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Martin Daniel S - - 2013
The study of healthy human volunteers ascending to high altitude provides a robust model of the complex physiological interplay that emulates human adaptation to hypoxaemia in clinical conditions. Nitric oxide (NO) metabolism may play an important role in both adaptation to high altitude and response to hypoxaemia during critical illness ...
Dieter Brad P - - 2013
The dicarbonyl methylglyoxal (MGO) is an endogenous metabolite and a known intracellular precursor of advanced glycation endproducts (AGEs). High serum levels of MGO have been correlated with MGO-derived AGEs in individuals with type 2 diabetes (T2DM). Furthermore, there is human and animal evidence to suggest that MGO is causal in ...
Baraas Faisal F Department of Cardiology, Medical Faculty, National Cardiovascular Center Harapan Kita Hospital, University of Indonesia, Jakarta, - - 2013
Moderate-to-high intensity of exercise training within 2 to 3 months decreases oxygen free radicals (reactive oxygen species, ROS) and increases nitric oxide (NO) in outpatients with myocardial infarction. There is no data about the association of ROS and NO after short-term low-intensity exercise training within 5 days in patients hospitalized ...
Ko Il Gyu - - 2013
An overactive bladder (OAB) may be defined as urgency that is a sudden, compelling, difficult to defer desire to pass urine that is usually accompanied by frequency and nocturia and possibly by incontinence. Obesity and old age are two factors in various causes of OAB. Several epidemiologic studies have identified ...
Li Yong-Qiang - - 2013
To investigate the prevalence and distribution of metabolic syndrome (MetS) and the impact of exercise, smoking, and educational level on the risk of MetS in a southern Chinese population. A cross-sectional study was conducted in Zhuhai City, China from June to August 2012. Data on exercise, smoking, and educational level, ...
Jacobs Kevin A KA University of Miami, Miami, FL, USA. - - 2013
To describe and compare substrate oxidation and partitioning during voluntary arm ergometry in individuals with paraplegia and non-disabled individuals over a wide range of exercise intensities. Cross-sectional study. Clinical research facility. Ten apparently healthy, sedentary men with paraplegia and seven healthy, non-disabled subjects. Rest and continuous progressive voluntary arm ergometry ...
Braakhuis Andrea J - - 2013
The beneficial effects of exercise and a healthy diet are well documented in the general population but poorly understood in elite athletes. Previous research in subelite athletes suggests that regular training and an antioxidant-rich diet enhance antioxidant defenses but not performance. Purpose: To investigate whether habitual diet and/or exercise (training ...
Araneda O F - - 2013
It is a well-established fact that exercise increases pro-oxidants and favors oxidative stress; however, this phenomenon has been poorly studied in human lungs. Pro-oxidative generation (H2O2, NO2 (-)), lipid peroxidation markers (MDA), and inflammation (pH) in exhaled breath condensate (EBC) have been determined through data from 10 active subjects who ...
Wright David C DC Department of Human Health and Nutritional Sciences, University of Guelph, Guelph ON N1G 2W1, - - 2014
Owing to its obligatory role in locomotion and the fact that it accounts for the vast majority of whole-body glucose and lipid oxidation, much work has focused on studying the biochemical adaptations that occur in skeletal muscle in response to exercise. However, over the past several years there has been ...
Campos Juliane C - - 2013
Reactive oxygen and nitrogen species regulate a wide array of signaling pathways that governs cardiovascular physiology. However, oxidant stress resulting from disrupted redox signaling has an adverse impact on the pathogenesis and progression of cardiovascular diseases. In this review, we address how redox signaling and oxidant stress affect the pathophysiology ...
Sarga L L Research Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Budapest H-1123, Hungary; Department of Microbiology and Immunology, Sealy Center for Molecular Medicine, University of Texas Medical Branch at Galveston, Galveston, TX 77555, - - 2013
Regular exercise promotes brain function via a wide range of adaptive responses, including the increased expression of antioxidant and oxidative DNA damage-repairing systems. Accumulation of oxidized DNA base lesions and strand breaks is etiologically linked to for example aging processes and age-associated diseases. Here we tested whether exercise training has ...
Fittipaldi Simona - - 2013
Abstract The multiple roles that have been associated with heat shock proteins (HSPs), inside and outside cells are remarkable. HSPs have been found to play a fundamental role in multiple stress conditions and to offer protection from subsequent insults. Exercise, because of the physiological stresses associated with it, is one ...
Finkler Maya - - 2013
Abstract Physical exercise has many benefits, but it might also have a negative impact on the body, depending on the training level, length of workout, gender, age and fitness. The negative effects of physical exercise are commonly attributed to an imbalance between the levels of antioxidants (both low molecular weight ...
Shan Lingling - - 2013
L-arginine (L-Arg) supplementation has been shown to enhance physical exercise capacity and delay onset of fatigue. This work investigated the potential beneficial mechanism(s) of L-Arg supplementation by examining its effect on the cellular oxidative and nitrosative stress pathways in the exercise rats. Forty-eight rats were randomly divided into six groups: ...
Rengo Giuseppe - - 2013
Aging is a well-recognized risk factor for several different forms of cardiovascular disease. However, mechanisms by which aging exerts its negative effect on outcome have been only partially clarified. Numerous evidence indicate that aging is associated with alterations of several mechanisms whose integrity confers protective action on the heart and ...
Lavoy Emily C P - - 2013
This study compared the acute immune response, inflammation, and lipid peroxidation to a 75 km cycling time trial in male athletes testing positive or negative for latent cytomegalovirus (CMV) infection. Trained cyclists (N = 20) were tested for CMV serostatus, and cycled 75 km on a mountainous course using indoor trainers with continuous workload ...
Wawrzyniak Agata - - 2013
We hypothesized that α-tocopherol, ascorbic acid, and β-carotene, either applied individually or in combination, would modulate redox homeostasis and affect the regulation of genes involved in DNA repair under stress conditions. To test this hypothesis, we analyzed the influence of these vitamins, either supplied individually or in combination, on the ...
Powers Scott K - - 2013
Abstract Endurance exercise training is known to promote beneficial adaptations to numerous tissues including the heart. Indeed, endurance exercise training results in a cardioprotective phenotype that resists injury during an ischemia-reperfusion (IR) insult. Because IR-induced cardiac injury is due, in part, to increased production of radicals and other reactive oxygen ...
Mullins Anna L - - 2013
Abstract The oxidative stress response to maximal exercise may provide useful clinical biomarkers for assessing redox homeostasis. The aim was to determine the between-individual variability in the exercise-induced change in oxidative stress measures and investigate predictors of these responses. Plasma F2-isoprostanes (Isop), protein carbonyls (PCs), glutathione peroxidase (GPX) activity and ...
Kaplan Ozgür - - 2013
In this study the antioxidant enzyme [catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) ] levels at rest in patients with syndrome X and coronary slow flow are measured. Then it has been investigated whether there is any enzymatic difference between the normal controls and syndrome X patients or ...
Marin Douglas Popp - - 2013
The chronic exposure to regular exercise training seems to improve antioxidant defense systems. However, the intense physical training imposed on elite athletes may lead to overtraining associated with oxidative stress. The purpose of the present study was to investigate the effect of different training loads and competition on oxidative stress, ...
Botero João P - - 2013
The aim of this study was to compare the effect of a cycling training programme performed at intensity corresponding to the lowest value of the respiratory quotient (RQ) versus at intensity corresponding to the ventilatory threshold (VT), on body composition and health-related parameters in overweight women. Thirty-two sedentary obese women ...
Smith-Ryan Abbie E AE a Applied Physiology Laboratory, Department of Exercise and Sport Science, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, - - 2014
β-Alanine (BA) has been linked with oxidative protection. This study evaluated antioxidant properties of BA. Twenty-five men consumed BA or placebo for 4 weeks, and completed a 40-min run to induce oxidative stress. Blood draws were taken to measure 8-isoprostane, total antioxidant capacity, superoxide dismutase, and glutathione. BA had no ...
Turner James E - - 2013
ABSTRACT Purpose: Peroxiredoxin-2 (PRDX-2) is an antioxidant and chaperone-like protein critical for cell function. This study examined whether the levels of lymphocyte PRDX-2 are altered over one month following ultra-endurance exercise. Methods: Nine middle-aged men undertook a single-stage, multi-day 233 km (145 mile) ultra-endurance running race. Blood was collected immediately ...
Xiong Yanlian - - 2013
The aim of this study is to explore the effect of exhaustive exercise on erythrocyte band 3 (SLC4A1; EB3). The association between the alterations of EB3 and red blood cell (RBC) deformability induced by exercise-induced dysfunction has been investigated. Rats were divided among 2 groups: (i) control (C), and (ii) ...
Morales-Alamo David - - 2013
Abstract Sprint exercise ability has been critical for survival. The remarkably high power output levels achieved during sprint exercise are achieved through strong activation of anaerobic, and to a lesser extent, aerobic energy supplying metabolic reactions, which generate reactive oxygen and nitrogen species (RONS). Sprint exercise may cause oxidative stress ...
Gliemann Lasse L L. Gliemann, Universitetsparken 13, 2nd Floor, 2100 Copenhagen, Denmark. - - 2013
Ageing is thought to be associated with decreased vascular function partly due to oxidative stress. Resveratrol is a polyphenol, which in animal studies has been shown to decrease atherosclerosis, and improve cardiovascular health and physical capacity, in part through its effects on Sirtuin 1 signalling and through an improved antioxidant ...
Radák Zsolt - - 2013
Abstract Reactive oxygen species (ROS) are continuously generated during metabolism. ROS are involved in redox signalling but, in significant concentrations they can greatly elevate oxidative damage leading to neurodegeneration. Because of the enhanced sensitivity of brain to ROS, it is especially important to maintain a normal redox state in brain ...
Lam T - - 2013
Study design:Review article.Objectives:To provide an overview of free radical biology, particularly with respect to muscle physiology, as well as the potential effects of muscle morphological changes, physical capacity and nutritional status on oxidative stress in people with chronic spinal cord injury (SCI). The potential implications of these factors for determining ...
Tung Bui Thanh - - 2013
Aging is a multifactorial process in which oxidative damage plays an important role. Resveratrol (RSV) and exercise delay some of the damages occurring during aging and increase life span and health span. We treated mice at different ages with RSV during 6 months and trained them during the last 6 ...
Tessutti L S - - 2013
The use of potentiometry to measure the plasma antioxidant capacity to contribute to oxidative stress evaluation is presented. In this assay, the plasma (n=60) diluted (0.3 to 1 mL) in phosphate buffer pH 7.4, NaCl 9%, was submitted to the potentiometer. A platinum wire was the working electrode and the ...
Silva Luiz Fernando Almeida LF Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica, Departamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, Rio Grande do Sul, - - 2013
Traumatic brain injury (TBI) is a major cause of acquired epilepsy, and significant resources are required to develop a better understanding of the pathologic mechanism as targets for potential therapies. Thus, we decided to investigate whether physical exercise after fluid percussion injury (FPI) protects from oxidative and neurochemical alterations as ...
Debevec Tadej - - 2013
Both acute hypoxia and physical exercise are known to increase oxidative stress. This randomized prospective trial investigated whether the addition of moderate exercise can alter oxidative stress induced by continuous hypoxic exposure. Fourteen male participants were confined to 10-day continuous normobaric hypoxia (FIO2=0.139±0.003; PIO2=88.2±0.6 mmHg; ∼4000 m simulated altitude) either ...
Knez W L - - 2013
This study examined the influence of training volume on resting and exercise-induced plasma markers of oxidative stress (MDA concentration) and antioxidant status (GPX, CAT & SOD erythrocyte activities). Moderately trained participants (TG) (n=6; 4 males and 2 females; 25±1.8 years) and sedentary control subjects (CG) participated in the 8-week investigation. ...
Xu Zhi-Qiang - - 2013
The present study evaluated the combined treatment effects of aerobic exercise and antioxidative stress on moderate-stage Alzheimer's disease (AD). Ten-month-old APP/PS1 mice were given antioxidative treatment with acetylcysteine, along with aerobic exercise for 6 weeks. Spatial learning and memory were tested using the Morris water maze, and β-amyloid (Aβ) plaque deposits ...
Moon Hyo Youl - - 2013
AbstractPhysical inactivity can lead to obesity and fat accumulation in various tissues. Critical complications of obesity include type II diabetes and nonalcoholic fatty liver disease (NAFLD). Exercise has been reported to have ameliorating effects on obesity and NAFLD. However, the underlying mechanism is not fully understood. We showed that liver ...
Calvert John W JW Department of Surgery, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, Georgia, USA. - - 2013
Exercise promotes cardioprotection in both humans and animals not only by reducing risk factors associated with cardiovascular disease but by reducing myocardial infarction and improving survival following ischemia. This article will define the role that nitric oxide and β-adrenergic receptors play in mediating the cardioprotective effects of exercise in the ...
Rosety-Rodríguez Manuel - - 2013
Recent studies concluded long-term training programs have improved antioxidant system in young and adults diabetic rats. However, to our knowledge, little attention has been paid to elderly individuals. To assess the influence of a shorter training program in reducing oxidative damage in elderly diabetic rats. Twenty-four male homozygous Zucker diabetic ...
Rossman Matthew J MJ Geriatric Research, Education, and Clinical Center, George E Whalen VA Medical Center, Salt Lake City, UT 84148, - - 2013
Oxidative stress may contribute to exercise intolerance in patients with chronic obstructive pulmonary disease (COPD). This study sought to determine the effect of an acute oral antioxidant cocktail (AOC, vitamins C and E, and alpha-lipoic acid) on skeletal muscle function during dynamic quadriceps exercise in COPD. Ten patients with COPD ...
Lee Nam Jin - - 2013
This study was performed to investigate whether IH901, a ginseng intestinal metabolite, administration has the ability to ameliorate exercise-induced oxidative stress and reserving antioxidant defense capability in rat skeletal muscles and lung. Eight adult male SD rats per group were randomly assigned to the resting control (RC), exercise control (EC), ...
Wu A A Department of Integrative Biology and Physiology, University of California at Los Angeles, 621 Charles E. Young Drive, Los Angeles, CA 90095, USA. - - 2013
The abilities of docosahexaenoic acid (DHA) and exercise to counteract cognitive decay after traumatic brain injury (TBI) is getting increasing recognition; however, the possibility that these actions can be complementary remains just as an intriguing possibility. Here we have examined the likelihood that the combination of diet and exercise has ...
Haberkamp Katrin - - 2013
This study was performed to give first insight into the effects of a single bout of exercise under field conditions on serum myeloperoxidase-activity (MPOa) in Standardbreds over a time interval of 48h. Myeloperoxidase is an interesting parameter for the activity of leucocytes. Additionally malondialdehyde (MDA) as a parameter for oxidative ...
Aguer Céline C 2M.-E.H., Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Rd., Ottawa, ON K1H 8M5, Canada. - - 2013
Exercise substantially improves metabolic health, making the elicited mechanisms important targets for novel therapeutic strategies. Uncoupling protein 3 (UCP3) is a mitochondrial inner membrane protein highly selectively expressed in skeletal muscle. Here we report that moderate UCP3 overexpression (roughly 3-fold) in muscles of UCP3 transgenic (UCP3 Tg) mice acts as ...
Ordonez Francisco J - - 2013
To assess the influence of a 12-week arm-cranking exercise program on reducing oxidative damage in untrained adults with chronic spinal cord injury (SCI). Longitudinal study. Community-based supervised intervention. A total of 17 male adults with complete SCI at or below the 5(th) thoracic level (T5) volunteered for this study. Participants ...
Lira Vitor A VA 1University of Virginia School of Medicine, 409 Ln. Rd., MR4-6041A, Charlottesville, VA 22908, USA. - - 2013
Pathological and physiological stimuli, including acute exercise, activate autophagy; however, it is unknown whether exercise training alters basal levels of autophagy and whether autophagy is required for skeletal muscle adaptation to training. We observed greater autophagy flux (i.e., a combination of increased LC3-II/LC3-I ratio and LC3-II levels and reduced p62 ...
McCormack S E - - 2013
What is already known about this subject Obesity-related insulin resistance is highly prevalent in children and adolescents, and contributes to an increased lifetime risk of type 2 diabetes mellitus and cardiovascular disease. Intensive exercise training may improve insulin sensitivity. What this study adds Three monitored exercise training sessions per week ...
Musumeci Giuseppe - - 2013
Physical exercise induces oxidative stress through production of reactive oxygen species and can cause damage to muscle tissue. Oxidative stress, resulting from exhaustive exercise is high and improvement of antioxidant defenses of the body may ameliorate damage caused by free radicals. Extra-virgin olive oil is widely considered to possess anti-oxidative ...
Toborek Michal - - 2013
There is no effective therapeutic intervention developed targeting cerebrovascular toxicity of drugs of abuse, including methamphetamine (METH). We hypothesize that exercise protects against METH-induced disruption of the blood--brain barrier (BBB) by enhancing the antioxidant capacity of cerebral microvessels and modulating caveolae-associated signaling. Mice were subjected to voluntary wheel running for ...
Wang Ya-Ling - - 2013
Chronic kidney disease (CKD) and obesity are important public health concerns. Because obesity may initiate and/or accelerate kidney damage, weight control may benefit CKD patients. We examined the influence of dietary management and physical exercise in 38 obese CKD patients with or without target reduction of body weight 3% or ...
Casuso Rafael A - - 2013
Abstract Quercetin is suggested as a nitric oxide regulator which may in turn influence blood parameters and weight gain. Wistar rats were classified as: quercetin-exercise training, QT; placebo-exercise training, PT; quercetin-sedentary, QS; and placebo sedentary, PS. After 6 weeks of treatment with quercetin and/or exercise, an incremental test was run ...
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