI), and to present a practical approach to patient evaluation and treatment selection. METHODS: In view of a lack of objective published information, perspectives on the use of biofeedback in UUI are derived ...

Characterization of optical activity and simultaneous analysis of racemic ethylamphetamine (EAMP) and its metabolites, as well as the urinary excretion of the optical isomers, were examined in rats by high-performance liquid chromatography (HPLC). Analysis of the optical isomers of EAMP, amphetamine (AMP), para-hydroxy-ethylamphetamine (p-OH-EAMP), and para-hydroxy-amphetamine (p-OH-AMP) was performed within ...

BACKGROUND AND PURPOSE: Urinary incontinence (UI) is a significant psychological, social and healthcare problem across the lifespan. Although there is evidence of physical therapy (PT) efficacy, no literature was located pertaining to UI in PT curricula. The aim was to compare curricular content on UI (of non-neuropathic origin) in PT ...

The maximum watts factor (WFmax) is often used to characterize detrusor contractility. It was recently shown that the WFmax may increase in some patients with chronic outlet obstruction. It is, however, unclear whether this increase reflects a dependence of the WFmax on the degree of outlet obstruction or whether it ...

In order to investigate the effect of triathlon and renal function of normal subjects, we evaluated the excretion of urinary enzymes and proteins before and after triathlon. From 6 subjects samples were obtained 24 hours after the first urine collection. We performed quantification of urinary total protein, beta2-microglobulin (beta2-M), N-acetyl-beta-D-glucosaminidase ...

The aim of the study was, to determine whether maximum cystometric capacity accurately reflects the maximum functional bladder volume in women with urinary incontinence. We performed a retrospective chart review involving 85 women between the ages of 22 and 89 with primary complaints of urinary incontinence. The maximum cystometric capacity ...

A randomized controlled trial was carried out to evaluate the extent to which a program of reinforced pelvic floor muscle exercises (PFME) reduces urinary incontinence 1 year after delivery. Two hundred and thirty women who were incontinent 3 months postpartum were randomized to either a control group doing standard postnatal ...

The changes in some nocturnal urine urolithogenic parameters in response to the extradietary ingestion of 2.16 g potassium citrate (20 meq) after dinner have been determined. The study included 15 patients (hypocitraturic calcium oxalate stone formers). On the basis of the different pH changes three groups have been differentiated. Different ...

We assessed the renal effects of moderate treadmill exercise in the spontaneously hypertensive rats (SHR) remnant kidney model of chronic renal failure (CRF). The effects of chronic administration of a specific endothelin (ET) subtype A (ETA) receptor antagonist, FR139317 (32 mg/kg/day i.p.) and an angiotensin-converting enzyme inhibitor, enalapril (2 mg/kg/day ...

Thirty-seven women with stress incontinence were given biofeedback instruction on how to perform pelvic floor exercises correctly. After 3 months with home exercises 31 patients performed a new standardized pad-weighing test: 39% were objectively cured and 42% improved. After a mean of 2 years 15 patients were evaluated with another ...

To obtain optimal training effects and avoid overtraining, it is necessary to monitor the intensity of training. In cycling, speed is not an accurate indicator of exercise intensity, and therefore alternatives have to be found to monitor exercise intensity during training and competition. Power output may be the most direct ...

PURPOSE: Resiniferatoxin, a substance isolated from some species of euphorbia, a cactus-like plant, presents pharmacological effects similar to those of capsaicin. We studied the urodynamic effects of intravesical resiniferatoxin* in normal subjects and patients with unstable detrusor contraction to provide insight into the action mechanism of the molecule on sensory ...

Metabolic acidosis increases urinary calcium excretion in humans as a result of administration of ammonium chloride, an increase in dietary protein intake, and fasting-induced ketoacidosis. An intense bout of exercise, exceeding aerobic capacity, also causes significant decrease in blood pH as a result of increase in blood lactate concentration. In ...

BACKGROUND: Tripterygium wilfordii Hook F is a medicinal plant used for the treatment of glomerulonephritis in China. We studied the effect of Tripterygium wilfordii multiglycoside (TWG) on glomerular albumin permeability (Palbumin) in vitro. METHODS: Isolated rat glomeruli were incubated with protamine (600 micrograms/ml) for 30 min, or with human recombinant ...

One-third of 450 female soldiers surveyed indicated that they experienced problematic urinary incontinence during exercise and field training activities. The other crucial finding of this survey was probably that 13.3% of the respondents restricted fluids significantly while participating in field exercises. Although only 5.3% of respondents felt that their urine ...

Thirty women with pelvic relaxation and genuine stress urinary incontinence were evaluated with a contrast ultrasonography technique developed for the diagnosis of paravaginal defects. Control subjects were continent women with vaginal prolapse and nulliparous asymptomatic women. Seventeen incontinent patients had unilateral right-sided paravaginal defects and 13 had bilateral paravaginal defects. ...

BACKGROUND: The mechanisms by which regular exercise is associated with decreases in all-cause and cardiovascular mortality are unknown. Nitric oxide (NO) may have a role, as it is known to be an important factor in cardiovascular regulation. The relationships between physical activity and systemic formation of NO were evaluated in ...

Contraction of the rat detrusor muscle is mediated by cholinergic and purinergic mechanisms. The present study was carried out to look at the influence of cromakalim, compared with atropine, suramin and nifedipine on the contractile response evoked by single shock and exogenous agonists (carbachol and ATP) in rat urinary bladder. ...

OBJECTIVE: To determine the effect of pelvic floor muscle exercises combined with electrical stimulation of pelvic floor on lower urinary tract dysfunction in multiple sclerosis (MS) patients with near normal (< 100 ml) postvoid residual volumes. DESIGN: Open, controlled, randomized study in two parallel groups. SETTING: Rehabilitation centre for MS ...

We investigated the effect of a single bout of intensive exercise on the excretion of 8-hydroxy-deoxyguanosine in the 24 h urine from healthy non-smokers. We studied three exercise tests in Experiment 1; which consisted of incremental exercise to exhaustion on a treadmill in eleven male long distance runners. Experiment 2; ...

The purpose of this study was to investigate the effect of repeated exercise on oxidative damage to DNA in 10 well trained long distance runners who participated in an 8-day training camp. The average running distance during the camp was 30 +/- 3 km/day. The amount of urinary 8-hydroxy-deoxyguanosine (8-OHdG) ...

OBJECTIVE: To determine the effectiveness of pelvic floor exercises and urethral milking as treatments for post-micturition dribble. PATIENTS AND METHODS: A method of measuring small amounts of urine loss during normal activity was developed; pads were worn for short periods (< 4 h) and then stored in two sealed plastic ...

Faecal incontinence is a distressing condition that affects approximately 1% of the population. Poor anal canal function can be determined by physiological testing using manometry and electromyographic techniques. Surgical repair of the anal canal does not always restore continence but biofeedback training either alone or in combination with other techniques ...

Multiple unit activity (MUA) was recorded from the ventral tegmental area (VTA) and mesencephalic locomotor region (MLR) during copulatory behavior of freely moving male rats. Simultaneous accelerometric recordings of the copulatory pelvic thrusting performed by the male rat were taken to precisely correlate in time the changes in MUA with ...

OBJECTIVES: Our purpose was to evaluate risk factors for severe vaginal-perineal trauma and to ascertain determinants of pelvic floor strength. STUDY DESIGN: Secondary analysis of 459 nulliparous women enrolled in a randomized controlled trial of episiotomy was carried out. In a multivariate analysis we examined the association between (1) sulcus ...

The aim of this study was to evaluate the effect of postpartum pelvic floor muscle exercise in the prevention and treatment of urinary incontinence. A prospective comparison design of 99 matched pairs (n= 198) of mothers, a training group and a control group, was used. Eight weeks postpartum the training ...

In this multicentric prospective and randomized study we compared the results obtained by application of a vaginal ultrasound probe in the vaginal introitus to those obtained by the transabdominal one. 66 examined patients were separated in five groups according to the history and gynaecological investigation. Stress urinary incontinence was urodynamically ...

Head-out water immersion (HOI) induces various renal functional changes, such as diuresis, natriuresis, and kaliuresis. The present study was undertaken 1) to characterize the renal response to HOI in Koreans who routinely ingest high salt diet and 2) to evaluate the impact of exercise on the renal response to HOI. ...

The aim of the investigation was to study the repeatability of urethral pressure profile (UPP) and to quantify the influence of voluntary pelvic floor contraction on the UPP. Seventy-two patients underwent one UPP at rest and one UPP during a pelvic floor contraction. The functional urethral length (FUL) and the ...

Pelvic floor muscle exercises are recommended as an initial treatment to women with stress urinary incontinence. This treatment is often unsuccessful because of patient noncompliance. A post-test, experimental control group design was used to examine Pender's (1992) concept of an external cue to action, an audiocassette tape, to enhance patient ...

Urine dissolved oxygen (DO) was measured in 40 healthy subjects and 115 patients divided into 4 groups according to their disease. Group 1 (20 patients) had lower urinary tract infection (UI), Group 2 (30 patients) had urinary stone disease (USD), Group 3 consisted of 50 end-stage chronic renal failure patients ...

Urinary incontinence is a complicated problem, both in terms of diagnosis and treatment. There are, however, quite a few therapies for its treatment. Teleac, a Dutch broadcasting company for adult education, has offered people who suffer from urinary incontinence 'a training therapy' on a distance. This therapy consists of exercise ...

A newly marketed vaginal sponge intended to support the urethra was tested during aerobic exercise in a group of 6 women suffering from stress urinary incontinence. The patients performed half an hour of aerobic exercises on 2 consecutive days, with and without the vaginal sponge. A pad was worn during ...

Pelvic floor muscle exercises, in the treatment of genuine stress incontinence, have been used successfully since 1948. One may expect a significant improvement (warranting no further therapy), or cure rate of about 50%. These exercises have a long-lasting effect. Poorly motivated women should be discouraged to follow exercise sessions. An ...

In connection with a national anti-doping control program, including analysis of 8946 urine samples, 28 athletes were found to have delivered samples free from xenobiotic anabolic steroids but with an increased testosterone/epitestosterone (T/E) ratio (> 6). Unannounced testing of the above athletes produced 2-4 additional urine samples during the next ...

It is not clear if exercise could be useful to identify diabetic patients at risk for the development of nephropathy. We evaluated the responses of blood pressure (BP) and urinary albumin (Alb) and retinol-binding protein (RBP) excretion to standardized sub-maximal exercise in 17 normoalbuminuric normotensive children with IDDM and 17 ...

The effects of outdoor exercise on urinary excretion of the 17-hydroxycorticosteroids (17-OHCS), catecholamine rhythm, and sleep-wake patterns in cockpit crewmembers were investigated before, during and after jet travel between Tokyo and Los Angeles (8-h time difference). On the day following arrival at Los Angeles (day 3) 5 crewmembers exercised outdoors ...

This study was designed to measure whether a single dose of 120 mg pseudoephedrine ingested 120 min before exercise influences performance during 1 h of high-intensity exercise. The effects of exercise on urinary excretion of the drug were also studied. Ten healthy male cyclists were tested on two occasions, separated ...

One of the major signs of inflammation is a change in vascular flow and caliber. It is possible to detect these changes with the help of transvaginal color Doppler velocitometry. The purpose of this study was to evaluate the changes in pelvic circulation in cases with pelvic infection and to ...

The results of a study in which urinary ethylenethiourea (ETU) was assayed in the general population (167 subjects) of four Regions of Italy (Veneto, Lombardy, Piedmont and Trentino Alto Adige) are reported. The results are compared with those in a population of 97 subjects from Rovescala, a hillside wine-producing town ...

OBJECTIVE: To assess the effects of detubularization and outflow competence on the clinical and urodynamic results of patients undergoing substitution cystoplasty. PATIENTS AND METHODS: The study included 142 patients undergoing orthotopic substitution cystoplasty, of whom 85 underwent a 'straight' and 57 a detubularized substitution cystoplasty using the ileo-colonic segment. All ...

PURPOSE: To determine if differences in the viscosity of defecographic contrast media influence radiographic findings. MATERIALS AND METHODS: Twenty asymptomatic volunteers underwent defecography three times with a different contrast medium used for each examination. The contrast media varied in viscosity from a thin barium liquid to a commercial barium paste ...