OBJECTIVE: Increased levels of the light-chain neurofilament protein (NFL) in CSF provide a marker of CNS injury in several neurodegenerative disorders and have been reported in the AIDS dementia complex (ADC). We examined the effects of highly active antiretroviral treatment (HAART) on CSF NFL in HIV-1-infected subjects with and without ...

To investigate brain activation in the prefrontal cortex (PFC) during the Wisconsin Card Sorting Test (Keio Version) (KWCST), we examined changes in total hemoglobin volume (THV) in 8 patients with traumatic brain injury (TBI) and 20 healthy control subjects using two-channel near-infrared spectroscopy. As a result, average THV in the ...

INTRODUCTION: Anterior cruciate ligament (ACL) injuries are more common among female athletes compared to male athletes. Several studies have been reported to explain the gender difference in ACL injury rates and several risk factors underlying gender disparity are believed to exist. Hormonal effects are considered to be one of the ...

The purpose of this study was to identify changes due to whole body vibration in peroneus longus (PL) activation following ankle inversion perturbation. Participants were 22 (age 22.1 +/- 1.8 yrs, ht 168.8 +/- 8.2 cm, mass 65.5 +/- 11.2 kg) physically active male and female students with no recent ...

PURPOSE: To examine relationships between physical characteristics and injuries in adult figure skaters. METHODS: One hundred thirty adult figure skaters (113 women and 17 men, 43 +/- 9 and 55 +/- 10 y old, respectively) completed study questionnaires concerning health, height and weight, exercise habits, and injuries in the preceding ...

BACKGROUND AND PURPOSE: Goal-oriented, task-specific training has been shown to improve function; however, it can be difficult to maintain patient interest. This report describes a rehabilitation protocol for the maintenance of balance in a short-sitting position following spinal cord and head injuries by use of a center-of-pressure-controlled video game-based tool. ...

OBJECTIVES: The objective of this work was to investigate if the application of factor analysis to the SELDI-TOF MS data could contribute to the characterization of the serum low-molecular weight proteins/peptides in liver injury. DESIGN AND METHODS: Distinguished SELDI-TOF mass spectral peaks of the liver injury group were identified by ...

It is widely accepted, based on the principle of respect for autonomy, that there are ethical constraints on the range of tactics that persons may use to influence the decisions and behaviors of others. However, accurate ascriptions of autonomy to either persons or acts may vary considerably, depending on properties ...

BACKGROUND: Hamstring strains can be of 2 types with different injury mechanisms, 1 occurring during high-speed running and the other during stretching exercises. HYPOTHESIS: A stretching type of injury to the proximal rear thigh may involve specific muscle-tendon structures that could affect recovery time. STUDY DESIGN: Case series (prognosis); Level ...

OBJECTIVE: To determine whether individuals who have a spinal cord injury have neuromuscular and physiologic responses to a personalized exercise program during dynamic weight bearing (DWB). DESIGN: Four subjects with spinal cord injuries (T6, T5-6, C2-5, and C5) completed a 12-wk exercise program that included DWB. Surface electromyography (EMG) was ...

OBJECTIVE: To investigate the relationship between intestinal mucosa injury and changes in stereologic parameters for its vessels. STUDY DESIGN: PAS stain was used to observe the basement membrane of intestinal epithelium. To measure the parameters of microvasculature by stereology, microvasculature was shown by alkaline phosphatase stain. Diamine oxidase (DAO) activity ...

OBJECTIVE: To determine the feasibility and impact of an outpatient, electric stimulation cycling (ESC) protocol on a patient with incomplete spinal cord injury (SCI). DESIGN: Pre-post case study. SETTING: Outpatient rehabilitation hospital. PARTICIPANT: A 24-year old man with an incomplete SCI occurring 25 months before study entry at the T12-L1 ...

OBJECTIVE: To investigate whether reporting blood redistribution by means of graduated elastic stockings affects exercise and postexercise responses in people with spinal cord injury (SCI). DESIGN: Crossover trial. SETTING: Physical medicine and rehabilitation department in France. PARTICIPANTS: Fourteen men with traumatic SCI, grouped according to their level of injury. INTERVENTIONS: ...

Due to the prevalence of neuromuscular disorders such as amyotrophic lateral sclerosis and spinal muscular atrophy in modern societies, defining new and efficient strategies for the treatment of these two neurodegenerative diseases has become a vital and still unfulfilled urge. Several lines of experimental evidence have emphasized the benefits of ...

OBJECTIVE: The purpose of this study was to compare the posterior superior iliac spine (PSIS) and the iliac crest as accurate anatomical landmarks for identifying spinal level. METHODS: This study was conducted in 2 stages. First, 4 examiners examined 60 patients and blindly identified iliac crest and PSIS levels, and ...

Hyaline globules (HGs; thanatosomes) are well-defined morphologic and functional entities representing a degenerative phenomenon common to all cell types. We present the first quantitative and qualitative study of HGs in normal and pathologic gastrointestinal (GI) epithelium from a series of 2,230 biopsies. HGs were very rarely found in normal epithelium ...

The purpose of the present study was to investigate whether mechanical efficiency (ME) relates to wheelchair propulsion capacity and wheelchair performance tasks during and after rehabilitation of people with a spinal cord injury (SCI). Eighty participants with a SCI were tested during rehabilitation (3 x) and 1 year after discharge. ...

Exercise, through manual step training, robotic step training or voluntary wheel running, is emerging as a promising therapy after spinal cord injury (SCI). Animal models provide a tool to investigate the mechanisms by which physical activity influences recovery from SCI. In the present study, we extend previous experiments showing improved ...

OBJECTIVE: To describe the effects of upper body training on the physical capacity of people with a spinal cord injury. DATA SOURCES: The databases of PubMed, CINAHL, Sport Discus and Cochrane were searched from 1970 to May 2006. REVIEW METHODS: The keywords 'spinal cord injury', 'paraplegia', 'tetraplegia' and 'quadriplegia' were ...

Non-randomized study. To determine natural killer cell cytotoxic activity (NKCA) to 2-h arm ergometer exercise in persons with spinal cord injuries (SCI) and the underlying mechanism of such response. University of Occupational and Environmental Health, Japan. We examined NKCA response to 2-h arm crank ergometer exercise at 60% of maximum ...

Recent data on spinal cord plasticity after spinal cord injury (SCI) were reviewed to analyze the influence of training on the neurophysiological organization of locomotor spinal circuits in SCI patients. In particular, the authors studied the relationship between central pattern generators (CPGs) and motor neuron pool activation during gait. An ...

Load carriage is an inevitable part of military life both during training and operations. Loads carried are frequently as high as 60% bodyweight, and this increases injury risk. In the military, load is carried in a backpack (also referred to as a Bergen) and webbing, these combined form a load ...

The purpose of the study was to assess whether postural stability in persons with spinal cord injury (SCI) could be affected by training. Ten post-rehabilitated persons with thoracic SCI performed 30 sessions of kayak ergometer training during a 10-week period. The ergometer was modified with a balance module adjustable in ...

While the theoretical basis for a relationship between ground and environmental conditions and injury in rugby league is compelling, corroborative research is far from substantive. This study investigated the relationship between environmental and ground conditions and injury risk in 156 semi-professional rugby league players. Injuries were prospectively recorded from 157 ...

OBJECTIVE: The objective was to study the effectiveness of a modified washing toilet seat equipped with a CCD camera monitor and an electronic bidet to facilitate precise hitting of the anal area with water streams to stimulate bowel movement in patients with spinal cord injury (SCI). DESIGN: There were 20 ...

PURPOSE: One aim of this study was to find if there was a difference between balance and stability between elite level gymnasts and non-gymnasts. Another aim was to find if there was a relationship between dynamic posturographic scores associated with sway fatigue or adaptability and the ability to learn new ...

Prospective analysis. To investigate the influence of exercise and major competition on infectious episodes in athletes with spinal cord injuries (SCI). Japan. We examined the self-reported infectious episodes of upper respiratory tract infection (URTI) in athletes with SCI during a 1-month period before the race and 2 weeks after the ...

PURPOSE: Exercise-related lower-leg pain (ERLLP) is a common chronic sports injury. In clinical practice, deviant gait biomechanics are frequently considered to play a role in the development of ERLLP, although there is scarce scientific evidence that gait-related variables predispose athletes to this injury. The purpose of this study was to ...

BACKGROUND CONTEXT: Elongation-induced vertebral artery (VA) injury has been hypothesized to occur during nonphysiological coupled head motions during automobile impacts. Although previous work has investigated VA elongation during head-turned and head-forward rear impacts, no studies have performed similar investigations for frontal or side impacts. PURPOSE: The present study quantified dynamic ...

OBJECTIVES: This study describes event rates and associated costs from non-fatal work-related motor vehicle traffic crash (WR MVTC) injuries on public roads in New Zealand based on an analysis of the Accident Compensation Corporation (ACC) entitlement claims database. METHODS: WR MVTC injury claims between July 2004 and June 2006 were ...

INTRODUCTION: Intracerebral hemorrhage (ICH) is a devastating form of stroke commonly resulting in severe morbidity and high mortality. Secondary brain injury often occurs in the days following the initial hemorrhage and is associated with significant neurological deterioration. The neurochemistry associated with secondary injury is poorly understood. The purpose of this ...

The topic of exercise-induced skeletal muscle injury has received considerable attention in recent years. Likewise, strategies to minimise the injury resulting from heavy resistance exercise have been studied. Over the past 15 years, several investigations have been performed focused on the role of nutritional supplements to attenuate signs and symptoms ...

We retrospectively evaluated the effect of exercise on the degree of decrement in ulnar, spinal accessory, and facial repetitive nerve stimulation (RNS) in 179 patients with myasthenia gravis (MG) to assess whether exercise increases the diagnostic yield of identifying significant decrements. The mean worsening of decrement following exercise was 1.9% ...

The anterior cruciate ligament (ACL) is the most frequently injured ligament of the knee. The ACL may be damaged in isolation but often other ligaments and menisci are implicated. The injury may be managed surgically or conservatively. Injury causes pain, effusion and inflammation leading to alteration in muscle function. Regaining ...

A Thai women, aged 22 years old, came to hospital with Patent Ductus Arteriosis (PDA). Left thoracotomy, with division and suturing PDA, was performed. The second day after operation, she developed paraplegia below umbilical level. The CT-scan detected an extradural hematoma in the spinal cavity from T3-T6. To remove the ...

Exercise and antidepressants used independently have been shown to increase hippocampal brain-derived neurotrophic factor (BDNF) and neurogenesis. Despite the fact that patients with depression are often prescribed both, the effects of the exercise and fluoxetine antidepressant treatment used in combination are unknown. Using C57Bl/10 female mice, BDNF protein, insulin-like growth ...

This paper examines the road safety effects of roundabouts built in Flanders between 1994 and 2000. While the overall effect is positive (39% reduction of injury accidents), the results vary considerably with the speed limit on the main and adjacent road (the higher, the more effective) and the pre-roundabout signalization ...

Acute ankle injury, a common musculoskeletal injury, can cause ankle sprains. Some evidence suggests that previous injuries or limited joint flexibility may contribute to ankle sprains. The initial assessment of an acute ankle injury should include questions about the timing and mechanism of the injury. The Ottawa Ankle and Foot ...

There are many articles that support stretching, strengthening, good nutrition, hydration, rest, and ergonomics along with many other concepts that may be helpful in preventing repetitive stress injuries. The most conclusive literature proposes early recognition of onset symptoms, and immediate reduction or cessation of the casual activity. This is not ...

Estimation of self-similarity is a promising tool for quantifying alterations in cardiovascular dynamics. To evaluate the as yet unexplored influence of sympathetic vascular regulation on the scaling exponent, namely on the parameter characterizing self-similarity, we studied patients with a spinal cord injury as a model of progressively impaired vascular control. ...

Vascular changes after acute spinal cord trauma are important factors that predispose quadriplegia, in most cases irreversible. Repair of the spinal blood flow helps the spinal cord recovery. The average time to arrive and perform surgery is 3 h in most cases. It is important to determine the critical ischemia ...

Debate continues over bicycle helmet laws. Proponents argue that case-control studies of voluntary wearing show helmets reduce head injuries. Opponents argue, even when legislation substantially increased percent helmet wearing, there was no obvious response in percentages of cyclist hospital admissions with head injury-trends for cyclists were virtually identical to those ...

BACKGROUND: Studies have suggested that exercise programs can reduce the incidence of noncontact injuries of the anterior cruciate ligament in female athletes. We conducted a two-year prospective study to assess the effects of a knee ligament injury prevention exercise program on the incidence of noncontact anterior cruciate ligament injuries in ...

The effect of long-term (4 weeks) moderate locomotor exercise on segmental distribution of glutamate (Glu), aspartate, gamma-aminobutyric acid, glycine (Gly), serotonin and noradrenaline in the spinal cord of adult rats was investigated. In light of the data showing modulation of some neurotransmitters in the low-lumbar segments of the rat due ...

The purpose of this study was to determine if robotic-assisted treadmill training improved hindlimb stepping in complete spinal cord transected (ST) rats. In addition, we examined whether chronic quipazine treatment would enhance the effectiveness of robotic-assisted training. Hindlimb stepping was examined in four groups of ST rats: trained + quipazine; ...

BACKGROUND AND OBJECTIVES: Glucocorticosteroids are widely used in medicine and have shown unchallenged therapeutic potential in several chronic inflammatory and other diseases. They are also widely used in sports medicine for the treatment of conditions such as asthma and acute injuries. In fact, as banned substances, most requests for therapeutic ...

OBJECTIVE: The spinal cord is capable of activity-dependent plasticity, but the extent of its participation in human motor learning is not known. Here, we tested the hypothesis that acquisition of a locomotor-related skill modulates the pathway of the H-reflex, a measure of spinal cord excitability that is susceptible to plastic ...

BACKGROUND: Intelligence was assessed in a group of 74 people with head injury, 16 years after injury (mean 16.77 years; range 10-32 years), and compared with their performance when assessed at an early stage in recovery (mean 1.05 years). AIMS: To confirm the presence of long-term impairment relative to estimates ...

Environmental enrichment and exercise may be neuroprotective or promote recovery after different forms of CNS injury. Here, we tested the possible effects of moderate environmental enrichment and voluntary exercise on the outcome of incomplete spinal cord injury in rats. We provided rats in standard cages with basic environmental enrichment (carton ...

OBJECTIVES: To compare lower-limb overuse injury and low back pain incidence among cadets with and without limb length inequality (LLI) over 1 year of military training and athletic participation. METHODS: A total of 1,100 cadets were screened for LLIs; 126 of 1,100 were identified to have a LLI of > ...