The peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) controls metabolic adaptations. We now show that PGC-1α in skeletal muscle drives the expression of lactate dehydrogenase (LDH) B in an estrogen-related receptor-α-dependent manner. Concomitantly, PGC-1α reduces the expression of LDH A and one of its regulators, the transcription factor myelocytomatosis oncogene. PGC-1α ...

A 9-year-old Thoroughbred gelding presented with a 97-day history of poor performance and intermittent fever. Clinicopathologic changes included increased serum activity of γ-glutamyltransferase and alkaline phosphatase, mild hyperbilirubinemia, and leukocytosis with neutrophilia and lymphopenia. Abdominal ultrasound revealed hepatomegaly with hyperechoic hepatic parenchyma and biliary distention. Pathologic findings included marked hepatomegaly ...

Obesity is a major health issue that impedes the ability of preconditioning and postconditioning to protect the myocardium against infarction secondary to dysregulation of kinase signalling pathways. Moreover, exercise decreases cardiovascular mortality in obese patients but the mechanism remains to be established. Wild-type (WT) and obese (ob/ob) mice were assigned ...

Prior exercise by rats can induce a sustained increase in muscle Akt substrate of 160kDa (AS160) phosphorylation on Thr(642) (pAS160Thr(642)). Because phosphorylation of AS160 on both AS160Thr(642) and AS160Ser(588) is important for insulin-stimulated glucose transport (GT), we determined if exercise would also induce a sustained increase in pAS160(Ser588) concomitant with ...

The objective of this study was to use self-determination theory to analyze the relationships of several motivational variables with exercise dependence. The study involved 531 exercisers, ranging in age from 16 to 60 years old, who responded to differentquestionnaires assessing perception of motivational climate, satisfaction of basic psychological needs, motivation ...

Variation in mechanical loading is known to influence chondrogenesis during joint formation. However, the interaction among chondrocyte behavior and variation in activity patterns is incompletely understood, hindering our knowledge of limb ontogeny and function. Here, the role of endurance exercise in the development of articular and physeal cartilage in the ...

Forensic mortuaries in all Australian jurisdictions are dealing with increasing workloads, with routine cases regularly occupying greater than 50%, and often as much as 85%, of existing cold room body storage capacity, particularly over long weekends and during seasonal increases in respiratory infections. Hence the need to deal with a ...

Excessive concentrations of L-glutamate (glutamate) have been found to posses neurotoxic properties. This study investigates how stress induced by strong physical exercise effects blood glutamate, 2-ketoglutarate, Alanine aminotransferase (ALT) and Aspartate Aminotransferase (AST) levels. The relationship between muscle damage caused by strong physical exercise and blood glutamate levels was also ...

Motivation is a critical factor in supporting sustained exercise, which in turn is associated with important health outcomes. Accordingly, research on exercise motivation from the perspective of self-determination theory (SDT) has grown considerably in recent years. Previous reviews have been mostly narrative and theoretical. Aiming at a more comprehensive review ...

PURPOSE: To examine variations in physical, physiological and performance parameters over an annual training cycle in a world champion rowing crew. METHODS: Four world-class rowers, all of them members of the men's heavyweight quadruple sculls squad who are current world rowing champions, were assessed 3 times at regular 4-month intervals ...

Physical activity after bariatric surgery is associated with sustained weight loss and improved quality of life. Some bariatric patients engage insufficiently in physical activity. This may be due to exercise cognitions, i.e., specific beliefs about benefits of and barriers to physical exercise. The aim of this study was to examine ...

Given the widespread use of water immersion during recovery from exercise, we aimed to investigate the effect of contrast water immersion on recovery of sprint cycling performance, HR and, blood lactate. Two groups completed high-intensity sprint exercise before and after a 30-min randomized recovery. The Wingate group (n = 8) ...

Understanding the contextual preferences that people have for engaging in a health-enhancing physical activity has been identified as particularly important, as these preferences have been implicated in the maintenance of active lifestyle behaviors. The primary purpose of this study was to examine adults' preferences for exercising in both gender-segregated and ...

This paper aims to examine the similarities in effects of exercise training and a hypocaloric diet within overweight female monozygotic twin pairs and to assess differences in twin partners' responses depending on the timing of exercise bouts and main meals. Six previously untrained twin pairs (aged 20-37years, body fat 35.8±6.3%) ...

People with stroke typically must perform much of their hand exercise at home without professional assistance as soon as two weeks after the stroke. Without feedback and encouragement, individuals often lose motivation to practice using the affected hand, and this disuse contributes to further declines in hand function. We developed ...

To evaluate the association of exercise and knee-bending activities with magnetic resonance imaging (MRI)-based knee cartilage T2 relaxation times and morphologic abnormalities in asymptomatic subjects from the Osteoarthritis Initiative, with or without osteoarthritis (OA) risk factors. We studied 128 subjects with knee OA risk factors and 33 normal control subjects ...

Studies examining trends over time in mainstream magazines observe decreases in women's figure size, and increases in figure exposure and amount of diet/exercise content. Little is known, however, regarding the content of African American magazines. Utilizing methods from classic studies, this investigation examined content in Ebony, a magazine with wide ...

Studies have demonstrated that postnatal women are at high risk for physical inactivity and generally show lower levels of leisure-time physical activity (LTPA) compared to prepregnancy. The overall purpose of the current study was to investigate social cognitive correlates of LTPA among postnatal women during a 6-month period following childbirth. ...

A single exercise bout stimulates skeletal muscle glucose transport (GT) in the absence or presence of insulin. It has been suggested that the kallikrein-kinin system may contribute to exercise effects on both insulin-independent and insulin-dependent GT. Plasma kininogen, a key kallikrein-kinin system component, is a protein substrate for the enzyme ...

The purpose of this study was to assess the effect of exercise intensity during an incremental exercise test on plasma Mg concentration in well-trained euhydrated athletes. Twenty-seven well-trained endurance athletes carried out a cycloergometer test: after a warm-up of 10 min at 2.0 W·kg(-1), the workload increased by 0.5 W·kg(-1) ...

It is well established that the metabolic cost of horizontal locomotion decreases as a regular function of animal body mass, regardless of body form and phylogeny. How body size affects the cost of incline exercise remains much less clear. Studies on vertebrates have led to the hypotheses that the cost ...

Compared with isometric and dynamic velocity-constrained (isokinetic) tasks, less is known regarding velocity-dependent (isotonic) muscle power and recovery in older adults following repeated fatiguing lengthening contractions. We investigated voluntary and evoked neuromuscular properties of the dorsiflexors in nine old (68.3 ± 6.1 years) and nine young women (25.1 ± 1.3 years) during and following 150 lengthening ...

The aim of this study was to monitor muscle contractile performance in vivo, using an electrical stimulation protocol, immediately following an acute high and low intensity exercise session conducted at the same average intensity performed on a cycle ergometer. Eighteen healthy males (25.1 ± 4.5 years, 81.6 ± 9.8 kg, 1.83 ± 0.06 m; mean ± SD) participated in the study. ...

PURPOSE:: We compared the effects of exercise intensity (EI) on the cytokine response to an acute bout of running. METHODS:: Ten males (mean ± 1SD VO2max: 56.2 ± 8.1 mL·min-·kg-) completed three, counterbalanced, 8-day trials. Following three control days, on Day 4, participants completed 60 min of running at 55%, ...

The synergistic effect of resistance exercise and protein ingestion on muscle protein anabolism in young adults has been well described. However, it is unclear if this relationship is maintained in older adults who are at greater risk of sarcopenic muscle loss. To this end, we sought to determine if the ...

Ferguson-Stegall, L, McCleave, EL, Ding, Z, Doerner III, PG, Wang, B, Liao, Y-H, Kammer, L, Liu, Y, Hwang, J, Dessard, BM, and Ivy, JL. Postexercise carbohydrate-protein supplementation improves subsequent exercise performance and intracellular signaling for protein synthesis. J Strength Cond Res 25(5): 1210-1224, 2011-Postexercise carbohydrate-protein (CHO + PRO) supplementation has ...

: The aim of this study was to determine the influence of five different recovery strategies on repeated simulated time trial (TT) performance on a stationary cycle ergometer. : Study 1 (n = 8, male, club-level trained; V˙O2max: 56.9 ± 3.8 mL·min·kg) investigated the influence of passive rest with or ...

Zuniga, JM, Berg, K, Noble, J, Harder, J, Chaffin, ME, and Hanumanthu, VS. Physiological responses during interval training with different intensities and duration of exercise. J Strength Cond Res 25(5): 1279-1284, 2011-The purpose of this study was to compare 4 interval training (IT) sessions with different intensities and durations of ...

We evaluated the expression of MSTN and ActRIIB mRNA in muscle and adipose tissue in diet-induced obesity and insulin resistance in rats subjected to exercise. There was no difference in the expression of MSTN between exercised and sedentary high-fat fed rats in muscle after swimming training. The expression of ActRIIB ...

The aim of this study was to investigate the effects of a combination of nutrients on physical performance, oxidative stress and mitochondrial biogenesis in rats subjected to exhaustive exercise. Rats were divided into sedentary control (SC), exhaustive exercise (EC) and exhaustive exercise with nutrient supplementation (EN). The nutrients include (mg/kg/day): ...

The goal of this study was to determine if increasing strength in primary knee extensors and flexors would directly affect net knee joint moments during a common functional task in persons with knee osteoarthritis. An exploratory single sample clinical trial with pre-post treatment measures was used to study volunteers with ...

Substrate metabolism differs between children and adults and is important for weight management during childhood. A direct comparison of fat oxidation over a range of exercise intensities and the estimation of Fatmax (exercise intensity that elicits maximal fat oxidation (MFO)) during treadmill (TM) and cycling exercise (CE) does not appear ...

The aim of this study was to test the hypotheses that 1) skeletal muscles of elderly subjects can adapt to a single endurance exercise bout and 2) endurance trained elderly subjects have higher expression/activity of oxidative and angiogenic proteins in skeletal muscle than untrained elderly people. To investigate this, lifelong ...

We compared the effects of consuming a 2-day low-carbohydrate (CHO) diet (low-CHO; 20% CHO, 40% protein, 40% fat) versus an isocaloric 2-day moderate-CHO diet (mod-CHO; 55% CHO, 15% protein, 30% fat) on substrate oxidation during and after exercise in ten active, young women. Subjects were 24.9 ± 6.2% body fat with a ...

We analyzed the effect of a 6-week aerobic exercise training program on the in vivo macrophage reverse cholesterol transport (RCT) in human cholesteryl ester transfer protein (CETP) transgenic (CETP-tg) mice. Male CETP-tg mice were randomly assigned to a sedentary group or a carefully supervised exercise training group (treadmill 15 m/min, 30 min ...

Ishizuka, T, Hess, RA, Reuter, B, Federico, MS, and Yamada, Y. Recovery of time on limits of stability from functional fatigue in division II collegiate athletes. J Strength Cond Res 25(X): 000-000, 2011-Health and fitness professionals working with athletes could establish effective and safe practice and training programs if recovery ...

The recent surge in childhood obesity has renewed interest in studying exercise as a therapeutic means of metabolizing fat. However, carbohydrate (CHO) intake attenuates whole body fat oxidation during exercise in healthy children and may suppress fat metabolism in obese youth. To determine the impact of CHO intake on substrate ...

This study examined the effects of 30 and 60 min of moderate intensity exercise on postprandial triacylglycerol concentration [TAG] in 11 healthy, 13-year-old boys. The boys completed three counterbalanced conditions. On day 1, they either rested (CON), or jogged for 30 min (EX30) or 60 min (EX60) at 55% peak [Formula: see text] ...

The aim of the present study was to examine the effect of sodium bicarbonate ingestion on consecutive "all out" sprint tests, analyzing the acid-base status and its influence on performance and perceived effort. Ten elite bicycle motocross (BMX) riders (20.7 ± 1.4 years, training experience 8-12 years) participated in this study which consisted of ...

PURPOSE:: Dietary nitrate supplementation has been shown to reduce the O2 cost of sub-maximal exercise and to improve high-intensity exercise tolerance. However, it is presently unknown whether it may enhance performance during simulated competition. The present study investigated the effects of acute dietary nitrate supplementation on power output (PO), V˙o2, ...

Objective This study analysed cardiopulmonary, metabolic and rating of perceived exertion (RPE) responses during exercise bouts performed below, at and above the second lactate threshold (LT2) intensity. Methods 10 healthy men performed constant workloads to exhaustion at the first lactate threshold (LT1), LT2 and 25% of the difference between LT2 ...

The purpose of this study was to investigate the potential of bovine colostrum to attenuate postexercise decline in immune function. The authors evaluated the time course of a number of immune variables after short-term intense exercise in 9 male athletes after 10 d of supplementation with either colostrum or skim-milk ...

The purpose of this study was to examine the effects of a 6-wk intervention that used guided relaxation and exercise imagery (GREI) to increase self-reported leisure-time exercise behavior among older adults. A total of 93 community-dwelling healthy older adults (age 70.38 ± 8.15 yr, 66 female) were randomly placed in ...

Aims.  (1) To explore the types and three components (frequency, duration and caloric expenditure) of leisure-time physical activity in community older people with chronic diseases. (2) To identify leisure-time physical activity-related factors in these community older people. Background.  Previous research has focused primarily on measuring the actual physiological or psychological ...

Brunner-Ziegler, S, Strasser, B, and Haber, P. Comparison of metabolic and biomechanic responses to active vs. passive warm-up procedures before physical exercise. J Strength Cond Res 25(4): 909-914, 2011-Active warm-up before physical exercise is a widely accepted practice to enhance physical performance, whereas data on modalities to passively raise tissue ...

: Regular exercise is inversely related to markers of chronic inflammation, but we do not know to what extent these changes are the product of recent exercise behavior. The aim of the present investigation was to examine the stability of markers of chronic inflammation in the face of short-term positive ...

MiRNAs regulate cardiac development, hypertrophy, and angiogenesis, but their role in cardiac hypertrophy (CH) induced by aerobic training has not previously been studied. Aerobic training promotes physiological CH preserving cardiac function. This study assessed involvement of miRNAs-29 in CH of trained rats. Female Wistar rats (n=7/group) were randomized into three ...

This study examined the effects of cold therapy (COLD) on recovery of voluntary and evoked contractile properties following high-intensity, muscle-damaging and fatiguing exercise. Ten resistance-trained males performed 6 × 25 maximal concentric/eccentric muscle contractions of the dominant knee extensors (KE) followed by a 20-min recovery (COLD v control) in a randomized cross-over ...

Objectives: Different models to assess HR recovery have been developed but knowledge of their reliability is poor at different submaximal exercise intensities and recovery durations. Our aim was to determine the reliability of HR recovery after a test on a cycle ergometer. Design: Twenty-one healthy individuals performed a submaximal exercise ...

INTRODUCTION: High intensity interval training (HIT) increases skeletal muscle oxidative capacity similar to traditional endurance training, despite a low total exercise volume. Much of this work has focused on young active individuals and it is unclear if the results are applicable to older, less active populations. In addition, many studies ...