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Results 301 - 350 of 1161
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Germanou Evangelia I - - 2012
BACKGROUND: Obesity is associated with osteoarthritis and it is accompanied by chronic inflammation and elevated oxidative stress. Strengthening-type exercise is used in knee osteoarthritis (KOA) rehabilitation. This study determined how acute isokinetic exercise influences inflammatory responses of obese middle-aged women with KOA. METHODS: Ten obese women with KOA and 10 ...
Gu Qi - - 2012
It is well known that exercise training attenuates aortic remodeling and improves endothelial function in spontaneously hypertensive rats (SHR). However, the underlying molecular mechanism remains unclear. Hydrogen sulfide (H(2)S) and nitric oxide (NO), as two established physiologic messenger molecules, have important roles in the development of aortic remodeling and endothelial ...
Randell Rebecca K - - 2012
PURPOSE: The aim of this study was to investigate the effects of 1 day and 7 days ingestion of a green tea extract (GTE) on whole body fat oxidation during moderate-intensity exercise. METHODS: Thirty one males completed two exercise trials (60 min cycle 50% Wmax). Following the baseline trial (Day ...
Azizbeigi Kamal - - 2012
This study was undertaken to investigate the effects of progressive resistance training exercise (PRT) on plasma oxidative stress and antioxidant enzyme activity in erythrocytes. Twenty male volunteers were randomly assigned to two groups; progressive resistance training and control. Blood samples were collected before and after eight weeks of PRT, and ...
Rouffet David - - 2012
AIMS: Intramyocellular lipids (IMCL) variations in older men are poorly explored. In young adults, IMCL can be influenced both by diet and exercise interventions; this flexibility is related to aerobic fitness. We evaluated in active older adults, the influence of maximal aerobic capacity on short-term diet and exercise-induced variations in ...
Dalla Corte Cristiane L - - 2013
This study aimed to assess the potential protective effect of organic purple grape juice (PGJ) on oxidative stress produced by an exhaustive exercise bout in rats. To test this hypothesis, rats were acutely treated with organic PGJ (Vitis labrusca) and subsequently submitted to an exhaustive exercise bout. Parameters of oxidative ...
Schippers Marie-Pierre - - 2012
The low oxygen levels at high altitude are a potent and unavoidable physiological stressor to which highland mammals must adapt. One hypothesized adaptation to high altitude is an increased reliance on carbohydrates to support aerobic activities. Based on stoichiometries of combustion, ATP yield per mole of oxygen from carbohydrates is ...
Sjøgaard Gisela - - 2013
The aim was to assess mRNA and/or protein levels of heat shock proteins, cytokines, growth regulating, and metabolic proteins in myalgic muscle at rest and in response to work tasks and prolonged exercise training. A randomized controlled trial included 28 females with trapezius myalgia and 16 healthy controls. Those with ...
Bresciani Guilherme - - 2012
OBJECTIVES: In humans, the manganese-superoxide dismutase (MnSOD) gene contains a polymorphism (Ala16Val) that has been related to several metabolic dysfunctions and chronic diseases. However, the obtained results suggest that risks related to this polymorphism are directly influenced by environmental factors. Because few studies have analyzed this possible influence, we performed ...
Morencos E - - 2012
Background and aim: Many exercise studies, although generally showing the beneficial effects of supervised aerobic, resistance or combined exercise on blood lipids, have sometimes reached equivocal conclusions. The aim of this study is to evaluate the impact of different programs that combined exercise and dietary restriction on blood lipids versus ...
Song Woo Jung - - 2012
To investigate the effect of progressive resistance training (PRT) on body composition, physical fitness, quality of life, lipid and nutritional profile of patients on hemodialysis (HD). A non equivalent comparison group pretest and posttest design study was used with 40 participants who were randomly assigned to the exercise group (20 ...
Shiraev Tim - - 2012
Obesity rates in Australia are among the highest in the world, with one in 4 adults being obese. Obesity increases the risk of coronary heart disease, type 2 diabetes mellitus (T2DM) and stroke, three of the top five causes of burden of disease and injury in Australia.2 Dietary modification is ...
Jówko Ewa - - 2012
To evaluate the effect of acute ingestion of green tea polyphenols (GTP) on blood markers of oxidative stress and muscle damage in soccer players exposed to intense exercise. This randomized, double-blinded study was conducted on 16 players during a general preparation period, when all athletes participated in a strength-training program ...
Chi Aiping - - 2012
To investigate the effects of polysaccharide from Gynostemma pentaphyllum on antioxidant activity in skeletal muscle of mice exercised to exhaustion. Three polysaccharide fractions were obtained from G. pentaphyllum polysaccharide (GPP) and termed GPP1-a, GPP2-b, and GPP3-a. Gas chromatography (GC) and infrared spectrum of the polysaccharides were determined. The fractions were ...
Pugh Meredith E ME Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. - - 2012
The 6-min walk test, commonly used to assess exercise capacity and response to therapy in pulmonary arterial hypertension (PAH), has many well-described limitations. Sedentary time is associated with adverse cardiovascular outcomes and reduced quality of life, and measuring sedentary time and physical activity using accelerometry is another potential way to ...
Siciliano Gabriele G Department of Neuroscience, University of Pisa, Pisa, Italy. - - 2012
In mitochondrial myopathies with respiratory chain deficiency impairment of energy cell production may lead to in excess reactive oxygen species generation with consequent oxidative stress and cell damage. Aerobic training has been showed to increase muscle performance in patients with mitochondrial myopathies. Aim of this study has been to evaluate, ...
Conley Kevin - - 2012
Increased VO2max, mitochondrial capacity and energy coupling efficiency are reported after endurance training (ET) in adult subjects. Here we test whether leg exercise performance (power output of the legs, Pmax, at VO2max) reflects these improvements with ET in the elderly. Fifteen male and female subjects were endurance trained for a ...
Arikawa Andrea Y AY University of Minnesota, Department of Food Science and Nutrition, Paul, MN 55108, USA. - - 2013
The purpose of this trial was to determine whether exercise without weight loss would reduce F2-isoprostanes in previously sedentary young women. Participants (N=319) were randomized to four months of 150min/week aerobic exercise or a control group. Plasma free F2-isoprostanes were measured by gas chromatography-mass spectrometry. Other assessments included fitness and ...
Koves Timothy R TR Sarah W. Stedman Nutrition & Metabolism Center, Duke University, Durham, NC, - - 2013
Intramuscular accumulation of triacylglycerol, in the form of lipid droplets (LD), has gained widespread attention as a hallmark of metabolic disease and insulin resistance. Paradoxically, LDs also amass in muscles of highly trained endurance athletes who are exquisitely insulin sensitive. Understanding the molecular mechanisms that mediate the expansion and appropriate ...
Quinn Lebris S LS S-182 Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA. - - 2013
Endurance exercise initiates a pattern of gene expression that promotes fat oxidation, which in turn improves endurance, body composition, and insulin sensitivity. The signals from exercise that initiate these pathways have not been completely characterized. IL-15 is a cytokine that is up-regulated in skeletal muscle after exercise and correlates with ...
Radak Zsolt Z Faculty of Physical Education and Sport Science, Institute of Sport Science, Semmelweis University, Budapest, Hungary. - - 2013
The complexity of human DNA has been affected by aerobic metabolism, including endurance exercise and oxygen toxicity. Aerobic endurance exercise could play an important role in the evolution of Homo sapiens, and oxygen was not important just for survival, but it was crucial to redox-mediated adaptation. The metabolic challenge during ...
Knaub Leslie A LA Division of Endocrinology, Diabetes and Metabolism, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO 80045, - - 2013
Physical activity decreases risk for diabetes and cardiovascular disease morbidity and mortality; however, the specific impact of exercise on the diabetic vasculature is unexamined. We hypothesized that an acute, moderate exercise intervention in diabetic and hypertensive rats would induce mitochondrial biogenesis and mitochondrial antioxidant defence to improve vascular resilience. SHHF/Mcc-fa(cp) ...
Taito Shunsuke - - 2013
Cigarette smoking increases oxidative stress, which is a risk factor for several diseases. Smoking has also been reported to enhance plasma oxidative stress during strenuous exercise. However, no prior study has examined the changes in plasma oxidative stress after single-sprint anaerobic exercise in cigarette smokers. The purpose of this study ...
Conti Valeria - - 2012
PURPOSE: Moderate aerobic exercise reduces oxidative stress, intense physical activity may produce the opposite result. At present, the effects of different exercise loads on oxidative stress markers and the response of human cells to different exercise volumes have not been fully elucidated. METHODS: Human (Eahy-926) endothelial cells (ECs), exposed or ...
Copp Steven W - - 2012
Excess reactive oxygen species are implicated in the impaired peripheral vascular function evident during exercise in older individuals. We tested the hypothesis that an acute infusion of the antioxidant ascorbic acid (AA) in old rats would improve antioxidant capacity and reduce oxidative stress and, therefore, elevate hindlimb muscle blood flow ...
Ranković Goran - - 2012
BACGROUND/AIM: Regular physical activity is widely accepted as factor that reduces all-cause mortality and improves a number of health outcomes. The aim of this study was to investigate the effects of aerobic exercise training on cardiovascular parameters, lipid profile and endothelial function in patients with stable coronary artery disease (CAD). ...
Takahashi Masaki - - 2012
The purpose of this study was to investigate the effects of low-volume exercise training (100 min/week) on oxidative stress and neutrophils activation markers in older adults. Twenty-eight older adults (age range 65-78 years) were assigned into control (n = 14) or exercise (n = 14) groups. The exercise program consisted of walking 30-60 min/session, 2 days each week ...
Sharman James E - - 2012
OBJECTIVE: Exaggerated exercise blood pressure (BP) predicts mortality. Some studies suggest this could be explained by chronic hyperlipidemia, but whether acute-hyperlipidemia effects exercise BP has never been tested, and was the aim of this study. METHODS: Intravenous infusion of saline (control) and Intralipid were administered over 60 min in 15 healthy ...
Kadoglou N P E - - 2012
OBJECTIVE: Adipokines, visfatin, apelin, vaspin and ghrelin have emerged as novel cardiovascular risk factors. We aimed to evaluate the effects of different exercise modalities on the aforementioned novel adipokines and carotid intima-media thickness in patients with Type 2 diabetes mellitus. METHODS: One hundred patients with Type 2 diabetes were equivalently (n = 25) randomized ...
Gholitabar Samira - - 2012
This study evaluates the effect of treadmill exercise and Ferula gummosa (FG) on heat shock protein (HSP72), biomarkers related to vascular function, and oxidant/antioxidant system in the heart tissue of spontaneously hypertensive rats treated with N(ω)-nitro-l-arginine-methyl ester (l-NAME). Fifty adult male Wistar rats are randomly classified into five groups: treadmill ...
Knab Amy M - - 2012
The effects of a flavonoid-rich fresh fruit/vegetable juice (JUICE) on chronic resting and post-exercise inflammation, oxidative stress, immune function, and metabolic profiles (metabolomics analysis, GC-MS platform) in elite sprint and middle-distance swimmers were studied. Utilizing a randomized, crossover design with a 3-wk washout period, swimmers (n = 9) completed 10-d ...
Brinkmann Christian - - 2012
Peroxiredoxins (PRDXs) are multifunctional proteins that have recently received much attention. They are part of the endogenous antioxidative capacity and function as efficient scavengers, especially for hydrogen peroxides. Studies show that physical training can induce an upregulation of PRDX isoform contents in the long term. This might help counteract chronic ...
Silva Isabela M W - - 2012
The aim of the present study was to evaluate the effect of a 12 week program of physical exercise (PE) on butyrylcholinesterase (BChE) in obese adolescents. This study compared obese adolescents (N = 54) before and after PE, regarding the relative intensity (RI) and activity of different molecular forms (G1, ...
Laher Ismail - - 2012
Abstract Moderate exercise improves cardiac antioxidant status in young humans and animals with type 2 diabetes (T2D). Given that both diabetes and advancing age synergistically decrease antioxidant expression in most tissues, it is unclear whether exercise can upregulate cardiac antioxidants in chronic animal models of T2D. To this end, 8-month ...
Wozniak Alina - - 2013
The effect of whole-body cryostimulation (WBC) on the biomarkers of oxidative stress, lysosomal enzymes, creatine kinase and cortisol was studied. The rowers underwent two 6-day training cycles: with pre-training daily WBC (temperature: from -125°C to -150°C) and without cryostimulation (control). Blood samples were taken before and after the third and ...
Kim Hee-jae - - 2013
The synergic effect of regular exercise and resveratrol, a polyphenolic compound with potent antioxidant activity, was investigated against kainate-induced seizures and oxidative stress in mice. After 6 weeks of swimming training, the total body weight decreased and the blood concentration of lactate stabilized statistically in comparison with the sedentary mice, ...
Tuon T - - 2012
The effect of physical training on the neurochemical and oxidative stress markers were evaluated in the striatum of rats with Parkinson's disease (PD). Untrained+sham-operated (USO), untrained+PD (UPD), trained+sham-operated (TSO), and trained+PD (TPD) were submitted to training on the treadmill. The PD was induced and seven days after the lesion, the ...
Phillips Shaun M - - 2012
In the last decade, research has begun to investigate the efficacy of carbohydrate supplementation for improving aspects of physical capacity and skill performance during sport-specific exercise in adolescent team games players. This research remains in its infancy, and further study would be beneficial considering the large youth population actively involved ...
Hussain Sabiha S Department of Pulmonary and Critical Care Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ, USA. - - 2012
To determine whether oxidative/nitrosative stress plays a role in the acute effects of diesel exhaust (DE) on subjects with asthma. In this crossover study, 16 subjects with mild to moderate asthma were exposed to clean filtered air or diluted DE (300 μg/m as PM2.5) for 1 hour with intermittent exercise. ...
Miller Lindsey E - - 2012
Oxidative stress occurs as a result of altitude induced hypobaric hypoxia and physical exercise. The effect of exercise on oxidative stress under hypobaric hypoxia is not well understood. Purpose: To determine the effect of high altitude exercise on blood oxidative stress. Nine male participants completed a 2-day trek up and ...
Barbosa Viviane A - - 2012
BACKGROUND: Acute exercise increases reactive oxygen species (ROS) levels, including hydrogen peroxide (H(2)O(2)). H(2)O(2) promotes endothelial nitric oxide synthase (eNOS) activation and phosphorylation in endothelial cells. With this in mind, the present study was designed to evaluate ex vivo eNOS phosphorylation in rat aortas incubated with H(2)O(2) and to test ...
de Farias J M - - 2012
It is well known that high-fat diets (HFDs) induce obesity and result in an increase in oxidative stress in adipose tissue, which leads to an impairment of fat mobilization by a downregulation of the lipases, such as hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL). On the other hand, exercise ...
Marosi Krisztina - - 2012
Exercise can exert beneficial effects on cognitive functions of older subjects and it can also play an important role in the prevention of neurodegenerative diseases. At the same time it is perceivable that limited information is available on the nature of molecular pathways supporting the antioxidant effects of exercise in ...
Cardoso Andréia Machado - - 2012
The present study investigated the effects of a 6-week swimming training on blood pressure, nitric oxide (NO) levels and oxidative stress parameters such as protein and lipid oxidation, antioxidant enzyme activity and endogenous non-enzymatic antioxidant content in kidney and circulating fluids, as well as on serum biochemical parameters (cholesterol, triglycerides, ...
Witman Melissa A H MA Geriatric Research, Education, and Clinical Center, George E. Whalen Veterans Affairs Medical Center, Salt Lake City, UT 84148, USA. - - 2012
This study sought to characterize the role of free radicals in regulating central and peripheral hemodynamics at rest and during exercise in patients with heart failure (HF). We examined cardiovascular responses to dynamic handgrip exercise (4, 8, and 12 kg at 1 Hz) following consumption of either a placebo or ...
Salimeh Afshin - - 2012
This study was aimed to evaluate the preventive effect of diosgenin and exercise on tissue antioxidant status in isoproterenol-induced myocardial infarction (MI) in male Wistar rats. Levels of lipid peroxides, reduced glutathione (GSH), and the activities of glutathione-dependent antioxidant enzymes (glutathione peroxidise and glutathione reductase) and antiperoxidative enzymes (catalase and ...
O'Connor Patrick J - - 2012
Compounds found in the skins of grapes, including catechins, quercetin and resveratrol have been added to the diet of rodents and improved run time to exhaustion, fitness and skeletal muscle mitochondrial function. It is unknown if such effects occur in humans. The purpose of this experiment was to investigate whether ...
Xu Jiansheng - - 2012
Intense exercise increases oxygen consumption and may produce an imbalance between reactive oxygen species (ROS) and antioxidants, inducing oxidative stress as a result of increased ROS production. Exogenous antioxidants may prevent oxidative damages since they are able to detoxify certain peroxides by scavenging the ROS produced during exercise. The aim ...
Leak Rehana K RK Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA. - - 2012
Ceruloplasmin is a protective ferroxidase. Although some studies suggest that plasma ceruloplasmin levels are raised by exercise, the impact of exercise on brain ceruloplasmin is unknown. We have examined whether striatal ceruloplasmin is raised with treadmill exercise and/or is correlated with spontaneous physical activity in rhesus monkeys. Parkinson's disease is ...
Jacobson Bert H - - 2012
Aging is accompanied by a significant loss of strength which further contributes to loss of functional ability and a propensity for injury. The purpose of this study was to assess the effectiveness of power assisted exercises on muscle endurance and functional capacity of elderly participants following 12 weeks of supervised ...
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