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Mameletzi Dimitra - - 2011
To investigate whether a structured long-term exercise training programme in patients with coronary artery disease affects baroreflex function and cardiorespiratory efficiency. Twenty-five elderly male patients with coronary artery disease. The patients were randomized into exercise (group A) or control group (group B). Group A followed a seven-month supervised exercise programme, ...
Chaudhry Sundeep S Research and Development Department, MET-TEST, Atlanta, GA, USA. - - 2010
Evidence demonstrating the potential value of noninvasive cardiopulmonary exercise testing (CPET) to accurately detect exercise-induced myocardial ischemia is emerging. This case-based concept report describes CPET abnormalities in an asymptomatic at-risk man with suspected early-stage ischemic heart disease. When CPET was repeated 1 year after baseline assessment, his cardiovascular function had ...
Budzyński Jacek J Department of Gastroenterology, Vascular Diseases and Internal Medicine, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Ujejskiego 75 Street, 85-168 Bydgoszcz, Poland. - - 2010
To investigate the relationship between exercise-provoked esophageal motility disorders and the prognosis for patients with chest pain. The study involved 63 subjects with recurrent angina-like chest pain non-responsive to empirical therapy with proton pump inhibitor (PPI). In all, a coronary artery angiography, panendoscopy, 24-h esophageal pH-metry and manometry, as well ...
Desch S - - 2010
We conducted a three-arm, parallel-group, randomized, controlled trial to compare the effects of rosiglitazone and physical exercise on endothelial function in patients with coronary artery disease and impaired fasting glucose or impaired glucose tolerance over a 6-month period. Group A received rosiglitazone tablets 8 mg daily (n = 16), group ...
Bouzas-Mosquera Alberto - - 2010
Elderly patients with suspected or known coronary artery disease are often referred for pharmacological stress testing. Data on the value of exercise echocardiography (ExEcho) for predicting outcome (particularly all-cause mortality) in these patients are scarce. Peak treadmill ExEcho was performed in 2159 patients ≥ 70 years of age with known ...
Kapinos Kandice A - - 2011
This study investigated the importance of environmental influences in explaining weight gain and related behaviors among freshman college students. We exploited a natural experiment that takes place on most college campuses in the United States--randomized dormitory assignments. We estimated the effects of living in dormitories with varying physical environment characteristics ...
Togni Mario - - 2010
The instantaneous response of the collateral circulation to isometric physical exercise in patients with non-occlusive coronary artery disease (CAD) is not known. Thirty patients (age 59 +/- 9 years) undergoing percutaneous coronary intervention because of stable CAD were included in the study. Collateral function was determined before and during the ...
Sheridan Stacey L SL Division of General Medicine and Clinical Epidemiology, University of North Carolina, Chapel Hill, 27599, USA. - - 2010
Experts have called for the inclusion of values clarification (VC) exercises in decision aids (DAs) as a means of improving their effectiveness, but little research has examined the effects of such exercises. To determine whether adding a VC exercise to a DA on heart disease prevention improves decision-making outcomes. Randomized ...
Michaelides Andreas P - - 2010
BACKGROUND: The incorporation of right-sided chest leads (V(3)R through V(5)R) into standard exercise testing has been reported to improve its diagnostic utility. HYPOTHESIS: The purpose of this study was to evaluate any improvement in the ability of exercise testing in detecting restenosis, using additional V(3)R through V(5)R leads, in asymptomatic ...
Stringer William W - - 2010
Cardiopulmonary exercise testing (CPET) is under-utilized in assessing patients with prominent complaints of dyspnea or exercise limitation and should be one of the early tests used to assess exercise intolerance. The standard 12-lead ECG treadmill stress test focuses on coronary artery disease and is inadequate to assess the various subsystems ...
Soga Yoshimitsu - - 2010
BACKGROUND: Early exercise after coronary stenting is considered to have a risk of stent thrombosis (ST). We investigate the safety of submaximal exercise training based on the Borg scale from the next day after coronary stenting. METHODS: We enrolled 2351 patients who underwent successful coronary stenting. They were divided into ...
Long Xin - - 2010
The purpose of this study was to determine the effects of exercise on coronary blood flow and macrovascular atherosclerosis in response to stent deployment. Male Yucatan swine were placed on a control diet (C); on a high-fat/cholesterol diet (hypercholesterolemic; H); or on a high-fat/cholesterol diet and aerobically exercise trained (HX) ...
Wise Frances M - - 2010
Cardiovascular disease is the leading cause of death in developed nations, and there is a clear link between cardiovascular disease and physical inactivity. This article describes the benefits of exercise for cardiac patients, details how exercise is prescribed in this group, and considers safety and contraindications to exercise in this ...
Hansen Dominique - - 2010
OBJECTIVE: To assess whether exercise volume during phase II rehabilitation affects long-term clinical benefits in patients with coronary artery disease. DESIGN: Prospective randomized clinical trial with long-term follow-up. SETTING: Hospital outpatient clinic. SUBJECTS: Coronary artery disease patients (age 65 +/- 9 years, 82% males) attending a phase II rehabilitation programme ...
Baba Reizo - - 2010
Oxygen uptake efficiency slope (OUES) and ventilatory efficiency (VE/VCO2 slope) are widely used as submaximal measurements of cardiopulmonary exercise testing as the evaluator or prognosticator of cardiac diseases. However, very few studies have compared the effects of submaximal exercise on these measurements. A total of 58 patients with coronary artery ...
Hietanen H - - 2010
Elevated ankle blood pressure (ABP) may be one of the earliest signs of subclinical atherosclerosis. However, its behavior in different degrees of atherosclerotic vascular damage has not been well characterized. We examined the association of ABP and brachial exercise blood pressure with the incidence of future coronary events. A cohort ...
Yanagisawa Osamu - - 2010
we used magnetic resonance (MR) imaging and ultrasonography in combination with a dynamometer to assess physiological and functional aspects of the skeletal muscles after strenuous exercise that included eccentric contraction. seven male subjects (mean age, 21.7 years) performed ankle plantar flexion that included eccentric contraction and underwent diffusion-weighted MR imaging ...
Borbouse Léna - - 2010
This investigation was designed to examine the hypothesis that impaired function of coronary microvascular large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels in metabolic syndrome (MetS) significantly attenuates the balance between myocardial oxygen delivery and metabolism at rest and during exercise-induced increases in myocardial oxygen consumption (MVo(2)). Studies were conducted in conscious, chronically ...
Bender Shawn B - - 2010
Coronary blood flow (CBF) is reduced and transiently reversed during systole via cardiac contraction. Cardiac contractility, coronary tone, and arterial pressure each influence systolic CBF (CBF(SYS)), particularly by modulating the retrograde component of CBF(SYS). The effect of concurrent changes in these factors on CBF(SYS) during dynamic exercise has not been ...
Scalone Giancarla - - 2009
OBJECTIVE: Previous studies have shown that exercise increases platelet reactivity in patients with coronary artery disease (CAD). However, the response of platelet reactivity to exercise is considerably variable and its predictors are poorly known. METHODS: We studied 214 consecutive patients (age 61.9 +/- 9 years, 167 men) with stable angina ...
Andersen Karl - - 2009
OBJECTIVES: In-stent restenosis (ISR) is the main limitation of percutaneous coronary interventions (PCI), occurring in approximately 25% of cases. Although frequently asymptomatic, many PCI patients present with recurrent symptoms of chest pain at follow-up raising a clinical suspicion of ISR. The diagnosis of ISR can be challenging in these patients ...
Chalela W A - - 2009
The aim of this study was to test the hypothesis of differences in performance including differences in ST-T wave changes between healthy men and women submitted to an exercise stress test. Two hundred (45.4%) men and 241 (54.6%) women (mean age: 38.7 +/- 11.0 years) were submitted to an exercise ...
Tanaka Shinichiro - - 2009
BACKGROUND: Some stable angina patients with significant coronary function have low exercise capacity, whereas some have high exercise capacity. The aim of the present study was to determine whether coronary pressure-derived fractional flow reserve (FFRmyo), a functional index of coronary stenosis, is a better indicator of exercise capacity than angiographic ...
Sixt Sebastian - - 2010
Patients with type 2 diabetes mellitus (T2DM) suffer from accelerated coronary artery disease. We assessed the effects of a multifactorial intervention with focus on exercise training on coronary endothelial function, vascular structure, and inflammation in serum and skeletal muscle biopsies, including mRNA expression of diabetes candidate genes. Twenty-three patients were ...
Cournot Maxime - - 2009
BACKGROUND: The choice of noninvasive tests used in primary prevention of cardiovascular diseases must be based on medical evidence. The aim of this study was to assess the additional prognostic value, over conventional risk factors, of physical examination, exercise testing, and arterial ultrasonography, in predicting a first coronary event. METHODS: ...
Mori Masayuki - - 2009
Habitual exercise training, including a high-intensity interval walking programme, improves cardiorespiratory fitness and alleviates lifestyle-related diseases, such as obesity, hypertension and dyslipidaemia. However, the extent of improvement has been shown to differ substantially among individuals for various exercise regimens. A body of literature has demonstrated that gene polymorphisms could account ...
Lahav Dror - - 2009
The present study, using a decision analysis, evaluates whether an exercise tolerance test (ETT) is indicated before initiating regular physical activity to reduce the risk of sudden death during exercise training. The study encompasses a decision tree, Monte Carlo simulation, and utility analysis for adults at low to high risk ...
Angadi Siddhartha S - - 2009
Coronary heart disease is a major cause of morbidity and mortality in persons with diabetes mellitus. Exercise is an important cornerstone in the treatment and management of diabetes but is also associated with a heightened risk of sudden cardiac death in those with occult coronary heart disease. Before beginning a ...
Halon David A - - 2010
Impaired heart rate recovery after exercise (HRR) is a marker of autonomic dysfunction and a predictor of long-term mortality either directly or due to associated cardiovascular disease. In a cohort of 552 asymptomatic type 2 diabetics (age 63.2 ± 5.4 yr, 54.9% women) participating in a long-term prospective outcomes study, ...
Knoell Keith Allen - - 2009
Exercised-induced vasculitis (EIV) is an underreported and frequently misdiagnosed condition that occurs on the lower extremities shortly after exercise. Most reported cases have presented in healthy-appearing individuals, but some cases have been linked to other disease processes. A case report is presented of recurring EIV in a 65-year-old woman with ...
Vissing John - - 2009
Over 100 mutations in the myophosphorylase gene, which cause McArdle disease, are known. All these mutations have resulted in a complete block of muscle glycogenolysis, and accordingly, no genotype-phenotype correlation has been identified in this condition. We evaluated physiologic and genetic features of two patients with a variant form of ...
Cay Serkan - - 2009
BACKGROUND: Coronary artery disease is the leading cause of morbidity and mortality around the world. Autonomic nervous system abnormalities are associated with coronary artery disease and its complications. Exercise stress tests are routinely used for the detection of the presence of coronary artery disease. In this study, we observed the ...
Girotra Saket - - 2009
Impaired heart rate response to exercise is associated with adverse clinical outcomes in healthy adults and those with established coronary artery disease. It is unclear whether this association persists in subjects who have undergone coronary artery bypass grafting (CABG). In this study, 920 subjects enrolled in the Post CABG trial ...
Hansen D - - 2009
The exercise carbon dioxide equivalent slope predicts prognosis in coronary artery disease patients. However, no study examined whether the carbon dioxide equivalent slope in coronary artery disease patients is dependent on the type of exercise. Twenty-nine coronary artery disease patients performed maximal cardiopulmonary exercise tests on bike, treadmill and arm ...
Ranković Goran - - 2009
BACKGROUND/AIM: Inflammation is an important factor in the pathogenesis of atherosclerosis, and several markers of inflammation have been associated with an increased risk of cardiovascular events. Physical activity may lower the risk for coronary heart disease (CHD) by mitigating inflammation. The aim of this study was to investigate the effects ...
Barna Laszlo - - 2009
Exercise testing is a safe diagnostic procedure which is widely used in the evaluation of patients suspected of having coronary heart disease or for the assessment of the prognosis in patients with established disease. Its complications are mainly cardiac disorders. Here, we report a rectus sheath haematoma as a complication ...
Tiryakioglu Selma - - 2009
Earlier studies have reported that a decrease in exercise capacity might indicate endothelial dysfunction. However, the effects of improvement of endothelial functions on exercise capacity have not been evaluated. The aim of the present study is to investigate the effects of nebivolol on flow-mediated dilatation (FMD), and on the exercise ...
Kuper Hannah H Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT. - - 2009
To develop a new methodology to systematically compare evidence across diverse risk markers for coronary heart disease and to compare this evidence with guideline recommendations. "Horizontal" systematic review incorporating different sources of evidence. Electronic search of Medline and hand search of guidelines. Study selection Two reviewers independently determined eligibility of ...
Miao Ning - - 2009
Cytoreductive surgery and continuous hyperthermic peritoneal perfusion (CHPP) involve the conduct of a complex surgical procedure and delivery of high-dose hyperthermic chemotherapy to the peritoneum. This therapeutic modality has been shown to benefit patients with peritoneal carcinomatosis resulting from gastrointestinal and ovarian tumors and mesothelioma. However, it is unknown whether ...
Conti Alberto - - 2008
BACKGROUND: Patients with chest pain (CP) and nondiagnostic ECG represent heterogeneous population in whom the evaluation of coronary risk factors including metabolic syndrome (MetS) and diabetes mellitus (DM) might improve risk stratification. METHODS: We enrolled 798 consecutive CP patients; 14% presented with MetS and 10% with DM; the remaining 76% ...
Aron Adrian - - 2009
There is growing evidence linking obstructive sleep apnea hypopnea syndrome (OSAHS) with multiple cardiovascular and metabolic diseases. Exercise testing is generally available and routinely used to provide valuable information on cardiopulmonary function in healthy and diseased populations. This review summarizes and integrates recent findings on exercise testing in OSAHS and ...
Nagy Edit - - 2008
Previous studies have established a link/relationship between haemostatic factors and increased risk of cardiovascular disease. In addition, physical conditioning is associated with lower coronary heart disease risk. The purpose of this study was to assess the association between physical exercise and haemostatic factors among middle-aged women surviving an acute coronary ...
Cheema Birinder Singh Bobby - - 2008
Life expectancy in haemodialysis patients is reduced fourfold on average versus healthy age-matched individuals. The purpose of this review is to present empirical evidence that intradialytic exercise can mitigate primary independent risk factors for early mortality in end-stage renal disease. These risk factors include measures of skeletal muscle wasting, systemic ...
Brothers J A - - 2009
We sought to evaluate exercise performance and quality of life in children after surgical repair of anomalous aortic origin of a coronary artery with an interarterial course. Patients who had surgery from October 2001 to January 2007 were eligible for inclusion. Exercise performance and quality of life were prospectively assessed ...
Kurl S - - 2009
OBJECTIVE: We investigated the prognostic significance of risk scores and exercise workload with respect to stroke. Background. There are no data on exercise workload combined with European Systematic Coronary Risk Evaluation (SCORE) in the prediction of stroke. METHODS: Exercise workload was measured by exercise test with an electrically braked cycle ...
Serruys Patrick W - - 2008
BACKGROUND: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is expressed abundantly in the necrotic core of coronary lesions, and products of its enzymatic activity may contribute to inflammation and cell death, rendering plaque vulnerable to rupture. METHODS AND RESULTS: This study compared the effects of 12 months of treatment with darapladib (an oral ...
Hartmann Marc - - 2009
Intravascular ultrasound radiofrequency (RF-IVUS) data permit the analysis of coronary plaque composition in vivo and is used as an endpoint of ongoing pharmacological intervention trials. We assessed the reproducibility of volumetric RF-IVUS analyses in mild-to-moderately diseased atherosclerotic human coronary arteries in vivo. A total of 9,212 IVUS analyses on cross-sectional ...
Gotoh Norimoto - - 2008
BACKGROUND: Typical exudative age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are two of the major macular diseases found in Asians. Although genomic studies have shown a contribution by CFH and LOC387715/HTRA1 polymorphisms to the development of these two diseases, the correlation of the clinical phenotypes to these genotypes ...
Becker, Dietmar
Infiltration of the arterial vessel wall with monocytes is one of the initial inflammatory events. Monocyte chemoattractant protein-1 (MCP-1) is the key chemokine for the recruitment of monocytes to the atherosclerotic lesion. So far, it is unknown, if strenuous exercise enhances or reduces the release of MCP-1, the key initiator ...
Laukkanen Jari A - - 2008
BACKGROUND: No data exist on exercise workload combined with European Systematic Coronary Risk Evaluation (SCORE) with respect to death from cardiovascular diseases and other causes. We therefore investigated the prognostic significance of risk scores and exercise capacity with respect to cardiovascular diseases. DESIGN: A population-based follow-up study. METHODS: Exercise workload ...
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